Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 5, putative

Species:

Leishmania major

UniProt:

Q4QFZ3_LEIMA

TriTrypDb:

LmjF.13.1610 , LMJLV39_130020800 , LMJSD75_130020800

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	16
GO:0099080	supramolecular complex	2	16
GO:0099081	supramolecular polymer	3	16
GO:0099512	supramolecular fiber	4	16
GO:0099513	polymeric cytoskeletal fiber	5	16
GO:0110165	cellular anatomical entity	1	16
GO:0000922	spindle pole	2	1
GO:0005634	nucleus	5	1
GO:0005819	spindle	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

Q4QFZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFZ3

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	3
GO:0007017	microtubule-based process	2	16
GO:0007018	microtubule-based movement	3	16
GO:0007019	microtubule depolymerization	5	3
GO:0009987	cellular process	1	16
GO:0016043	cellular component organization	3	3
GO:0022411	cellular component disassembly	4	3
GO:0031109	microtubule polymerization or depolymerization	4	3
GO:0032984	protein-containing complex disassembly	5	3
GO:0043933	protein-containing complex organization	4	3
GO:0051261	protein depolymerization	6	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:0097435	supramolecular fiber organization	4	3
GO:0007051	spindle organization	3	1
GO:0007052	mitotic spindle organization	4	1
GO:0022402	cell cycle process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	16
GO:0003774	cytoskeletal motor activity	1	16
GO:0003777	microtubule motor activity	2	16
GO:0005488	binding	1	16
GO:0005515	protein binding	2	16
GO:0005524	ATP binding	5	16
GO:0008017	microtubule binding	5	16
GO:0008092	cytoskeletal protein binding	3	16
GO:0015631	tubulin binding	4	16
GO:0017076	purine nucleotide binding	4	16
GO:0030554	adenyl nucleotide binding	5	16
GO:0032553	ribonucleotide binding	3	16
GO:0032555	purine ribonucleotide binding	4	16
GO:0032559	adenyl ribonucleotide binding	5	16
GO:0035639	purine ribonucleoside triphosphate binding	4	16
GO:0036094	small molecule binding	2	16
GO:0043167	ion binding	2	16
GO:0043168	anion binding	3	16
GO:0097159	organic cyclic compound binding	2	16
GO:0097367	carbohydrate derivative binding	2	16
GO:0140657	ATP-dependent activity	1	16
GO:1901265	nucleoside phosphate binding	3	16
GO:1901363	heterocyclic compound binding	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.357
CLV_C14_Caspase3-7	222	226	PF00656	0.338
CLV_C14_Caspase3-7	431	435	PF00656	0.297
CLV_C14_Caspase3-7	590	594	PF00656	0.713
CLV_C14_Caspase3-7	646	650	PF00656	0.654
CLV_NRD_NRD_1	115	117	PF00675	0.651
CLV_NRD_NRD_1	125	127	PF00675	0.728
CLV_NRD_NRD_1	142	144	PF00675	0.648
CLV_NRD_NRD_1	181	183	PF00675	0.671
CLV_NRD_NRD_1	193	195	PF00675	0.667
