Calponin-homology (CH) domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFX5_LEIMA

TriTrypDb:

LmjF.14.0100 , LMJLV39_140006000 , LMJSD75_140006000

Length:

1029

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFX5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.577
CLV_NRD_NRD_1	22	24	PF00675	0.707
CLV_NRD_NRD_1	222	224	PF00675	0.591
CLV_NRD_NRD_1	233	235	PF00675	0.445
CLV_NRD_NRD_1	355	357	PF00675	0.654
CLV_NRD_NRD_1	507	509	PF00675	0.535
CLV_NRD_NRD_1	548	550	PF00675	0.507
CLV_NRD_NRD_1	818	820	PF00675	0.525
CLV_NRD_NRD_1	909	911	PF00675	0.673
CLV_NRD_NRD_1	932	934	PF00675	0.511
CLV_NRD_NRD_1	977	979	PF00675	0.419
CLV_PCSK_FUR_1	505	509	PF00082	0.521
CLV_PCSK_KEX2_1	178	180	PF00082	0.662
CLV_PCSK_KEX2_1	202	204	PF00082	0.651
CLV_PCSK_KEX2_1	222	224	PF00082	0.302
CLV_PCSK_KEX2_1	232	234	PF00082	0.526
CLV_PCSK_KEX2_1	507	509	PF00082	0.501
CLV_PCSK_KEX2_1	80	82	PF00082	0.679
CLV_PCSK_KEX2_1	818	820	PF00082	0.525
CLV_PCSK_KEX2_1	909	911	PF00082	0.700
CLV_PCSK_KEX2_1	977	979	PF00082	0.508
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.651
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.592
CLV_PCSK_SKI1_1	203	207	PF00082	0.577
CLV_PCSK_SKI1_1	321	325	PF00082	0.606
CLV_PCSK_SKI1_1	327	331	PF00082	0.630
CLV_PCSK_SKI1_1	367	371	PF00082	0.632
CLV_PCSK_SKI1_1	384	388	PF00082	0.414
CLV_PCSK_SKI1_1	400	404	PF00082	0.437
CLV_PCSK_SKI1_1	47	51	PF00082	0.672
CLV_PCSK_SKI1_1	557	561	PF00082	0.550
CLV_PCSK_SKI1_1	571	575	PF00082	0.339
CLV_PCSK_SKI1_1	659	663	PF00082	0.519
CLV_PCSK_SKI1_1	707	711	PF00082	0.446
CLV_PCSK_SKI1_1	788	792	PF00082	0.421
CLV_PCSK_SKI1_1	818	822	PF00082	0.485
CLV_PCSK_SKI1_1	901	905	PF00082	0.505
CLV_PCSK_SKI1_1	922	926	PF00082	0.560
DEG_APCC_DBOX_1	817	825	PF00400	0.533
DEG_APCC_DBOX_1	855	863	PF00400	0.493
DEG_Kelch_Keap1_1	472	477	PF01344	0.533
DEG_SPOP_SBC_1	38	42	PF00917	0.704
DEG_SPOP_SBC_1	702	706	PF00917	0.494
DOC_CKS1_1	647	652	PF01111	0.631
DOC_CKS1_1	753	758	PF01111	0.563
DOC_CYCLIN_RxL_1	381	389	PF00134	0.529
DOC_CYCLIN_RxL_1	397	407	PF00134	0.479
DOC_MAPK_DCC_7	165	175	PF00069	0.529
DOC_MAPK_gen_1	232	240	PF00069	0.559
DOC_MAPK_gen_1	818	826	PF00069	0.548
DOC_MAPK_HePTP_8	230	242	PF00069	0.390
DOC_MAPK_MEF2A_6	233	242	PF00069	0.609
DOC_MAPK_MEF2A_6	883	892	PF00069	0.465
