Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFZ4_LEIMA

TriTrypDb:

LmjF.13.1600 , LMJLV39_130020700 , LMJSD75_130020700

Length:

1217

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QFZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFZ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1005	1009	PF00656	0.504
CLV_C14_Caspase3-7	238	242	PF00656	0.550
CLV_C14_Caspase3-7	293	297	PF00656	0.427
CLV_C14_Caspase3-7	774	778	PF00656	0.486
CLV_C14_Caspase3-7	799	803	PF00656	0.401
CLV_NRD_NRD_1	1206	1208	PF00675	0.524
CLV_NRD_NRD_1	180	182	PF00675	0.731
CLV_NRD_NRD_1	269	271	PF00675	0.766
CLV_NRD_NRD_1	347	349	PF00675	0.581
CLV_NRD_NRD_1	391	393	PF00675	0.738
CLV_NRD_NRD_1	711	713	PF00675	0.772
CLV_NRD_NRD_1	887	889	PF00675	0.653
CLV_PCSK_FUR_1	885	889	PF00082	0.656
CLV_PCSK_KEX2_1	1057	1059	PF00082	0.718
CLV_PCSK_KEX2_1	180	182	PF00082	0.743
CLV_PCSK_KEX2_1	269	271	PF00082	0.766
CLV_PCSK_KEX2_1	347	349	PF00082	0.581
CLV_PCSK_KEX2_1	391	393	PF00082	0.738
CLV_PCSK_KEX2_1	711	713	PF00082	0.772
CLV_PCSK_KEX2_1	887	889	PF00082	0.653
CLV_PCSK_PC1ET2_1	1057	1059	PF00082	0.718
CLV_PCSK_PC7_1	883	889	PF00082	0.694
CLV_PCSK_SKI1_1	180	184	PF00082	0.778
CLV_PCSK_SKI1_1	270	274	PF00082	0.763
CLV_PCSK_SKI1_1	335	339	PF00082	0.672
CLV_PCSK_SKI1_1	693	697	PF00082	0.618
CLV_PCSK_SKI1_1	879	883	PF00082	0.739
CLV_PCSK_SKI1_1	887	891	PF00082	0.643
DEG_APCC_DBOX_1	334	342	PF00400	0.469
DEG_APCC_DBOX_1	692	700	PF00400	0.413
DEG_APCC_DBOX_1	754	762	PF00400	0.568
DEG_APCC_DBOX_1	793	801	PF00400	0.563
DEG_APCC_DBOX_1	882	890	PF00400	0.549
DEG_SCF_FBW7_1	152	157	PF00400	0.512
DEG_SPOP_SBC_1	1127	1131	PF00917	0.444
DEG_SPOP_SBC_1	147	151	PF00917	0.604
DEG_SPOP_SBC_1	33	37	PF00917	0.491
DOC_CYCLIN_yClb5_NLxxxL_5	219	227	PF00134	0.491
DOC_MAPK_gen_1	79	88	PF00069	0.543
DOC_MAPK_MEF2A_6	491	499	PF00069	0.573
DOC_MAPK_MEF2A_6	755	762	PF00069	0.405
DOC_MIT_MIM_1	343	353	PF04212	0.384
DOC_USP7_MATH_1	1031	1035	PF00917	0.547
DOC_USP7_MATH_1	1127	1131	PF00917	0.444
DOC_USP7_MATH_1	115	119	PF00917	0.559
DOC_USP7_MATH_1	1193	1197	PF00917	0.766
DOC_USP7_MATH_1	17	21	PF00917	0.618
DOC_USP7_MATH_1	193	197	PF00917	0.552
DOC_USP7_MATH_1	235	239	PF00917	0.528
DOC_USP7_MATH_1	260	264	PF00917	0.468
DOC_USP7_MATH_1	309	313	PF00917	0.508
DOC_USP7_MATH_1	360	364	PF00917	0.587
DOC_USP7_MATH_1	396	400	PF00917	0.514
DOC_USP7_MATH_1	434	438	PF00917	0.527
DOC_USP7_MATH_1	458	462	PF00917	0.548
DOC_USP7_MATH_1	645	649	PF00917	0.521
DOC_USP7_MATH_1	724	728	PF00917	0.594
DOC_USP7_MATH_1	901	905	PF00917	0.447
DOC_USP7_MATH_1	979	983	PF00917	0.495
DOC_USP7_UBL2_3	1204	1208	PF12436	0.693
DOC_USP7_UBL2_3	277	281	PF12436	0.505
