Leucine-rich_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania major

UniProt:

Q4QG11_LEIMA

TriTrypDb:

LmjF.13.1430 , LMJLV39_130018800 , LMJSD75_130018900

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	8

Expansion

Sequence features

Q4QG11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.721
CLV_C14_Caspase3-7	73	77	PF00656	0.574
CLV_NRD_NRD_1	320	322	PF00675	0.830
CLV_NRD_NRD_1	339	341	PF00675	0.591
CLV_NRD_NRD_1	409	411	PF00675	0.621
CLV_NRD_NRD_1	522	524	PF00675	0.578
CLV_NRD_NRD_1	561	563	PF00675	0.694
CLV_NRD_NRD_1	87	89	PF00675	0.691
CLV_PCSK_FUR_1	520	524	PF00082	0.628
CLV_PCSK_KEX2_1	320	322	PF00082	0.727
CLV_PCSK_KEX2_1	339	341	PF00082	0.582
CLV_PCSK_KEX2_1	409	411	PF00082	0.621
CLV_PCSK_KEX2_1	520	522	PF00082	0.566
CLV_PCSK_KEX2_1	561	563	PF00082	0.692
CLV_PCSK_KEX2_1	59	61	PF00082	0.558
CLV_PCSK_KEX2_1	87	89	PF00082	0.685
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.558
CLV_PCSK_SKI1_1	119	123	PF00082	0.785
CLV_PCSK_SKI1_1	162	166	PF00082	0.586
CLV_PCSK_SKI1_1	60	64	PF00082	0.690
DEG_SPOP_SBC_1	48	52	PF00917	0.663
DEG_SPOP_SBC_1	605	609	PF00917	0.777
DOC_CKS1_1	581	586	PF01111	0.697
DOC_PP2B_LxvP_1	366	369	PF13499	0.555
DOC_PP4_FxxP_1	115	118	PF00568	0.774
DOC_USP7_MATH_1	243	247	PF00917	0.480
DOC_USP7_MATH_1	328	332	PF00917	0.728
DOC_USP7_MATH_1	350	354	PF00917	0.672
DOC_USP7_MATH_1	429	433	PF00917	0.832
DOC_USP7_MATH_1	460	464	PF00917	0.774
DOC_USP7_MATH_1	47	51	PF00917	0.664
DOC_USP7_MATH_1	54	58	PF00917	0.609
DOC_USP7_MATH_1	570	574	PF00917	0.764
DOC_USP7_MATH_1	591	595	PF00917	0.611
DOC_USP7_UBL2_3	615	619	PF12436	0.733
DOC_WW_Pin1_4	425	430	PF00397	0.732
DOC_WW_Pin1_4	580	585	PF00397	0.740
LIG_14-3-3_CanoR_1	108	116	PF00244	0.684
LIG_14-3-3_CanoR_1	119	129	PF00244	0.689
LIG_14-3-3_CanoR_1	162	170	PF00244	0.527
LIG_14-3-3_CanoR_1	320	330	PF00244	0.757
LIG_14-3-3_CanoR_1	340	346	PF00244	0.486
LIG_14-3-3_CanoR_1	349	357	PF00244	0.693
LIG_14-3-3_CanoR_1	363	367	PF00244	0.808
LIG_14-3-3_CanoR_1	434	442	PF00244	0.703
LIG_14-3-3_CanoR_1	508	514	PF00244	0.566
LIG_14-3-3_CanoR_1	87	93	PF00244	0.772
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BRCT_BRCA1_1	438	442	PF00533	0.723
LIG_BRCT_BRCA1_1	482	486	PF00533	0.479
LIG_CaM_IQ_9	513	529	PF13499	0.623
LIG_Clathr_ClatBox_1	539	543	PF01394	0.602
LIG_FHA_1	130	136	PF00498	0.545
LIG_FHA_1	152	158	PF00498	0.521
LIG_FHA_1	425	431	PF00498	0.770
LIG_FHA_1	462	468	PF00498	0.628
