Nodulin-like domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein Associated with Differentiation, putative

Species:

Leishmania major

UniProt:

Q4QFY5_LEIMA

TriTrypDb:

LmjF.13.1690 , LMJLV39_130021600 , LMJSD75_130021600

Length:

607

Annotations

LeishMANIAdb annotations

Nutrient transporter belonging to the Major Facilitator Superfamily (MFS). Probable nutrient transporter. Heavily expanded in all parazitic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 117
NetGPI	no	yes: 0, no: 117

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	110
GO:0110165	cellular anatomical entity	1	110
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4QFY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFY5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	55
GO:0022857	transmembrane transporter activity	2	55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	274	276	PF00675	0.468
CLV_NRD_NRD_1	306	308	PF00675	0.426
CLV_NRD_NRD_1	544	546	PF00675	0.540
CLV_NRD_NRD_1	574	576	PF00675	0.338
CLV_NRD_NRD_1	585	587	PF00675	0.355
CLV_PCSK_KEX2_1	306	308	PF00082	0.435
CLV_PCSK_KEX2_1	442	444	PF00082	0.314
CLV_PCSK_KEX2_1	544	546	PF00082	0.580
CLV_PCSK_KEX2_1	574	576	PF00082	0.344
CLV_PCSK_KEX2_1	584	586	PF00082	0.350
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.329
CLV_PCSK_PC7_1	438	444	PF00082	0.319
CLV_PCSK_SKI1_1	230	234	PF00082	0.337
CLV_PCSK_SKI1_1	278	282	PF00082	0.487
CLV_PCSK_SKI1_1	306	310	PF00082	0.437
CLV_PCSK_SKI1_1	365	369	PF00082	0.303
CLV_PCSK_SKI1_1	410	414	PF00082	0.378
CLV_PCSK_SKI1_1	469	473	PF00082	0.527
DEG_APCC_DBOX_1	26	34	PF00400	0.468
DEG_APCC_DBOX_1	409	417	PF00400	0.348
DEG_Nend_Nbox_1	1	3	PF02207	0.716
DOC_AGCK_PIF_1	43	48	PF00069	0.426
DOC_CYCLIN_RxL_1	362	369	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	207	213	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	472	478	PF00134	0.242
DOC_MAPK_FxFP_2	101	104	PF00069	0.421
DOC_MAPK_gen_1	275	281	PF00069	0.315
DOC_MAPK_gen_1	442	450	PF00069	0.471
DOC_MAPK_gen_1	5	13	PF00069	0.602
DOC_MAPK_gen_1	544	552	PF00069	0.349
DOC_MAPK_MEF2A_6	27	35	PF00069	0.495
DOC_MAPK_MEF2A_6	365	372	PF00069	0.544
DOC_MAPK_MEF2A_6	442	450	PF00069	0.478
DOC_MAPK_MEF2A_6	5	13	PF00069	0.685
DOC_MAPK_MEF2A_6	545	554	PF00069	0.304
DOC_PP1_RVXF_1	276	282	PF00149	0.276
DOC_PP2B_LxvP_1	207	210	PF13499	0.462
DOC_PP2B_LxvP_1	450	453	PF13499	0.308
DOC_PP2B_LxvP_1	465	468	PF13499	0.411
DOC_PP2B_LxvP_1	472	475	PF13499	0.300
DOC_PP4_FxxP_1	101	104	PF00568	0.409
DOC_PP4_FxxP_1	338	341	PF00568	0.722
DOC_USP7_MATH_1	134	138	PF00917	0.410
DOC_USP7_MATH_1	453	457	PF00917	0.389
DOC_USP7_MATH_1	513	517	PF00917	0.301
DOC_USP7_MATH_1	562	566	PF00917	0.398