CLV_NRD_NRD_1	202	204	PF00675	0.344
CLV_NRD_NRD_1	258	260	PF00675	0.458
CLV_NRD_NRD_1	51	53	PF00675	0.406
CLV_NRD_NRD_1	552	554	PF00675	0.649
CLV_NRD_NRD_1	695	697	PF00675	0.584
CLV_NRD_NRD_1	706	708	PF00675	0.541
CLV_NRD_NRD_1	712	714	PF00675	0.538
CLV_PCSK_KEX2_1	115	117	PF00082	0.678
CLV_PCSK_KEX2_1	125	127	PF00082	0.728
CLV_PCSK_KEX2_1	142	144	PF00082	0.648
CLV_PCSK_KEX2_1	181	183	PF00082	0.679
CLV_PCSK_KEX2_1	192	194	PF00082	0.643
CLV_PCSK_KEX2_1	204	206	PF00082	0.342
CLV_PCSK_KEX2_1	51	53	PF00082	0.406
CLV_PCSK_KEX2_1	552	554	PF00082	0.649
CLV_PCSK_KEX2_1	62	64	PF00082	0.486
CLV_PCSK_KEX2_1	695	697	PF00082	0.583
CLV_PCSK_KEX2_1	706	708	PF00082	0.540
CLV_PCSK_KEX2_1	712	714	PF00082	0.536
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.370
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.486
CLV_PCSK_SKI1_1	115	119	PF00082	0.725
CLV_PCSK_SKI1_1	181	185	PF00082	0.726
CLV_PCSK_SKI1_1	33	37	PF00082	0.442
CLV_PCSK_SKI1_1	448	452	PF00082	0.338
CLV_PCSK_SKI1_1	515	519	PF00082	0.527
CLV_PCSK_SKI1_1	52	56	PF00082	0.409
CLV_PCSK_SKI1_1	552	556	PF00082	0.746
CLV_PCSK_SKI1_1	557	561	PF00082	0.763
CLV_PCSK_SKI1_1	6	10	PF00082	0.464
CLV_PCSK_SKI1_1	605	609	PF00082	0.817
DEG_APCC_DBOX_1	50	58	PF00400	0.393
DEG_Nend_UBRbox_2	1	3	PF02207	0.425
DEG_SCF_FBW7_1	620	625	PF00400	0.684
DEG_SPOP_SBC_1	558	562	PF00917	0.712
DEG_SPOP_SBC_1	606	610	PF00917	0.717
DOC_AGCK_PIF_1	415	420	PF00069	0.297
DOC_ANK_TNKS_1	181	188	PF00023	0.762
DOC_CKS1_1	110	115	PF01111	0.755
DOC_CKS1_1	573	578	PF01111	0.639
DOC_CKS1_1	635	640	PF01111	0.753
DOC_CYCLIN_RxL_1	445	455	PF00134	0.338
DOC_MAPK_gen_1	192	202	PF00069	0.518
DOC_MAPK_gen_1	302	310	PF00069	0.425
DOC_MAPK_gen_1	319	328	PF00069	0.457
DOC_MAPK_gen_1	51	60	PF00069	0.489
DOC_MAPK_HePTP_8	316	328	PF00069	0.316
DOC_MAPK_MEF2A_6	193	202	PF00069	0.508
DOC_MAPK_MEF2A_6	319	328	PF00069	0.297
DOC_MAPK_MEF2A_6	398	407	PF00069	0.338
DOC_PP2B_LxvP_1	97	100	PF13499	0.528
DOC_USP7_MATH_1	111	115	PF00917	0.656
DOC_USP7_MATH_1	386	390	PF00917	0.308
DOC_USP7_MATH_1	394	398	PF00917	0.307
DOC_USP7_MATH_1	497	501	PF00917	0.297
DOC_USP7_MATH_1	606	610	PF00917	0.795
DOC_USP7_MATH_1	622	626	PF00917	0.571
DOC_USP7_MATH_1	66	70	PF00917	0.624
DOC_USP7_MATH_1	686	690	PF00917	0.513
DOC_USP7_MATH_1	78	82	PF00917	0.594
DOC_USP7_UBL2_3	515	519	PF12436	0.454
DOC_WW_Pin1_4	109	114	PF00397	0.661
DOC_WW_Pin1_4	115	120	PF00397	0.684
DOC_WW_Pin1_4	172	177	PF00397	0.677
DOC_WW_Pin1_4	492	497	PF00397	0.338
DOC_WW_Pin1_4	572	577	PF00397	0.661
DOC_WW_Pin1_4	608	613	PF00397	0.683
DOC_WW_Pin1_4	618	623	PF00397	0.581
DOC_WW_Pin1_4	634	639	PF00397	0.627
DOC_WW_Pin1_4	71	76	PF00397	0.664
DOC_WW_Pin1_4	83	88	PF00397	0.629
LIG_14-3-3_CanoR_1	136	145	PF00244	0.769
