EF hand-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EF hand-like protein

Species:

Leishmania major

UniProt:

Q4QG09_LEIMA

TriTrypDb:

LmjF.13.1450 , LMJLV39_130019000 , LMJSD75_130019100

Length:

216

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG09

PDB structure(s): 1y1x_A , 1y1x_B

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0005509	calcium ion binding	5	14
GO:0043167	ion binding	2	14
GO:0043169	cation binding	3	14
GO:0046872	metal ion binding	4	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.327
CLV_NRD_NRD_1	137	139	PF00675	0.423
CLV_NRD_NRD_1	160	162	PF00675	0.325
CLV_PCSK_KEX2_1	137	139	PF00082	0.434
CLV_PCSK_SKI1_1	138	142	PF00082	0.310
CLV_PCSK_SKI1_1	187	191	PF00082	0.452
DOC_MAPK_gen_1	165	173	PF00069	0.302
DOC_MAPK_gen_1	195	203	PF00069	0.518
DOC_USP7_MATH_1	60	64	PF00917	0.351
DOC_USP7_MATH_1	77	81	PF00917	0.407
DOC_USP7_MATH_2	51	57	PF00917	0.514
LIG_14-3-3_CanoR_1	84	88	PF00244	0.251
LIG_BRCT_BRCA1_1	169	173	PF00533	0.314
LIG_BRCT_BRCA1_1	79	83	PF00533	0.228
LIG_Clathr_ClatBox_1	202	206	PF01394	0.337
LIG_CtBP_PxDLS_1	51	55	PF00389	0.396
LIG_EVH1_1	48	52	PF00568	0.408
LIG_FHA_1	88	94	PF00498	0.302
LIG_FHA_2	104	110	PF00498	0.361
LIG_FHA_2	127	133	PF00498	0.225
LIG_Integrin_isoDGR_2	66	68	PF01839	0.228
LIG_LIR_Gen_1	108	117	PF02991	0.404
LIG_LIR_Gen_1	153	163	PF02991	0.302
LIG_LIR_Gen_1	174	184	PF02991	0.302
LIG_LIR_Nem_3	108	113	PF02991	0.310
LIG_LIR_Nem_3	153	159	PF02991	0.339
LIG_LIR_Nem_3	170	176	PF02991	0.218
LIG_LIR_Nem_3	188	193	PF02991	0.422
LIG_LIR_Nem_3	3	8	PF02991	0.639
LIG_PTB_Apo_2	17	24	PF02174	0.777
LIG_PTB_Phospho_1	17	23	PF10480	0.778
LIG_SH2_CRK	43	47	PF00017	0.596
LIG_SH2_CRK	8	12	PF00017	0.515
LIG_SH2_GRB2like	192	195	PF00017	0.311
LIG_SH2_NCK_1	43	47	PF00017	0.593
LIG_SH2_PTP2	176	179	PF00017	0.318
LIG_SH2_SRC	43	46	PF00017	0.666
LIG_SH2_STAT3	23	26	PF00017	0.528
LIG_SH2_STAT5	176	179	PF00017	0.316
LIG_SH3_1	43	49	PF00018	0.598
LIG_SH3_1	8	14	PF00018	0.550
LIG_SH3_3	43	49	PF00018	0.572
LIG_SH3_3	8	14	PF00018	0.507
LIG_TRAF2_1	106	109	PF00917	0.350
LIG_WRC_WIRS_1	205	210	PF05994	0.480
LIG_WW_1	45	48	PF00397	0.466
MOD_CK1_1	86	92	PF00069	0.327
MOD_CK2_1	103	109	PF00069	0.390
MOD_GlcNHglycan	100	104	PF01048	0.427
MOD_GlcNHglycan	128	132	PF01048	0.329
MOD_GlcNHglycan	146	149	PF01048	0.203
MOD_GlcNHglycan	55	58	PF01048	0.452
MOD_GlcNHglycan	79	82	PF01048	0.285
MOD_GSK3_1	204	211	PF00069	0.456
MOD_GSK3_1	27	34	PF00069	0.744
MOD_GSK3_1	83	90	PF00069	0.208
MOD_GSK3_1	99	106	PF00069	0.302
MOD_NEK2_1	144	149	PF00069	0.337
MOD_NEK2_1	208	213	PF00069	0.398
MOD_NEK2_1	83	88	PF00069	0.242
MOD_NEK2_1	99	104	PF00069	0.223
MOD_PK_1	101	107	PF00069	0.200
MOD_PKA_2	144	150	PF00069	0.399
MOD_PKA_2	167	173	PF00069	0.303
MOD_PKA_2	83	89	PF00069	0.290
MOD_Plk_1	152	158	PF00069	0.323
MOD_Plk_1	177	183	PF00069	0.353
MOD_Plk_4	177	183	PF00069	0.369
MOD_Plk_4	204	210	PF00069	0.457
TRG_DiLeu_BaEn_2	177	183	PF01217	0.353
TRG_DiLeu_BaEn_4	108	114	PF01217	0.350
TRG_ENDOCYTIC_2	176	179	PF00928	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P882	Leptomonas seymouri	53%	93%
A0A0N0P8K6	Leptomonas seymouri	54%	94%
A0A0S4JBG2	Bodo saltans	51%	75%
A0A1X0NJH7	Trypanosomatidae	49%	88%
A0A3Q8I9P0	Leishmania donovani	53%	92%
A0A422P491	Trypanosoma rangeli	37%	89%
A4H7C7	Leishmania braziliensis	53%	92%
A4HVS3	Leishmania infantum	53%	92%
E9APG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9APH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	92%
G3V7W1	Rattus norvegicus	29%	100%
O75340	Homo sapiens	29%	100%
P02585	Homo sapiens	28%	100%
P02586	Oryctolagus cuniculus	28%	100%
P02587	Sus scrofa	28%	100%
P02588	Gallus gallus	26%	100%
P02589	Pelophylax lessonae	26%	100%
P05044	Cricetulus griseus	26%	100%
P05434	Chlamydomonas reinhardtii	28%	100%
P10246	Meleagris gallopavo	26%	100%
P12815	Mus musculus	29%	100%
P20801	Mus musculus	28%	100%
P28676	Homo sapiens	25%	100%
P30626	Homo sapiens	26%	100%
P81660	Anguilla anguilla	28%	100%
Q24956	Giardia intestinalis	24%	100%
Q2QY10	Oryza sativa subsp. japonica	28%	74%
Q4QG08	Leishmania major	54%	100%
Q5PQ53	Xenopus laevis	29%	76%
Q5R4U9	Pongo abelii	26%	100%
Q5RAI6	Pongo abelii	25%	99%
Q641Z8	Rattus norvegicus	24%	76%
Q6DC93	Danio rerio	26%	80%
Q6P069	Mus musculus	27%	100%
Q8BFY6	Mus musculus	25%	79%
Q8VC88	Mus musculus	28%	98%
Q94743	Schistosoma japonicum	31%	100%
Q95YL4	Dictyostelium discoideum	29%	100%
Q95YL5	Dictyostelium discoideum	29%	100%
Q9UBV8	Homo sapiens	27%	76%
Q9ZQH1	Arabidopsis thaliana	23%	95%
V5BM44	Trypanosoma cruzi	41%	100%