AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATPase family associated with various cellular activities (AAA), putative

Species:

Leishmania major

UniProt:

Q4QG02_LEIMA

TriTrypDb:

LmjF.13.1520 , LMJLV39_130019900 , LMJSD75_130019900

Length:

945

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QG02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG02

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	493	497	PF00656	0.445
CLV_C14_Caspase3-7	79	83	PF00656	0.386
CLV_NRD_NRD_1	131	133	PF00675	0.367
CLV_NRD_NRD_1	302	304	PF00675	0.417
CLV_NRD_NRD_1	427	429	PF00675	0.596
CLV_NRD_NRD_1	432	434	PF00675	0.569
CLV_NRD_NRD_1	491	493	PF00675	0.535
CLV_NRD_NRD_1	532	534	PF00675	0.576
CLV_NRD_NRD_1	537	539	PF00675	0.589
CLV_NRD_NRD_1	73	75	PF00675	0.436
CLV_NRD_NRD_1	927	929	PF00675	0.356
CLV_PCSK_KEX2_1	131	133	PF00082	0.363
CLV_PCSK_KEX2_1	266	268	PF00082	0.470
CLV_PCSK_KEX2_1	432	434	PF00082	0.605
CLV_PCSK_KEX2_1	491	493	PF00082	0.465
CLV_PCSK_KEX2_1	532	534	PF00082	0.622
CLV_PCSK_KEX2_1	614	616	PF00082	0.458
CLV_PCSK_KEX2_1	73	75	PF00082	0.409
CLV_PCSK_KEX2_1	757	759	PF00082	0.270
CLV_PCSK_KEX2_1	927	929	PF00082	0.356
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.470
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.630
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.445
CLV_PCSK_PC1ET2_1	757	759	PF00082	0.257
CLV_PCSK_PC7_1	428	434	PF00082	0.646
CLV_PCSK_SKI1_1	132	136	PF00082	0.494
CLV_PCSK_SKI1_1	257	261	PF00082	0.426
CLV_PCSK_SKI1_1	266	270	PF00082	0.476
CLV_PCSK_SKI1_1	323	327	PF00082	0.463
CLV_PCSK_SKI1_1	499	503	PF00082	0.398
CLV_PCSK_SKI1_1	541	545	PF00082	0.704
CLV_PCSK_SKI1_1	614	618	PF00082	0.522
CLV_PCSK_SKI1_1	694	698	PF00082	0.297
CLV_PCSK_SKI1_1	770	774	PF00082	0.237
CLV_PCSK_SKI1_1	78	82	PF00082	0.321
CLV_PCSK_SKI1_1	824	828	PF00082	0.372
DEG_APCC_DBOX_1	498	506	PF00400	0.371
DEG_ODPH_VHL_1	197	208	PF01847	0.335
DOC_ANK_TNKS_1	491	498	PF00023	0.367
DOC_CYCLIN_RxL_1	204	213	PF00134	0.522
DOC_CYCLIN_yClb5_NLxxxL_5	515	524	PF00134	0.412
DOC_MAPK_DCC_7	572	582	PF00069	0.497
DOC_MAPK_gen_1	216	226	PF00069	0.444
DOC_MAPK_gen_1	248	255	PF00069	0.335
DOC_MAPK_gen_1	353	361	PF00069	0.505
DOC_MAPK_gen_1	53	63	PF00069	0.500
DOC_MAPK_gen_1	735	744	PF00069	0.308
DOC_MAPK_MEF2A_6	219	228	PF00069	0.485