LIG_14-3-3_CanoR_1	170	176	PF00244	0.702
LIG_14-3-3_CanoR_1	197	201	PF00244	0.443
LIG_14-3-3_CanoR_1	249	253	PF00244	0.321
LIG_14-3-3_CanoR_1	417	421	PF00244	0.297
LIG_14-3-3_CanoR_1	597	603	PF00244	0.712
LIG_14-3-3_CanoR_1	605	612	PF00244	0.749
LIG_BRCT_BRCA1_1	545	549	PF00533	0.626
LIG_EH1_1	40	48	PF00400	0.557
LIG_EH1_1	663	671	PF00400	0.561
LIG_FHA_1	197	203	PF00498	0.444
LIG_FHA_1	240	246	PF00498	0.325
LIG_FHA_1	369	375	PF00498	0.285
LIG_FHA_1	436	442	PF00498	0.316
LIG_FHA_1	473	479	PF00498	0.338
LIG_FHA_1	486	492	PF00498	0.338
LIG_FHA_1	535	541	PF00498	0.635
LIG_FHA_2	116	122	PF00498	0.758
LIG_FHA_2	220	226	PF00498	0.297
LIG_FHA_2	229	235	PF00498	0.297
LIG_FHA_2	259	265	PF00498	0.383
LIG_FHA_2	274	280	PF00498	0.307
LIG_FHA_2	34	40	PF00498	0.429
LIG_FHA_2	417	423	PF00498	0.338
LIG_FHA_2	437	443	PF00498	0.155
LIG_LIR_Apic_2	616	620	PF02991	0.632
LIG_LIR_Gen_1	214	224	PF02991	0.352
LIG_LIR_Gen_1	251	256	PF02991	0.301
LIG_LIR_Gen_1	296	303	PF02991	0.294
LIG_LIR_Gen_1	315	324	PF02991	0.410
LIG_LIR_Gen_1	39	48	PF02991	0.427
LIG_LIR_Gen_1	419	424	PF02991	0.331
LIG_LIR_Nem_3	214	220	PF02991	0.352
LIG_LIR_Nem_3	251	255	PF02991	0.296
LIG_LIR_Nem_3	296	300	PF02991	0.294
LIG_LIR_Nem_3	315	320	PF02991	0.410
LIG_LIR_Nem_3	329	334	PF02991	0.338
LIG_LIR_Nem_3	39	43	PF02991	0.454
LIG_LIR_Nem_3	419	423	PF02991	0.331
LIG_NRBOX	337	343	PF00104	0.338
LIG_NRBOX	4	10	PF00104	0.440
LIG_NRP_CendR_1	727	728	PF00754	0.635
LIG_Pex14_2	414	418	PF04695	0.297
LIG_Rb_LxCxE_1	344	365	PF01857	0.297
LIG_REV1ctd_RIR_1	412	421	PF16727	0.297
LIG_SH2_CRK	217	221	PF00017	0.297
LIG_SH2_CRK	252	256	PF00017	0.297
LIG_SH2_CRK	297	301	PF00017	0.316
LIG_SH2_CRK	339	343	PF00017	0.425
LIG_SH2_CRK	40	44	PF00017	0.420
LIG_SH2_CRK	617	621	PF00017	0.717
LIG_SH2_SRC	266	269	PF00017	0.425
LIG_SH2_STAP1	217	221	PF00017	0.297
LIG_SH2_STAP1	252	256	PF00017	0.297
LIG_SH2_STAP1	510	514	PF00017	0.338
LIG_SH2_STAP1	718	722	PF00017	0.593
LIG_SH2_STAT5	244	247	PF00017	0.325
LIG_SH2_STAT5	297	300	PF00017	0.298
LIG_SH2_STAT5	309	312	PF00017	0.275
LIG_SH2_STAT5	693	696	PF00017	0.443
LIG_SH2_STAT5	718	721	PF00017	0.492
LIG_SH3_2	104	109	PF14604	0.678
LIG_SH3_3	101	107	PF00018	0.632
LIG_SH3_3	157	163	PF00018	0.715
LIG_SH3_3	570	576	PF00018	0.676
LIG_SH3_3	72	78	PF00018	0.688
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.441
LIG_SUMO_SIM_par_1	228	234	PF11976	0.342
LIG_TRAF2_1	526	529	PF00917	0.579
LIG_TRAF2_2	235	240	PF00917	0.297
LIG_UBA3_1	229	238	PF00899	0.325
LIG_UBA3_1	450	454	PF00899	0.338
LIG_UBA3_1	54	62	PF00899	0.410
LIG_UBA3_1	669	674	PF00899	0.434
LIG_WRC_WIRS_1	581	586	PF05994	0.743
MOD_CDC14_SPxK_1	611	614	PF00782	0.760
MOD_CDK_SPxK_1	109	115	PF00069	0.720
