Squalene monooxygenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

squalene monooxygenase-like protein

Species:

Leishmania major

UniProt:

Q4QFZ2_LEIMA

TriTrypDb:

LmjF.13.1620 , LMJLV39_130020900 , LMJSD75_130020900

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QFZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0006694	steroid biosynthetic process	5	12
GO:0008152	metabolic process	1	12
GO:0008202	steroid metabolic process	4	12
GO:0008610	lipid biosynthetic process	4	12
GO:0009058	biosynthetic process	2	12
GO:0016125	sterol metabolic process	4	12
GO:0016126	sterol biosynthetic process	5	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1901615	organic hydroxy compound metabolic process	3	12
GO:1901617	organic hydroxy compound biosynthetic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004497	monooxygenase activity	3	12
GO:0004506	squalene monooxygenase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	12
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0071949	FAD binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.522
CLV_NRD_NRD_1	204	206	PF00675	0.469
CLV_NRD_NRD_1	563	565	PF00675	0.585
CLV_NRD_NRD_1	58	60	PF00675	0.368
CLV_PCSK_KEX2_1	548	550	PF00082	0.476
CLV_PCSK_PC1ET2_1	548	550	PF00082	0.476
CLV_PCSK_SKI1_1	206	210	PF00082	0.357
CLV_PCSK_SKI1_1	548	552	PF00082	0.437
CLV_PCSK_SKI1_1	59	63	PF00082	0.338
CLV_PCSK_SKI1_1	66	70	PF00082	0.368
DEG_MDM2_SWIB_1	530	537	PF02201	0.437
DEG_Nend_Nbox_1	1	3	PF02207	0.475
DOC_CYCLIN_RxL_1	60	73	PF00134	0.395
DOC_MAPK_gen_1	122	130	PF00069	0.493
DOC_MAPK_gen_1	252	260	PF00069	0.423
DOC_MAPK_gen_1	562	569	PF00069	0.580
DOC_MAPK_MEF2A_6	206	215	PF00069	0.318
DOC_MAPK_MEF2A_6	517	525	PF00069	0.490
DOC_PP4_FxxP_1	423	426	PF00568	0.282
DOC_PP4_FxxP_1	536	539	PF00568	0.445
DOC_PP4_FxxP_1	69	72	PF00568	0.363
DOC_USP7_MATH_1	30	34	PF00917	0.513
DOC_USP7_MATH_1	334	338	PF00917	0.411
DOC_WW_Pin1_4	228	233	PF00397	0.359
DOC_WW_Pin1_4	25	30	PF00397	0.520
DOC_WW_Pin1_4	422	427	PF00397	0.379
DOC_WW_Pin1_4	538	543	PF00397	0.463
LIG_14-3-3_CanoR_1	205	211	PF00244	0.402
LIG_14-3-3_CanoR_1	31	35	PF00244	0.518
LIG_14-3-3_CanoR_1	368	374	PF00244	0.423
LIG_14-3-3_CanoR_1	403	412	PF00244	0.367
LIG_14-3-3_CanoR_1	549	554	PF00244	0.380
LIG_Actin_WH2_2	11	28	PF00022	0.491
LIG_Actin_WH2_2	366	382	PF00022	0.399
LIG_Actin_WH2_2	415	431	PF00022	0.318
LIG_Actin_WH2_2	73	91	PF00022	0.444
LIG_BRCT_BRCA1_1	128	132	PF00533	0.335
LIG_BRCT_BRCA1_1	140	144	PF00533	0.342
LIG_BRCT_BRCA1_1	458	462	PF00533	0.255
LIG_CtBP_PxDLS_1	306	310	PF00389	0.402
LIG_FHA_1	12	18	PF00498	0.442
LIG_FHA_1	161	167	PF00498	0.388
LIG_FHA_1	195	201	PF00498	0.441
LIG_FHA_1	207	213	PF00498	0.308
LIG_FHA_1	245	251	PF00498	0.364
LIG_FHA_1	261	267	PF00498	0.239
LIG_FHA_1	318	324	PF00498	0.337
LIG_FHA_1	538	544	PF00498	0.362
LIG_FHA_2	150	156	PF00498	0.354
LIG_FHA_2	176	182	PF00498	0.441
LIG_FHA_2	30	36	PF00498	0.397
LIG_FHA_2	68	74	PF00498	0.430
LIG_G3BP_FGDF_1	130	135	PF02136	0.375
LIG_HP1_1	211	215	PF01393	0.387
LIG_LIR_Apic_2	181	186	PF02991	0.464