LIG_FHA_1	485	491	PF00498	0.535
LIG_FHA_1	534	540	PF00498	0.611
LIG_FHA_1	546	552	PF00498	0.407
LIG_FHA_2	308	314	PF00498	0.640
LIG_FHA_2	471	477	PF00498	0.600
LIG_FHA_2	5	11	PF00498	0.558
LIG_Integrin_RGD_1	474	476	PF01839	0.583
LIG_LIR_Gen_1	221	230	PF02991	0.497
LIG_LIR_Nem_3	221	225	PF02991	0.489
LIG_NRP_CendR_1	632	633	PF00754	0.831
LIG_PCNA_PIPBox_1	496	505	PF02747	0.553
LIG_SH2_CRK	14	18	PF00017	0.686
LIG_SH2_CRK	481	485	PF00017	0.576
LIG_SH2_SRC	222	225	PF00017	0.450
LIG_SH2_STAP1	535	539	PF00017	0.557
LIG_SH2_STAT3	277	280	PF00017	0.585
LIG_SH2_STAT5	180	183	PF00017	0.510
LIG_SH2_STAT5	222	225	PF00017	0.450
LIG_SH2_STAT5	277	280	PF00017	0.552
LIG_SH2_STAT5	535	538	PF00017	0.558
LIG_SH3_1	621	627	PF00018	0.767
LIG_SH3_2	627	632	PF14604	0.809
LIG_SH3_3	154	160	PF00018	0.612
LIG_SH3_3	572	578	PF00018	0.815
LIG_SH3_3	610	616	PF00018	0.732
LIG_SH3_3	621	627	PF00018	0.690
LIG_SH3_4	615	622	PF00018	0.663
LIG_SH3_CIN85_PxpxPR_1	627	632	PF14604	0.809
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.531
LIG_SUMO_SIM_anti_2	231	238	PF11976	0.660
LIG_SUMO_SIM_par_1	536	543	PF11976	0.601
LIG_TRAF2_1	7	10	PF00917	0.596
LIG_TYR_ITIM	220	225	PF00017	0.506
LIG_UBA3_1	539	544	PF00899	0.566
LIG_WRC_WIRS_1	27	32	PF05994	0.480
LIG_WW_3	382	386	PF00397	0.699
LIG_WW_3	629	633	PF00397	0.810
MOD_CK1_1	120	126	PF00069	0.719
MOD_CK1_1	246	252	PF00069	0.521
MOD_CK1_1	306	312	PF00069	0.823
MOD_CK1_1	371	377	PF00069	0.744
MOD_CK1_1	432	438	PF00069	0.698
MOD_CK1_1	533	539	PF00069	0.694
MOD_CK1_1	557	563	PF00069	0.682
MOD_CK1_1	603	609	PF00069	0.813
MOD_CK2_1	4	10	PF00069	0.563
MOD_CK2_1	75	81	PF00069	0.807
MOD_Cter_Amidation	57	60	PF01082	0.560
MOD_GlcNHglycan	110	113	PF01048	0.633
MOD_GlcNHglycan	119	122	PF01048	0.688
MOD_GlcNHglycan	124	127	PF01048	0.581
MOD_GlcNHglycan	321	324	PF01048	0.727
MOD_GlcNHglycan	373	376	PF01048	0.828
MOD_GlcNHglycan	378	382	PF01048	0.717
MOD_GlcNHglycan	385	388	PF01048	0.585
MOD_GlcNHglycan	417	420	PF01048	0.673
MOD_GlcNHglycan	438	441	PF01048	0.658
MOD_GlcNHglycan	466	470	PF01048	0.648
MOD_GlcNHglycan	532	535	PF01048	0.656
MOD_GlcNHglycan	54	57	PF01048	0.773
MOD_GlcNHglycan	572	575	PF01048	0.740
MOD_GlcNHglycan	593	596	PF01048	0.724
MOD_GlcNHglycan	97	100	PF01048	0.605
MOD_GSK3_1	120	127	PF00069	0.744
MOD_GSK3_1	246	253	PF00069	0.586
MOD_GSK3_1	303	310	PF00069	0.819
MOD_GSK3_1	411	418	PF00069	0.738
MOD_GSK3_1	421	428	PF00069	0.782