MOD_CDK_SPxK_1	608	614	PF00069	0.758
MOD_CDK_SPxxK_3	109	116	PF00069	0.663
MOD_CDK_SPxxK_3	174	181	PF00069	0.677
MOD_CDK_SPxxK_3	572	579	PF00069	0.624
MOD_CDK_SPxxK_3	608	615	PF00069	0.760
MOD_CK1_1	174	180	PF00069	0.666
MOD_CK1_1	196	202	PF00069	0.534
MOD_CK1_1	293	299	PF00069	0.336
MOD_CK1_1	318	324	PF00069	0.335
MOD_CK1_1	396	402	PF00069	0.322
MOD_CK1_1	435	441	PF00069	0.316
MOD_CK1_1	472	478	PF00069	0.338
MOD_CK1_1	495	501	PF00069	0.297
MOD_CK1_1	522	528	PF00069	0.692
MOD_CK1_1	561	567	PF00069	0.669
MOD_CK1_1	592	598	PF00069	0.727
MOD_CK1_1	601	607	PF00069	0.612
MOD_CK1_1	629	635	PF00069	0.661
MOD_CK1_1	647	653	PF00069	0.573
MOD_CK1_1	81	87	PF00069	0.668
MOD_CK2_1	115	121	PF00069	0.644
MOD_CK2_1	228	234	PF00069	0.500
MOD_CK2_1	273	279	PF00069	0.296
MOD_CK2_1	326	332	PF00069	0.355
MOD_CK2_1	436	442	PF00069	0.338
MOD_CK2_1	522	528	PF00069	0.657
MOD_Cter_Amidation	179	182	PF01082	0.773
MOD_Cter_Amidation	725	728	PF01082	0.576
MOD_GlcNHglycan	292	295	PF01048	0.342
MOD_GlcNHglycan	497	500	PF01048	0.297
MOD_GlcNHglycan	524	527	PF01048	0.653
MOD_GlcNHglycan	545	548	PF01048	0.653
MOD_GlcNHglycan	628	631	PF01048	0.725
MOD_GlcNHglycan	632	635	PF01048	0.709
MOD_GlcNHglycan	646	649	PF01048	0.564
MOD_GlcNHglycan	68	71	PF01048	0.656
MOD_GlcNHglycan	690	693	PF01048	0.479
MOD_GSK3_1	111	118	PF00069	0.592
MOD_GSK3_1	162	169	PF00069	0.656
MOD_GSK3_1	432	439	PF00069	0.297
MOD_GSK3_1	497	504	PF00069	0.297
MOD_GSK3_1	539	546	PF00069	0.609
MOD_GSK3_1	557	564	PF00069	0.663
MOD_GSK3_1	588	595	PF00069	0.756
MOD_GSK3_1	601	608	PF00069	0.479
MOD_GSK3_1	618	625	PF00069	0.561
MOD_GSK3_1	626	633	PF00069	0.676
MOD_GSK3_1	640	647	PF00069	0.703
MOD_GSK3_1	88	95	PF00069	0.773
MOD_LATS_1	624	630	PF00433	0.659
MOD_N-GLC_1	207	212	PF02516	0.303
MOD_N-GLC_1	326	331	PF02516	0.425
MOD_N-GLC_1	446	451	PF02516	0.338
MOD_N-GLC_1	492	497	PF02516	0.297
MOD_N-GLC_1	598	603	PF02516	0.665
MOD_N-GLC_1	66	71	PF02516	0.622
MOD_N-GLC_2	359	361	PF02516	0.297
MOD_NEK2_1	14	19	PF00069	0.486
MOD_NEK2_1	273	278	PF00069	0.352
MOD_NEK2_1	403	408	PF00069	0.297
MOD_NEK2_1	469	474	PF00069	0.338
MOD_NEK2_1	483	488	PF00069	0.338
MOD_NEK2_1	580	585	PF00069	0.730
MOD_NEK2_2	281	286	PF00069	0.363
MOD_NEK2_2	380	385	PF00069	0.297
MOD_PIKK_1	137	143	PF00454	0.552
MOD_PIKK_1	563	569	PF00454	0.655
MOD_PIKK_1	675	681	PF00454	0.590
MOD_PIKK_1	700	706	PF00454	0.504
MOD_PIKK_1	98	104	PF00454	0.527
MOD_PKA_1	181	187	PF00069	0.763
MOD_PKA_1	193	199	PF00069	0.498
MOD_PKA_2	181	187	PF00069	0.770
MOD_PKA_2	193	199	PF00069	0.449
MOD_PKA_2	248	254	PF00069	0.297
MOD_PKA_2	258	264	PF00069	0.297
MOD_PKA_2	318	324	PF00069	0.459
MOD_PKA_2	416	422	PF00069	0.328
MOD_PKA_2	436	442	PF00069	0.422
MOD_PKA_2	469	475	PF00069	0.338