DOC_WW_Pin1_4	14	19	PF00397	0.575
DOC_WW_Pin1_4	599	604	PF00397	0.703
LIG_14-3-3_CanoR_1	20	28	PF00244	0.554
LIG_14-3-3_CanoR_1	410	416	PF00244	0.428
LIG_14-3-3_CanoR_1	425	431	PF00244	0.319
LIG_14-3-3_CanoR_1	574	581	PF00244	0.582
LIG_14-3-3_CanoR_1	58	66	PF00244	0.335
LIG_BRCT_BRCA1_1	393	397	PF00533	0.376
LIG_BRCT_BRCA1_1	44	48	PF00533	0.360
LIG_BRCT_BRCA1_1	99	103	PF00533	0.345
LIG_CORNRBOX	194	202	PF00104	0.169
LIG_eIF4E_1	187	193	PF01652	0.319
LIG_eIF4E_1	248	254	PF01652	0.283
LIG_EVH1_2	298	302	PF00568	0.571
LIG_FHA_1	262	268	PF00498	0.324
LIG_FHA_1	283	289	PF00498	0.375
LIG_FHA_1	407	413	PF00498	0.278
LIG_FHA_1	445	451	PF00498	0.465
LIG_FHA_1	45	51	PF00498	0.295
LIG_FHA_1	452	458	PF00498	0.345
LIG_FHA_1	487	493	PF00498	0.298
LIG_FHA_2	213	219	PF00498	0.436
LIG_FHA_2	348	354	PF00498	0.525
LIG_HP1_1	157	161	PF01393	0.460
LIG_IRF3_LxIS_1	444	449	PF10401	0.376
LIG_LIR_Apic_2	351	357	PF02991	0.507
LIG_LIR_Apic_2	88	92	PF02991	0.469
LIG_LIR_Apic_2	99	104	PF02991	0.318
LIG_LIR_Gen_1	269	277	PF02991	0.281
LIG_LIR_Gen_1	378	388	PF02991	0.326
LIG_LIR_Gen_1	45	55	PF02991	0.345
LIG_LIR_Gen_1	84	95	PF02991	0.411
LIG_LIR_Nem_3	136	141	PF02991	0.323
LIG_LIR_Nem_3	164	168	PF02991	0.336
LIG_LIR_Nem_3	175	180	PF02991	0.317
LIG_LIR_Nem_3	25	31	PF02991	0.502
LIG_LIR_Nem_3	269	273	PF02991	0.256
LIG_LIR_Nem_3	378	383	PF02991	0.309
LIG_LIR_Nem_3	394	400	PF02991	0.326
LIG_LIR_Nem_3	42	46	PF02991	0.339
LIG_LIR_Nem_3	47	51	PF02991	0.347
LIG_LIR_Nem_3	527	531	PF02991	0.333
LIG_LIR_Nem_3	572	576	PF02991	0.528
LIG_LIR_Nem_3	84	90	PF02991	0.364
LIG_PCNA_PIPBox_1	254	263	PF02747	0.314
LIG_Pex14_1	245	249	PF04695	0.458
LIG_Pex14_1	376	380	PF04695	0.320
LIG_Pex14_2	177	181	PF04695	0.282
LIG_Pex14_2	191	195	PF04695	0.367
LIG_Pex14_2	247	251	PF04695	0.344
LIG_PTB_Apo_2	389	396	PF02174	0.350
LIG_PTB_Phospho_1	389	395	PF10480	0.436
LIG_SH2_CRK	249	253	PF00017	0.387
LIG_SH2_CRK	83	87	PF00017	0.322
LIG_SH2_PTP2	354	357	PF00017	0.501
LIG_SH2_PTP2	89	92	PF00017	0.428
LIG_SH2_SRC	217	220	PF00017	0.576
LIG_SH2_SRC	476	479	PF00017	0.329
LIG_SH2_SRC	87	90	PF00017	0.520
LIG_SH2_STAP1	46	50	PF00017	0.349
LIG_SH2_STAP1	576	580	PF00017	0.564
LIG_SH2_STAP1	83	87	PF00017	0.338
LIG_SH2_STAT3	529	532	PF00017	0.357
LIG_SH2_STAT5	150	153	PF00017	0.512
LIG_SH2_STAT5	187	190	PF00017	0.346
LIG_SH2_STAT5	270	273	PF00017	0.276
LIG_SH2_STAT5	354	357	PF00017	0.508
LIG_SH2_STAT5	395	398	PF00017	0.304
LIG_SH2_STAT5	430	433	PF00017	0.508
LIG_SH2_STAT5	46	49	PF00017	0.315
LIG_SH2_STAT5	476	479	PF00017	0.313
LIG_SH2_STAT5	529	532	PF00017	0.310
LIG_SH2_STAT5	89	92	PF00017	0.486
LIG_SH3_3	15	21	PF00018	0.605
LIG_SH3_3	545	551	PF00018	0.324
