Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QG05_LEIMA

TriTrypDb:

LmjF.13.1490 , LMJLV39_130019400 , LMJSD75_130019500

Length:

775

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG05

Function

Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006302	double-strand break repair	6	2
GO:0006303	double-strand break repair via nonhomologous end joining	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0031848	protection from non-homologous end joining at telomere	6	2
GO:0032200	telomere organization	6	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0036297	interstrand cross-link repair	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043247	telomere maintenance in response to DNA damage	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051276	chromosome organization	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003684	damaged DNA binding	5	2
GO:0003824	catalytic activity	1	2
GO:0004518	nuclease activity	4	2
GO:0004527	exonuclease activity	5	2
GO:0004529	DNA exonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0005488	binding	1	2
GO:0008409	5'-3' exonuclease activity	6	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0035312	5'-3' DNA exonuclease activity	7	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.487
CLV_C14_Caspase3-7	768	772	PF00656	0.640
CLV_C14_Caspase3-7	95	99	PF00656	0.671
CLV_NRD_NRD_1	223	225	PF00675	0.486
CLV_PCSK_KEX2_1	223	225	PF00082	0.486
CLV_PCSK_KEX2_1	403	405	PF00082	0.682
CLV_PCSK_KEX2_1	705	707	PF00082	0.721
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.650
CLV_PCSK_PC1ET2_1	705	707	PF00082	0.721
CLV_PCSK_SKI1_1	153	157	PF00082	0.481
CLV_PCSK_SKI1_1	283	287	PF00082	0.418
CLV_PCSK_SKI1_1	307	311	PF00082	0.460
CLV_PCSK_SKI1_1	61	65	PF00082	0.420
CLV_PCSK_SKI1_1	738	742	PF00082	0.693
CLV_Separin_Metazoa	412	416	PF03568	0.404
DEG_Nend_UBRbox_1	1	4	PF02207	0.445
DEG_SCF_FBW7_1	251	256	PF00400	0.649
DEG_SPOP_SBC_1	253	257	PF00917	0.678
DEG_SPOP_SBC_1	643	647	PF00917	0.694
DOC_ANK_TNKS_1	671	678	PF00023	0.645
DOC_CKS1_1	126	131	PF01111	0.453
DOC_CYCLIN_RxL_1	58	69	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	481	487	PF00134	0.385
DOC_MAPK_DCC_7	403	413	PF00069	0.645
DOC_MAPK_gen_1	598	606	PF00069	0.571
DOC_MAPK_gen_1	672	680	PF00069	0.546
DOC_MAPK_gen_1	705	711	PF00069	0.594
DOC_MAPK_gen_1	72	80	PF00069	0.376
DOC_MAPK_HePTP_8	500	512	PF00069	0.556
DOC_MAPK_JIP1_4	600	606	PF00069	0.543
DOC_MAPK_MEF2A_6	2	10	PF00069	0.506
DOC_MAPK_MEF2A_6	268	277	PF00069	0.525
DOC_MAPK_MEF2A_6	404	413	PF00069	0.639
DOC_MAPK_MEF2A_6	503	512	PF00069	0.558
DOC_MAPK_MEF2A_6	705	713	PF00069	0.594
DOC_MAPK_MEF2A_6	72	80	PF00069	0.438
DOC_MAPK_MEF2A_6	748	755	PF00069	0.620
