Phosphoprotein phosphatase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid-specific phospho-protein phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QFZ7_LEIMA

TriTrypDb:

LmjF.13.1570 , LMJLV39_130020400 , LMJSD75_130020400

Length:

586

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	4
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0005955	calcineurin complex	3	1
GO:0008287	protein serine/threonine phosphatase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1903293	phosphatase complex	3	1

Expansion

Sequence features

Q4QFZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFZ7

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	3
GO:0000725	recombinational repair	6	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006259	DNA metabolic process	4	3
GO:0006281	DNA repair	5	3
GO:0006302	double-strand break repair	6	3
GO:0006310	DNA recombination	5	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0006950	response to stress	2	3
GO:0006974	DNA damage response	4	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	8
GO:0033554	cellular response to stress	3	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	3
GO:0046483	heterocycle metabolic process	3	3
GO:0050896	response to stimulus	1	3
GO:0051716	cellular response to stimulus	2	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0007165	signal transduction	2	5
GO:0019722	calcium-mediated signaling	5	5
GO:0019932	second-messenger-mediated signaling	4	5
GO:0035556	intracellular signal transduction	3	5
GO:0050789	regulation of biological process	2	5
GO:0050794	regulation of cellular process	3	5
GO:0065007	biological regulation	1	5
GO:0097720	calcineurin-mediated signaling	6	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004721	phosphoprotein phosphatase activity	3	17
GO:0004722	protein serine/threonine phosphatase activity	4	17
GO:0016787	hydrolase activity	2	17
GO:0016788	hydrolase activity, acting on ester bonds	3	17
GO:0016791	phosphatase activity	5	17
GO:0017018	myosin phosphatase activity	5	17
GO:0042578	phosphoric ester hydrolase activity	4	17
GO:0140096	catalytic activity, acting on a protein	2	17
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	5	5
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005516	calmodulin binding	3	1
GO:0033192	calmodulin-dependent protein phosphatase activity	6	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.541
CLV_C14_Caspase3-7	260	264	PF00656	0.561
CLV_C14_Caspase3-7	467	471	PF00656	0.242
CLV_C14_Caspase3-7	53	57	PF00656	0.561
CLV_NRD_NRD_1	247	249	PF00675	0.406
CLV_NRD_NRD_1	331	333	PF00675	0.390
CLV_PCSK_KEX2_1	226	228	PF00082	0.465
CLV_PCSK_KEX2_1	247	249	PF00082	0.406
