LeishMANIAdb
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Mitogen-activated protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Mitogen-activated protein kinase
Gene product:
mitogen-activated protein kinase, putative
Species:
Leishmania major
UniProt:
Q4QFZ0_LEIMA
TriTrypDb:
LmjF.13.1640 , LMJLV39_130021100 , LMJSD75_130021100 *
Length:
605

Annotations

LeishMANIAdb annotations

Acyltransferase involved in GPI anchor remodelling (homologue of yeast GUP1)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 2
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 27
NetGPI no yes: 0, no: 27
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 6
GO:0005737 cytoplasm 2 6
GO:0043226 organelle 2 6
GO:0043227 membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
GO:0043231 intracellular membrane-bounded organelle 4 6
GO:0110165 cellular anatomical entity 1 6
GO:0005829 cytosol 2 1
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0005654 nucleoplasm 2 1

Expansion

Sequence features

Q4QFZ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFZ0

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 28
GO:0006793 phosphorus metabolic process 3 28
GO:0006796 phosphate-containing compound metabolic process 4 28
GO:0006807 nitrogen compound metabolic process 2 28
GO:0007165 signal transduction 2 6
GO:0008152 metabolic process 1 28
GO:0009987 cellular process 1 28
GO:0016310 phosphorylation 5 28
GO:0019538 protein metabolic process 3 28
GO:0035556 intracellular signal transduction 3 6
GO:0036211 protein modification process 4 28
GO:0043170 macromolecule metabolic process 3 28
GO:0043412 macromolecule modification 4 28
GO:0044237 cellular metabolic process 2 28
GO:0044238 primary metabolic process 2 28
GO:0050789 regulation of biological process 2 6
GO:0050794 regulation of cellular process 3 6
GO:0065007 biological regulation 1 6
GO:0071704 organic substance metabolic process 2 28
GO:1901564 organonitrogen compound metabolic process 3 28
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
GO:0009266 response to temperature stimulus 3 1
GO:0009628 response to abiotic stimulus 2 1
GO:0050896 response to stimulus 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 28
GO:0003824 catalytic activity 1 28
GO:0004672 protein kinase activity 3 28
GO:0004674 protein serine/threonine kinase activity 4 20
GO:0004707 MAP kinase activity 5 20
GO:0005488 binding 1 28
GO:0005524 ATP binding 5 28
GO:0016301 kinase activity 4 28
GO:0016740 transferase activity 2 28
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 28
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 28
GO:0017076 purine nucleotide binding 4 28
GO:0030554 adenyl nucleotide binding 5 28
GO:0032553 ribonucleotide binding 3 28
GO:0032555 purine ribonucleotide binding 4 28
GO:0032559 adenyl ribonucleotide binding 5 28
GO:0035639 purine ribonucleoside triphosphate binding 4 28
GO:0036094 small molecule binding 2 28
GO:0043167 ion binding 2 28
GO:0043168 anion binding 3 28
GO:0097159 organic cyclic compound binding 2 28
GO:0097367 carbohydrate derivative binding 2 28
GO:0140096 catalytic activity, acting on a protein 2 28
GO:1901265 nucleoside phosphate binding 3 28
GO:1901363 heterocyclic compound binding 2 28