DOC_WW_Pin1_4	109	114	PF00397	0.605
DOC_WW_Pin1_4	117	122	PF00397	0.576
DOC_WW_Pin1_4	148	153	PF00397	0.599
DOC_WW_Pin1_4	361	366	PF00397	0.553
DOC_WW_Pin1_4	486	491	PF00397	0.497
DOC_WW_Pin1_4	558	563	PF00397	0.606
DOC_WW_Pin1_4	591	596	PF00397	0.541
DOC_WW_Pin1_4	597	602	PF00397	0.478
DOC_WW_Pin1_4	694	699	PF00397	0.540
DOC_WW_Pin1_4	7	12	PF00397	0.545
DOC_WW_Pin1_4	858	863	PF00397	0.526
LIG_14-3-3_CanoR_1	1072	1082	PF00244	0.422
LIG_14-3-3_CanoR_1	1183	1192	PF00244	0.684
LIG_14-3-3_CanoR_1	25	31	PF00244	0.532
LIG_14-3-3_CanoR_1	269	279	PF00244	0.486
LIG_14-3-3_CanoR_1	537	544	PF00244	0.545
LIG_14-3-3_CanoR_1	785	793	PF00244	0.421
LIG_14-3-3_CanoR_1	794	804	PF00244	0.499
LIG_14-3-3_CanoR_1	877	886	PF00244	0.482
LIG_14-3-3_CanoR_1	887	896	PF00244	0.475
LIG_Actin_WH2_2	254	271	PF00022	0.493
LIG_Actin_WH2_2	337	355	PF00022	0.555
LIG_Actin_WH2_2	435	452	PF00022	0.591
LIG_Actin_WH2_2	84	101	PF00022	0.479
LIG_AP2alpha_1	762	766	PF02296	0.520
LIG_APCC_ABBA_1	401	406	PF00400	0.518
LIG_BRCT_BRCA1_1	736	740	PF00533	0.553
LIG_eIF4E_1	1160	1166	PF01652	0.411
LIG_FHA_1	1044	1050	PF00498	0.397
LIG_FHA_1	1110	1116	PF00498	0.542
LIG_FHA_1	1133	1139	PF00498	0.575
LIG_FHA_1	181	187	PF00498	0.549
LIG_FHA_1	201	207	PF00498	0.524
LIG_FHA_1	263	269	PF00498	0.492
LIG_FHA_1	271	277	PF00498	0.490
LIG_FHA_1	382	388	PF00498	0.479
LIG_FHA_1	422	428	PF00498	0.581
LIG_FHA_1	479	485	PF00498	0.525
LIG_FHA_1	563	569	PF00498	0.539
LIG_FHA_1	571	577	PF00498	0.459
LIG_FHA_1	592	598	PF00498	0.593
LIG_FHA_1	634	640	PF00498	0.518
LIG_FHA_1	721	727	PF00498	0.584
LIG_FHA_1	755	761	PF00498	0.471
LIG_FHA_1	768	774	PF00498	0.512
LIG_FHA_1	8	14	PF00498	0.618
LIG_FHA_1	832	838	PF00498	0.538
LIG_FHA_1	888	894	PF00498	0.471
LIG_FHA_1	936	942	PF00498	0.506
LIG_FHA_1	992	998	PF00498	0.496
LIG_FHA_2	1118	1124	PF00498	0.592
LIG_FHA_2	1192	1198	PF00498	0.804
LIG_FHA_2	163	169	PF00498	0.428
LIG_FHA_2	283	289	PF00498	0.621
LIG_FHA_2	293	299	PF00498	0.459
LIG_FHA_2	35	41	PF00498	0.498
LIG_FHA_2	439	445	PF00498	0.533
LIG_FHA_2	536	542	PF00498	0.541
LIG_FHA_2	570	576	PF00498	0.512
LIG_FHA_2	699	705	PF00498	0.513
LIG_FHA_2	73	79	PF00498	0.466
LIG_FHA_2	787	793	PF00498	0.515
LIG_GBD_Chelix_1	525	533	PF00786	0.778
LIG_LIR_Gen_1	29	34	PF02991	0.551
LIG_LIR_Gen_1	489	499	PF02991	0.499
LIG_LIR_Gen_1	764	773	PF02991	0.512
LIG_LIR_Gen_1	82	91	PF02991	0.513
LIG_LIR_Nem_3	1157	1162	PF02991	0.411
LIG_LIR_Nem_3	29	33	PF02991	0.556
LIG_LIR_Nem_3	304	310	PF02991	0.579
LIG_LIR_Nem_3	489	495	PF02991	0.572
LIG_LIR_Nem_3	600	606	PF02991	0.486
LIG_LIR_Nem_3	764	769	PF02991	0.515
LIG_LIR_Nem_3	82	86	PF02991	0.516