DOC_PP1_RVXF_1	1011	1018	PF00149	0.609
DOC_PP1_RVXF_1	705	711	PF00149	0.428
DOC_PP1_RVXF_1	920	927	PF00149	0.526
DOC_USP7_MATH_1	1021	1025	PF00917	0.754
DOC_USP7_MATH_1	28	32	PF00917	0.702
DOC_USP7_MATH_1	39	43	PF00917	0.710
DOC_USP7_MATH_1	404	408	PF00917	0.694
DOC_USP7_MATH_1	437	441	PF00917	0.546
DOC_USP7_MATH_1	465	469	PF00917	0.552
DOC_USP7_MATH_1	601	605	PF00917	0.583
DOC_USP7_MATH_1	8	12	PF00917	0.647
DOC_USP7_MATH_1	803	807	PF00917	0.555
DOC_USP7_MATH_1	938	942	PF00917	0.506
DOC_USP7_UBL2_3	135	139	PF12436	0.581
DOC_WW_Pin1_4	30	35	PF00397	0.731
DOC_WW_Pin1_4	578	583	PF00397	0.601
DOC_WW_Pin1_4	646	651	PF00397	0.646
DOC_WW_Pin1_4	752	757	PF00397	0.458
DOC_WW_Pin1_4	788	793	PF00397	0.519
DOC_WW_Pin1_4	829	834	PF00397	0.537
LIG_14-3-3_CanoR_1	274	279	PF00244	0.531
LIG_14-3-3_CanoR_1	288	294	PF00244	0.512
LIG_14-3-3_CanoR_1	335	343	PF00244	0.666
LIG_14-3-3_CanoR_1	367	376	PF00244	0.545
LIG_14-3-3_CanoR_1	557	565	PF00244	0.592
LIG_14-3-3_CanoR_1	600	610	PF00244	0.542
LIG_14-3-3_CanoR_1	618	622	PF00244	0.323
LIG_14-3-3_CanoR_1	767	774	PF00244	0.662
LIG_14-3-3_CanoR_1	869	876	PF00244	0.577
LIG_14-3-3_CanoR_1	883	892	PF00244	0.371
LIG_14-3-3_CanoR_1	933	942	PF00244	0.561
LIG_14-3-3_CanoR_1	993	1001	PF00244	0.504
LIG_Actin_WH2_2	493	509	PF00022	0.526
LIG_Actin_WH2_2	658	676	PF00022	0.600
LIG_APCC_ABBA_1	953	958	PF00400	0.384
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	613	617	PF00533	0.613
LIG_BRCT_BRCA1_1	705	709	PF00533	0.495
LIG_CaM_IQ_9	195	211	PF13499	0.651
LIG_Clathr_ClatBox_1	50	54	PF01394	0.643
LIG_eIF4E_1	280	286	PF01652	0.613
LIG_eIF4E_1	317	323	PF01652	0.670
LIG_eIF4E_1	85	91	PF01652	0.507
LIG_FHA_1	1004	1010	PF00498	0.535
LIG_FHA_1	129	135	PF00498	0.472
LIG_FHA_1	293	299	PF00498	0.533
LIG_FHA_1	30	36	PF00498	0.784
LIG_FHA_1	364	370	PF00498	0.599
LIG_FHA_1	59	65	PF00498	0.596
LIG_FHA_1	674	680	PF00498	0.628
LIG_FHA_1	689	695	PF00498	0.475
LIG_FHA_1	703	709	PF00498	0.399
LIG_FHA_1	753	759	PF00498	0.563
LIG_FHA_1	815	821	PF00498	0.524
LIG_FHA_1	826	832	PF00498	0.594
LIG_FHA_1	889	895	PF00498	0.457
LIG_FHA_1	919	925	PF00498	0.598
LIG_FHA_1	957	963	PF00498	0.460
LIG_FHA_1	996	1002	PF00498	0.510
LIG_FHA_2	323	329	PF00498	0.690
LIG_FHA_2	38	44	PF00498	0.773
LIG_FHA_2	564	570	PF00498	0.515
LIG_FHA_2	691	697	PF00498	0.575