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 12 16 PF00656 0.421
CLV_C14_Caspase3-7 158 162 PF00656 0.263
CLV_C14_Caspase3-7 599 603 PF00656 0.504
CLV_NRD_NRD_1 135 137 PF00675 0.517
CLV_NRD_NRD_1 163 165 PF00675 0.282
CLV_NRD_NRD_1 373 375 PF00675 0.338
CLV_NRD_NRD_1 430 432 PF00675 0.271
CLV_NRD_NRD_1 473 475 PF00675 0.416
CLV_NRD_NRD_1 583 585 PF00675 0.456
CLV_NRD_NRD_1 99 101 PF00675 0.493
CLV_PCSK_FUR_1 97 101 PF00082 0.493
CLV_PCSK_KEX2_1 134 136 PF00082 0.546
CLV_PCSK_KEX2_1 163 165 PF00082 0.301
CLV_PCSK_KEX2_1 373 375 PF00082 0.282
CLV_PCSK_KEX2_1 429 431 PF00082 0.322
CLV_PCSK_KEX2_1 475 477 PF00082 0.352
CLV_PCSK_KEX2_1 583 585 PF00082 0.419
CLV_PCSK_KEX2_1 99 101 PF00082 0.492
CLV_PCSK_PC1ET2_1 134 136 PF00082 0.546
CLV_PCSK_PC1ET2_1 475 477 PF00082 0.304
CLV_PCSK_SKI1_1 111 115 PF00082 0.441
CLV_PCSK_SKI1_1 150 154 PF00082 0.457
CLV_PCSK_SKI1_1 163 167 PF00082 0.291
CLV_PCSK_SKI1_1 253 257 PF00082 0.299
CLV_PCSK_SKI1_1 287 291 PF00082 0.449
CLV_PCSK_SKI1_1 374 378 PF00082 0.354
CLV_PCSK_SKI1_1 549 553 PF00082 0.355
CLV_PCSK_SKI1_1 588 592 PF00082 0.447
CLV_PCSK_SKI1_1 93 97 PF00082 0.768
CLV_Separin_Metazoa 497 501 PF03568 0.476
DEG_APCC_DBOX_1 162 170 PF00400 0.287
DEG_Nend_Nbox_1 1 3 PF02207 0.352
DOC_CDC14_PxL_1 342 350 PF14671 0.223
DOC_CKS1_1 390 395 PF01111 0.325
DOC_CKS1_1 399 404 PF01111 0.297
DOC_CYCLIN_RxL_1 371 378 PF00134 0.320
DOC_CYCLIN_RxL_1 464 472 PF00134 0.272
DOC_CYCLIN_RxL_1 546 555 PF00134 0.411
DOC_CYCLIN_RxL_1 583 595 PF00134 0.440
DOC_MAPK_gen_1 163 171 PF00069 0.318
DOC_MAPK_gen_1 253 262 PF00069 0.277
DOC_MAPK_gen_1 341 350 PF00069 0.277
DOC_MAPK_gen_1 426 436 PF00069 0.207
DOC_MAPK_HePTP_8 338 350 PF00069 0.319
DOC_MAPK_MEF2A_6 140 149 PF00069 0.346
DOC_MAPK_MEF2A_6 341 350 PF00069 0.319
DOC_MAPK_MEF2A_6 454 463 PF00069 0.206
DOC_MAPK_MEF2A_6 521 528 PF00069 0.434
DOC_PP1_RVXF_1 465 472 PF00149 0.348
DOC_PP4_FxxP_1 487 490 PF00568 0.402
DOC_USP7_MATH_1 196 200 PF00917 0.290
DOC_USP7_MATH_1 295 299 PF00917 0.587
DOC_USP7_UBL2_3 150 154 PF12436 0.277
DOC_WW_Pin1_4 141 146 PF00397 0.378
DOC_WW_Pin1_4 389 394 PF00397 0.303
DOC_WW_Pin1_4 398 403 PF00397 0.326
DOC_WW_Pin1_4 528 533 PF00397 0.440
DOC_WW_Pin1_4 572 577 PF00397 0.425
LIG_14-3-3_CanoR_1 135 139 PF00244 0.429
LIG_14-3-3_CanoR_1 221 228 PF00244 0.209
LIG_14-3-3_CanoR_1 317 323 PF00244 0.698
LIG_14-3-3_CanoR_1 500 506 PF00244 0.460
LIG_14-3-3_CanoR_1 541 548 PF00244 0.362
LIG_14-3-3_CanoR_1 571 576 PF00244 0.521
LIG_14-3-3_CanoR_1 583 587 PF00244 0.482
LIG_14-3-3_CanoR_1 73 81 PF00244 0.317
