Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFY0_LEIMA

TriTrypDb:

LmjF.14.0050 , LMJLV39_140005500 , LMJSD75_140005500

Length:

733

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFY0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	545	549	PF00656	0.528
CLV_C14_Caspase3-7	711	715	PF00656	0.605
CLV_NRD_NRD_1	181	183	PF00675	0.451
CLV_NRD_NRD_1	36	38	PF00675	0.370
CLV_NRD_NRD_1	371	373	PF00675	0.526
CLV_NRD_NRD_1	434	436	PF00675	0.681
CLV_NRD_NRD_1	531	533	PF00675	0.523
CLV_NRD_NRD_1	719	721	PF00675	0.606
CLV_PCSK_FUR_1	728	732	PF00082	0.440
CLV_PCSK_KEX2_1	180	182	PF00082	0.447
CLV_PCSK_KEX2_1	2	4	PF00082	0.655
CLV_PCSK_KEX2_1	371	373	PF00082	0.568
CLV_PCSK_KEX2_1	415	417	PF00082	0.571
CLV_PCSK_KEX2_1	436	438	PF00082	0.626
CLV_PCSK_KEX2_1	530	532	PF00082	0.486
CLV_PCSK_KEX2_1	718	720	PF00082	0.612
CLV_PCSK_KEX2_1	730	732	PF00082	0.446
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.655
CLV_PCSK_PC1ET2_1	415	417	PF00082	0.571
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.626
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.514
CLV_PCSK_PC1ET2_1	718	720	PF00082	0.447
CLV_PCSK_PC1ET2_1	730	732	PF00082	0.446
CLV_PCSK_SKI1_1	143	147	PF00082	0.618
CLV_PCSK_SKI1_1	173	177	PF00082	0.343
CLV_PCSK_SKI1_1	331	335	PF00082	0.440
CLV_PCSK_SKI1_1	456	460	PF00082	0.479
CLV_PCSK_SKI1_1	494	498	PF00082	0.430
CLV_PCSK_SKI1_1	6	10	PF00082	0.524
CLV_PCSK_SKI1_1	614	618	PF00082	0.531
CLV_PCSK_SKI1_1	628	632	PF00082	0.611
CLV_PCSK_SKI1_1	724	728	PF00082	0.529
CLV_Separin_Metazoa	440	444	PF03568	0.402
DEG_Nend_UBRbox_1	1	4	PF02207	0.531
DEG_SCF_FBW7_2	147	154	PF00400	0.525
DEG_SPOP_SBC_1	542	546	PF00917	0.574
DOC_ANK_TNKS_1	709	716	PF00023	0.542
DOC_CKS1_1	148	153	PF01111	0.450
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.363
DOC_MAPK_gen_1	2	13	PF00069	0.486
DOC_MAPK_gen_1	252	261	PF00069	0.381
DOC_MAPK_gen_1	77	84	PF00069	0.431
DOC_MAPK_MEF2A_6	16	24	PF00069	0.406
DOC_MAPK_MEF2A_6	252	261	PF00069	0.381
DOC_MAPK_MEF2A_6	262	269	PF00069	0.293
DOC_PP1_RVXF_1	91	97	PF00149	0.364
DOC_PP2B_LxvP_1	119	122	PF13499	0.500
DOC_USP7_MATH_1	106	110	PF00917	0.592
DOC_USP7_MATH_1	210	214	PF00917	0.394
DOC_USP7_MATH_1	348	352	PF00917	0.288
DOC_USP7_MATH_1	543	547	PF00917	0.712
DOC_USP7_UBL2_3	327	331	PF12436	0.291
DOC_USP7_UBL2_3	658	662	PF12436	0.584
DOC_WW_Pin1_4	147	152	PF00397	0.467
DOC_WW_Pin1_4	472	477	PF00397	0.438
DOC_WW_Pin1_4	538	543	PF00397	0.692
DOC_WW_Pin1_4	635	640	PF00397	0.705
DOC_WW_Pin1_4	693	698	PF00397	0.609
LIG_14-3-3_CanoR_1	180	185	PF00244	0.447
LIG_14-3-3_CanoR_1	37	42	PF00244	0.473
LIG_14-3-3_CanoR_1	6	12	PF00244	0.486
LIG_14-3-3_CanoR_1	614	623	PF00244	0.635
LIG_14-3-3_CanoR_1	628	637	PF00244	0.492
LIG_14-3-3_CanoR_1	703	709	PF00244	0.574