LIG_FHA_2	893	899	PF00498	0.525
LIG_IBAR_NPY_1	186	188	PF08397	0.477
LIG_LIR_Apic_2	393	398	PF02991	0.598
LIG_LIR_Apic_2	431	437	PF02991	0.677
LIG_LIR_Gen_1	17	26	PF02991	0.723
LIG_LIR_Gen_1	377	387	PF02991	0.612
LIG_LIR_Gen_1	477	487	PF02991	0.417
LIG_LIR_Gen_1	683	694	PF02991	0.538
LIG_LIR_Gen_1	952	961	PF02991	0.413
LIG_LIR_Nem_3	17	22	PF02991	0.683
LIG_LIR_Nem_3	377	382	PF02991	0.552
LIG_LIR_Nem_3	460	466	PF02991	0.579
LIG_LIR_Nem_3	477	482	PF02991	0.258
LIG_LIR_Nem_3	683	689	PF02991	0.553
LIG_LIR_Nem_3	706	712	PF02991	0.417
LIG_LIR_Nem_3	722	728	PF02991	0.377
LIG_LIR_Nem_3	852	858	PF02991	0.433
LIG_LIR_Nem_3	952	956	PF02991	0.393
LIG_PCNA_yPIPBox_3	848	858	PF02747	0.460
LIG_PDZ_Class_1	1024	1029	PF00595	0.754
LIG_Pex14_2	469	473	PF04695	0.404
LIG_Pex14_2	483	487	PF04695	0.381
LIG_Pex14_2	880	884	PF04695	0.493
LIG_PTB_Apo_2	183	190	PF02174	0.418
LIG_SH2_CRK	379	383	PF00017	0.586
LIG_SH2_CRK	520	524	PF00017	0.542
LIG_SH2_CRK	87	91	PF00017	0.420
LIG_SH2_PTP2	395	398	PF00017	0.433
LIG_SH2_SRC	479	482	PF00017	0.434
LIG_SH2_SRC	750	753	PF00017	0.541
LIG_SH2_STAP1	379	383	PF00017	0.586
LIG_SH2_STAP1	750	754	PF00017	0.507
LIG_SH2_STAP1	87	91	PF00017	0.424
LIG_SH2_STAT3	481	484	PF00017	0.517
LIG_SH2_STAT5	158	161	PF00017	0.485
LIG_SH2_STAT5	188	191	PF00017	0.455
LIG_SH2_STAT5	293	296	PF00017	0.538
LIG_SH2_STAT5	395	398	PF00017	0.589
LIG_SH2_STAT5	479	482	PF00017	0.400
LIG_SH2_STAT5	512	515	PF00017	0.537
LIG_SH2_STAT5	606	609	PF00017	0.570
LIG_SH2_STAT5	858	861	PF00017	0.419
LIG_SH3_1	395	401	PF00018	0.628
LIG_SH3_1	459	465	PF00018	0.638
LIG_SH3_2	462	467	PF14604	0.623
LIG_SH3_3	174	180	PF00018	0.599
LIG_SH3_3	395	401	PF00018	0.628
LIG_SH3_3	459	465	PF00018	0.616
LIG_SH3_3	750	756	PF00018	0.458
LIG_SH3_3	968	974	PF00018	0.457
LIG_SUMO_SIM_anti_2	46	52	PF11976	0.513
LIG_SUMO_SIM_anti_2	958	964	PF11976	0.510
LIG_SUMO_SIM_par_1	997	1003	PF11976	0.554
LIG_TRAF2_1	329	332	PF00917	0.680
LIG_TRAF2_1	41	44	PF00917	0.532
LIG_TRAF2_1	635	638	PF00917	0.557
LIG_TRAF2_1	781	784	PF00917	0.509
LIG_TRAF2_1	837	840	PF00917	0.355
LIG_TRFH_1	520	524	PF08558	0.532
LIG_TYR_ITIM	518	523	PF00017	0.520
LIG_WRC_WIRS_1	466	471	PF05994	0.501
LIG_WRC_WIRS_1	50	55	PF05994	0.636
LIG_WRC_WIRS_1	939	944	PF05994	0.578
MOD_CDK_SPxxK_3	829	836	PF00069	0.612
MOD_CK1_1	128	134	PF00069	0.441