MOD_PKA_2	562	568	PF00069	0.646
MOD_Plk_1	14	20	PF00069	0.439
MOD_Plk_1	239	245	PF00069	0.405
MOD_Plk_1	326	332	PF00069	0.425
MOD_Plk_1	446	452	PF00069	0.338
MOD_Plk_1	501	507	PF00069	0.338
MOD_Plk_1	592	598	PF00069	0.760
MOD_Plk_1	640	646	PF00069	0.730
MOD_Plk_1	675	681	PF00069	0.555
MOD_Plk_1	686	692	PF00069	0.610
MOD_Plk_2-3	144	150	PF00069	0.625
MOD_Plk_4	273	279	PF00069	0.338
MOD_Plk_4	295	301	PF00069	0.347
MOD_Plk_4	326	332	PF00069	0.354
MOD_Plk_4	446	452	PF00069	0.338
MOD_ProDKin_1	109	115	PF00069	0.662
MOD_ProDKin_1	172	178	PF00069	0.672
MOD_ProDKin_1	492	498	PF00069	0.338
MOD_ProDKin_1	572	578	PF00069	0.662
MOD_ProDKin_1	608	614	PF00069	0.686
MOD_ProDKin_1	618	624	PF00069	0.581
MOD_ProDKin_1	634	640	PF00069	0.626
MOD_ProDKin_1	71	77	PF00069	0.664
MOD_ProDKin_1	83	89	PF00069	0.625
MOD_SUMO_for_1	673	676	PF00179	0.489
MOD_SUMO_rev_2	253	261	PF00179	0.344
TRG_DiLeu_BaEn_1	306	311	PF01217	0.297
TRG_DiLeu_BaEn_1	654	659	PF01217	0.586
TRG_DiLeu_BaEn_2	55	61	PF01217	0.541
TRG_DiLeu_BaEn_3	654	660	PF01217	0.503
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.341
TRG_ENDOCYTIC_2	217	220	PF00928	0.297
TRG_ENDOCYTIC_2	252	255	PF00928	0.323
TRG_ENDOCYTIC_2	297	300	PF00928	0.305
TRG_ENDOCYTIC_2	339	342	PF00928	0.395
TRG_ENDOCYTIC_2	40	43	PF00928	0.449
TRG_ER_diArg_1	192	194	PF00400	0.643
TRG_ER_diArg_1	202	205	PF00400	0.320
TRG_ER_diArg_1	695	697	PF00400	0.615
TRG_ER_diArg_1	705	707	PF00400	0.567
TRG_ER_diArg_1	711	713	PF00400	0.486
TRG_NLS_Bipartite_1	192	207	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.338
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	706	710	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P6	Leptomonas seymouri	47%	100%
A0A0N1PAZ2	Leptomonas seymouri	81%	97%
A0A0N1PDD6	Leptomonas seymouri	29%	96%
A0A1X0NL76	Trypanosomatidae	66%	100%
A0A3S5H4S8	Leishmania donovani	46%	100%
A0A3S7WST0	Leishmania donovani	98%	100%
A0A422P4C5	Trypanosoma rangeli	64%	100%
A4H7F1	Leishmania braziliensis	93%	100%
A4HAQ7	Leishmania braziliensis	27%	100%
A4HRC5	Leishmania infantum	46%	100%
A4HSA6	Leishmania infantum	30%	100%
A4HVT9	Leishmania infantum	98%	100%
A4I9W6	Leishmania infantum	27%	68%
B9EY52	Oryza sativa subsp. japonica	42%	100%
B9FMJ3	Oryza sativa subsp. japonica	38%	89%
C9ZXH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A6E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9ABZ2	Leishmania major	46%	100%
E9AJ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9API5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B4X8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	67%
Q940B8	Arabidopsis thaliana	40%	92%
Q940Y8	Arabidopsis thaliana	42%	100%
V5BHI2	Trypanosoma cruzi	66%	100%
V5BMP0	Trypanosoma cruzi	29%	94%