Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFY2_LEIMA

TriTrypDb:

LmjF.14.0030 , LMJLV39_140005300 , LMJSD75_140005300

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QFY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.705
CLV_NRD_NRD_1	141	143	PF00675	0.698
CLV_NRD_NRD_1	81	83	PF00675	0.523
CLV_NRD_NRD_1	9	11	PF00675	0.440
CLV_PCSK_KEX2_1	120	122	PF00082	0.676
CLV_PCSK_KEX2_1	137	139	PF00082	0.774
CLV_PCSK_KEX2_1	80	82	PF00082	0.500
CLV_PCSK_KEX2_1	9	11	PF00082	0.472
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.665
CLV_PCSK_SKI1_1	142	146	PF00082	0.698
CLV_PCSK_SKI1_1	224	228	PF00082	0.710
CLV_PCSK_SKI1_1	258	262	PF00082	0.757
CLV_PCSK_SKI1_1	9	13	PF00082	0.392
DEG_SCF_FBW7_1	174	181	PF00400	0.585
DEG_SCF_FBW7_1	226	233	PF00400	0.495
DEG_SPOP_SBC_1	57	61	PF00917	0.595
DOC_CKS1_1	175	180	PF01111	0.576
DOC_CKS1_1	227	232	PF01111	0.498
DOC_MAPK_gen_1	89	97	PF00069	0.558
DOC_PP4_FxxP_1	227	230	PF00568	0.499
DOC_USP7_MATH_1	128	132	PF00917	0.488
DOC_USP7_MATH_1	178	182	PF00917	0.612
DOC_USP7_MATH_1	192	196	PF00917	0.535
DOC_USP7_MATH_1	230	234	PF00917	0.494
DOC_USP7_MATH_1	41	45	PF00917	0.669
DOC_USP7_MATH_1	56	60	PF00917	0.653
DOC_USP7_MATH_1	65	69	PF00917	0.715
DOC_WW_Pin1_4	109	114	PF00397	0.606
DOC_WW_Pin1_4	174	179	PF00397	0.563
DOC_WW_Pin1_4	226	231	PF00397	0.500
LIG_14-3-3_CanoR_1	58	63	PF00244	0.730
LIG_Actin_WH2_2	104	122	PF00022	0.380
LIG_BRCT_BRCA1_1	199	203	PF00533	0.526
LIG_FHA_1	238	244	PF00498	0.540
LIG_FHA_1	251	257	PF00498	0.544
LIG_FHA_1	260	266	PF00498	0.503
LIG_LIR_Apic_2	225	230	PF02991	0.502
LIG_LIR_Gen_1	218	227	PF02991	0.531
LIG_LIR_Gen_1	44	52	PF02991	0.652
LIG_LIR_Nem_3	44	49	PF02991	0.649
LIG_PCNA_yPIPBox_3	8	17	PF02747	0.656
LIG_Pex14_2	238	242	PF04695	0.469
LIG_SH2_STAT5	125	128	PF00017	0.508
LIG_SH2_STAT5	14	17	PF00017	0.645
LIG_SH3_3	169	175	PF00018	0.527
LIG_SH3_3	30	36	PF00018	0.659
LIG_SH3_4	212	219	PF00018	0.401
LIG_WRC_WIRS_1	94	99	PF05994	0.401
MOD_CK1_1	190	196	PF00069	0.603
MOD_CK1_1	264	270	PF00069	0.572
MOD_CK1_1	44	50	PF00069	0.648
MOD_CK1_1	60	66	PF00069	0.664
MOD_CK1_1	68	74	PF00069	0.715
MOD_CK2_1	128	134	PF00069	0.548
MOD_CK2_1	178	184	PF00069	0.622
MOD_CK2_1	215	221	PF00069	0.548
MOD_CK2_1	44	50	PF00069	0.611
MOD_GlcNHglycan	189	192	PF01048	0.739
MOD_GlcNHglycan	231	235	PF01048	0.744
MOD_GlcNHglycan	43	46	PF01048	0.479
MOD_GlcNHglycan	62	65	PF01048	0.383
MOD_GlcNHglycan	67	70	PF01048	0.466
MOD_GlcNHglycan	72	76	PF01048	0.425
MOD_GSK3_1	124	131	PF00069	0.483
MOD_GSK3_1	174	181	PF00069	0.567
MOD_GSK3_1	192	199	PF00069	0.397
MOD_GSK3_1	226	233	PF00069	0.494
MOD_GSK3_1	247	254	PF00069	0.492
MOD_GSK3_1	259	266	PF00069	0.510
MOD_GSK3_1	56	63	PF00069	0.647
MOD_NEK2_1	115	120	PF00069	0.490
MOD_NEK2_1	203	208	PF00069	0.554
MOD_NEK2_1	238	243	PF00069	0.470
MOD_NEK2_1	252	257	PF00069	0.474
MOD_NEK2_1	261	266	PF00069	0.542
MOD_NEK2_2	160	165	PF00069	0.602
MOD_PIKK_1	190	196	PF00454	0.567
MOD_PK_1	58	64	PF00069	0.694
MOD_PKA_2	57	63	PF00069	0.724
MOD_Plk_1	203	209	PF00069	0.587
MOD_Plk_1	238	244	PF00069	0.509
MOD_Plk_1	247	253	PF00069	0.500
MOD_Plk_4	198	204	PF00069	0.557
MOD_Plk_4	238	244	PF00069	0.540
MOD_Plk_4	93	99	PF00069	0.429
MOD_ProDKin_1	109	115	PF00069	0.607
MOD_ProDKin_1	174	180	PF00069	0.564
MOD_ProDKin_1	226	232	PF00069	0.498
MOD_SUMO_for_1	144	147	PF00179	0.457
MOD_SUMO_for_1	155	158	PF00179	0.505
TRG_ENDOCYTIC_2	46	49	PF00928	0.680
TRG_ER_diArg_1	79	82	PF00400	0.729
TRG_ER_diArg_1	9	11	PF00400	0.662
TRG_NLS_MonoExtC_3	141	147	PF00514	0.560
TRG_NLS_MonoExtN_4	140	146	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.783
TRG_Pf-PMV_PEXEL_1	81	85	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXV2	Leptomonas seymouri	50%	100%
A0A0S4IQN6	Bodo saltans	25%	97%
A0A1X0NNV6	Trypanosomatidae	24%	100%
A0A3S5H6Q5	Leishmania donovani	90%	100%
A0A422NXF3	Trypanosoma rangeli	25%	100%
A4H7G4	Leishmania braziliensis	71%	100%
A4HVU5	Leishmania infantum	90%	100%
E9APJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%