MOD_CK1_1	289	295	PF00069	0.591
MOD_CK1_1	457	463	PF00069	0.662
MOD_CK1_1	580	586	PF00069	0.684
MOD_CK1_1	770	776	PF00069	0.581
MOD_CK1_1	868	874	PF00069	0.645
MOD_CK1_1	875	881	PF00069	0.578
MOD_CK1_1	886	892	PF00069	0.301
MOD_CK1_1	917	923	PF00069	0.509
MOD_CK2_1	322	328	PF00069	0.641
MOD_CK2_1	37	43	PF00069	0.694
MOD_CK2_1	414	420	PF00069	0.798
MOD_CK2_1	471	477	PF00069	0.476
MOD_CK2_1	535	541	PF00069	0.437
MOD_CK2_1	555	561	PF00069	0.533
MOD_CK2_1	578	584	PF00069	0.616
MOD_CK2_1	690	696	PF00069	0.578
MOD_CK2_1	716	722	PF00069	0.521
MOD_CK2_1	892	898	PF00069	0.524
MOD_Cter_Amidation	907	910	PF01082	0.631
MOD_DYRK1A_RPxSP_1	788	792	PF00069	0.470
MOD_GlcNHglycan	1	4	PF01048	0.732
MOD_GlcNHglycan	10	13	PF01048	0.699
MOD_GlcNHglycan	127	130	PF01048	0.479
MOD_GlcNHglycan	167	170	PF01048	0.638
MOD_GlcNHglycan	203	206	PF01048	0.596
MOD_GlcNHglycan	408	411	PF01048	0.779
MOD_GlcNHglycan	437	440	PF01048	0.651
MOD_GlcNHglycan	456	459	PF01048	0.429
MOD_GlcNHglycan	666	669	PF01048	0.377
MOD_GlcNHglycan	730	734	PF01048	0.505
MOD_GlcNHglycan	788	791	PF01048	0.474
MOD_GlcNHglycan	905	909	PF01048	0.675
MOD_GlcNHglycan	916	919	PF01048	0.536
MOD_GlcNHglycan	936	939	PF01048	0.472
MOD_GlcNHglycan	947	950	PF01048	0.496
MOD_GlcNHglycan	990	993	PF01048	0.508
MOD_GSK3_1	10	17	PF00069	0.750
MOD_GSK3_1	115	122	PF00069	0.359
MOD_GSK3_1	24	31	PF00069	0.606
MOD_GSK3_1	288	295	PF00069	0.536
MOD_GSK3_1	363	370	PF00069	0.597
MOD_GSK3_1	39	46	PF00069	0.622
MOD_GSK3_1	553	560	PF00069	0.600
MOD_GSK3_1	825	832	PF00069	0.472
MOD_GSK3_1	864	871	PF00069	0.620
MOD_GSK3_1	888	895	PF00069	0.511
MOD_GSK3_1	910	917	PF00069	0.681
MOD_GSK3_1	934	941	PF00069	0.564
MOD_GSK3_1	945	952	PF00069	0.588
MOD_GSK3_1	96	103	PF00069	0.588
MOD_N-GLC_1	115	120	PF02516	0.615
MOD_N-GLC_1	367	372	PF02516	0.555
MOD_N-GLC_1	767	772	PF02516	0.666
MOD_N-GLC_1	910	915	PF02516	0.683
MOD_N-GLC_1	995	1000	PF02516	0.576
MOD_NEK2_1	1	6	PF00069	0.715
MOD_NEK2_1	100	105	PF00069	0.524
MOD_NEK2_1	1000	1005	PF00069	0.539
MOD_NEK2_1	107	112	PF00069	0.426
MOD_NEK2_1	125	130	PF00069	0.358
MOD_NEK2_1	189	194	PF00069	0.444
MOD_NEK2_1	238	243	PF00069	0.524
MOD_NEK2_1	322	327	PF00069	0.715
MOD_NEK2_1	386	391	PF00069	0.582
MOD_NEK2_1	535	540	PF00069	0.470
MOD_NEK2_1	575	580	PF00069	0.691
MOD_NEK2_1	617	622	PF00069	0.620
