Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFX7_LEIMA

TriTrypDb:

LmjF.14.0080 , LMJLV39_140005800 , LMJSD75_140005800

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.425
CLV_NRD_NRD_1	100	102	PF00675	0.404
CLV_NRD_NRD_1	106	108	PF00675	0.405
CLV_NRD_NRD_1	267	269	PF00675	0.435
CLV_NRD_NRD_1	95	97	PF00675	0.404
CLV_PCSK_KEX2_1	106	108	PF00082	0.479
CLV_PCSK_KEX2_1	51	53	PF00082	0.531
CLV_PCSK_KEX2_1	95	97	PF00082	0.384
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.551
CLV_PCSK_SKI1_1	116	120	PF00082	0.357
CLV_PCSK_SKI1_1	148	152	PF00082	0.430
CLV_PCSK_SKI1_1	167	171	PF00082	0.384
CLV_PCSK_SKI1_1	91	95	PF00082	0.368
CLV_PCSK_SKI1_1	96	100	PF00082	0.354
DEG_Nend_Nbox_1	1	3	PF02207	0.567
DOC_CKS1_1	18	23	PF01111	0.522
DOC_PP2B_PxIxI_1	242	248	PF00149	0.410
DOC_PP4_FxxP_1	5	8	PF00568	0.593
DOC_USP7_MATH_1	162	166	PF00917	0.578
DOC_WW_Pin1_4	127	132	PF00397	0.537
DOC_WW_Pin1_4	17	22	PF00397	0.522
DOC_WW_Pin1_4	77	82	PF00397	0.400
LIG_14-3-3_CanoR_1	10	18	PF00244	0.606
LIG_14-3-3_CanoR_1	67	72	PF00244	0.441
LIG_14-3-3_CanoR_1	83	88	PF00244	0.384
LIG_14-3-3_CanoR_1	95	101	PF00244	0.334
LIG_deltaCOP1_diTrp_1	60	68	PF00928	0.487
LIG_FHA_1	18	24	PF00498	0.523
LIG_FHA_2	140	146	PF00498	0.355
LIG_FHA_2	219	225	PF00498	0.491
LIG_FHA_2	37	43	PF00498	0.539
LIG_FHA_2	51	57	PF00498	0.503
LIG_LIR_Gen_1	117	125	PF02991	0.412
LIG_LIR_Gen_1	183	192	PF02991	0.344
LIG_LIR_Gen_1	198	205	PF02991	0.295
LIG_LIR_Gen_1	216	227	PF02991	0.365
LIG_LIR_Gen_1	241	250	PF02991	0.381
LIG_LIR_Nem_3	109	113	PF02991	0.495
LIG_LIR_Nem_3	117	122	PF02991	0.495
LIG_LIR_Nem_3	132	137	PF02991	0.496
LIG_LIR_Nem_3	165	169	PF02991	0.526
LIG_LIR_Nem_3	183	188	PF02991	0.352
LIG_LIR_Nem_3	198	203	PF02991	0.298
LIG_LIR_Nem_3	224	228	PF02991	0.315
LIG_LIR_Nem_3	241	247	PF02991	0.381
LIG_SH2_CRK	84	88	PF00017	0.376
LIG_SH2_GRB2like	30	33	PF00017	0.427
LIG_SH2_NCK_1	84	88	PF00017	0.390
LIG_SH2_STAP1	178	182	PF00017	0.440
LIG_SH2_STAP1	84	88	PF00017	0.400
LIG_SH2_STAT3	191	194	PF00017	0.345
LIG_SH2_STAT5	30	33	PF00017	0.427
LIG_SH2_STAT5	84	87	PF00017	0.397
LIG_SH3_3	233	239	PF00018	0.565
LIG_TYR_ITIM	82	87	PF00017	0.371
LIG_UBA3_1	149	154	PF00899	0.516
LIG_WRC_WIRS_1	182	187	PF05994	0.357
MOD_CDK_SPxK_1	77	83	PF00069	0.406
MOD_CK1_1	165	171	PF00069	0.573
MOD_CK1_1	36	42	PF00069	0.517
MOD_CK2_1	139	145	PF00069	0.369
MOD_CK2_1	173	179	PF00069	0.565
MOD_CK2_1	218	224	PF00069	0.404
MOD_CK2_1	36	42	PF00069	0.546
MOD_GSK3_1	123	130	PF00069	0.394
MOD_GSK3_1	42	49	PF00069	0.542
MOD_LATS_1	121	127	PF00433	0.265
MOD_N-GLC_1	33	38	PF02516	0.505
MOD_NEK2_1	201	206	PF00069	0.342
MOD_NEK2_1	271	276	PF00069	0.461
MOD_NEK2_1	33	38	PF00069	0.564
MOD_PIKK_1	10	16	PF00454	0.556
MOD_PIKK_1	193	199	PF00454	0.477
MOD_PIKK_1	258	264	PF00454	0.464
MOD_PIKK_1	42	48	PF00454	0.635
MOD_PK_1	83	89	PF00069	0.400
MOD_PKA_2	138	144	PF00069	0.379
MOD_PKA_2	211	217	PF00069	0.468
MOD_PKA_2	82	88	PF00069	0.434
MOD_PKA_2	9	15	PF00069	0.679
MOD_Plk_1	33	39	PF00069	0.521
MOD_Plk_2-3	181	187	PF00069	0.472
MOD_Plk_2-3	218	224	PF00069	0.423
MOD_Plk_4	218	224	PF00069	0.445
MOD_ProDKin_1	127	133	PF00069	0.533
MOD_ProDKin_1	17	23	PF00069	0.524
MOD_ProDKin_1	77	83	PF00069	0.406
TRG_ENDOCYTIC_2	225	228	PF00928	0.365
TRG_ENDOCYTIC_2	30	33	PF00928	0.427
TRG_ENDOCYTIC_2	84	87	PF00928	0.397
TRG_ER_diArg_1	106	108	PF00400	0.455
TRG_ER_diArg_1	209	212	PF00400	0.488
TRG_ER_diArg_1	94	96	PF00400	0.393
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I365	Leptomonas seymouri	79%	100%
A0A0S4IUM2	Bodo saltans	56%	82%
A0A1X0NNS4	Trypanosomatidae	71%	100%
A0A3S5H6Q6	Leishmania donovani	97%	100%
A0A3S5IS70	Trypanosoma rangeli	67%	100%
A4H7G9	Leishmania braziliensis	91%	81%
A4HVV0	Leishmania infantum	97%	100%
C9ZT77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9APK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5AXQ5	Trypanosoma cruzi	70%	100%