LIG_LIR_Apic_2	281	285	PF02991	0.318
LIG_LIR_Apic_2	421	426	PF02991	0.391
LIG_LIR_Apic_2	67	72	PF02991	0.363
LIG_LIR_Gen_1	311	319	PF02991	0.423
LIG_LIR_Gen_1	33	41	PF02991	0.343
LIG_LIR_Gen_1	430	437	PF02991	0.370
LIG_LIR_Gen_1	504	513	PF02991	0.446
LIG_LIR_LC3C_4	209	214	PF02991	0.423
LIG_LIR_Nem_3	129	135	PF02991	0.343
LIG_LIR_Nem_3	225	230	PF02991	0.334
LIG_LIR_Nem_3	238	243	PF02991	0.233
LIG_LIR_Nem_3	311	316	PF02991	0.423
LIG_LIR_Nem_3	33	39	PF02991	0.348
LIG_LIR_Nem_3	416	420	PF02991	0.314
LIG_LIR_Nem_3	430	436	PF02991	0.289
LIG_LIR_Nem_3	459	464	PF02991	0.285
LIG_LIR_Nem_3	532	537	PF02991	0.412
LIG_MAD2	74	82	PF02301	0.357
LIG_MLH1_MIPbox_1	458	462	PF16413	0.255
LIG_MYND_3	287	291	PF01753	0.359
LIG_NBox_RRM_1	363	373	PF00076	0.423
LIG_PDZ_Class_2	564	569	PF00595	0.507
LIG_Pex14_1	223	227	PF04695	0.423
LIG_Pex14_2	501	505	PF04695	0.415
LIG_Pex14_2	530	534	PF04695	0.399
LIG_REV1ctd_RIR_1	257	264	PF16727	0.263
LIG_RPA_C_Fungi	15	27	PF08784	0.425
LIG_SH2_CRK	282	286	PF00017	0.318
LIG_SH2_CRK	36	40	PF00017	0.319
LIG_SH2_CRK	464	468	PF00017	0.422
LIG_SH2_NCK_1	177	181	PF00017	0.457
LIG_SH2_NCK_1	183	187	PF00017	0.517
LIG_SH2_NCK_1	230	234	PF00017	0.337
LIG_SH2_NCK_1	282	286	PF00017	0.280
LIG_SH2_PTP2	107	110	PF00017	0.376
LIG_SH2_PTP2	341	344	PF00017	0.318
LIG_SH2_SRC	234	237	PF00017	0.421
LIG_SH2_STAP1	34	38	PF00017	0.333
LIG_SH2_STAP1	555	559	PF00017	0.596
LIG_SH2_STAT3	555	558	PF00017	0.598
LIG_SH2_STAT5	107	110	PF00017	0.342
LIG_SH2_STAT5	177	180	PF00017	0.416
LIG_SH2_STAT5	230	233	PF00017	0.337
LIG_SH2_STAT5	3	6	PF00017	0.495
LIG_SH2_STAT5	341	344	PF00017	0.318
LIG_SH2_STAT5	406	409	PF00017	0.346
LIG_SH2_STAT5	435	438	PF00017	0.302
LIG_SH2_STAT5	464	467	PF00017	0.329
LIG_SH2_STAT5	513	516	PF00017	0.399
LIG_SH2_STAT5	555	558	PF00017	0.560
LIG_SH3_1	183	189	PF00018	0.446
LIG_SH3_1	282	288	PF00018	0.318
LIG_SH3_1	330	336	PF00018	0.369
LIG_SH3_2	186	191	PF14604	0.522
LIG_SH3_3	114	120	PF00018	0.463
LIG_SH3_3	183	189	PF00018	0.446
LIG_SH3_3	245	251	PF00018	0.359
LIG_SH3_3	282	288	PF00018	0.316
LIG_SH3_3	300	306	PF00018	0.226
LIG_SH3_3	330	336	PF00018	0.387
LIG_SH3_3	440	446	PF00018	0.302
LIG_SH3_3	536	542	PF00018	0.445
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.481
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.373
LIG_SUMO_SIM_par_1	60	65	PF11976	0.341
LIG_WRC_WIRS_1	498	503	PF05994	0.433
MOD_CDC14_SPxK_1	28	31	PF00782	0.506
MOD_CDK_SPxK_1	25	31	PF00069	0.517
MOD_CDK_SPxxK_3	422	429	PF00069	0.379
MOD_CK1_1	126	132	PF00069	0.459
MOD_CK1_1	138	144	PF00069	0.428
MOD_CK1_1	317	323	PF00069	0.456
MOD_CK1_1	378	384	PF00069	0.367
MOD_CK1_1	421	427	PF00069	0.423
MOD_CK2_1	149	155	PF00069	0.358
MOD_CK2_1	164	170	PF00069	0.397
MOD_CK2_1	175	181	PF00069	0.400
MOD_CK2_1	487	493	PF00069	0.546
MOD_Cter_Amidation	57	60	PF01082	0.447
MOD_GlcNHglycan	125	128	PF01048	0.466
MOD_GlcNHglycan	484	487	PF01048	0.461
MOD_GSK3_1	160	167	PF00069	0.474
MOD_GSK3_1	218	225	PF00069	0.381
MOD_GSK3_1	25	32	PF00069	0.515
MOD_GSK3_1	418	425	PF00069	0.395
MOD_GSK3_1	476	483	PF00069	0.314