LIG_SH3_3	76	82	PF00018	0.387
LIG_SUMO_SIM_anti_2	142	149	PF11976	0.372
LIG_SUMO_SIM_anti_2	264	269	PF11976	0.352
LIG_SUMO_SIM_anti_2	411	417	PF11976	0.281
LIG_SUMO_SIM_par_1	263	269	PF11976	0.323
LIG_SUMO_SIM_par_1	444	449	PF11976	0.431
LIG_SUMO_SIM_par_1	489	494	PF11976	0.305
LIG_SUMO_SIM_par_1	93	100	PF11976	0.490
LIG_TRAF2_1	54	57	PF00917	0.271
LIG_TYR_ITIM	268	273	PF00017	0.294
LIG_TYR_ITIM	81	86	PF00017	0.329
LIG_UBA3_1	1	7	PF00899	0.508
LIG_UBA3_1	463	469	PF00899	0.389
LIG_WRC_WIRS_1	128	133	PF05994	0.360
LIG_WRC_WIRS_1	162	167	PF05994	0.374
LIG_WRC_WIRS_1	98	103	PF05994	0.329
MOD_CDC14_SPxK_1	17	20	PF00782	0.472
MOD_CDK_SPxK_1	14	20	PF00069	0.460
MOD_CK1_1	143	149	PF00069	0.364
MOD_CK1_1	406	412	PF00069	0.364
MOD_CK1_1	42	48	PF00069	0.265
MOD_CK1_1	67	73	PF00069	0.338
MOD_CK2_1	212	218	PF00069	0.445
MOD_CK2_1	220	226	PF00069	0.434
MOD_CK2_1	426	432	PF00069	0.319
MOD_CK2_1	51	57	PF00069	0.316
MOD_CMANNOS	373	376	PF00535	0.357
MOD_Cter_Amidation	273	276	PF01082	0.548
MOD_GlcNHglycan	420	423	PF01048	0.313
MOD_GlcNHglycan	51	54	PF01048	0.467
MOD_GlcNHglycan	560	563	PF01048	0.361
MOD_GSK3_1	139	146	PF00069	0.370
MOD_GSK3_1	402	409	PF00069	0.366
MOD_GSK3_1	453	460	PF00069	0.328
MOD_GSK3_1	487	494	PF00069	0.360
MOD_GSK3_1	536	543	PF00069	0.388
MOD_GSK3_1	558	565	PF00069	0.379
MOD_GSK3_1	599	606	PF00069	0.646
MOD_GSK3_1	64	71	PF00069	0.269
MOD_N-GLC_1	390	395	PF02516	0.462
MOD_NEK2_1	139	144	PF00069	0.357
MOD_NEK2_1	161	166	PF00069	0.396
MOD_NEK2_1	375	380	PF00069	0.295
MOD_NEK2_1	426	431	PF00069	0.312
MOD_NEK2_1	446	451	PF00069	0.325
MOD_NEK2_1	463	468	PF00069	0.331
MOD_NEK2_1	486	491	PF00069	0.358
MOD_NEK2_1	536	541	PF00069	0.414
MOD_NEK2_1	556	561	PF00069	0.321
MOD_NEK2_2	134	139	PF00069	0.392
MOD_PIKK_1	432	438	PF00454	0.513
MOD_PIKK_1	59	65	PF00454	0.260
MOD_PKA_1	574	580	PF00069	0.541
MOD_PKA_2	57	63	PF00069	0.301
MOD_PKA_2	574	580	PF00069	0.492
MOD_Plk_1	390	396	PF00069	0.418
MOD_Plk_1	64	70	PF00069	0.259
MOD_Plk_2-3	347	353	PF00069	0.624
MOD_Plk_4	127	133	PF00069	0.340
MOD_Plk_4	134	140	PF00069	0.331
MOD_Plk_4	146	152	PF00069	0.474
MOD_Plk_4	161	167	PF00069	0.362
MOD_Plk_4	172	178	PF00069	0.373
MOD_Plk_4	283	289	PF00069	0.346
MOD_Plk_4	359	365	PF00069	0.516
MOD_Plk_4	391	397	PF00069	0.324
MOD_Plk_4	411	417	PF00069	0.412
MOD_Plk_4	426	432	PF00069	0.335
MOD_Plk_4	453	459	PF00069	0.332
MOD_Plk_4	487	493	PF00069	0.337
MOD_Plk_4	536	542	PF00069	0.389
MOD_Plk_4	71	77	PF00069	0.365
MOD_Plk_4	81	87	PF00069	0.381
MOD_Plk_4	97	103	PF00069	0.301
MOD_ProDKin_1	14	20	PF00069	0.576
MOD_ProDKin_1	599	605	PF00069	0.698
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.331
TRG_DiLeu_BaLyEn_6	548	553	PF01217	0.317
