P-loop containing nucleoside triphosphate hydrolase protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFX9_LEIMA

TriTrypDb:

LmjF.14.0060 , LMJLV39_140005600 , LMJSD75_140005600

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFX9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0003924	GTPase activity	7	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	81	83	PF00675	0.556
CLV_PCSK_SKI1_1	116	120	PF00082	0.531
CLV_PCSK_SKI1_1	150	154	PF00082	0.542
DOC_MAPK_gen_1	57	64	PF00069	0.550
DOC_MAPK_MEF2A_6	57	64	PF00069	0.508
DOC_USP7_MATH_1	109	113	PF00917	0.422
DOC_WW_Pin1_4	36	41	PF00397	0.554
DOC_WW_Pin1_4	50	55	PF00397	0.477
LIG_14-3-3_CanoR_1	116	125	PF00244	0.542
LIG_BRCT_BRCA1_1	111	115	PF00533	0.420
LIG_eIF4E_1	25	31	PF01652	0.499
LIG_FHA_1	15	21	PF00498	0.384
LIG_FHA_1	174	180	PF00498	0.302
LIG_FHA_1	25	31	PF00498	0.428
LIG_FHA_1	59	65	PF00498	0.447
LIG_FHA_1	90	96	PF00498	0.489
LIG_FHA_2	143	149	PF00498	0.388
LIG_FHA_2	40	46	PF00498	0.561
LIG_LIR_Gen_1	24	31	PF02991	0.340
LIG_LIR_Gen_1	74	79	PF02991	0.454
LIG_LIR_Gen_1	91	100	PF02991	0.494
LIG_LIR_Nem_3	112	118	PF02991	0.433
LIG_LIR_Nem_3	169	174	PF02991	0.397
LIG_LIR_Nem_3	184	190	PF02991	0.536
LIG_LIR_Nem_3	24	28	PF02991	0.329
LIG_LIR_Nem_3	74	78	PF02991	0.441
LIG_LIR_Nem_3	91	97	PF02991	0.498
LIG_SH2_STAT3	117	120	PF00017	0.557
LIG_SH2_STAT5	117	120	PF00017	0.530
LIG_SH2_STAT5	25	28	PF00017	0.435
LIG_SH2_STAT5	7	10	PF00017	0.382
LIG_SH2_STAT5	98	101	PF00017	0.468
LIG_SH3_3	154	160	PF00018	0.518
LIG_SUMO_SIM_par_1	164	170	PF11976	0.482
LIG_SUMO_SIM_par_1	60	66	PF11976	0.459
LIG_TRAF2_1	145	148	PF00917	0.465
LIG_TRAF2_1	42	45	PF00917	0.561
LIG_TYR_ITIM	23	28	PF00017	0.320
LIG_WRC_WIRS_1	149	154	PF05994	0.466
MOD_CDK_SPxxK_3	50	57	PF00069	0.591
MOD_CK1_1	89	95	PF00069	0.535
MOD_CK2_1	142	148	PF00069	0.418
MOD_CK2_1	39	45	PF00069	0.568
MOD_CK2_1	74	80	PF00069	0.481
MOD_GlcNHglycan	88	91	PF01048	0.568
MOD_GSK3_1	10	17	PF00069	0.406
MOD_GSK3_1	67	74	PF00069	0.514
MOD_GSK3_1	86	93	PF00069	0.556
MOD_N-GLC_2	50	52	PF02516	0.357
MOD_NEK2_1	110	115	PF00069	0.506
MOD_NEK2_1	30	35	PF00069	0.546
MOD_NEK2_1	67	72	PF00069	0.499
MOD_NEK2_1	78	83	PF00069	0.348
MOD_PIKK_1	116	122	PF00454	0.575
MOD_PK_1	137	143	PF00069	0.532
MOD_Plk_1	90	96	PF00069	0.479
MOD_Plk_4	110	116	PF00069	0.349
MOD_Plk_4	128	134	PF00069	0.469
MOD_Plk_4	67	73	PF00069	0.484
MOD_Plk_4	74	80	PF00069	0.447
MOD_Plk_4	90	96	PF00069	0.481
MOD_ProDKin_1	36	42	PF00069	0.558
MOD_ProDKin_1	50	56	PF00069	0.486
TRG_ENDOCYTIC_2	25	28	PF00928	0.333
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE8	Leptomonas seymouri	61%	78%
A0A0S4IRL4	Bodo saltans	28%	66%
A0A1X0NNU1	Trypanosomatidae	38%	100%
A0A3R7LA27	Trypanosoma rangeli	42%	100%
A0A3S7WSS1	Leishmania donovani	95%	100%
A4H7G7	Leishmania braziliensis	84%	100%
A4HVU8	Leishmania infantum	96%	100%
C9ZT78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9APK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DE15	Trypanosoma cruzi	42%	100%