LIG_Actin_WH2_2 152 169 PF00022 0.275
LIG_Actin_WH2_2 205 223 PF00022 0.326
LIG_Actin_WH2_2 382 398 PF00022 0.282
LIG_Actin_WH2_2 559 575 PF00022 0.374
LIG_AP2alpha_2 485 487 PF02296 0.282
LIG_APCC_ABBA_1 48 53 PF00400 0.277
LIG_BRCT_BRCA1_1 129 133 PF00533 0.465
LIG_BRCT_BRCA1_1 198 202 PF00533 0.223
LIG_BRCT_BRCA1_1 447 451 PF00533 0.262
LIG_BRCT_BRCA1_1 530 534 PF00533 0.398
LIG_Clathr_ClatBox_1 468 472 PF01394 0.282
LIG_CtBP_PxDLS_1 458 462 PF00389 0.282
LIG_deltaCOP1_diTrp_1 304 311 PF00928 0.479
LIG_EH1_1 205 213 PF00400 0.301
LIG_EH1_1 416 424 PF00400 0.282
LIG_eIF4E_1 206 212 PF01652 0.280
LIG_eIF4E_1 343 349 PF01652 0.310
LIG_FHA_1 108 114 PF00498 0.555
LIG_FHA_1 333 339 PF00498 0.330
LIG_FHA_1 390 396 PF00498 0.279
LIG_FHA_2 10 16 PF00498 0.452
LIG_FHA_2 292 298 PF00498 0.446
LIG_FHA_2 399 405 PF00498 0.256
LIG_FHA_2 433 439 PF00498 0.301
LIG_FHA_2 476 482 PF00498 0.290
LIG_FHA_2 85 91 PF00498 0.426
LIG_GBD_Chelix_1 234 242 PF00786 0.282
LIG_LIR_Apic_2 340 346 PF02991 0.277
LIG_LIR_Apic_2 485 490 PF02991 0.282
LIG_LIR_Gen_1 144 152 PF02991 0.238
LIG_LIR_Gen_1 153 160 PF02991 0.277
LIG_LIR_Gen_1 199 208 PF02991 0.400
LIG_LIR_Nem_3 144 149 PF02991 0.225
LIG_LIR_Nem_3 153 159 PF02991 0.233
LIG_LIR_Nem_3 199 205 PF02991 0.334
LIG_LIR_Nem_3 304 309 PF02991 0.537
LIG_LIR_Nem_3 485 491 PF02991 0.283
LIG_NRBOX 215 221 PF00104 0.315
LIG_Pex14_2 534 538 PF04695 0.435
LIG_SH2_CRK 63 67 PF00017 0.370
LIG_SH2_GRB2like 80 83 PF00017 0.376
LIG_SH2_NCK_1 129 133 PF00017 0.524
LIG_SH2_SRC 244 247 PF00017 0.299
LIG_SH2_STAT3 382 385 PF00017 0.250
LIG_SH2_STAT5 107 110 PF00017 0.536
LIG_SH2_STAT5 174 177 PF00017 0.338
LIG_SH2_STAT5 206 209 PF00017 0.354
LIG_SH2_STAT5 244 247 PF00017 0.306
LIG_SH2_STAT5 31 34 PF00017 0.440
LIG_SH2_STAT5 337 340 PF00017 0.328
LIG_SH2_STAT5 382 385 PF00017 0.250
LIG_SH3_1 396 402 PF00018 0.282
LIG_SH3_3 120 126 PF00018 0.515
LIG_SH3_3 184 190 PF00018 0.277
LIG_SH3_3 278 284 PF00018 0.382
LIG_SH3_3 396 402 PF00018 0.269
LIG_SH3_3 452 458 PF00018 0.256
LIG_SUMO_SIM_anti_2 347 352 PF11976 0.250
LIG_SUMO_SIM_anti_2 384 392 PF11976 0.282
LIG_SUMO_SIM_par_1 432 438 PF11976 0.209
LIG_TRAF2_1 222 225 PF00917 0.354
LIG_TRAF2_1 401 404 PF00917 0.219
LIG_TRAF2_1 87 90 PF00917 0.423
LIG_UBA3_1 165 170 PF00899 0.404
LIG_WRC_WIRS_1 468 473 PF05994 0.282
LIG_WW_1 329 332 PF00397 0.223
MOD_CDK_SPxxK_3 389 396 PF00069 0.282
MOD_CDK_SPxxK_3 572 579 PF00069 0.422
MOD_CK1_1 504 510 PF00069 0.517
MOD_CK1_1 589 595 PF00069 0.520
MOD_CK2_1 219 225 PF00069 0.276
