Tcp10_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spindle assembly abnormal 4

Species:

Leishmania major

UniProt:

Q4QFZ5_LEIMA

TriTrypDb:

LmjF.13.1590 , LMJLV39_130020600 , LMJSD75_130020600

Length:

750

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005813	centrosome	3	2
GO:0005814	centriole	5	2
GO:0005815	microtubule organizing center	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFZ5

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022402	cell cycle process	2	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0061511	centriole elongation	3	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008092	cytoskeletal protein binding	3	2
GO:0015631	tubulin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.643
CLV_C14_Caspase3-7	309	313	PF00656	0.529
CLV_C14_Caspase3-7	320	324	PF00656	0.525
CLV_C14_Caspase3-7	449	453	PF00656	0.597
CLV_C14_Caspase3-7	54	58	PF00656	0.608
CLV_NRD_NRD_1	120	122	PF00675	0.686
CLV_NRD_NRD_1	22	24	PF00675	0.674
CLV_NRD_NRD_1	235	237	PF00675	0.665
CLV_NRD_NRD_1	316	318	PF00675	0.528
CLV_NRD_NRD_1	350	352	PF00675	0.550
CLV_NRD_NRD_1	385	387	PF00675	0.438
CLV_NRD_NRD_1	393	395	PF00675	0.442
CLV_NRD_NRD_1	459	461	PF00675	0.663
CLV_NRD_NRD_1	504	506	PF00675	0.565
CLV_NRD_NRD_1	515	517	PF00675	0.530
CLV_NRD_NRD_1	541	543	PF00675	0.535
CLV_NRD_NRD_1	548	550	PF00675	0.589
CLV_NRD_NRD_1	55	57	PF00675	0.603
CLV_NRD_NRD_1	561	563	PF00675	0.487
CLV_NRD_NRD_1	583	585	PF00675	0.812
CLV_NRD_NRD_1	86	88	PF00675	0.653
CLV_PCSK_FUR_1	383	387	PF00082	0.439
CLV_PCSK_FUR_1	484	488	PF00082	0.537
CLV_PCSK_FUR_1	53	57	PF00082	0.616
CLV_PCSK_KEX2_1	120	122	PF00082	0.686
CLV_PCSK_KEX2_1	22	24	PF00082	0.695
CLV_PCSK_KEX2_1	235	237	PF00082	0.665
CLV_PCSK_KEX2_1	316	318	PF00082	0.528
CLV_PCSK_KEX2_1	350	352	PF00082	0.550
CLV_PCSK_KEX2_1	385	387	PF00082	0.438
CLV_PCSK_KEX2_1	393	395	PF00082	0.442
CLV_PCSK_KEX2_1	459	461	PF00082	0.718
CLV_PCSK_KEX2_1	486	488	PF00082	0.503
CLV_PCSK_KEX2_1	506	508	PF00082	0.530
CLV_PCSK_KEX2_1	517	519	PF00082	0.535
CLV_PCSK_KEX2_1	541	543	PF00082	0.613
CLV_PCSK_KEX2_1	55	57	PF00082	0.603
CLV_PCSK_KEX2_1	582	584	PF00082	0.676
CLV_PCSK_KEX2_1	597	599	PF00082	0.507
CLV_PCSK_KEX2_1	645	647	PF00082	0.298
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.527
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.495
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.535
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.669
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.670
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.298
CLV_PCSK_PC7_1	231	237	PF00082	0.639
CLV_PCSK_PC7_1	346	352	PF00082	0.501
CLV_PCSK_SKI1_1	550	554	PF00082	0.415
