J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFX6_LEIMA

TriTrypDb:

LmjF.14.0090 , LMJLV39_140005900 , LMJSD75_140005900

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.774
CLV_NRD_NRD_1	163	165	PF00675	0.813
CLV_NRD_NRD_1	197	199	PF00675	0.677
CLV_NRD_NRD_1	207	209	PF00675	0.581
CLV_NRD_NRD_1	260	262	PF00675	0.661
CLV_NRD_NRD_1	347	349	PF00675	0.689
CLV_PCSK_KEX2_1	162	164	PF00082	0.839
CLV_PCSK_KEX2_1	197	199	PF00082	0.677
CLV_PCSK_KEX2_1	207	209	PF00082	0.581
CLV_PCSK_KEX2_1	259	261	PF00082	0.672
CLV_PCSK_KEX2_1	347	349	PF00082	0.689
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.633
CLV_PCSK_PC7_1	255	261	PF00082	0.646
CLV_PCSK_SKI1_1	40	44	PF00082	0.602
CLV_Separin_Metazoa	116	120	PF03568	0.527
DEG_Nend_UBRbox_2	1	3	PF02207	0.536
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.558
DOC_CYCLIN_yCln2_LP_2	61	67	PF00134	0.521
DOC_MAPK_gen_1	162	172	PF00069	0.738
DOC_MAPK_gen_1	197	203	PF00069	0.658
DOC_MAPK_gen_1	34	43	PF00069	0.529
DOC_MAPK_MEF2A_6	163	172	PF00069	0.735
DOC_MAPK_MEF2A_6	368	375	PF00069	0.573
DOC_MAPK_NFAT4_5	368	376	PF00069	0.577
DOC_PP2B_LxvP_1	65	68	PF13499	0.532
DOC_USP7_MATH_1	137	141	PF00917	0.837
DOC_USP7_MATH_1	15	19	PF00917	0.540
DOC_USP7_MATH_1	178	182	PF00917	0.645
DOC_USP7_MATH_1	187	191	PF00917	0.533
DOC_USP7_MATH_1	226	230	PF00917	0.728
DOC_USP7_MATH_1	246	250	PF00917	0.722
DOC_USP7_MATH_1	275	279	PF00917	0.729
DOC_USP7_MATH_1	312	316	PF00917	0.818
DOC_USP7_MATH_1	340	344	PF00917	0.605
DOC_USP7_MATH_1	96	100	PF00917	0.643
DOC_USP7_UBL2_3	144	148	PF12436	0.746
DOC_WW_Pin1_4	276	281	PF00397	0.721
DOC_WW_Pin1_4	294	299	PF00397	0.650
DOC_WW_Pin1_4	300	305	PF00397	0.791
DOC_WW_Pin1_4	328	333	PF00397	0.693
DOC_WW_Pin1_4	94	99	PF00397	0.454
LIG_14-3-3_CanoR_1	106	110	PF00244	0.600
LIG_14-3-3_CanoR_1	198	204	PF00244	0.638
LIG_14-3-3_CanoR_1	223	231	PF00244	0.770
LIG_14-3-3_CanoR_1	259	267	PF00244	0.746
LIG_14-3-3_CanoR_1	276	280	PF00244	0.828
LIG_14-3-3_CanoR_1	361	371	PF00244	0.647
LIG_Actin_WH2_2	103	121	PF00022	0.582
LIG_FHA_1	178	184	PF00498	0.663
LIG_FHA_1	222	228	PF00498	0.764
LIG_FHA_1	242	248	PF00498	0.704
LIG_FHA_1	269	275	PF00498	0.745
LIG_FHA_1	311	317	PF00498	0.783
LIG_FHA_1	334	340	PF00498	0.732
LIG_FHA_1	364	370	PF00498	0.655
LIG_FHA_2	306	312	PF00498	0.732
LIG_LIR_Apic_2	289	295	PF02991	0.542
LIG_LIR_Gen_1	102	110	PF02991	0.394
LIG_LIR_Gen_1	18	29	PF02991	0.495
LIG_LIR_Gen_1	213	220	PF02991	0.567
LIG_LIR_Gen_1	30	38	PF02991	0.606
LIG_LIR_Gen_1	82	90	PF02991	0.624
LIG_LIR_Nem_3	102	107	PF02991	0.401
LIG_LIR_Nem_3	18	24	PF02991	0.482
LIG_LIR_Nem_3	213	218	PF02991	0.588
LIG_LIR_Nem_3	327	333	PF02991	0.602
LIG_LIR_Nem_3	372	378	PF02991	0.549
LIG_LIR_Nem_3	82	86	PF02991	0.623
LIG_SH2_CRK	292	296	PF00017	0.542
LIG_SH2_STAP1	32	36	PF00017	0.524
LIG_SH3_1	162	168	PF00018	0.741
LIG_SH3_1	292	298	PF00018	0.543
LIG_SH3_2	295	300	PF14604	0.631
LIG_SH3_3	151	157	PF00018	0.755