LIG_14-3-3_CterR_2	728	733	PF00244	0.522
LIG_Actin_WH2_2	342	359	PF00022	0.371
LIG_BRCT_BRCA1_1	193	197	PF00533	0.349
LIG_eIF4E_1	163	169	PF01652	0.411
LIG_FHA_1	126	132	PF00498	0.583
LIG_FHA_1	186	192	PF00498	0.370
LIG_FHA_1	301	307	PF00498	0.309
LIG_FHA_1	341	347	PF00498	0.462
LIG_FHA_1	368	374	PF00498	0.534
LIG_FHA_1	418	424	PF00498	0.468
LIG_FHA_1	615	621	PF00498	0.618
LIG_FHA_1	644	650	PF00498	0.582
LIG_FHA_1	667	673	PF00498	0.629
LIG_FHA_2	105	111	PF00498	0.323
LIG_FHA_2	332	338	PF00498	0.342
LIG_FHA_2	543	549	PF00498	0.727
LIG_FHA_2	552	558	PF00498	0.551
LIG_FHA_2	573	579	PF00498	0.674
LIG_FHA_2	588	594	PF00498	0.483
LIG_HP1_1	20	24	PF01393	0.481
LIG_Integrin_isoDGR_2	505	507	PF01839	0.351
LIG_IRF3_LxIS_1	20	27	PF10401	0.420
LIG_LIR_Apic_2	337	342	PF02991	0.401
LIG_LIR_Apic_2	40	45	PF02991	0.459
LIG_LIR_Gen_1	194	204	PF02991	0.367
LIG_LIR_Gen_1	334	342	PF02991	0.314
LIG_LIR_Gen_1	452	459	PF02991	0.367
LIG_LIR_Gen_1	578	589	PF02991	0.573
LIG_LIR_LC3C_4	420	425	PF02991	0.342
LIG_LIR_Nem_3	194	200	PF02991	0.379
LIG_LIR_Nem_3	578	584	PF02991	0.563
LIG_MYND_1	147	151	PF01753	0.543
LIG_NRBOX	13	19	PF00104	0.441
LIG_Pex14_2	450	454	PF04695	0.346
LIG_PTB_Apo_2	502	509	PF02174	0.438
LIG_PTB_Phospho_1	502	508	PF10480	0.433
LIG_SH2_CRK	42	46	PF00017	0.446
LIG_SH2_GRB2like	503	506	PF00017	0.419
LIG_SH2_SRC	503	506	PF00017	0.419
LIG_SH2_STAP1	324	328	PF00017	0.384
LIG_SH2_STAT3	323	326	PF00017	0.389
LIG_SH2_STAT3	722	725	PF00017	0.528
LIG_SH2_STAT5	25	28	PF00017	0.432
LIG_SH2_STAT5	335	338	PF00017	0.464
LIG_SH2_STAT5	405	408	PF00017	0.352
LIG_SH2_STAT5	449	452	PF00017	0.409
LIG_SH2_STAT5	503	506	PF00017	0.484
LIG_SH3_3	120	126	PF00018	0.600
LIG_SH3_3	128	134	PF00018	0.674
LIG_SH3_3	145	151	PF00018	0.524
LIG_SH3_3	631	637	PF00018	0.738
LIG_SH3_3	691	697	PF00018	0.539
LIG_SUMO_SIM_anti_2	419	426	PF11976	0.331
LIG_SUMO_SIM_anti_2	551	557	PF11976	0.500
LIG_SUMO_SIM_par_1	345	351	PF11976	0.372
LIG_SUMO_SIM_par_1	427	433	PF11976	0.411
LIG_SxIP_EBH_1	628	639	PF03271	0.507
LIG_TRAF2_1	151	154	PF00917	0.525
LIG_TRAF2_1	458	461	PF00917	0.388
LIG_TRAF2_1	499	502	PF00917	0.380
LIG_TRAF2_1	63	66	PF00917	0.294
LIG_TRAF2_1	665	668	PF00917	0.646
LIG_WRC_WIRS_1	312	317	PF05994	0.316
MOD_CDK_SPK_2	693	698	PF00069	0.554
MOD_CK1_1	159	165	PF00069	0.522
MOD_CK1_1	198	204	PF00069	0.309
MOD_CK1_1	235	241	PF00069	0.421
MOD_CK1_1	297	303	PF00069	0.454
MOD_CK1_1	304	310	PF00069	0.360
MOD_CK1_1	351	357	PF00069	0.551
MOD_CK1_1	462	468	PF00069	0.452
MOD_CK1_1	513	519	PF00069	0.481
MOD_CK1_1	541	547	PF00069	0.649
MOD_CK1_1	676	682	PF00069	0.750
MOD_CK1_1	693	699	PF00069	0.431
MOD_CK2_1	104	110	PF00069	0.466
MOD_CK2_1	331	337	PF00069	0.465
MOD_CK2_1	496	502	PF00069	0.492
MOD_CK2_1	551	557	PF00069	0.601
MOD_CK2_1	662	668	PF00069	0.645