DOC_MAPK_NFAT4_5	221	229	PF00069	0.522
DOC_MAPK_RevD_3	253	267	PF00069	0.292
DOC_PP2B_LxvP_1	119	122	PF13499	0.354
DOC_PP2B_LxvP_1	573	576	PF13499	0.357
DOC_PP2B_LxvP_1	816	819	PF13499	0.426
DOC_PP4_FxxP_1	585	588	PF00568	0.491
DOC_USP7_MATH_1	164	168	PF00917	0.574
DOC_USP7_MATH_1	286	290	PF00917	0.506
DOC_USP7_MATH_1	383	387	PF00917	0.717
DOC_USP7_MATH_1	389	393	PF00917	0.701
DOC_USP7_MATH_1	427	431	PF00917	0.754
DOC_USP7_MATH_1	439	443	PF00917	0.449
DOC_USP7_MATH_1	668	672	PF00917	0.312
DOC_USP7_MATH_1	702	706	PF00917	0.371
DOC_USP7_MATH_1	843	847	PF00917	0.455
DOC_USP7_MATH_1	848	852	PF00917	0.409
DOC_USP7_UBL2_3	528	532	PF12436	0.499
DOC_USP7_UBL2_3	544	548	PF12436	0.515
DOC_USP7_UBL2_3	607	611	PF12436	0.472
DOC_USP7_UBL2_3	721	725	PF12436	0.375
DOC_USP7_UBL2_3	757	761	PF12436	0.252
DOC_USP7_UBL2_3	770	774	PF12436	0.260
DOC_USP7_UBL2_3	829	833	PF12436	0.356
DOC_WW_Pin1_4	112	117	PF00397	0.449
DOC_WW_Pin1_4	710	715	PF00397	0.260
LIG_14-3-3_CanoR_1	323	331	PF00244	0.490
LIG_14-3-3_CanoR_1	428	432	PF00244	0.729
LIG_14-3-3_CanoR_1	462	467	PF00244	0.404
LIG_14-3-3_CanoR_1	581	586	PF00244	0.424
LIG_14-3-3_CanoR_1	601	606	PF00244	0.329
LIG_14-3-3_CanoR_1	658	668	PF00244	0.361
LIG_14-3-3_CanoR_1	857	862	PF00244	0.425
LIG_BIR_II_1	1	5	PF00653	0.409
LIG_CaM_IQ_9	206	222	PF13499	0.414
LIG_CaM_IQ_9	599	614	PF13499	0.494
LIG_Clathr_ClatBox_1	512	516	PF01394	0.365
LIG_deltaCOP1_diTrp_1	610	620	PF00928	0.448
LIG_EVH1_1	179	183	PF00568	0.666
LIG_EVH1_2	448	452	PF00568	0.521
LIG_FHA_1	123	129	PF00498	0.455
LIG_FHA_1	174	180	PF00498	0.645
LIG_FHA_1	282	288	PF00498	0.492
LIG_FHA_1	331	337	PF00498	0.582
LIG_FHA_1	367	373	PF00498	0.596
LIG_FHA_1	600	606	PF00498	0.650
LIG_FHA_1	680	686	PF00498	0.326
LIG_FHA_1	718	724	PF00498	0.257
LIG_FHA_1	784	790	PF00498	0.242
LIG_FHA_1	801	807	PF00498	0.242
LIG_FHA_1	874	880	PF00498	0.383
LIG_FHA_1	902	908	PF00498	0.453
LIG_FHA_2	106	112	PF00498	0.449
LIG_FHA_2	150	156	PF00498	0.373
LIG_FHA_2	182	188	PF00498	0.602
LIG_FHA_2	244	250	PF00498	0.469
LIG_FHA_2	472	478	PF00498	0.525
LIG_FHA_2	553	559	PF00498	0.597
LIG_FHA_2	565	571	PF00498	0.460
LIG_FHA_2	77	83	PF00498	0.328
LIG_FHA_2	792	798	PF00498	0.327
LIG_Integrin_RGD_1	74	76	PF01839	0.392
LIG_LIR_Apic_2	583	588	PF02991	0.499
LIG_LIR_Gen_1	101	109	PF02991	0.357