MOD_GSK3_1	493	500	PF00069	0.299
MOD_GSK3_1	525	532	PF00069	0.394
MOD_GSK3_1	549	556	PF00069	0.564
MOD_N-GLC_1	149	154	PF02516	0.410
MOD_N-GLC_1	18	23	PF02516	0.409
MOD_N-GLC_1	544	549	PF02516	0.527
MOD_NEK2_1	135	140	PF00069	0.356
MOD_NEK2_1	18	23	PF00069	0.391
MOD_NEK2_1	260	265	PF00069	0.313
MOD_NEK2_1	369	374	PF00069	0.370
MOD_NEK2_1	476	481	PF00069	0.317
MOD_NEK2_1	515	520	PF00069	0.451
MOD_NEK2_1	553	558	PF00069	0.544
MOD_NEK2_2	375	380	PF00069	0.333
MOD_NEK2_2	418	423	PF00069	0.402
MOD_PIKK_1	516	522	PF00454	0.280
MOD_PKA_2	254	260	PF00069	0.397
MOD_PKA_2	30	36	PF00069	0.509
MOD_PKA_2	314	320	PF00069	0.423
MOD_PKA_2	404	410	PF00069	0.449
MOD_Plk_1	149	155	PF00069	0.392
MOD_Plk_1	175	181	PF00069	0.420
MOD_Plk_1	18	24	PF00069	0.492
MOD_Plk_1	64	70	PF00069	0.376
MOD_Plk_2-3	164	170	PF00069	0.524
MOD_Plk_4	11	17	PF00069	0.422
MOD_Plk_4	149	155	PF00069	0.372
MOD_Plk_4	254	260	PF00069	0.280
MOD_Plk_4	418	424	PF00069	0.423
MOD_Plk_4	456	462	PF00069	0.263
MOD_Plk_4	497	503	PF00069	0.397
MOD_Plk_4	529	535	PF00069	0.398
MOD_Plk_4	549	555	PF00069	0.491
MOD_ProDKin_1	228	234	PF00069	0.359
MOD_ProDKin_1	25	31	PF00069	0.517
MOD_ProDKin_1	422	428	PF00069	0.379
MOD_ProDKin_1	538	544	PF00069	0.463
MOD_SUMO_for_1	526	529	PF00179	0.493
MOD_SUMO_rev_2	317	323	PF00179	0.449
MOD_SUMO_rev_2	385	394	PF00179	0.371
TRG_DiLeu_BaEn_1	275	280	PF01217	0.291
TRG_DiLeu_BaLyEn_6	274	279	PF01217	0.333
TRG_ENDOCYTIC_2	107	110	PF00928	0.340
TRG_ENDOCYTIC_2	341	344	PF00928	0.310
TRG_ENDOCYTIC_2	36	39	PF00928	0.307
TRG_ENDOCYTIC_2	420	423	PF00928	0.282
TRG_ENDOCYTIC_2	464	467	PF00928	0.297
TRG_ER_diArg_1	24	27	PF00400	0.452
TRG_NES_CRM1_1	493	506	PF08389	0.525
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K9	Leptomonas seymouri	80%	100%
A0A0S4IT90	Bodo saltans	55%	87%
A0A1X0NLC9	Trypanosomatidae	62%	100%
A0A3S7WSP8	Leishmania donovani	94%	100%
A0A422P4A3	Trypanosoma rangeli	61%	100%
A4H7F2	Leishmania braziliensis	86%	100%
A4HVU0	Leishmania infantum	94%	100%
B7TWW5	Panax ginseng	34%	100%
D0A6E5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	98%
E9API6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9R5G2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	34%	100%
I1RQ76	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
O13306	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	31%	100%
O48651	Panax ginseng	32%	100%
O65402	Arabidopsis thaliana	28%	100%
O65403	Arabidopsis thaliana	26%	100%
O65404	Arabidopsis thaliana	26%	100%
O65726	Brassica napus	26%	100%
O65727	Brassica napus	27%	100%
O81000	Arabidopsis thaliana	35%	97%
P32476	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P52019	Mus musculus	35%	99%
P52020	Rattus norvegicus	33%	99%
Q14534	Homo sapiens	34%	99%
Q75F69	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	100%
Q8VYH2	Arabidopsis thaliana	35%	100%
Q92206	Candida albicans (strain SC5314 / ATCC MYA-2876)	31%	100%
Q9C1W3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
Q9SM02	Arabidopsis thaliana	34%	100%
V5BRL1	Trypanosoma cruzi	59%	99%