TRG_ENDOCYTIC_2	129	132	PF00928	0.290
TRG_ENDOCYTIC_2	190	193	PF00928	0.310
TRG_ENDOCYTIC_2	248	251	PF00928	0.367
TRG_ENDOCYTIC_2	270	273	PF00928	0.262
TRG_ENDOCYTIC_2	83	86	PF00928	0.324
TRG_ENDOCYTIC_2	87	90	PF00928	0.486
TRG_ER_diArg_1	306	308	PF00400	0.691
TRG_ER_diArg_1	573	575	PF00400	0.549
TRG_ER_diArg_1	584	586	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	585	589	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G0	Leptomonas seymouri	39%	95%
A0A0N1HT40	Leptomonas seymouri	45%	100%
A0A0N1HZC2	Leptomonas seymouri	31%	97%
A0A0N1IKC5	Leptomonas seymouri	71%	100%
A0A0N1PAX2	Leptomonas seymouri	23%	100%
A0A0N1PB63	Leptomonas seymouri	28%	92%
A0A0N1PD04	Leptomonas seymouri	25%	95%
A0A0N1PFR4	Leptomonas seymouri	25%	92%
A0A0S4JR45	Bodo saltans	32%	100%
A0A1X0NKK0	Trypanosomatidae	32%	100%
A0A1X0NL32	Trypanosomatidae	35%	97%
A0A1X0NM09	Trypanosomatidae	30%	99%
A0A1X0NRW5	Trypanosomatidae	40%	87%
A0A1X0NV13	Trypanosomatidae	50%	93%
A0A1X0NV19	Trypanosomatidae	52%	100%
A0A1X0NV27	Trypanosomatidae	52%	100%
A0A1X0NVH8	Trypanosomatidae	45%	92%
A0A1X0NVM7	Trypanosomatidae	47%	94%
A0A1X0NWQ1	Trypanosomatidae	49%	95%
A0A1X0NZE6	Trypanosomatidae	32%	100%
A0A1X0NZU2	Trypanosomatidae	29%	94%
A0A1X0NZU5	Trypanosomatidae	33%	100%
A0A1X0NZW1	Trypanosomatidae	29%	100%
A0A1X0P0M7	Trypanosomatidae	33%	100%
A0A381MMW5	Leishmania infantum	32%	93%
A0A3Q8I7Y9	Leishmania donovani	44%	100%
A0A3Q8IEC4	Leishmania donovani	31%	94%
A0A3Q8IF95	Leishmania donovani	29%	96%
A0A3Q8ISY9	Leishmania donovani	40%	96%
A0A3R7JPZ0	Trypanosoma rangeli	25%	100%
A0A3R7JSQ9	Trypanosoma rangeli	27%	100%
A0A3R7KKN8	Trypanosoma rangeli	30%	100%
A0A3R7MAQ7	Trypanosoma rangeli	38%	86%
A0A3R7N415	Trypanosoma rangeli	29%	100%
A0A3R7N921	Trypanosoma rangeli	31%	100%
A0A3R7R443	Trypanosoma rangeli	29%	100%
A0A3R7R6N6	Trypanosoma rangeli	25%	100%
A0A3S7WRJ4	Leishmania donovani	54%	95%
A0A3S7WRJ5	Leishmania donovani	50%	87%
A0A3S7WRL4	Leishmania donovani	45%	98%
A0A3S7WRS3	Leishmania donovani	24%	97%
A0A3S7WSR4	Leishmania donovani	94%	100%
A0A3S7WWU1	Leishmania donovani	25%	91%
A0A3S7X2G0	Leishmania donovani	31%	93%
A0A3S7X2K5	Leishmania donovani	30%	100%
A0A3S7XB11	Leishmania donovani	31%	100%
A0A422MSE4	Trypanosoma rangeli	48%	100%
A0A422MSP6	Trypanosoma rangeli	34%	100%
A0A422MST9	Trypanosoma rangeli	28%	100%
A0A422MU68	Trypanosoma rangeli	26%	100%
A4H6J0	Leishmania braziliensis	52%	94%
A4H6J1	Leishmania braziliensis	51%	93%
A4H6J3	Leishmania braziliensis	46%	100%
A4H6Q5	Leishmania braziliensis	25%	97%
A4HC19	Leishmania braziliensis	26%	94%
A4HHG3	Leishmania braziliensis	31%	94%
A4HHG4	Leishmania braziliensis	31%	93%