LIG_LIR_Gen_1	460	471	PF02991	0.432
LIG_LIR_Gen_1	662	669	PF02991	0.302
LIG_LIR_LC3C_4	787	792	PF02991	0.308
LIG_LIR_Nem_3	101	105	PF02991	0.350
LIG_LIR_Nem_3	460	466	PF02991	0.398
LIG_LIR_Nem_3	49	54	PF02991	0.282
LIG_LIR_Nem_3	610	616	PF02991	0.531
LIG_LIR_Nem_3	636	642	PF02991	0.368
LIG_LIR_Nem_3	662	667	PF02991	0.302
LIG_NRP_CendR_1	943	945	PF00754	0.612
LIG_Pex14_1	467	471	PF04695	0.401
LIG_Pex14_1	47	51	PF04695	0.294
LIG_SH2_CRK	10	14	PF00017	0.455
LIG_SH2_CRK	664	668	PF00017	0.276
LIG_SH2_CRK	687	691	PF00017	0.314
LIG_SH2_GRB2like	563	566	PF00017	0.457
LIG_SH2_GRB2like	569	572	PF00017	0.401
LIG_SH2_NCK_1	699	703	PF00017	0.308
LIG_SH2_PTP2	102	105	PF00017	0.493
LIG_SH2_PTP2	54	57	PF00017	0.406
LIG_SH2_SRC	485	488	PF00017	0.493
LIG_SH2_SRC	699	702	PF00017	0.308
LIG_SH2_STAP1	43	47	PF00017	0.330
LIG_SH2_STAP1	485	489	PF00017	0.443
LIG_SH2_STAP1	569	573	PF00017	0.482
LIG_SH2_STAP1	732	736	PF00017	0.375
LIG_SH2_STAT3	262	265	PF00017	0.443
LIG_SH2_STAT3	42	45	PF00017	0.442
LIG_SH2_STAT3	6	9	PF00017	0.395
LIG_SH2_STAT3	642	645	PF00017	0.361
LIG_SH2_STAT5	102	105	PF00017	0.493
LIG_SH2_STAT5	126	129	PF00017	0.339
LIG_SH2_STAT5	141	144	PF00017	0.337
LIG_SH2_STAT5	26	29	PF00017	0.557
LIG_SH2_STAT5	262	265	PF00017	0.394
LIG_SH2_STAT5	51	54	PF00017	0.280
LIG_SH2_STAT5	563	566	PF00017	0.392
LIG_SH2_STAT5	642	645	PF00017	0.374
LIG_SH2_STAT5	732	735	PF00017	0.275
LIG_SH2_STAT5	743	746	PF00017	0.203
LIG_SH3_1	177	183	PF00018	0.661
LIG_SH3_3	118	124	PF00018	0.357
LIG_SH3_3	177	183	PF00018	0.627
LIG_SH3_3	27	33	PF00018	0.296
LIG_SH3_3	428	434	PF00018	0.597
LIG_SH3_3	492	498	PF00018	0.367
LIG_SUMO_SIM_anti_2	333	340	PF11976	0.439
LIG_SUMO_SIM_anti_2	369	374	PF11976	0.536
LIG_SUMO_SIM_anti_2	786	795	PF11976	0.244
LIG_SUMO_SIM_par_1	786	795	PF11976	0.288
LIG_TRAF2_1	108	111	PF00917	0.474
LIG_TRAF2_1	201	204	PF00917	0.526
LIG_TRAF2_1	893	896	PF00917	0.440
LIG_TRFH_1	710	714	PF08558	0.285
LIG_TYR_ITIM	52	57	PF00017	0.415
LIG_WRC_WIRS_1	582	587	PF05994	0.486
LIG_WRC_WIRS_1	828	833	PF05994	0.387
LIG_WW_2	121	124	PF00397	0.471
MOD_CK1_1	2	8	PF00069	0.359
MOD_CK1_1	405	411	PF00069	0.700
MOD_CK1_1	457	463	PF00069	0.340
MOD_CK1_1	692	698	PF00069	0.268
MOD_CK1_1	860	866	PF00069	0.502
MOD_CK2_1	105	111	PF00069	0.472
MOD_CK2_1	149	155	PF00069	0.476
MOD_CK2_1	181	187	PF00069	0.594
MOD_CK2_1	198	204	PF00069	0.517
MOD_CK2_1	389	395	PF00069	0.692
MOD_CK2_1	471	477	PF00069	0.511
MOD_CK2_1	552	558	PF00069	0.585
MOD_CK2_1	564	570	PF00069	0.419
MOD_CK2_1	650	656	PF00069	0.448
MOD_CK2_1	791	797	PF00069	0.327
MOD_CK2_1	843	849	PF00069	0.449
MOD_CK2_1	935	941	PF00069	0.546
MOD_Cter_Amidation	530	533	PF01082	0.512
MOD_Cter_Amidation	536	539	PF01082	0.549
MOD_Cter_Amidation	755	758	PF01082	0.315
MOD_Cter_Amidation	768	771	PF01082	0.175
MOD_GlcNHglycan	166	169	PF01048	0.539
MOD_GlcNHglycan	27	30	PF01048	0.437
MOD_GlcNHglycan	381	384	PF01048	0.682
MOD_GlcNHglycan	390	394	PF01048	0.568
MOD_GlcNHglycan	441	444	PF01048	0.683
MOD_GlcNHglycan	456	459	PF01048	0.369
MOD_GlcNHglycan	591	594	PF01048	0.519
MOD_GlcNHglycan	651	655	PF01048	0.422
MOD_GlcNHglycan	691	694	PF01048	0.270
MOD_GlcNHglycan	704	707	PF01048	0.223
MOD_GlcNHglycan	794	797	PF01048	0.237
MOD_GlcNHglycan	845	848	PF01048	0.518
MOD_GlcNHglycan	866	869	PF01048	0.321
MOD_GSK3_1	237	244	PF00069	0.612
MOD_GSK3_1	379	386	PF00069	0.648
MOD_GSK3_1	391	398	PF00069	0.563
MOD_GSK3_1	399	406	PF00069	0.478
MOD_GSK3_1	559	566	PF00069	0.397
MOD_GSK3_1	76	83	PF00069	0.334
MOD_GSK3_1	779	786	PF00069	0.320
MOD_GSK3_1	835	842	PF00069	0.499
MOD_GSK3_1	860	867	PF00069	0.318
MOD_GSK3_1	873	880	PF00069	0.333
MOD_N-GLC_1	399	404	PF02516	0.722
MOD_N-GLC_1	564	569	PF02516	0.482
MOD_N-GLC_1	702	707	PF02516	0.242
MOD_N-GLC_1	710	715	PF02516	0.242
MOD_NEK2_1	279	284	PF00069	0.478
MOD_NEK2_1	373	378	PF00069	0.576
MOD_NEK2_1	399	404	PF00069	0.667
MOD_NEK2_1	471	476	PF00069	0.475
MOD_NEK2_1	564	569	PF00069	0.353
MOD_NEK2_1	589	594	PF00069	0.549
MOD_NEK2_1	599	604	PF00069	0.485
MOD_NEK2_1	717	722	PF00069	0.397
MOD_NEK2_1	80	85	PF00069	0.326
MOD_NEK2_1	827	832	PF00069	0.410
MOD_NEK2_1	901	906	PF00069	0.561
MOD_NEK2_1	918	923	PF00069	0.344
MOD_NEK2_2	427	432	PF00069	0.797
MOD_NEK2_2	46	51	PF00069	0.306
MOD_PIKK_1	324	330	PF00454	0.494
MOD_PIKK_1	599	605	PF00454	0.538
MOD_PIKK_1	668	674	PF00454	0.307
MOD_PIKK_1	873	879	PF00454	0.510
MOD_PK_1	737	743	PF00069	0.308
MOD_PKA_2	374	380	PF00069	0.633
MOD_PKA_2	410	416	PF00069	0.568
MOD_PKA_2	427	433	PF00069	0.667
MOD_PKA_2	580	586	PF00069	0.422
MOD_Plk_1	105	111	PF00069	0.512
MOD_Plk_1	564	570	PF00069	0.485
MOD_Plk_1	848	854	PF00069	0.541
MOD_Plk_2-3	76	82	PF00069	0.320
MOD_Plk_4	122	128	PF00069	0.438
MOD_Plk_4	166	172	PF00069	0.428
MOD_Plk_4	368	374	PF00069	0.590
MOD_Plk_4	447	453	PF00069	0.395
MOD_Plk_4	46	52	PF00069	0.284
MOD_Plk_4	462	468	PF00069	0.347
MOD_Plk_4	559	565	PF00069	0.373
MOD_Plk_4	581	587	PF00069	0.480
MOD_Plk_4	644	650	PF00069	0.435
MOD_Plk_4	692	698	PF00069	0.297
MOD_Plk_4	737	743	PF00069	0.251
MOD_Plk_4	827	833	PF00069	0.356
MOD_Plk_4	857	863	PF00069	0.386
MOD_ProDKin_1	112	118	PF00069	0.448
MOD_ProDKin_1	710	716	PF00069	0.260
MOD_SUMO_for_1	772	775	PF00179	0.242
MOD_SUMO_rev_2	106	115	PF00179	0.350
MOD_SUMO_rev_2	297	305	PF00179	0.407
MOD_SUMO_rev_2	933	938	PF00179	0.583
TRG_DiLeu_BaEn_3	203	209	PF01217	0.514
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.526
TRG_ENDOCYTIC_2	10	13	PF00928	0.459
TRG_ENDOCYTIC_2	102	105	PF00928	0.490
TRG_ENDOCYTIC_2	347	350	PF00928	0.422
TRG_ENDOCYTIC_2	463	466	PF00928	0.310
TRG_ENDOCYTIC_2	54	57	PF00928	0.349
TRG_ENDOCYTIC_2	664	667	PF00928	0.275
TRG_ENDOCYTIC_2	915	918	PF00928	0.381
TRG_ER_diArg_1	306	309	PF00400	0.411
TRG_ER_diArg_1	431	433	PF00400	0.666
TRG_ER_diArg_1	473	476	PF00400	0.601
TRG_ER_diArg_1	490	492	PF00400	0.447
TRG_ER_diArg_1	926	928	PF00400	0.344
TRG_NES_CRM1_1	503	516	PF08389	0.378
TRG_NLS_Bipartite_1	532	551	PF00514	0.606
TRG_NLS_Bipartite_1	757	774	PF00514	0.258
TRG_NLS_MonoCore_2	531	536	PF00514	0.553
TRG_NLS_MonoCore_2	546	551	PF00514	0.518
TRG_NLS_MonoExtC_3	537	542	PF00514	0.557
TRG_NLS_MonoExtC_3	756	761	PF00514	0.249
TRG_NLS_MonoExtC_3	769	774	PF00514	0.320
TRG_NLS_MonoExtN_4	532	537	PF00514	0.572
TRG_NLS_MonoExtN_4	538	545	PF00514	0.599
TRG_NLS_MonoExtN_4	754	761	PF00514	0.239
TRG_NLS_MonoExtN_4	768	774	PF00514	0.275
TRG_Pf-PMV_PEXEL_1	323	328	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	492	496	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	598	603	PF00026	0.597
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P878	Leptomonas seymouri	62%	96%
A0A1X0NLC0	Trypanosomatidae	43%	100%
A0A3S7WSN9	Leishmania donovani	94%	100%
A0A422P4A2	Trypanosoma rangeli	46%	100%
A4HVT1	Leishmania infantum	94%	100%
D0A6G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9APH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q9CUL5	Mus musculus	24%	100%
V5B216	Trypanosoma cruzi	44%	78%