Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QFX8_LEIMA

TriTrypDb:

LmjF.14.0070 , LMJLV39_140005700 , LMJSD75_140005700

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0016020	membrane	2	8
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QFX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFX8

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016417	S-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	8
GO:0019707	protein-cysteine S-acyltransferase activity	3	8
GO:0140096	catalytic activity, acting on a protein	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	151	153	PF00675	0.280
CLV_NRD_NRD_1	176	178	PF00675	0.300
CLV_NRD_NRD_1	274	276	PF00675	0.344
CLV_PCSK_KEX2_1	151	153	PF00082	0.276
CLV_PCSK_KEX2_1	176	178	PF00082	0.309
CLV_PCSK_SKI1_1	177	181	PF00082	0.233
DEG_APCC_DBOX_1	176	184	PF00400	0.476
DEG_MDM2_SWIB_1	62	69	PF02201	0.322
DOC_CYCLIN_yClb5_NLxxxL_5	112	121	PF00134	0.511
DOC_MAPK_DCC_7	80	90	PF00069	0.276
DOC_MAPK_gen_1	151	159	PF00069	0.448
DOC_MAPK_gen_1	176	183	PF00069	0.509
DOC_MAPK_MEF2A_6	207	216	PF00069	0.248
DOC_MAPK_NFAT4_5	207	215	PF00069	0.248
DOC_PP1_RVXF_1	36	42	PF00149	0.571
DOC_PP2B_PxIxI_1	85	91	PF00149	0.333
DOC_USP7_MATH_1	144	148	PF00917	0.448
DOC_USP7_MATH_1	187	191	PF00917	0.476
DOC_USP7_MATH_1	255	259	PF00917	0.572
DOC_USP7_MATH_1	43	47	PF00917	0.551
DOC_USP7_MATH_1	94	98	PF00917	0.289
DOC_WW_Pin1_4	39	44	PF00397	0.576
DOC_WW_Pin1_4	70	75	PF00397	0.326
LIG_14-3-3_CanoR_1	242	251	PF00244	0.486
LIG_14-3-3_CanoR_1	259	265	PF00244	0.601
LIG_14-3-3_CanoR_1	70	74	PF00244	0.348
LIG_Actin_WH2_2	223	241	PF00022	0.289
LIG_Actin_WH2_2	56	72	PF00022	0.326
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_CSL_BTD_1	40	43	PF09270	0.553
LIG_CtBP_PxDLS_1	118	122	PF00389	0.584
LIG_EH1_1	46	54	PF00400	0.327
LIG_eIF4E_1	178	184	PF01652	0.268
LIG_FHA_1	136	142	PF00498	0.542
LIG_FHA_1	215	221	PF00498	0.435
LIG_FHA_1	97	103	PF00498	0.299
LIG_GBD_Chelix_1	230	238	PF00786	0.289
LIG_LIR_Apic_2	68	74	PF02991	0.335
LIG_LIR_Gen_1	2	11	PF02991	0.661
LIG_LIR_Gen_1	263	273	PF02991	0.483
LIG_LIR_Gen_1	46	56	PF02991	0.410
LIG_LIR_Gen_1	59	69	PF02991	0.242
LIG_LIR_Nem_3	2	7	PF02991	0.666
LIG_LIR_Nem_3	263	268	PF02991	0.568
LIG_LIR_Nem_3	46	51	PF02991	0.436
LIG_LIR_Nem_3	59	65	PF02991	0.281
LIG_NRBOX	60	66	PF00104	0.322
LIG_Pex14_2	62	66	PF04695	0.327
LIG_SH2_CRK	71	75	PF00017	0.330
LIG_SH2_GRB2like	250	253	PF00017	0.448
LIG_SH2_NCK_1	71	75	PF00017	0.330
LIG_SH2_STAT5	129	132	PF00017	0.572
LIG_SH2_STAT5	135	138	PF00017	0.465
LIG_SH2_STAT5	178	181	PF00017	0.268
LIG_SH2_STAT5	199	202	PF00017	0.276
LIG_SH2_STAT5	213	216	PF00017	0.339
LIG_SH2_STAT5	233	236	PF00017	0.345
LIG_SH2_STAT5	71	74	PF00017	0.325
LIG_SH3_3	199	205	PF00018	0.277
LIG_SH3_3	268	274	PF00018	0.545
LIG_SUMO_SIM_par_1	222	227	PF11976	0.327
LIG_SUMO_SIM_par_1	91	97	PF11976	0.289
LIG_SUMO_SIM_par_1	98	105	PF11976	0.268
LIG_TYR_ITIM	197	202	PF00017	0.463