LIG_SH3_3	162	168	PF00018	0.602
LIG_SH3_3	292	298	PF00018	0.707
LIG_SH3_3	329	335	PF00018	0.702
LIG_SH3_3	45	51	PF00018	0.631
LIG_SH3_3	61	67	PF00018	0.474
LIG_SH3_4	146	153	PF00018	0.747
LIG_TRAF2_1	266	269	PF00917	0.712
MOD_CDC14_SPxK_1	297	300	PF00782	0.556
MOD_CDK_SPxK_1	294	300	PF00069	0.548
MOD_CK1_1	191	197	PF00069	0.585
MOD_CK1_1	229	235	PF00069	0.726
MOD_CK1_1	262	268	PF00069	0.712
MOD_CK1_1	279	285	PF00069	0.685
MOD_CK1_1	305	311	PF00069	0.802
MOD_CK1_1	315	321	PF00069	0.634
MOD_CK1_1	7	13	PF00069	0.550
MOD_CK2_1	246	252	PF00069	0.778
MOD_CK2_1	96	102	PF00069	0.593
MOD_Cter_Amidation	122	125	PF01082	0.532
MOD_DYRK1A_RPxSP_1	276	280	PF00069	0.748
MOD_GlcNHglycan	151	154	PF01048	0.792
MOD_GlcNHglycan	218	221	PF01048	0.609
MOD_GlcNHglycan	264	267	PF01048	0.774
MOD_GlcNHglycan	318	321	PF01048	0.782
MOD_GlcNHglycan	325	329	PF01048	0.676
MOD_GlcNHglycan	74	77	PF01048	0.662
MOD_GlcNHglycan	98	101	PF01048	0.651
MOD_GSK3_1	16	23	PF00069	0.482
MOD_GSK3_1	174	181	PF00069	0.713
MOD_GSK3_1	187	194	PF00069	0.710
MOD_GSK3_1	218	225	PF00069	0.692
MOD_GSK3_1	275	282	PF00069	0.816
MOD_GSK3_1	312	319	PF00069	0.840
MOD_GSK3_1	324	331	PF00069	0.621
MOD_N-GLC_1	15	20	PF02516	0.479
MOD_NEK2_1	105	110	PF00069	0.612
MOD_NEK2_1	149	154	PF00069	0.706
MOD_NEK2_1	196	201	PF00069	0.630
MOD_NEK2_1	218	223	PF00069	0.663
MOD_NEK2_1	241	246	PF00069	0.705
MOD_NEK2_1	285	290	PF00069	0.786
MOD_NEK2_1	362	367	PF00069	0.724
MOD_NEK2_1	4	9	PF00069	0.544
MOD_NEK2_2	312	317	PF00069	0.818
MOD_PIKK_1	191	197	PF00454	0.638
MOD_PIKK_1	218	224	PF00454	0.666
MOD_PIKK_1	259	265	PF00454	0.798
MOD_PKA_1	259	265	PF00069	0.636
MOD_PKA_2	105	111	PF00069	0.606
MOD_PKA_2	196	202	PF00069	0.632
MOD_PKA_2	222	228	PF00069	0.758
MOD_PKA_2	259	265	PF00069	0.656
MOD_PKA_2	275	281	PF00069	0.717
MOD_PKA_2	30	36	PF00069	0.543
MOD_PKA_2	72	78	PF00069	0.612
MOD_PKB_1	259	267	PF00069	0.726
MOD_Plk_1	15	21	PF00069	0.478
MOD_Plk_1	324	330	PF00069	0.795
MOD_Plk_1	371	377	PF00069	0.602
MOD_Plk_4	105	111	PF00069	0.606
MOD_Plk_4	16	22	PF00069	0.398
MOD_Plk_4	286	292	PF00069	0.788
MOD_Plk_4	4	10	PF00069	0.555
MOD_ProDKin_1	276	282	PF00069	0.716
MOD_ProDKin_1	294	300	PF00069	0.653
MOD_ProDKin_1	302	308	PF00069	0.813
MOD_ProDKin_1	328	334	PF00069	0.691
MOD_ProDKin_1	94	100	PF00069	0.447
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.710
TRG_ENDOCYTIC_2	21	24	PF00928	0.484
TRG_ENDOCYTIC_2	291	294	PF00928	0.777
TRG_ENDOCYTIC_2	32	35	PF00928	0.436
TRG_ENDOCYTIC_2	330	333	PF00928	0.608
TRG_ER_diArg_1	162	164	PF00400	0.829
TRG_ER_diArg_1	196	198	PF00400	0.655
TRG_ER_diArg_1	259	261	PF00400	0.693
TRG_ER_diArg_1	346	348	PF00400	0.693
TRG_ER_diArg_1	355	358	PF00400	0.537
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB18	Leptomonas seymouri	50%	97%
A0A3S7WSS6	Leishmania donovani	94%	100%
A4H7H0	Leishmania braziliensis	73%	100%
A4HVV1	Leishmania infantum	94%	100%
E9APK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%