CLV_PCSK_SKI1_1	637	641	PF00082	0.463
CLV_PCSK_SKI1_1	656	660	PF00082	0.183
CLV_PCSK_SKI1_1	70	74	PF00082	0.599
CLV_PCSK_SKI1_1	720	724	PF00082	0.384
DEG_APCC_DBOX_1	359	367	PF00400	0.465
DEG_SCF_FBW7_1	470	477	PF00400	0.487
DOC_MAPK_gen_1	334	343	PF00069	0.432
DOC_MAPK_gen_1	459	469	PF00069	0.604
DOC_MAPK_gen_1	524	531	PF00069	0.478
DOC_PP2B_LxvP_1	145	148	PF13499	0.628
DOC_PP4_FxxP_1	234	237	PF00568	0.574
DOC_USP7_MATH_1	14	18	PF00917	0.697
DOC_USP7_MATH_1	175	179	PF00917	0.675
DOC_USP7_MATH_1	244	248	PF00917	0.692
DOC_USP7_MATH_1	252	256	PF00917	0.603
DOC_USP7_MATH_1	415	419	PF00917	0.551
DOC_USP7_MATH_1	474	478	PF00917	0.555
DOC_USP7_MATH_1	585	589	PF00917	0.745
DOC_USP7_MATH_1	716	720	PF00917	0.522
DOC_USP7_MATH_1	734	738	PF00917	0.605
DOC_USP7_UBL2_3	11	15	PF12436	0.564
DOC_USP7_UBL2_3	272	276	PF12436	0.462
DOC_WW_Pin1_4	139	144	PF00397	0.650
DOC_WW_Pin1_4	199	204	PF00397	0.655
DOC_WW_Pin1_4	248	253	PF00397	0.635
DOC_WW_Pin1_4	34	39	PF00397	0.614
DOC_WW_Pin1_4	413	418	PF00397	0.633
DOC_WW_Pin1_4	422	427	PF00397	0.631
DOC_WW_Pin1_4	470	475	PF00397	0.616
DOC_WW_Pin1_4	568	573	PF00397	0.606
LIG_14-3-3_CanoR_1	212	217	PF00244	0.641
LIG_14-3-3_CanoR_1	27	31	PF00244	0.631
LIG_14-3-3_CanoR_1	3	7	PF00244	0.612
LIG_14-3-3_CanoR_1	329	335	PF00244	0.478
LIG_14-3-3_CanoR_1	350	359	PF00244	0.646
LIG_14-3-3_CanoR_1	420	426	PF00244	0.656
LIG_14-3-3_CanoR_1	541	548	PF00244	0.529
LIG_14-3-3_CanoR_1	549	559	PF00244	0.591
LIG_14-3-3_CanoR_1	584	594	PF00244	0.658
LIG_14-3-3_CanoR_1	70	78	PF00244	0.587
LIG_14-3-3_CanoR_1	94	99	PF00244	0.676
LIG_Actin_WH2_2	651	669	PF00022	0.430
LIG_APCC_ABBAyCdc20_2	720	726	PF00400	0.400
LIG_BIR_II_1	1	5	PF00653	0.753
LIG_BRCT_BRCA1_1	16	20	PF00533	0.660
LIG_BRCT_BRCA1_1	423	427	PF00533	0.532
LIG_FHA_1	147	153	PF00498	0.537
LIG_FHA_1	652	658	PF00498	0.500
LIG_FHA_1	91	97	PF00498	0.646
LIG_FHA_2	149	155	PF00498	0.639
LIG_FHA_2	359	365	PF00498	0.636
LIG_FHA_2	367	373	PF00498	0.535
LIG_FHA_2	551	557	PF00498	0.418
LIG_FHA_2	601	607	PF00498	0.459
LIG_FHA_2	667	673	PF00498	0.457
LIG_LIR_Apic_2	133	137	PF02991	0.656
LIG_LIR_Nem_3	16	21	PF02991	0.658
LIG_LIR_Nem_3	332	338	PF02991	0.488
LIG_LIR_Nem_3	726	732	PF02991	0.396
LIG_Rb_LxCxE_1	404	424	PF01857	0.568
LIG_SH2_CRK	198	202	PF00017	0.667
LIG_SH2_CRK	213	217	PF00017	0.636
LIG_SH2_CRK	729	733	PF00017	0.389
LIG_SH2_GRB2like	650	653	PF00017	0.457
LIG_SH2_NCK_1	30	34	PF00017	0.675
LIG_SH2_NCK_1	686	690	PF00017	0.425
LIG_SH2_SRC	218	221	PF00017	0.608
LIG_SH2_SRC	281	284	PF00017	0.503
LIG_SH2_SRC	650	653	PF00017	0.443
LIG_SH2_STAT5	160	163	PF00017	0.628
LIG_SH2_STAT5	233	236	PF00017	0.649
LIG_SH2_STAT5	239	242	PF00017	0.643