MOD_CK2_1 291 297 PF00069 0.581
MOD_CK2_1 398 404 PF00069 0.363
MOD_CK2_1 41 47 PF00069 0.354
MOD_CK2_1 475 481 PF00069 0.303
MOD_CK2_1 491 497 PF00069 0.338
MOD_CK2_1 84 90 PF00069 0.407
MOD_Cter_Amidation 161 164 PF01082 0.214
MOD_GlcNHglycan 198 201 PF01048 0.271
MOD_GlcNHglycan 247 250 PF01048 0.297
MOD_GlcNHglycan 297 301 PF01048 0.623
MOD_GlcNHglycan 313 316 PF01048 0.524
MOD_GlcNHglycan 320 323 PF01048 0.532
MOD_GlcNHglycan 361 364 PF01048 0.320
MOD_GlcNHglycan 543 546 PF01048 0.322
MOD_GlcNHglycan 591 594 PF01048 0.582
MOD_GlcNHglycan 598 601 PF01048 0.608
MOD_GSK3_1 191 198 PF00069 0.441
MOD_GSK3_1 287 294 PF00069 0.506
MOD_GSK3_1 528 535 PF00069 0.440
MOD_GSK3_1 578 585 PF00069 0.553
MOD_GSK3_1 592 599 PF00069 0.546
MOD_LATS_1 285 291 PF00433 0.417
MOD_NEK2_1 219 224 PF00069 0.294
MOD_NEK2_1 273 278 PF00069 0.298
MOD_NEK2_1 309 314 PF00069 0.514
MOD_NEK2_1 424 429 PF00069 0.439
MOD_NEK2_1 445 450 PF00069 0.282
MOD_NEK2_1 586 591 PF00069 0.437
MOD_NEK2_1 74 79 PF00069 0.535
MOD_NEK2_1 9 14 PF00069 0.349
MOD_PIKK_1 220 226 PF00454 0.282
MOD_PIKK_1 381 387 PF00454 0.234
MOD_PIKK_1 439 445 PF00454 0.282
MOD_PKA_1 134 140 PF00069 0.552
MOD_PKA_1 150 156 PF00069 0.239
MOD_PKA_1 475 481 PF00069 0.344
MOD_PKA_2 134 140 PF00069 0.423
MOD_PKA_2 220 226 PF00069 0.192
MOD_PKA_2 41 47 PF00069 0.359
MOD_PKA_2 475 481 PF00069 0.312
MOD_PKA_2 540 546 PF00069 0.396
MOD_PKA_2 582 588 PF00069 0.458
MOD_Plk_1 285 291 PF00069 0.514
MOD_Plk_1 586 592 PF00069 0.480
MOD_Plk_2-3 432 438 PF00069 0.212
MOD_Plk_2-3 582 588 PF00069 0.422
MOD_Plk_4 41 47 PF00069 0.378
MOD_Plk_4 446 452 PF00069 0.434
MOD_Plk_4 75 81 PF00069 0.343
MOD_ProDKin_1 141 147 PF00069 0.364
MOD_ProDKin_1 389 395 PF00069 0.303
MOD_ProDKin_1 398 404 PF00069 0.326
MOD_ProDKin_1 528 534 PF00069 0.437
MOD_ProDKin_1 572 578 PF00069 0.425
MOD_SUMO_rev_2 248 257 PF00179 0.270
MOD_SUMO_rev_2 410 418 PF00179 0.282
TRG_DiLeu_BaEn_2 141 147 PF01217 0.380
TRG_DiLeu_BaEn_3 413 419 PF01217 0.282
TRG_DiLeu_BaEn_3 89 95 PF01217 0.487
TRG_ENDOCYTIC_2 236 239 PF00928 0.317
TRG_ENDOCYTIC_2 63 66 PF00928 0.418
TRG_ER_diArg_1 108 111 PF00400 0.503
TRG_ER_diArg_1 163 165 PF00400 0.282
TRG_ER_diArg_1 372 374 PF00400 0.282
TRG_ER_diArg_1 429 431 PF00400 0.358
TRG_ER_diArg_1 473 476 PF00400 0.379
TRG_ER_diArg_1 97 100 PF00400 0.635
TRG_NLS_MonoExtN_4 132 138 PF00514 0.514
TRG_NLS_MonoExtN_4 473 478 PF00514 0.286
TRG_Pf-PMV_PEXEL_1 164 168 PF00026 0.301
TRG_Pf-PMV_PEXEL_1 549 553 PF00026 0.363
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.505