LIG_PCNA_yPIPBox_3	179	189	PF02747	0.531
LIG_PCNA_yPIPBox_3	211	224	PF02747	0.456
LIG_PCNA_yPIPBox_3	380	392	PF02747	0.394
LIG_Pex14_2	762	766	PF04695	0.520
LIG_PTAP_UEV_1	470	475	PF05743	0.472
LIG_SH2_PTP2	30	33	PF00017	0.558
LIG_SH2_SRC	30	33	PF00017	0.558
LIG_SH2_SRC	605	608	PF00017	0.474
LIG_SH2_STAP1	18	22	PF00017	0.627
LIG_SH2_STAP1	76	80	PF00017	0.550
LIG_SH2_STAT5	1160	1163	PF00017	0.411
LIG_SH2_STAT5	1212	1215	PF00017	0.694
LIG_SH2_STAT5	30	33	PF00017	0.558
LIG_SH2_STAT5	605	608	PF00017	0.474
LIG_SH3_1	8	14	PF00018	0.618
LIG_SH3_3	1167	1173	PF00018	0.576
LIG_SH3_3	149	155	PF00018	0.568
LIG_SH3_3	468	474	PF00018	0.627
LIG_SH3_3	484	490	PF00018	0.438
LIG_SH3_3	676	682	PF00018	0.630
LIG_SH3_3	8	14	PF00018	0.545
LIG_SUMO_SIM_anti_2	29	38	PF11976	0.536
LIG_SUMO_SIM_anti_2	48	54	PF11976	0.546
LIG_SUMO_SIM_anti_2	894	900	PF11976	0.379
LIG_SUMO_SIM_par_1	1036	1042	PF11976	0.400
LIG_SUMO_SIM_par_1	840	846	PF11976	0.415
LIG_TRAF2_1	1114	1117	PF00917	0.589
LIG_TRAF2_1	252	255	PF00917	0.564
LIG_TRAF2_1	441	444	PF00917	0.555
LIG_TRAF2_1	618	621	PF00917	0.488
LIG_TRAF2_1	843	846	PF00917	0.574
LIG_TRAF2_1	847	850	PF00917	0.541
LIG_TRAF2_1	908	911	PF00917	0.517
LIG_WRC_WIRS_1	609	614	PF05994	0.549
LIG_WRC_WIRS_1	80	85	PF05994	0.647
MOD_CDK_SPK_2	486	491	PF00069	0.622
MOD_CDK_SPxxK_3	597	604	PF00069	0.622
MOD_CK1_1	1109	1115	PF00069	0.636
MOD_CK1_1	1121	1127	PF00069	0.676
MOD_CK1_1	148	154	PF00069	0.774
MOD_CK1_1	256	262	PF00069	0.714
MOD_CK1_1	282	288	PF00069	0.690
MOD_CK1_1	312	318	PF00069	0.730
MOD_CK1_1	363	369	PF00069	0.718
MOD_CK1_1	395	401	PF00069	0.614
MOD_CK1_1	437	443	PF00069	0.753
MOD_CK1_1	520	526	PF00069	0.720
MOD_CK1_1	539	545	PF00069	0.462
MOD_CK1_1	557	563	PF00069	0.708
MOD_CK1_1	608	614	PF00069	0.549
MOD_CK1_1	648	654	PF00069	0.767
MOD_CK1_1	728	734	PF00069	0.650
MOD_CK1_1	803	809	PF00069	0.711
MOD_CK2_1	1033	1039	PF00069	0.676
MOD_CK2_1	1050	1056	PF00069	0.483
MOD_CK2_1	1191	1197	PF00069	0.714
MOD_CK2_1	162	168	PF00069	0.688
MOD_CK2_1	282	288	PF00069	0.710
MOD_CK2_1	32	38	PF00069	0.636
MOD_CK2_1	396	402	PF00069	0.489
MOD_CK2_1	438	444	PF00069	0.634
MOD_CK2_1	535	541	PF00069	0.642
MOD_CK2_1	569	575	PF00069	0.648
MOD_CK2_1	615	621	PF00069	0.603
MOD_CK2_1	627	633	PF00069	0.626
MOD_CK2_1	698	704	PF00069	0.605
MOD_CK2_1	786	792	PF00069	0.663
MOD_CK2_1	79	85	PF00069	0.650
MOD_CK2_1	821	827	PF00069	0.738
MOD_GlcNHglycan	1052	1055	PF01048	0.507
MOD_GlcNHglycan	1093	1096	PF01048	0.595
MOD_GlcNHglycan	1112	1115	PF01048	0.486
MOD_GlcNHglycan	113	116	PF01048	0.796
MOD_GlcNHglycan	1185	1188	PF01048	0.649
MOD_GlcNHglycan	133	136	PF01048	0.438
MOD_GlcNHglycan	195	198	PF01048	0.733