A4HJW3	Leishmania braziliensis	40%	95%
A4HPE2	Leishmania braziliensis	31%	99%
A4HUX5	Leishmania infantum	54%	95%
A4HUX6	Leishmania infantum	49%	87%
A4HUX7	Leishmania infantum	45%	98%
A4HUX8	Leishmania infantum	45%	100%
A4HV40	Leishmania infantum	24%	97%
A4HZF5	Leishmania infantum	29%	96%
A4HZJ4	Leishmania infantum	25%	91%
A4I7C5	Leishmania infantum	40%	96%
A4ICI3	Leishmania infantum	31%	100%
C9ZL97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZL98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZL99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZLA0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZLA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZTR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZTR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
C9ZTR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZTR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZTR9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
C9ZTS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
C9ZUT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A7H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0AAQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	89%
E8NHE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	97%
E9AE01	Leishmania major	31%	100%
E9AE11	Leishmania major	31%	100%
E9AGK5	Leishmania infantum	94%	100%
E9AHJ0	Leishmania infantum	32%	94%
E9AHJ1	Leishmania infantum	30%	100%
E9ALS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	94%
E9ANL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	95%
E9ANL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	93%
E9ANL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9ANS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	96%
E9APJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AT53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AVF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9AVF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	92%
E9B2B8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	96%
Q4Q1E4	Leishmania major	31%	100%
Q4Q5T8	Leishmania major	41%	100%
Q4QC27	Leishmania major	25%	100%
Q4QC28	Leishmania major	28%	100%
Q4QGU8	Leishmania major	24%	97%
Q4QH10	Leishmania major	45%	100%
Q4QH11	Leishmania major	45%	100%
Q4QH12	Leishmania major	45%	100%
Q4QH13	Leishmania major	46%	100%
Q4QH14	Leishmania major	49%	93%
Q4QH15	Leishmania major	54%	100%
V5B647	Trypanosoma cruzi	47%	96%
V5B983	Trypanosoma cruzi	32%	100%
V5BBB1	Trypanosoma cruzi	47%	100%
V5BFV8	Trypanosoma cruzi	31%	91%
V5BQY6	Trypanosoma cruzi	37%	86%
V5BVP0	Trypanosoma cruzi	48%	100%
V5DT25	Trypanosoma cruzi	46%	98%