LIG_SH2_STAT5	512	515	PF00017	0.497
LIG_SH3_2	593	598	PF14604	0.663
LIG_SH3_3	126	132	PF00018	0.718
LIG_SH3_3	134	140	PF00018	0.613
LIG_SH3_3	150	156	PF00018	0.669
LIG_SH3_3	587	593	PF00018	0.639
LIG_SH3_3	654	660	PF00018	0.500
LIG_SH3_3	80	86	PF00018	0.620
LIG_SH3_3	93	99	PF00018	0.594
LIG_SH3_4	11	18	PF00018	0.635
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.592
LIG_SUMO_SIM_par_1	465	471	PF11976	0.595
LIG_TRAF2_1	330	333	PF00917	0.458
LIG_TRAF2_1	501	504	PF00917	0.530
LIG_TRAF2_1	747	750	PF00917	0.566
LIG_UBA3_1	263	272	PF00899	0.507
LIG_UBA3_1	398	403	PF00899	0.501
MOD_CDC14_SPxK_1	37	40	PF00782	0.665
MOD_CDK_SPK_2	199	204	PF00069	0.655
MOD_CDK_SPK_2	470	475	PF00069	0.625
MOD_CDK_SPK_2	568	573	PF00069	0.588
MOD_CDK_SPxK_1	34	40	PF00069	0.669
MOD_CDK_SPxxK_3	413	420	PF00069	0.581
MOD_CK1_1	106	112	PF00069	0.706
MOD_CK1_1	185	191	PF00069	0.758
MOD_CK1_1	2	8	PF00069	0.677
MOD_CK1_1	31	37	PF00069	0.725
MOD_CK1_1	358	364	PF00069	0.483
MOD_CK1_1	416	422	PF00069	0.766
MOD_CK1_1	425	431	PF00069	0.673
MOD_CK1_1	439	445	PF00069	0.586
MOD_CK1_1	661	667	PF00069	0.494
MOD_CK1_1	679	685	PF00069	0.287
MOD_CK1_1	737	743	PF00069	0.511
MOD_CK2_1	104	110	PF00069	0.680
MOD_CK2_1	148	154	PF00069	0.658
MOD_CK2_1	358	364	PF00069	0.637
MOD_CK2_1	366	372	PF00069	0.548
MOD_CK2_1	474	480	PF00069	0.537
MOD_CK2_1	550	556	PF00069	0.451
MOD_Cter_Amidation	514	517	PF01082	0.413
MOD_Cter_Amidation	643	646	PF01082	0.257
MOD_GlcNHglycan	106	109	PF01048	0.739
MOD_GlcNHglycan	169	172	PF01048	0.795
MOD_GlcNHglycan	177	180	PF01048	0.668
MOD_GlcNHglycan	204	207	PF01048	0.664
MOD_GlcNHglycan	219	224	PF01048	0.491
MOD_GlcNHglycan	226	229	PF01048	0.602
MOD_GlcNHglycan	30	33	PF01048	0.618
MOD_GlcNHglycan	338	341	PF01048	0.628
MOD_GlcNHglycan	413	416	PF01048	0.747
MOD_GlcNHglycan	432	436	PF01048	0.650
MOD_GlcNHglycan	439	442	PF01048	0.646
MOD_GlcNHglycan	564	567	PF01048	0.586
MOD_GlcNHglycan	575	578	PF01048	0.635
MOD_GlcNHglycan	587	590	PF01048	0.560
MOD_GlcNHglycan	642	645	PF01048	0.309
MOD_GlcNHglycan	660	663	PF01048	0.319
MOD_GlcNHglycan	678	681	PF01048	0.403
MOD_GlcNHglycan	96	99	PF01048	0.688
MOD_GSK3_1	100	107	PF00069	0.566
MOD_GSK3_1	161	168	PF00069	0.741
MOD_GSK3_1	244	251	PF00069	0.698
MOD_GSK3_1	411	418	PF00069	0.605
MOD_GSK3_1	421	428	PF00069	0.663
MOD_GSK3_1	470	477	PF00069	0.629
MOD_GSK3_1	573	580	PF00069	0.720
MOD_GSK3_1	658	665	PF00069	0.494
MOD_GSK3_1	676	683	PF00069	0.292
MOD_GSK3_1	704	711	PF00069	0.480
MOD_GSK3_1	90	97	PF00069	0.654
MOD_N-GLC_1	103	108	PF02516	0.706
MOD_N-GLC_1	336	341	PF02516	0.487
MOD_N-GLC_1	355	360	PF02516	0.506
MOD_N-GLC_1	651	656	PF02516	0.257
MOD_NEK2_1	161	166	PF00069	0.667