DOC_PP2B_LxvP_1	508	511	PF13499	0.576
DOC_PP2B_LxvP_1	604	607	PF13499	0.521
DOC_PP2B_LxvP_1	76	79	PF13499	0.479
DOC_PP2B_PxIxI_1	408	414	PF00149	0.531
DOC_PP4_FxxP_1	116	119	PF00568	0.358
DOC_PP4_FxxP_1	638	641	PF00568	0.731
DOC_USP7_MATH_1	147	151	PF00917	0.440
DOC_USP7_MATH_1	253	257	PF00917	0.719
DOC_USP7_MATH_1	398	402	PF00917	0.695
DOC_USP7_MATH_1	455	459	PF00917	0.592
DOC_USP7_MATH_1	605	609	PF00917	0.650
DOC_USP7_MATH_1	615	619	PF00917	0.641
DOC_USP7_MATH_1	655	659	PF00917	0.647
DOC_USP7_MATH_1	92	96	PF00917	0.631
DOC_WW_Pin1_4	125	130	PF00397	0.441
DOC_WW_Pin1_4	184	189	PF00397	0.726
DOC_WW_Pin1_4	249	254	PF00397	0.696
DOC_WW_Pin1_4	387	392	PF00397	0.690
DOC_WW_Pin1_4	432	437	PF00397	0.600
DOC_WW_Pin1_4	468	473	PF00397	0.430
DOC_WW_Pin1_4	485	490	PF00397	0.399
DOC_WW_Pin1_4	639	644	PF00397	0.651
DOC_WW_Pin1_4	81	86	PF00397	0.331
LIG_14-3-3_CanoR_1	307	312	PF00244	0.414
LIG_14-3-3_CanoR_1	447	455	PF00244	0.615
LIG_14-3-3_CanoR_1	483	488	PF00244	0.392
LIG_14-3-3_CanoR_1	679	684	PF00244	0.667
LIG_14-3-3_CanoR_1	688	696	PF00244	0.584
LIG_14-3-3_CanoR_1	725	733	PF00244	0.721
LIG_Actin_WH2_2	666	681	PF00022	0.553
LIG_BRCT_BRCA1_1	28	32	PF00533	0.354
LIG_BRCT_BRCA1_1	635	639	PF00533	0.633
LIG_eIF4E_1	545	551	PF01652	0.469
LIG_EVH1_2	593	597	PF00568	0.545
LIG_FHA_1	294	300	PF00498	0.497
LIG_FHA_1	48	54	PF00498	0.447
LIG_FHA_1	564	570	PF00498	0.593
LIG_FHA_1	58	64	PF00498	0.319
LIG_FHA_1	628	634	PF00498	0.658
LIG_FHA_1	644	650	PF00498	0.703
LIG_FHA_1	758	764	PF00498	0.713
LIG_FHA_1	82	88	PF00498	0.394
LIG_FHA_2	308	314	PF00498	0.448
LIG_FHA_2	469	475	PF00498	0.489
LIG_FHA_2	729	735	PF00498	0.562
LIG_HCF-1_HBM_1	162	165	PF13415	0.357
LIG_KLC1_Yacidic_2	162	167	PF13176	0.356
LIG_LIR_Apic_2	636	641	PF02991	0.631
LIG_LIR_Gen_1	167	178	PF02991	0.445
LIG_LIR_Gen_1	302	312	PF02991	0.411
LIG_LIR_Gen_1	477	485	PF02991	0.430
LIG_LIR_Nem_3	11	16	PF02991	0.445
LIG_LIR_Nem_3	167	173	PF02991	0.394
LIG_LIR_Nem_3	180	184	PF02991	0.583
LIG_LIR_Nem_3	302	308	PF02991	0.417
LIG_LIR_Nem_3	435	441	PF02991	0.450
LIG_LIR_Nem_3	443	448	PF02991	0.517
LIG_LIR_Nem_3	477	481	PF02991	0.434
LIG_LYPXL_SIV_4	544	552	PF13949	0.347
LIG_MLH1_MIPbox_1	635	639	PF16413	0.633
LIG_NRBOX	204	210	PF00104	0.576
LIG_PCNA_PIPBox_1	149	158	PF02747	0.436
LIG_PDZ_Class_2	770	775	PF00595	0.699
LIG_Pex14_2	33	37	PF04695	0.471
LIG_SH2_CRK	305	309	PF00017	0.469
LIG_SH2_CRK	438	442	PF00017	0.446
LIG_SH2_NCK_1	142	146	PF00017	0.359
LIG_SH2_SRC	545	548	PF00017	0.427
LIG_SH2_STAP1	142	146	PF00017	0.492
LIG_SH2_STAP1	305	309	PF00017	0.469
LIG_SH2_STAT3	227	230	PF00017	0.609
LIG_SH2_STAT5	125	128	PF00017	0.413
LIG_SH2_STAT5	134	137	PF00017	0.363
LIG_SH2_STAT5	142	145	PF00017	0.452
LIG_SH2_STAT5	165	168	PF00017	0.360
LIG_SH2_STAT5	276	279	PF00017	0.509
LIG_SH2_STAT5	507	510	PF00017	0.494
LIG_SH2_STAT5	545	548	PF00017	0.522
LIG_SH2_STAT5	549	552	PF00017	0.508
LIG_SH2_STAT5	637	640	PF00017	0.732
LIG_SH2_STAT5	696	699	PF00017	0.644
LIG_SH3_1	541	547	PF00018	0.518
LIG_SH3_3	1	7	PF00018	0.425
LIG_SH3_3	388	394	PF00018	0.684
LIG_SH3_3	541	547	PF00018	0.567
LIG_Sin3_3	548	555	PF02671	0.383
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.434
LIG_SUMO_SIM_par_1	307	313	PF11976	0.525
LIG_SUMO_SIM_par_1	483	488	PF11976	0.421
LIG_SUMO_SIM_par_1	5	12	PF11976	0.493
LIG_SUMO_SIM_par_1	760	768	PF11976	0.618
LIG_TRAF2_1	314	317	PF00917	0.479
LIG_TRAF2_1	341	344	PF00917	0.499
LIG_TRAF2_1	471	474	PF00917	0.487
LIG_TRAF2_1	588	591	PF00917	0.733
LIG_TYR_ITSM	433	440	PF00017	0.581
LIG_WRC_WIRS_1	152	157	PF05994	0.465
LIG_WW_3	592	596	PF00397	0.541
MOD_CK1_1	130	136	PF00069	0.440
MOD_CK1_1	151	157	PF00069	0.328
MOD_CK1_1	244	250	PF00069	0.638
MOD_CK1_1	254	260	PF00069	0.715
MOD_CK1_1	47	53	PF00069	0.469
MOD_CK1_1	642	648	PF00069	0.703
MOD_CK1_1	668	674	PF00069	0.801
MOD_CK1_1	690	696	PF00069	0.577
MOD_CK1_1	757	763	PF00069	0.665
MOD_CK2_1	24	30	PF00069	0.552
MOD_CK2_1	307	313	PF00069	0.452
MOD_CK2_1	338	344	PF00069	0.527
MOD_CK2_1	347	353	PF00069	0.480
MOD_CK2_1	468	474	PF00069	0.458
MOD_CK2_1	492	498	PF00069	0.590
MOD_CK2_1	615	621	PF00069	0.666
MOD_CK2_1	728	734	PF00069	0.560
MOD_CMANNOS	379	382	PF00535	0.487
MOD_Cter_Amidation	221	224	PF01082	0.482
MOD_Cter_Amidation	703	706	PF01082	0.760
MOD_GlcNHglycan	120	123	PF01048	0.410
MOD_GlcNHglycan	129	132	PF01048	0.496
MOD_GlcNHglycan	199	202	PF01048	0.629
MOD_GlcNHglycan	22	25	PF01048	0.620
MOD_GlcNHglycan	258	261	PF01048	0.742
MOD_GlcNHglycan	26	29	PF01048	0.579
MOD_GlcNHglycan	340	343	PF01048	0.595
MOD_GlcNHglycan	349	352	PF01048	0.468
MOD_GlcNHglycan	428	431	PF01048	0.623
MOD_GlcNHglycan	442	445	PF01048	0.413
MOD_GlcNHglycan	457	460	PF01048	0.592
MOD_GlcNHglycan	46	49	PF01048	0.258
MOD_GlcNHglycan	561	564	PF01048	0.736
MOD_GlcNHglycan	617	620	PF01048	0.668
MOD_GlcNHglycan	656	660	PF01048	0.827
MOD_GlcNHglycan	701	704	PF01048	0.738
MOD_GlcNHglycan	734	737	PF01048	0.790
MOD_GlcNHglycan	757	760	PF01048	0.693
MOD_GlcNHglycan	87	90	PF01048	0.519
MOD_GSK3_1	130	137	PF00069	0.444
MOD_GSK3_1	147	154	PF00069	0.545
MOD_GSK3_1	16	23	PF00069	0.653
MOD_GSK3_1	173	180	PF00069	0.448
MOD_GSK3_1	237	244	PF00069	0.511
MOD_GSK3_1	249	256	PF00069	0.729
MOD_GSK3_1	258	265	PF00069	0.615
MOD_GSK3_1	32	39	PF00069	0.286
MOD_GSK3_1	398	405	PF00069	0.747
MOD_GSK3_1	43	50	PF00069	0.413
MOD_GSK3_1	463	470	PF00069	0.460
MOD_GSK3_1	520	527	PF00069	0.693
MOD_GSK3_1	53	60	PF00069	0.413
MOD_GSK3_1	555	562	PF00069	0.621