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I304 Leptomonas seymouri 68% 100%
A0A0N1PB28 Leptomonas seymouri 24% 71%
A0A0S4JCX8 Bodo saltans 25% 100%
A0A0S4KIN4 Bodo saltans 37% 89%
A0A1X0P018 Trypanosomatidae 28% 100%
A0A3Q8IB74 Leishmania donovani 29% 100%
A0A3Q8IH39 Leishmania donovani 30% 100%
A0A3Q8ITZ9 Leishmania donovani 33% 100%
A0A3Q8IVR8 Leishmania donovani 32% 100%
A0A3R7KBU3 Trypanosoma rangeli 27% 100%
A0A3R7M0A0 Trypanosoma rangeli 30% 100%
A0A3S5IRQ5 Trypanosoma rangeli 28% 100%
A0A3S7WSP5 Leishmania donovani 94% 100%
A0A3S7X2Z6 Leishmania donovani 32% 100%
A0A422N878 Trypanosoma rangeli 23% 100%
A4H601 Leishmania braziliensis 31% 100%
A4H7F4 Leishmania braziliensis 80% 100%
A4HHY4 Leishmania braziliensis 32% 100%
A4HLJ9 Leishmania braziliensis 33% 100%
A4HNT2 Leishmania braziliensis 31% 100%
A4HUC8 Leishmania infantum 30% 100%
A4HVU2 Leishmania infantum 94% 100%
A4I564 Leishmania infantum 32% 100%
A4I910 Leishmania infantum 33% 100%
A4ICR2 Leishmania infantum 32% 100%
C9ZJF3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 78%
E9AGS0 Leishmania infantum 29% 100%
E9AN28 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9API8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
E9ASJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B3X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
O23145 Arabidopsis thaliana 28% 100%
P46551 Caenorhabditis elegans 29% 83%
P50873 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 100%
Q336M2 Oryza sativa subsp. japonica 27% 100%
Q4Q204 Leishmania major 31% 100%
Q4Q449 Leishmania major 33% 100%
Q4Q7S2 Leishmania major 32% 100%
Q4QHJ8 Leishmania major 31% 100%
Q6P5G0 Mus musculus 29% 100%
Q8I7M8 Caenorhabditis elegans 27% 91%
Q9TVL3 Caenorhabditis elegans 29% 100%
V5DBX9 Trypanosoma cruzi 25% 100%
V5DIC3 Trypanosoma cruzi 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS