Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QG00_LEIMA

TriTrypDb:

LmjF.13.1540 , LMJLV39_130020100 , LMJSD75_130020100

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QG00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.518
CLV_C14_Caspase3-7	380	384	PF00656	0.600
CLV_NRD_NRD_1	346	348	PF00675	0.727
CLV_NRD_NRD_1	357	359	PF00675	0.579
CLV_NRD_NRD_1	368	370	PF00675	0.576
CLV_PCSK_FUR_1	355	359	PF00082	0.513
CLV_PCSK_KEX2_1	346	348	PF00082	0.727
CLV_PCSK_KEX2_1	357	359	PF00082	0.579
CLV_PCSK_KEX2_1	368	370	PF00082	0.565
CLV_PCSK_SKI1_1	257	261	PF00082	0.472
DEG_APCC_DBOX_1	236	244	PF00400	0.412
DEG_APCC_DBOX_1	385	393	PF00400	0.618
DEG_Nend_UBRbox_1	1	4	PF02207	0.621
DEG_ODPH_VHL_1	112	125	PF01847	0.534
DOC_CKS1_1	394	399	PF01111	0.620
DOC_CYCLIN_yCln2_LP_2	175	181	PF00134	0.612
DOC_PP2B_LxvP_1	112	115	PF13499	0.572
DOC_PP2B_LxvP_1	175	178	PF13499	0.628
DOC_PP2B_LxvP_1	414	417	PF13499	0.544
DOC_PP2B_LxvP_1	467	470	PF13499	0.502
DOC_PP4_FxxP_1	170	173	PF00568	0.620
DOC_PP4_FxxP_1	8	11	PF00568	0.496
DOC_USP7_MATH_1	239	243	PF00917	0.418
DOC_USP7_MATH_1	281	285	PF00917	0.415
DOC_USP7_MATH_1	381	385	PF00917	0.705
DOC_WW_Pin1_4	125	130	PF00397	0.656
DOC_WW_Pin1_4	135	140	PF00397	0.747
DOC_WW_Pin1_4	164	169	PF00397	0.572
DOC_WW_Pin1_4	220	225	PF00397	0.464
DOC_WW_Pin1_4	235	240	PF00397	0.474
DOC_WW_Pin1_4	387	392	PF00397	0.649
DOC_WW_Pin1_4	393	398	PF00397	0.626
DOC_WW_Pin1_4	442	447	PF00397	0.518
DOC_WW_Pin1_4	70	75	PF00397	0.655
LIG_14-3-3_CanoR_1	117	125	PF00244	0.701
LIG_14-3-3_CanoR_1	237	245	PF00244	0.432
LIG_14-3-3_CanoR_1	368	372	PF00244	0.626
LIG_14-3-3_CterR_2	483	487	PF00244	0.678
LIG_APCC_ABBA_1	157	162	PF00400	0.558
LIG_APCC_ABBA_1	204	209	PF00400	0.581
LIG_BRCT_BRCA1_1	166	170	PF00533	0.582
LIG_Clathr_ClatBox_1	226	230	PF01394	0.367
LIG_FHA_1	102	108	PF00498	0.721
LIG_FHA_1	251	257	PF00498	0.589
LIG_FHA_1	319	325	PF00498	0.471
LIG_FHA_1	394	400	PF00498	0.622
LIG_FHA_1	411	417	PF00498	0.635
LIG_FHA_1	420	426	PF00498	0.447
LIG_FHA_2	250	256	PF00498	0.519
LIG_FHA_2	317	323	PF00498	0.425
LIG_FHA_2	371	377	PF00498	0.640
LIG_FHA_2	5	11	PF00498	0.758
LIG_FHA_2	56	62	PF00498	0.542
LIG_GBD_Chelix_1	227	235	PF00786	0.446
LIG_GBD_Chelix_1	303	311	PF00786	0.396
LIG_KLC1_Yacidic_2	158	162	PF13176	0.566
LIG_LIR_Apic_2	167	173	PF02991	0.632
LIG_LIR_Apic_2	7	11	PF02991	0.500
LIG_LIR_Gen_1	151	161	PF02991	0.566
LIG_LIR_Gen_1	482	487	PF02991	0.528
LIG_LIR_LC3C_4	223	228	PF02991	0.381
LIG_LIR_Nem_3	151	157	PF02991	0.549
LIG_LIR_Nem_3	19	24	PF02991	0.480
LIG_LIR_Nem_3	482	487	PF02991	0.528
LIG_NRBOX	462	468	PF00104	0.512
LIG_PDZ_Class_1	482	487	PF00595	0.679
LIG_Pex14_2	265	269	PF04695	0.353
LIG_Rb_pABgroove_1	148	156	PF01858	0.565
LIG_SH2_CRK	21	25	PF00017	0.502
LIG_SH2_CRK	218	222	PF00017	0.614
LIG_SH2_CRK	40	44	PF00017	0.588
LIG_SH2_GRB2like	40	43	PF00017	0.497
LIG_SH2_SRC	160	163	PF00017	0.569
LIG_SH2_STAP1	218	222	PF00017	0.614
LIG_SH2_STAP1	371	375	PF00017	0.525
LIG_SH2_STAT3	338	341	PF00017	0.492
LIG_SH2_STAT5	160	163	PF00017	0.637
LIG_SH2_STAT5	317	320	PF00017	0.438
LIG_SH3_3	218	224	PF00018	0.597
LIG_SH3_3	307	313	PF00018	0.523
LIG_SH3_3	322	328	PF00018	0.392
LIG_SH3_3	388	394	PF00018	0.667
LIG_SH3_3	8	14	PF00018	0.513
LIG_SH3_5	313	317	PF00018	0.403
LIG_SUMO_SIM_anti_2	421	430	PF11976	0.443
LIG_SUMO_SIM_par_1	223	230	PF11976	0.400
LIG_SUMO_SIM_par_1	421	430	PF11976	0.443
LIG_WW_3	114	118	PF00397	0.589
MOD_CK1_1	118	124	PF00069	0.660
MOD_CK1_1	130	136	PF00069	0.660
MOD_CK1_1	238	244	PF00069	0.594
MOD_CK1_1	384	390	PF00069	0.615
MOD_CK2_1	185	191	PF00069	0.626
MOD_CK2_1	249	255	PF00069	0.530
MOD_CK2_1	281	287	PF00069	0.399
MOD_CK2_1	295	301	PF00069	0.422
MOD_CK2_1	370	376	PF00069	0.683
MOD_CK2_1	4	10	PF00069	0.759
MOD_CK2_1	55	61	PF00069	0.639
MOD_CK2_1	70	76	PF00069	0.766
MOD_GlcNHglycan	109	112	PF01048	0.710
MOD_GlcNHglycan	120	123	PF01048	0.617
MOD_GlcNHglycan	132	135	PF01048	0.629
MOD_GlcNHglycan	144	147	PF01048	0.579
MOD_GlcNHglycan	213	216	PF01048	0.644
MOD_GlcNHglycan	452	455	PF01048	0.453
MOD_GSK3_1	103	110	PF00069	0.678
MOD_GSK3_1	160	167	PF00069	0.604
MOD_GSK3_1	231	238	PF00069	0.461
MOD_GSK3_1	479	486	PF00069	0.767
MOD_N-GLC_1	118	123	PF02516	0.628
MOD_NEK2_1	107	112	PF00069	0.600
MOD_NEK2_1	231	236	PF00069	0.371
MOD_NEK2_1	356	361	PF00069	0.618
MOD_NEK2_1	436	441	PF00069	0.484
MOD_NEK2_1	452	457	PF00069	0.509
MOD_NEK2_1	88	93	PF00069	0.574
MOD_NEK2_2	381	386	PF00069	0.690
MOD_PIKK_1	101	107	PF00454	0.539
MOD_PIKK_1	185	191	PF00454	0.614
MOD_PIKK_1	271	277	PF00454	0.352
MOD_PIKK_1	436	442	PF00454	0.517
MOD_PIKK_1	77	83	PF00454	0.519
MOD_PKA_2	356	362	PF00069	0.589
MOD_PKA_2	367	373	PF00069	0.622
MOD_Plk_1	118	124	PF00069	0.582
MOD_Plk_1	161	167	PF00069	0.623
MOD_Plk_1	195	201	PF00069	0.467
MOD_Plk_4	217	223	PF00069	0.636
MOD_Plk_4	231	237	PF00069	0.322
MOD_Plk_4	410	416	PF00069	0.633
MOD_Plk_4	452	458	PF00069	0.420
MOD_Plk_4	55	61	PF00069	0.540
MOD_ProDKin_1	125	131	PF00069	0.656
MOD_ProDKin_1	135	141	PF00069	0.741
MOD_ProDKin_1	164	170	PF00069	0.573
MOD_ProDKin_1	220	226	PF00069	0.451
MOD_ProDKin_1	235	241	PF00069	0.480
MOD_ProDKin_1	387	393	PF00069	0.646
MOD_ProDKin_1	442	448	PF00069	0.527
MOD_ProDKin_1	70	76	PF00069	0.653
TRG_DiLeu_BaEn_1	462	467	PF01217	0.509
TRG_DiLeu_BaEn_2	18	24	PF01217	0.532
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.603
TRG_ENDOCYTIC_2	21	24	PF00928	0.501
TRG_ENDOCYTIC_2	218	221	PF00928	0.626
TRG_ENDOCYTIC_2	40	43	PF00928	0.590
TRG_ER_diArg_1	210	213	PF00400	0.675
TRG_ER_diArg_1	355	358	PF00400	0.555
TRG_ER_diArg_1	481	484	PF00400	0.605
TRG_NES_CRM1_1	148	162	PF08389	0.513
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K4	Leptomonas seymouri	49%	83%
A0A3S7WSN4	Leishmania donovani	92%	100%
A4H7E3	Leishmania braziliensis	74%	100%
A4HVT3	Leishmania infantum	92%	100%
E9APH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%