CLV_PCSK_KEX2_1	330	332	PF00082	0.408
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.465
CLV_PCSK_SKI1_1	226	230	PF00082	0.401
CLV_PCSK_SKI1_1	341	345	PF00082	0.386
CLV_PCSK_SKI1_1	413	417	PF00082	0.328
CLV_PCSK_SKI1_1	530	534	PF00082	0.303
CLV_PCSK_SKI1_1	63	67	PF00082	0.530
CLV_PCSK_SKI1_1	95	99	PF00082	0.658
DEG_APCC_DBOX_1	505	513	PF00400	0.242
DEG_COP1_1	122	131	PF00400	0.525
DEG_Nend_UBRbox_2	1	3	PF02207	0.543
DEG_SPOP_SBC_1	215	219	PF00917	0.524
DOC_ANK_TNKS_1	331	338	PF00023	0.304
DOC_CYCLIN_yClb1_LxF_4	506	511	PF00134	0.252
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.343
DOC_MAPK_HePTP_8	288	300	PF00069	0.360
DOC_MAPK_MEF2A_6	291	300	PF00069	0.365
DOC_MAPK_MEF2A_6	351	360	PF00069	0.328
DOC_MAPK_MEF2A_6	413	420	PF00069	0.328
DOC_MAPK_NFAT4_5	413	421	PF00069	0.328
DOC_PP1_RVXF_1	506	512	PF00149	0.242
DOC_PP2B_LxvP_1	108	111	PF13499	0.515
DOC_PP2B_LxvP_1	180	183	PF13499	0.531
DOC_PP2B_LxvP_1	416	419	PF13499	0.343
DOC_PP4_FxxP_1	535	538	PF00568	0.352
DOC_SPAK_OSR1_1	430	434	PF12202	0.328
DOC_USP7_MATH_1	102	106	PF00917	0.524
DOC_USP7_MATH_1	129	133	PF00917	0.544
DOC_USP7_MATH_1	155	159	PF00917	0.504
DOC_USP7_MATH_1	215	219	PF00917	0.536
DOC_USP7_MATH_1	257	261	PF00917	0.628
DOC_USP7_MATH_1	35	39	PF00917	0.517
DOC_USP7_MATH_1	395	399	PF00917	0.278
DOC_USP7_MATH_1	497	501	PF00917	0.328
DOC_USP7_MATH_1	581	585	PF00917	0.528
DOC_USP7_MATH_1	96	100	PF00917	0.528
DOC_WW_Pin1_4	100	105	PF00397	0.479
DOC_WW_Pin1_4	122	127	PF00397	0.590
DOC_WW_Pin1_4	174	179	PF00397	0.558
DOC_WW_Pin1_4	183	188	PF00397	0.494
DOC_WW_Pin1_4	229	234	PF00397	0.409
DOC_WW_Pin1_4	236	241	PF00397	0.331
DOC_WW_Pin1_4	436	441	PF00397	0.331
DOC_WW_Pin1_4	55	60	PF00397	0.525
DOC_WW_Pin1_4	74	79	PF00397	0.495
DOC_WW_Pin1_4	82	87	PF00397	0.778
LIG_14-3-3_CanoR_1	136	146	PF00244	0.560
LIG_14-3-3_CanoR_1	195	205	PF00244	0.565
LIG_14-3-3_CanoR_1	351	357	PF00244	0.287
LIG_14-3-3_CanoR_1	430	440	PF00244	0.328
LIG_14-3-3_CanoR_1	530	535	PF00244	0.328
LIG_BIR_III_2	56	60	PF00653	0.535
LIG_BIR_III_4	154	158	PF00653	0.480
LIG_BRCT_BRCA1_1	234	238	PF00533	0.413
LIG_BRCT_BRCA1_1	499	503	PF00533	0.391
LIG_Clathr_ClatBox_1	295	299	PF01394	0.366
LIG_deltaCOP1_diTrp_1	569	580	PF00928	0.411
LIG_FHA_1	284	290	PF00498	0.353
LIG_FHA_1	303	309	PF00498	0.495
LIG_FHA_1	319	325	PF00498	0.220
LIG_FHA_1	383	389	PF00498	0.328
LIG_FHA_1	394	400	PF00498	0.250
LIG_FHA_1	456	462	PF00498	0.277
LIG_FHA_1	64	70	PF00498	0.524
LIG_FHA_2	11	17	PF00498	0.521
LIG_FHA_2	202	208	PF00498	0.577
LIG_FHA_2	51	57	PF00498	0.549
LIG_FHA_2	524	530	PF00498	0.422
LIG_Integrin_isoDGR_2	134	136	PF01839	0.545
LIG_Integrin_RGD_1	251	253	PF01839	0.446
LIG_IRF3_LxIS_1	194	199	PF10401	0.540
LIG_IRF3_LxIS_1	5	10	PF10401	0.525
LIG_LIR_Apic_2	533	538	PF02991	0.349
LIG_LIR_Gen_1	318	328	PF02991	0.328
LIG_LIR_Gen_1	339	349	PF02991	0.431
LIG_LIR_Gen_1	405	416	PF02991	0.348
LIG_LIR_Gen_1	426	433	PF02991	0.388
LIG_LIR_LC3C_4	105	110	PF02991	0.499
LIG_LIR_LC3C_4	304	308	PF02991	0.328
LIG_LIR_Nem_3	235	241	PF02991	0.389
LIG_LIR_Nem_3	318	323	PF02991	0.328
LIG_LIR_Nem_3	368	372	PF02991	0.518
LIG_LIR_Nem_3	386	392	PF02991	0.307
LIG_LIR_Nem_3	405	411	PF02991	0.348
LIG_LIR_Nem_3	426	431	PF02991	0.388
LIG_LIR_Nem_3	561	565	PF02991	0.402
LIG_LIR_Nem_3	570	576	PF02991	0.454
LIG_LYPXL_yS_3	369	372	PF13949	0.328
LIG_MAD2	530	538	PF02301	0.359
LIG_PCNA_PIPBox_1	517	526	PF02747	0.434
LIG_PCNA_yPIPBox_3	514	524	PF02747	0.340
LIG_PDZ_Class_1	581	586	PF00595	0.443
LIG_PTB_Apo_2	271	278	PF02174	0.364
LIG_PTB_Phospho_1	271	277	PF10480	0.371
LIG_SH2_CRK	320	324	PF00017	0.396
LIG_SH2_CRK	389	393	PF00017	0.318
LIG_SH2_NCK_1	267	271	PF00017	0.406
LIG_SH2_STAP1	320	324	PF00017	0.328
LIG_SH2_STAT5	267	270	PF00017	0.437
LIG_SH2_STAT5	277	280	PF00017	0.297
LIG_SH2_STAT5	320	323	PF00017	0.328
LIG_SH2_STAT5	348	351	PF00017	0.350
LIG_SH2_STAT5	374	377	PF00017	0.328
LIG_SH2_STAT5	523	526	PF00017	0.344
LIG_SH2_STAT5	540	543	PF00017	0.422
LIG_SH2_STAT5	72	75	PF00017	0.554
LIG_SH3_3	107	113	PF00018	0.595
LIG_SH3_3	120	126	PF00018	0.546
LIG_SH3_3	22	28	PF00018	0.534
LIG_SH3_3	251	257	PF00018	0.465
LIG_SH3_3	364	370	PF00018	0.440
LIG_SH3_3	83	89	PF00018	0.516
LIG_SPRY_1	542	547	PF00622	0.294
LIG_SUMO_SIM_anti_2	297	302	PF11976	0.469
LIG_SUMO_SIM_anti_2	304	311	PF11976	0.383
LIG_SUMO_SIM_anti_2	355	360	PF11976	0.308
LIG_SUMO_SIM_par_1	2	10	PF11976	0.520
LIG_SUMO_SIM_par_1	294	299	PF11976	0.389
LIG_SUMO_SIM_par_1	304	311	PF11976	0.342
LIG_SUMO_SIM_par_1	529	536	PF11976	0.358
LIG_TRAF2_1	115	118	PF00917	0.573
LIG_TRAF2_1	13	16	PF00917	0.523
LIG_TYR_ITIM	367	372	PF00017	0.328
LIG_UBA3_1	360	366	PF00899	0.426
MOD_CDK_SPK_2	229	234	PF00069	0.391
MOD_CK1_1	10	16	PF00069	0.524
MOD_CK1_1	127	133	PF00069	0.537
MOD_CK1_1	19	25	PF00069	0.502
MOD_CK1_1	199	205	PF00069	0.604
MOD_CK1_1	34	40	PF00069	0.525
MOD_CK1_1	485	491	PF00069	0.243
MOD_CK1_1	50	56	PF00069	0.506
MOD_CK2_1	10	16	PF00069	0.524
MOD_GlcNHglycan	104	107	PF01048	0.527
MOD_GlcNHglycan	131	134	PF01048	0.545
MOD_GlcNHglycan	170	174	PF01048	0.634
MOD_GlcNHglycan	234	237	PF01048	0.378
MOD_GlcNHglycan	32	36	PF01048	0.510
MOD_GlcNHglycan	37	40	PF01048	0.517
MOD_GlcNHglycan	408	411	PF01048	0.387
MOD_GlcNHglycan	535	538	PF01048	0.352
MOD_GlcNHglycan	553	556	PF01048	0.410
MOD_GlcNHglycan	98	101	PF01048	0.517
MOD_GSK3_1	155	162	PF00069	0.508
MOD_GSK3_1	165	172	PF00069	0.500
MOD_GSK3_1	196	203	PF00069	0.578
MOD_GSK3_1	216	223	PF00069	0.580
MOD_GSK3_1	232	239	PF00069	0.335