MOD_CK1_1	120	126	PF00069	0.551
MOD_CK2_1	243	249	PF00069	0.442
MOD_CK2_1	6	12	PF00069	0.659
MOD_GlcNHglycan	123	126	PF01048	0.416
MOD_GlcNHglycan	146	149	PF01048	0.248
MOD_GlcNHglycan	189	192	PF01048	0.364
MOD_GlcNHglycan	193	196	PF01048	0.322
MOD_GlcNHglycan	21	24	PF01048	0.476
MOD_GlcNHglycan	96	99	PF01048	0.331
MOD_GSK3_1	117	124	PF00069	0.605
MOD_GSK3_1	15	22	PF00069	0.732
MOD_GSK3_1	183	190	PF00069	0.424
MOD_GSK3_1	220	227	PF00069	0.401
MOD_GSK3_1	39	46	PF00069	0.558
MOD_GSK3_1	65	72	PF00069	0.358
MOD_N-GLC_2	154	156	PF02516	0.276
MOD_NEK2_1	101	106	PF00069	0.323
MOD_NEK2_1	121	126	PF00069	0.571
MOD_NEK2_1	182	187	PF00069	0.304
MOD_NEK2_1	220	225	PF00069	0.401
MOD_NEK2_1	243	248	PF00069	0.395
MOD_NEK2_1	65	70	PF00069	0.335
MOD_NEK2_2	135	140	PF00069	0.480
MOD_NEK2_2	260	265	PF00069	0.521
MOD_PIKK_1	142	148	PF00454	0.480
MOD_PKA_2	142	148	PF00069	0.483
MOD_PKA_2	260	266	PF00069	0.550
MOD_PKA_2	69	75	PF00069	0.346
MOD_Plk_1	43	49	PF00069	0.480
MOD_Plk_4	224	230	PF00069	0.307
MOD_Plk_4	260	266	PF00069	0.558
MOD_Plk_4	56	62	PF00069	0.387
MOD_Plk_4	96	102	PF00069	0.284
MOD_ProDKin_1	39	45	PF00069	0.573
MOD_ProDKin_1	70	76	PF00069	0.324
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.480
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.476
TRG_ENDOCYTIC_2	178	181	PF00928	0.268
TRG_ENDOCYTIC_2	199	202	PF00928	0.322
TRG_ENDOCYTIC_2	213	216	PF00928	0.196
TRG_ENDOCYTIC_2	28	31	PF00928	0.565
TRG_ER_diArg_1	176	178	PF00400	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B1	Leptomonas seymouri	60%	100%
A0A0S4JCH4	Bodo saltans	31%	76%
A0A3S7WSS8	Leishmania donovani	96%	100%
A0A3S7WZD9	Leishmania donovani	27%	85%
A4H7G8	Leishmania braziliensis	81%	100%
A4HVU9	Leishmania infantum	96%	100%
A4I1S8	Leishmania infantum	27%	85%
B3DN87	Arabidopsis thaliana	29%	83%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	91%
E9APK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AXW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	85%
F1QHM7	Danio rerio	26%	69%
F1R013	Danio rerio	27%	72%
F1RE57	Danio rerio	25%	88%
O74384	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	80%
O80685	Arabidopsis thaliana	27%	68%
P59268	Mus musculus	28%	77%
Q2TGJ1	Rattus norvegicus	30%	72%
Q2TGK3	Rattus norvegicus	24%	93%
Q4Q9K8	Leishmania major	26%	85%
Q58DA8	Bos taurus	28%	77%
Q58DT3	Bos taurus	27%	81%
Q5FVR1	Rattus norvegicus	30%	81%
Q5PNZ1	Arabidopsis thaliana	29%	68%
Q5R5J8	Pongo abelii	29%	77%
Q5Y5T2	Mus musculus	30%	73%
Q6CQB5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	79%
Q7ZVN4	Danio rerio	29%	72%
Q8R173	Mus musculus	24%	93%
Q8VYP5	Arabidopsis thaliana	26%	91%
Q91WU6	Mus musculus	27%	91%
Q923G5	Rattus norvegicus	27%	91%
Q93VV0	Arabidopsis thaliana	25%	98%
Q9D6H5	Mus musculus	29%	81%
Q9FLM3	Arabidopsis thaliana	25%	68%
Q9NUE0	Homo sapiens	30%	72%
Q9NXF8	Homo sapiens	27%	91%
Q9NYG2	Homo sapiens	25%	93%
Q9SB58	Arabidopsis thaliana	29%	69%
Q9Y397	Homo sapiens	28%	77%