MOD_GSK3_1	429	436	PF00069	0.641
MOD_GSK3_1	446	453	PF00069	0.598
MOD_GSK3_1	461	468	PF00069	0.627
MOD_GSK3_1	48	55	PF00069	0.678
MOD_GSK3_1	480	487	PF00069	0.461
MOD_GSK3_1	529	536	PF00069	0.722
MOD_GSK3_1	600	607	PF00069	0.816
MOD_N-GLC_1	174	179	PF02516	0.450
MOD_N-GLC_1	228	233	PF02516	0.631
MOD_N-GLC_1	250	255	PF02516	0.598
MOD_N-GLC_1	307	312	PF02516	0.589
MOD_N-GLC_1	432	437	PF02516	0.793
MOD_NEK2_1	174	179	PF00069	0.474
MOD_NEK2_1	223	228	PF00069	0.471
MOD_NEK2_1	250	255	PF00069	0.574
MOD_NEK2_1	470	475	PF00069	0.596
MOD_NEK2_1	480	485	PF00069	0.492
MOD_NEK2_1	63	68	PF00069	0.645
MOD_NEK2_2	13	18	PF00069	0.632
MOD_NEK2_2	334	339	PF00069	0.695
MOD_PIKK_1	129	135	PF00454	0.597
MOD_PIKK_1	193	199	PF00454	0.601
MOD_PIKK_1	328	334	PF00454	0.614
MOD_PIKK_1	484	490	PF00454	0.568
MOD_PK_1	622	628	PF00069	0.748
MOD_PK_1	88	94	PF00069	0.671
MOD_PKA_2	319	325	PF00069	0.757
MOD_PKA_2	362	368	PF00069	0.684
MOD_PKA_2	433	439	PF00069	0.735
MOD_PKA_2	554	560	PF00069	0.711
MOD_Plk_1	174	180	PF00069	0.451
MOD_Plk_1	465	471	PF00069	0.678
MOD_Plk_1	504	510	PF00069	0.534
MOD_Plk_2-3	218	224	PF00069	0.523
MOD_Plk_2-3	263	269	PF00069	0.467
MOD_Plk_2-3	307	313	PF00069	0.732
MOD_Plk_4	218	224	PF00069	0.510
MOD_Plk_4	26	32	PF00069	0.477
MOD_Plk_4	368	374	PF00069	0.810
MOD_Plk_4	535	541	PF00069	0.671
MOD_ProDKin_1	425	431	PF00069	0.733
MOD_ProDKin_1	580	586	PF00069	0.741
MOD_SUMO_rev_2	307	317	PF00179	0.590
MOD_SUMO_rev_2	450	457	PF00179	0.828
TRG_DiLeu_BaEn_1	136	141	PF01217	0.653
TRG_DiLeu_BaEn_1	190	195	PF01217	0.527
TRG_DiLeu_BaEn_1	398	403	PF01217	0.616
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.630
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.640
TRG_ENDOCYTIC_2	14	17	PF00928	0.610
TRG_ENDOCYTIC_2	222	225	PF00928	0.450
TRG_ENDOCYTIC_2	481	484	PF00928	0.525
TRG_ER_diArg_1	338	340	PF00400	0.664
TRG_ER_diArg_1	408	410	PF00400	0.655
TRG_ER_diArg_1	520	523	PF00400	0.575
TRG_ER_diArg_1	631	633	PF00400	0.823
TRG_ER_diArg_1	87	89	PF00400	0.685
TRG_NES_CRM1_1	193	207	PF08389	0.601
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.659
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P881	Leptomonas seymouri	41%	100%
A0A3S7WSM9	Leishmania donovani	87%	100%
A4H7C5	Leishmania braziliensis	65%	100%
A4HVS1	Leishmania infantum	88%	100%
D0A6G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9APG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%