F-box/LRR-repeat protein 20

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFY4_LEIMA

TriTrypDb:

LmjF.13.1700 , LMJLV39_130021700 , LMJSD75_130021700

Length:

457

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	19
GO:0042995	cell projection	2	19
GO:0043226	organelle	2	19
GO:0043227	membrane-bounded organelle	3	19
GO:0110165	cellular anatomical entity	1	19
GO:0120025	plasma membrane bounded cell projection	3	19
GO:0005743	mitochondrial inner membrane	5	1
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0000151	ubiquitin ligase complex	3	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

Q4QFY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFY4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	9	11	PF00675	0.495
CLV_PCSK_KEX2_1	9	11	PF00082	0.346
CLV_PCSK_SKI1_1	135	139	PF00082	0.461
CLV_PCSK_SKI1_1	369	373	PF00082	0.447
CLV_PCSK_SKI1_1	429	433	PF00082	0.302
CLV_PCSK_SKI1_1	78	82	PF00082	0.376
CLV_Separin_Metazoa	406	410	PF03568	0.395
DEG_APCC_DBOX_1	134	142	PF00400	0.280
DEG_APCC_DBOX_1	51	59	PF00400	0.619
DEG_Nend_UBRbox_2	1	3	PF02207	0.545
DOC_CDC14_PxL_1	199	207	PF14671	0.385
DOC_CDC14_PxL_1	332	340	PF14671	0.438
DOC_CDC14_PxL_1	377	385	PF14671	0.332
DOC_CDC14_PxL_1	422	430	PF14671	0.465
DOC_CYCLIN_RxL_1	133	144	PF00134	0.257
DOC_CYCLIN_RxL_1	277	286	PF00134	0.332
DOC_CYCLIN_RxL_1	72	83	PF00134	0.377
DOC_MAPK_DCC_7	148	156	PF00069	0.275
DOC_MAPK_gen_1	72	81	PF00069	0.419
DOC_MAPK_HePTP_8	69	81	PF00069	0.400
DOC_MAPK_MEF2A_6	112	119	PF00069	0.430
DOC_MAPK_MEF2A_6	139	147	PF00069	0.434
DOC_MAPK_MEF2A_6	148	156	PF00069	0.443
DOC_MAPK_MEF2A_6	72	81	PF00069	0.461
DOC_PP1_RVXF_1	315	321	PF00149	0.382
DOC_PP2B_LxvP_1	442	445	PF13499	0.283
DOC_USP7_MATH_1	169	173	PF00917	0.410
DOC_USP7_MATH_1	175	179	PF00917	0.384
DOC_USP7_MATH_1	325	329	PF00917	0.532
DOC_USP7_MATH_1	95	99	PF00917	0.398
DOC_WW_Pin1_4	372	377	PF00397	0.350
DOC_WW_Pin1_4	445	450	PF00397	0.515
DOC_WW_Pin1_4	56	61	PF00397	0.538
LIG_14-3-3_CanoR_1	139	144	PF00244	0.504
LIG_14-3-3_CanoR_1	190	199	PF00244	0.480
LIG_14-3-3_CanoR_1	22	28	PF00244	0.516
LIG_14-3-3_CanoR_1	252	261	PF00244	0.305
LIG_14-3-3_CanoR_1	280	285	PF00244	0.491
LIG_14-3-3_CanoR_1	317	321	PF00244	0.423
LIG_14-3-3_CanoR_1	369	377	PF00244	0.360
LIG_14-3-3_CanoR_1	52	56	PF00244	0.521
LIG_14-3-3_CanoR_1	72	78	PF00244	0.326
LIG_14-3-3_CanoR_1	9	15	PF00244	0.457
LIG_Actin_WH2_2	325	341	PF00022	0.457
LIG_Actin_WH2_2	36	54	PF00022	0.490
LIG_Clathr_ClatBox_1	157	161	PF01394	0.281
LIG_CtBP_PxDLS_1	444	448	PF00389	0.283
LIG_DLG_GKlike_1	139	146	PF00625	0.317
LIG_DLG_GKlike_1	280	287	PF00625	0.320
LIG_FHA_1	205	211	PF00498	0.331
LIG_FHA_1	270	276	PF00498	0.513
LIG_FHA_1	3	9	PF00498	0.515
LIG_FHA_1	360	366	PF00498	0.323
LIG_FHA_1	446	452	PF00498	0.338
LIG_FHA_1	74	80	PF00498	0.473
LIG_GBD_Chelix_1	65	73	PF00786	0.379
LIG_Integrin_RGD_1	120	122	PF01839	0.351
LIG_LIR_Gen_1	168	177	PF02991	0.436
LIG_LIR_Gen_1	387	396	PF02991	0.414
LIG_LIR_Nem_3	168	173	PF02991	0.428
LIG_LIR_Nem_3	297	303	PF02991	0.539
LIG_LIR_Nem_3	387	393	PF02991	0.449
LIG_MYND_1	445	449	PF01753	0.304
LIG_NRBOX	64	70	PF00104	0.374
LIG_NRBOX	76	82	PF00104	0.337
LIG_RPA_C_Fungi	185	197	PF08784	0.288
LIG_RPA_C_Fungi	5	17	PF08784	0.330
LIG_SH2_CRK	200	204	PF00017	0.416
LIG_SH2_PTP2	430	433	PF00017	0.268
LIG_SH2_STAT5	359	362	PF00017	0.411
LIG_SH2_STAT5	430	433	PF00017	0.268
LIG_SH3_3	171	177	PF00018	0.302