MOD_GSK3_1	627	634	PF00069	0.662
MOD_GSK3_1	639	646	PF00069	0.690
MOD_GSK3_1	655	662	PF00069	0.574
MOD_GSK3_1	664	671	PF00069	0.755
MOD_GSK3_1	679	686	PF00069	0.656
MOD_GSK3_1	692	699	PF00069	0.611
MOD_GSK3_1	728	735	PF00069	0.600
MOD_GSK3_1	753	760	PF00069	0.671
MOD_GSK3_1	81	88	PF00069	0.420
MOD_GSK3_1	92	99	PF00069	0.592
MOD_LATS_1	41	47	PF00433	0.514
MOD_N-GLC_1	244	249	PF02516	0.754
MOD_NEK2_1	155	160	PF00069	0.461
MOD_NEK2_1	16	21	PF00069	0.520
MOD_NEK2_1	166	171	PF00069	0.226
MOD_NEK2_1	32	37	PF00069	0.414
MOD_NEK2_1	53	58	PF00069	0.389
MOD_NEK2_1	550	555	PF00069	0.443
MOD_NEK2_1	564	569	PF00069	0.505
MOD_NEK2_1	678	683	PF00069	0.699
MOD_NEK2_1	692	697	PF00069	0.559
MOD_NEK2_1	754	759	PF00069	0.700
MOD_NEK2_2	398	403	PF00069	0.663
MOD_PIKK_1	237	243	PF00454	0.602
MOD_PIKK_1	365	371	PF00454	0.557
MOD_PIKK_1	447	453	PF00454	0.671
MOD_PIKK_1	550	556	PF00454	0.589
MOD_PIKK_1	690	696	PF00454	0.694
MOD_PK_1	483	489	PF00069	0.361
MOD_PKA_2	347	353	PF00069	0.491
MOD_PKA_2	416	422	PF00069	0.651
MOD_PKA_2	492	498	PF00069	0.542
MOD_PKA_2	678	684	PF00069	0.667
MOD_PKA_2	687	693	PF00069	0.559
MOD_Plk_1	166	172	PF00069	0.394
MOD_Plk_1	398	404	PF00069	0.725
MOD_Plk_1	665	671	PF00069	0.663
MOD_Plk_4	108	114	PF00069	0.383
MOD_Plk_4	130	136	PF00069	0.411
MOD_Plk_4	166	172	PF00069	0.384
MOD_Plk_4	307	313	PF00069	0.525
MOD_Plk_4	565	571	PF00069	0.634
MOD_Plk_4	633	639	PF00069	0.763
MOD_Plk_4	679	685	PF00069	0.723
MOD_Plk_4	692	698	PF00069	0.530
MOD_Plk_4	714	720	PF00069	0.565
MOD_ProDKin_1	125	131	PF00069	0.446
MOD_ProDKin_1	184	190	PF00069	0.726
MOD_ProDKin_1	249	255	PF00069	0.693
MOD_ProDKin_1	387	393	PF00069	0.694
MOD_ProDKin_1	432	438	PF00069	0.594
MOD_ProDKin_1	468	474	PF00069	0.429
MOD_ProDKin_1	485	491	PF00069	0.409
MOD_ProDKin_1	639	645	PF00069	0.652
MOD_ProDKin_1	81	87	PF00069	0.329
MOD_SUMO_rev_2	587	594	PF00179	0.755
TRG_DiLeu_BaEn_2	473	479	PF01217	0.519
TRG_DiLeu_BaEn_4	317	323	PF01217	0.507
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.466
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.569
TRG_ENDOCYTIC_2	305	308	PF00928	0.406
TRG_ENDOCYTIC_2	437	440	PF00928	0.447
TRG_ENDOCYTIC_2	507	510	PF00928	0.551
TRG_ENDOCYTIC_2	549	552	PF00928	0.403
TRG_ER_diArg_1	223	225	PF00400	0.486
TRG_ER_diArg_1	294	297	PF00400	0.504
TRG_ER_diArg_1	414	417	PF00400	0.421
TRG_ER_diArg_1	597	600	PF00400	0.713
TRG_ER_diArg_1	71	74	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAX7	Leptomonas seymouri	47%	100%
A0A3S5H6Q1	Leishmania donovani	89%	100%
A0A422P493	Trypanosoma rangeli	37%	100%
A4H7D0	Leishmania braziliensis	73%	96%
A4HVS7	Leishmania infantum	89%	100%
E9APH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%