MOD_GSK3_1	31	38	PF00069	0.525
MOD_GSK3_1	390	397	PF00069	0.413
MOD_GSK3_1	402	409	PF00069	0.310
MOD_GSK3_1	455	462	PF00069	0.291
MOD_GSK3_1	478	485	PF00069	0.308
MOD_GSK3_1	498	505	PF00069	0.263
MOD_GSK3_1	96	103	PF00069	0.522
MOD_N-GLC_1	144	149	PF02516	0.532
MOD_N-GLC_2	280	282	PF02516	0.269
MOD_N-GLC_2	539	541	PF02516	0.388
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	137	142	PF00069	0.565
MOD_NEK2_1	169	174	PF00069	0.528
MOD_NEK2_1	216	221	PF00069	0.553
MOD_NEK2_1	31	36	PF00069	0.490
MOD_NEK2_1	319	324	PF00069	0.287
MOD_NEK2_1	431	436	PF00069	0.343
MOD_NEK2_1	484	489	PF00069	0.262
MOD_NEK2_1	7	12	PF00069	0.562
MOD_NEK2_2	575	580	PF00069	0.532
MOD_NEK2_2	581	586	PF00069	0.524
MOD_PIKK_1	257	263	PF00454	0.656
MOD_PIKK_1	265	271	PF00454	0.478
MOD_PKA_2	40	46	PF00069	0.544
MOD_Plk_1	1	7	PF00069	0.551
MOD_Plk_1	31	37	PF00069	0.530
MOD_Plk_2-3	447	453	PF00069	0.270
MOD_Plk_4	268	274	PF00069	0.433
MOD_Plk_4	302	308	PF00069	0.503
MOD_Plk_4	319	325	PF00069	0.263
MOD_Plk_4	368	374	PF00069	0.427
MOD_Plk_4	423	429	PF00069	0.327
MOD_Plk_4	530	536	PF00069	0.308
MOD_ProDKin_1	100	106	PF00069	0.480
MOD_ProDKin_1	122	128	PF00069	0.590
MOD_ProDKin_1	174	180	PF00069	0.558
MOD_ProDKin_1	183	189	PF00069	0.494
MOD_ProDKin_1	229	235	PF00069	0.409
MOD_ProDKin_1	236	242	PF00069	0.329
MOD_ProDKin_1	436	442	PF00069	0.331
MOD_ProDKin_1	55	61	PF00069	0.525
MOD_ProDKin_1	74	80	PF00069	0.497
MOD_ProDKin_1	82	88	PF00069	0.780
MOD_SUMO_for_1	365	368	PF00179	0.328
MOD_SUMO_rev_2	218	228	PF00179	0.486
MOD_SUMO_rev_2	381	386	PF00179	0.397
TRG_DiLeu_BaEn_1	357	362	PF01217	0.314
TRG_DiLeu_BaEn_1	368	373	PF01217	0.264
TRG_DiLeu_BaLyEn_6	175	180	PF01217	0.535
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.560
TRG_DiLeu_LyEn_5	237	242	PF01217	0.368
TRG_ENDOCYTIC_2	320	323	PF00928	0.412
TRG_ENDOCYTIC_2	369	372	PF00928	0.340
TRG_ENDOCYTIC_2	389	392	PF00928	0.244
TRG_ENDOCYTIC_2	428	431	PF00928	0.316
TRG_ENDOCYTIC_2	540	543	PF00928	0.378
TRG_ER_diArg_1	246	248	PF00400	0.409
TRG_ER_diArg_1	330	332	PF00400	0.307
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8M6	Leishmania donovani	75%	100%
A0A3Q8II54	Leishmania donovani	91%	100%
A0A3S7XAY3	Leishmania donovani	32%	100%
A0A422N1U7	Trypanosoma rangeli	30%	98%
A4H7E7	Leishmania braziliensis	67%	100%
A4HP65	Leishmania braziliensis	32%	100%
A4HVT0	Leishmania infantum	75%	100%
A4HVT6	Leishmania infantum	90%	100%
A4IDH0	Leishmania infantum	32%	100%
E9APH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
E9API1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9ASX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q1M5	Leishmania major	32%	100%
Q4QG03	Leishmania major	78%	100%
V5BBS3	Trypanosoma cruzi	31%	98%