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.330
LIG_SUMO_SIM_anti_2	254	262	PF11976	0.399
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.356
LIG_SUMO_SIM_anti_2	404	409	PF11976	0.425
LIG_SUMO_SIM_par_1	206	212	PF11976	0.430
LIG_SUMO_SIM_par_1	279	286	PF11976	0.462
LIG_TYR_ITIM	428	433	PF00017	0.272
MOD_CDK_SPK_2	445	450	PF00069	0.338
MOD_CDK_SPK_2	56	61	PF00069	0.396
MOD_CDK_SPxxK_3	56	63	PF00069	0.507
MOD_CK1_1	204	210	PF00069	0.373
MOD_CK1_1	244	250	PF00069	0.420
MOD_CK1_1	256	262	PF00069	0.313
MOD_CK1_1	269	275	PF00069	0.428
MOD_CK1_1	283	289	PF00069	0.485
MOD_GlcNHglycan	192	195	PF01048	0.503
MOD_GlcNHglycan	23	26	PF01048	0.640
MOD_GlcNHglycan	243	246	PF01048	0.427
MOD_GlcNHglycan	255	258	PF01048	0.276
MOD_GlcNHglycan	261	264	PF01048	0.388
MOD_GlcNHglycan	300	303	PF01048	0.487
MOD_GlcNHglycan	345	348	PF01048	0.314
MOD_GlcNHglycan	390	393	PF01048	0.386
MOD_GSK3_1	124	131	PF00069	0.464
MOD_GSK3_1	17	24	PF00069	0.454
MOD_GSK3_1	252	259	PF00069	0.426
MOD_GSK3_1	292	299	PF00069	0.405
MOD_GSK3_1	359	366	PF00069	0.311
MOD_LATS_1	250	256	PF00433	0.283
MOD_LATS_1	292	298	PF00433	0.375
MOD_NEK2_1	128	133	PF00069	0.490
MOD_NEK2_1	141	146	PF00069	0.463
MOD_NEK2_1	241	246	PF00069	0.394
MOD_NEK2_1	251	256	PF00069	0.388
MOD_NEK2_1	282	287	PF00069	0.549
MOD_NEK2_1	363	368	PF00069	0.323
MOD_NEK2_1	51	56	PF00069	0.634
MOD_NEK2_1	68	73	PF00069	0.607
MOD_PIKK_1	175	181	PF00454	0.318
MOD_PK_1	206	212	PF00069	0.253
MOD_PK_1	294	300	PF00069	0.310
MOD_PKA_2	189	195	PF00069	0.490
MOD_PKA_2	21	27	PF00069	0.582
MOD_PKA_2	251	257	PF00069	0.490
MOD_PKA_2	316	322	PF00069	0.437
MOD_PKA_2	51	57	PF00069	0.618
MOD_Plk_1	17	23	PF00069	0.383
MOD_Plk_1	386	392	PF00069	0.413
MOD_Plk_1	82	88	PF00069	0.393
MOD_Plk_2-3	316	322	PF00069	0.391
MOD_Plk_4	10	16	PF00069	0.472
MOD_Plk_4	124	130	PF00069	0.420
MOD_Plk_4	141	147	PF00069	0.301
MOD_Plk_4	169	175	PF00069	0.282
MOD_Plk_4	256	262	PF00069	0.463
MOD_Plk_4	271	277	PF00069	0.499
MOD_Plk_4	82	88	PF00069	0.445
MOD_Plk_4	95	101	PF00069	0.400
MOD_ProDKin_1	372	378	PF00069	0.354
MOD_ProDKin_1	445	451	PF00069	0.509
MOD_ProDKin_1	56	62	PF00069	0.530
MOD_SUMO_rev_2	209	214	PF00179	0.334
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.529
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.327
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.505
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.486
TRG_ENDOCYTIC_2	430	433	PF00928	0.268
TRG_ER_diArg_1	336	339	PF00400	0.391
TRG_ER_diArg_1	381	384	PF00400	0.303
TRG_ER_diArg_1	8	10	PF00400	0.349
TRG_NES_CRM1_1	201	211	PF08389	0.299
TRG_Pf-PMV_PEXEL_1	206	211	PF00026	0.248
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.498
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F9	Leptomonas seymouri	35%	87%
A0A0N0P8N9	Leptomonas seymouri	32%	69%
A0A0N1I0W0	Leptomonas seymouri	27%	89%
A0A0N1I1E8	Leptomonas seymouri	27%	100%
A0A1X0NEN5	Trypanosomatidae	27%	78%
A0A1X0P4M6	Trypanosomatidae	25%	79%
A0A3Q8I8N4	Leishmania donovani	94%	100%
A0A3S5H5M6	Leishmania donovani	24%	85%
A4H3R1	Leishmania braziliensis	30%	66%
A4H7G0	Leishmania braziliensis	78%	99%
A4HCY0	Leishmania braziliensis	28%	98%
A4HSP5	Leishmania infantum	24%	85%
E9AGK6	Leishmania infantum	94%	100%
E9AKN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	85%
E9APJ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
E9B1R3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	73%
Q4QB46	Leishmania major	25%	94%