MOD_GlcNHglycan	237	240	PF01048	0.668
MOD_GlcNHglycan	258	261	PF01048	0.700
MOD_GlcNHglycan	262	265	PF01048	0.620
MOD_GlcNHglycan	292	295	PF01048	0.653
MOD_GlcNHglycan	393	397	PF01048	0.700
MOD_GlcNHglycan	436	439	PF01048	0.731
MOD_GlcNHglycan	456	459	PF01048	0.457
MOD_GlcNHglycan	460	463	PF01048	0.688
MOD_GlcNHglycan	471	474	PF01048	0.590
MOD_GlcNHglycan	538	541	PF01048	0.661
MOD_GlcNHglycan	648	651	PF01048	0.658
MOD_GlcNHglycan	741	744	PF01048	0.741
MOD_GlcNHglycan	789	792	PF01048	0.623
MOD_GlcNHglycan	823	826	PF01048	0.724
MOD_GlcNHglycan	867	870	PF01048	0.567
MOD_GlcNHglycan	903	906	PF01048	0.639
MOD_GlcNHglycan	994	997	PF01048	0.644
MOD_GSK3_1	1039	1046	PF00069	0.615
MOD_GSK3_1	1066	1073	PF00069	0.699
MOD_GSK3_1	1077	1084	PF00069	0.549
MOD_GSK3_1	1106	1113	PF00069	0.641
MOD_GSK3_1	111	118	PF00069	0.737
MOD_GSK3_1	1117	1124	PF00069	0.589
MOD_GSK3_1	1128	1135	PF00069	0.633
MOD_GSK3_1	142	149	PF00069	0.814
MOD_GSK3_1	150	157	PF00069	0.656
MOD_GSK3_1	256	263	PF00069	0.609
MOD_GSK3_1	3	10	PF00069	0.631
MOD_GSK3_1	392	399	PF00069	0.626
MOD_GSK3_1	417	424	PF00069	0.629
MOD_GSK3_1	434	441	PF00069	0.660
MOD_GSK3_1	454	461	PF00069	0.457
MOD_GSK3_1	469	476	PF00069	0.761
MOD_GSK3_1	517	524	PF00069	0.614
MOD_GSK3_1	535	542	PF00069	0.658
MOD_GSK3_1	554	561	PF00069	0.736
MOD_GSK3_1	570	577	PF00069	0.629
MOD_GSK3_1	615	622	PF00069	0.603
MOD_GSK3_1	627	634	PF00069	0.626
MOD_GSK3_1	694	701	PF00069	0.697
MOD_GSK3_1	720	727	PF00069	0.661
MOD_GSK3_1	765	772	PF00069	0.718
MOD_GSK3_1	796	803	PF00069	0.663
MOD_GSK3_1	819	826	PF00069	0.759
MOD_GSK3_1	887	894	PF00069	0.690
MOD_GSK3_1	931	938	PF00069	0.640
MOD_GSK3_1	992	999	PF00069	0.627
MOD_LATS_1	1064	1070	PF00433	0.572
MOD_N-GLC_1	597	602	PF02516	0.727
MOD_N-GLC_1	622	627	PF02516	0.716
MOD_N-GLC_1	901	906	PF02516	0.515
MOD_N-GLC_1	992	997	PF02516	0.640
MOD_NEK2_1	1007	1012	PF00069	0.570
MOD_NEK2_1	1048	1053	PF00069	0.543
MOD_NEK2_1	167	172	PF00069	0.660
MOD_NEK2_1	268	273	PF00069	0.676
MOD_NEK2_1	279	284	PF00069	0.576
MOD_NEK2_1	352	357	PF00069	0.729
MOD_NEK2_1	619	624	PF00069	0.674
MOD_NEK2_1	631	636	PF00069	0.551
MOD_NEK2_1	72	77	PF00069	0.606
MOD_NEK2_1	819	824	PF00069	0.770
MOD_PIKK_1	1013	1019	PF00454	0.665
MOD_PIKK_1	1023	1029	PF00454	0.603
MOD_PIKK_1	1118	1124	PF00454	0.735
MOD_PIKK_1	310	316	PF00454	0.628
MOD_PIKK_1	473	479	PF00454	0.788
MOD_PIKK_1	539	545	PF00454	0.737
MOD_PIKK_1	767	773	PF00454	0.638
MOD_PIKK_1	828	834	PF00454	0.576
MOD_PIKK_1	887	893	PF00454	0.622
MOD_PIKK_1	964	970	PF00454	0.651
MOD_PK_1	1099	1105	PF00069	0.617
MOD_PKA_1	180	186	PF00069	0.741
MOD_PKA_1	887	893	PF00069	0.563
MOD_PKA_2	1023	1029	PF00069	0.703