MOD_NEK2_1	28	33	PF00069	0.649
MOD_NEK2_1	366	371	PF00069	0.448
MOD_NEK2_1	640	645	PF00069	0.419
MOD_NEK2_1	666	671	PF00069	0.457
MOD_NEK2_1	705	710	PF00069	0.436
MOD_NEK2_2	14	19	PF00069	0.622
MOD_NEK2_2	577	582	PF00069	0.645
MOD_NEK2_2	651	656	PF00069	0.491
MOD_NEK2_2	662	667	PF00069	0.515
MOD_NEK2_2	688	693	PF00069	0.438
MOD_PIKK_1	350	356	PF00454	0.451
MOD_PIKK_1	358	364	PF00454	0.447
MOD_PIKK_1	623	629	PF00454	0.452
MOD_PIKK_1	691	697	PF00454	0.368
MOD_PK_1	583	589	PF00069	0.551
MOD_PKA_1	350	356	PF00069	0.451
MOD_PKA_1	459	465	PF00069	0.709
MOD_PKA_1	55	61	PF00069	0.534
MOD_PKA_1	562	568	PF00069	0.562
MOD_PKA_1	583	589	PF00069	0.676
MOD_PKA_2	185	191	PF00069	0.758
MOD_PKA_2	2	8	PF00069	0.609
MOD_PKA_2	26	32	PF00069	0.652
MOD_PKA_2	315	321	PF00069	0.511
MOD_PKA_2	328	334	PF00069	0.559
MOD_PKA_2	345	351	PF00069	0.384
MOD_PKA_2	419	425	PF00069	0.662
MOD_PKA_2	436	442	PF00069	0.501
MOD_PKA_2	459	465	PF00069	0.658
MOD_PKA_2	474	480	PF00069	0.482
MOD_PKA_2	540	546	PF00069	0.530
MOD_PKA_2	55	61	PF00069	0.534
MOD_PKA_2	583	589	PF00069	0.696
MOD_PKA_2	666	672	PF00069	0.430
MOD_PKA_2	705	711	PF00069	0.485
MOD_PKB_1	53	61	PF00069	0.600
MOD_Plk_1	161	167	PF00069	0.642
MOD_Plk_1	336	342	PF00069	0.464
MOD_Plk_1	355	361	PF00069	0.506
MOD_Plk_1	737	743	PF00069	0.462
MOD_Plk_4	148	154	PF00069	0.537
MOD_Plk_4	2	8	PF00069	0.658
MOD_Plk_4	680	686	PF00069	0.376
MOD_Plk_4	737	743	PF00069	0.442
MOD_ProDKin_1	139	145	PF00069	0.653
MOD_ProDKin_1	199	205	PF00069	0.653
MOD_ProDKin_1	248	254	PF00069	0.630
MOD_ProDKin_1	34	40	PF00069	0.614
MOD_ProDKin_1	413	419	PF00069	0.637
MOD_ProDKin_1	422	428	PF00069	0.630
MOD_ProDKin_1	470	476	PF00069	0.613
MOD_ProDKin_1	568	574	PF00069	0.608
MOD_SUMO_for_1	216	219	PF00179	0.619
MOD_SUMO_rev_2	266	274	PF00179	0.639
MOD_SUMO_rev_2	519	525	PF00179	0.537
MOD_SUMO_rev_2	54	61	PF00179	0.593
MOD_SUMO_rev_2	556	565	PF00179	0.586
TRG_DiLeu_BaEn_1	259	264	PF01217	0.464
TRG_DiLeu_BaEn_2	15	21	PF01217	0.655
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.610
TRG_ENDOCYTIC_2	198	201	PF00928	0.747
TRG_ENDOCYTIC_2	213	216	PF00928	0.591
TRG_ENDOCYTIC_2	729	732	PF00928	0.382
TRG_ER_diArg_1	21	23	PF00400	0.700
TRG_ER_diArg_1	234	236	PF00400	0.695
TRG_ER_diArg_1	316	319	PF00400	0.529
TRG_ER_diArg_1	350	352	PF00400	0.550
TRG_ER_diArg_1	383	386	PF00400	0.443
TRG_ER_diArg_1	526	529	PF00400	0.501
TRG_ER_diArg_1	583	585	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW13	Leptomonas seymouri	56%	98%
A0A3Q8I9S9	Leishmania donovani	94%	100%
A4H7E9	Leishmania braziliensis	76%	100%
A4HVT7	Leishmania infantum	94%	100%
E9API3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B213	Trypanosoma cruzi	40%	98%