MOD_Cter_Amidation	178	181	PF01082	0.380
MOD_GlcNHglycan	240	243	PF01048	0.434
MOD_GlcNHglycan	350	353	PF01048	0.432
MOD_GlcNHglycan	376	379	PF01048	0.411
MOD_GlcNHglycan	498	501	PF01048	0.445
MOD_GlcNHglycan	61	64	PF01048	0.406
MOD_GlcNHglycan	625	628	PF01048	0.688
MOD_GSK3_1	191	198	PF00069	0.446
MOD_GSK3_1	294	301	PF00069	0.419
MOD_GSK3_1	374	381	PF00069	0.400
MOD_GSK3_1	407	414	PF00069	0.464
MOD_GSK3_1	462	469	PF00069	0.436
MOD_GSK3_1	538	545	PF00069	0.648
MOD_GSK3_1	656	663	PF00069	0.731
MOD_GSK3_1	693	700	PF00069	0.546
MOD_N-GLC_1	513	518	PF02516	0.607
MOD_N-GLC_1	551	556	PF02516	0.627
MOD_NEK2_1	24	29	PF00069	0.553
MOD_NEK2_1	283	288	PF00069	0.362
MOD_NEK2_1	459	464	PF00069	0.348
MOD_NEK2_1	496	501	PF00069	0.496
MOD_NEK2_1	560	565	PF00069	0.481
MOD_NEK2_1	623	628	PF00069	0.689
MOD_NEK2_1	702	707	PF00069	0.532
MOD_PIKK_1	149	155	PF00454	0.481
MOD_PIKK_1	351	357	PF00454	0.520
MOD_PIKK_1	462	468	PF00454	0.374
MOD_PIKK_1	663	669	PF00454	0.568
MOD_PKA_1	180	186	PF00069	0.360
MOD_PKA_1	37	43	PF00069	0.450
MOD_PKA_1	77	83	PF00069	0.529
MOD_PKA_2	180	186	PF00069	0.502
MOD_PKA_2	697	703	PF00069	0.503
MOD_Plk_1	459	465	PF00069	0.435
MOD_Plk_1	551	557	PF00069	0.500
MOD_Plk_1	587	593	PF00069	0.599
MOD_Plk_2-3	551	557	PF00069	0.500
MOD_Plk_2-3	605	611	PF00069	0.601
MOD_Plk_4	311	317	PF00069	0.379
MOD_Plk_4	37	43	PF00069	0.610
MOD_Plk_4	407	413	PF00069	0.536
MOD_Plk_4	459	465	PF00069	0.435
MOD_Plk_4	466	472	PF00069	0.434
MOD_Plk_4	551	557	PF00069	0.563
MOD_Plk_4	587	593	PF00069	0.752
MOD_Plk_4	690	696	PF00069	0.471
MOD_ProDKin_1	147	153	PF00069	0.459
MOD_ProDKin_1	472	478	PF00069	0.442
MOD_ProDKin_1	538	544	PF00069	0.695
MOD_ProDKin_1	635	641	PF00069	0.704
MOD_ProDKin_1	693	699	PF00069	0.605
MOD_SUMO_rev_2	293	297	PF00179	0.306
MOD_SUMO_rev_2	322	328	PF00179	0.404
MOD_SUMO_rev_2	487	496	PF00179	0.531
MOD_SUMO_rev_2	574	581	PF00179	0.467
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.512
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.447
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.425
TRG_ENDOCYTIC_2	335	338	PF00928	0.397
TRG_ENDOCYTIC_2	95	98	PF00928	0.438
TRG_ER_diArg_1	180	182	PF00400	0.443
TRG_ER_diArg_1	371	373	PF00400	0.531
TRG_NES_CRM1_1	260	275	PF08389	0.295
TRG_NLS_MonoExtC_3	434	439	PF00514	0.500
TRG_NLS_MonoExtN_4	527	534	PF00514	0.559
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.332
TRG_Pf-PMV_PEXEL_1	628	632	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q1	Leptomonas seymouri	45%	96%
A0A1X0NNU6	Trypanosomatidae	26%	98%
A0A3Q8II63	Leishmania donovani	91%	100%
A0A422NXG9	Trypanosoma rangeli	26%	100%
A4HVU7	Leishmania infantum	91%	100%
E9APJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BM90	Trypanosoma cruzi	25%	100%