MOD_PKA_2	1109	1115	PF00069	0.636
MOD_PKA_2	1182	1188	PF00069	0.602
MOD_PKA_2	180	186	PF00069	0.699
MOD_PKA_2	235	241	PF00069	0.763
MOD_PKA_2	268	274	PF00069	0.717
MOD_PKA_2	352	358	PF00069	0.714
MOD_PKA_2	536	542	PF00069	0.685
MOD_PKA_2	662	668	PF00069	0.678
MOD_PKA_2	754	760	PF00069	0.720
MOD_PKA_2	784	790	PF00069	0.513
MOD_PKA_2	819	825	PF00069	0.682
MOD_PKA_2	887	893	PF00069	0.563
MOD_PKA_2	930	936	PF00069	0.651
MOD_PKB_1	877	885	PF00069	0.637
MOD_Plk_1	1007	1013	PF00069	0.612
MOD_Plk_1	1067	1073	PF00069	0.564
MOD_Plk_1	253	259	PF00069	0.719
MOD_Plk_1	493	499	PF00069	0.726
MOD_Plk_1	574	580	PF00069	0.566
MOD_Plk_1	615	621	PF00069	0.603
MOD_Plk_1	724	730	PF00069	0.642
MOD_Plk_2-3	575	581	PF00069	0.680
MOD_Plk_2-3	615	621	PF00069	0.603
MOD_Plk_4	1007	1013	PF00069	0.591
MOD_Plk_4	1081	1087	PF00069	0.630
MOD_Plk_4	1121	1127	PF00069	0.554
MOD_Plk_4	26	32	PF00069	0.712
MOD_Plk_4	396	402	PF00069	0.612
MOD_Plk_4	605	611	PF00069	0.584
MOD_Plk_4	725	731	PF00069	0.641
MOD_Plk_4	942	948	PF00069	0.648
MOD_Plk_4	979	985	PF00069	0.699
MOD_ProDKin_1	109	115	PF00069	0.774
MOD_ProDKin_1	117	123	PF00069	0.730
MOD_ProDKin_1	148	154	PF00069	0.762
MOD_ProDKin_1	361	367	PF00069	0.703
MOD_ProDKin_1	486	492	PF00069	0.624
MOD_ProDKin_1	558	564	PF00069	0.771
MOD_ProDKin_1	591	597	PF00069	0.683
MOD_ProDKin_1	694	700	PF00069	0.683
MOD_ProDKin_1	7	13	PF00069	0.689
MOD_ProDKin_1	858	864	PF00069	0.660
MOD_SUMO_for_1	1065	1068	PF00179	0.608
MOD_SUMO_for_1	544	547	PF00179	0.712
MOD_SUMO_for_1	613	616	PF00179	0.591
MOD_SUMO_rev_2	1034	1043	PF00179	0.644
MOD_SUMO_rev_2	1079	1085	PF00179	0.573
MOD_SUMO_rev_2	274	279	PF00179	0.607
TRG_DiLeu_BaEn_1	925	930	PF01217	0.632
TRG_DiLeu_BaLyEn_6	1055	1060	PF01217	0.723
TRG_DiLeu_BaLyEn_6	1144	1149	PF01217	0.397
TRG_DiLeu_BaLyEn_6	776	781	PF01217	0.482
TRG_ENDOCYTIC_2	1159	1162	PF00928	0.353
TRG_ENDOCYTIC_2	30	33	PF00928	0.708
TRG_ENDOCYTIC_2	603	606	PF00928	0.600
TRG_ER_diArg_1	180	182	PF00400	0.657
TRG_ER_diArg_1	268	270	PF00400	0.725
TRG_ER_diArg_1	347	349	PF00400	0.460
TRG_ER_diArg_1	390	392	PF00400	0.681
TRG_ER_diArg_1	710	712	PF00400	0.738
TRG_ER_diArg_1	885	888	PF00400	0.568
TRG_NES_CRM1_1	48	62	PF08389	0.594
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.723
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	711	715	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	920	924	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P568	Leptomonas seymouri	43%	89%
A0A3Q8I9Q1	Leishmania donovani	90%	100%
A4H7F0	Leishmania braziliensis	73%	93%
A4HVT8	Leishmania infantum	90%	100%
E9API4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%