MOD_NEK2_1	673	678	PF00069	0.635
MOD_NEK2_1	688	693	PF00069	0.480
MOD_NEK2_1	888	893	PF00069	0.456
MOD_NEK2_1	903	908	PF00069	0.578
MOD_NEK2_1	956	961	PF00069	0.392
MOD_NEK2_1	983	988	PF00069	0.469
MOD_PIKK_1	1015	1021	PF00454	0.552
MOD_PIKK_1	334	340	PF00454	0.689
MOD_PIKK_1	367	373	PF00454	0.642
MOD_PIKK_1	404	410	PF00454	0.755
MOD_PIKK_1	688	694	PF00454	0.552
MOD_PIKK_1	868	874	PF00454	0.612
MOD_PIKK_1	875	881	PF00454	0.556
MOD_PIKK_1	883	889	PF00454	0.321
MOD_PK_1	910	916	PF00069	0.743
MOD_PKA_1	909	915	PF00069	0.696
MOD_PKA_2	1021	1027	PF00069	0.755
MOD_PKA_2	14	20	PF00069	0.648
MOD_PKA_2	221	227	PF00069	0.555
MOD_PKA_2	289	295	PF00069	0.586
MOD_PKA_2	334	340	PF00069	0.642
MOD_PKA_2	404	410	PF00069	0.675
MOD_PKA_2	617	623	PF00069	0.512
MOD_PKA_2	673	679	PF00069	0.626
MOD_PKA_2	70	76	PF00069	0.660
MOD_PKA_2	868	874	PF00069	0.580
MOD_PKA_2	909	915	PF00069	0.694
MOD_PKB_1	272	280	PF00069	0.439
MOD_Plk_1	119	125	PF00069	0.559
MOD_Plk_1	238	244	PF00069	0.544
MOD_Plk_1	268	274	PF00069	0.624
MOD_Plk_1	367	373	PF00069	0.595
MOD_Plk_1	430	436	PF00069	0.760
MOD_Plk_1	55	61	PF00069	0.680
MOD_Plk_1	770	776	PF00069	0.581
MOD_Plk_1	872	878	PF00069	0.614
MOD_Plk_1	910	916	PF00069	0.654
MOD_Plk_1	995	1001	PF00069	0.570
MOD_Plk_2-3	420	426	PF00069	0.717
MOD_Plk_4	107	113	PF00069	0.470
MOD_Plk_4	149	155	PF00069	0.534
MOD_Plk_4	189	195	PF00069	0.490
MOD_Plk_4	274	280	PF00069	0.623
MOD_Plk_4	289	295	PF00069	0.578
MOD_Plk_4	490	496	PF00069	0.554
MOD_Plk_4	892	898	PF00069	0.417
MOD_Plk_4	995	1001	PF00069	0.519
MOD_ProDKin_1	30	36	PF00069	0.734
MOD_ProDKin_1	578	584	PF00069	0.606
MOD_ProDKin_1	646	652	PF00069	0.638
MOD_ProDKin_1	752	758	PF00069	0.456
MOD_ProDKin_1	788	794	PF00069	0.517
MOD_ProDKin_1	829	835	PF00069	0.531
MOD_SUMO_for_1	350	353	PF00179	0.661
MOD_SUMO_rev_2	567	573	PF00179	0.499
MOD_SUMO_rev_2	681	685	PF00179	0.413
TRG_DiLeu_BaEn_1	530	535	PF01217	0.420
TRG_DiLeu_BaEn_2	897	903	PF01217	0.540
TRG_DiLeu_BaEn_4	268	274	PF01217	0.542
TRG_DiLeu_BaEn_4	43	49	PF01217	0.522
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.680
TRG_DiLeu_BaLyEn_6	816	821	PF01217	0.518
TRG_ENDOCYTIC_2	379	382	PF00928	0.548
TRG_ENDOCYTIC_2	479	482	PF00928	0.410
TRG_ENDOCYTIC_2	520	523	PF00928	0.552
TRG_ENDOCYTIC_2	750	753	PF00928	0.508
TRG_ENDOCYTIC_2	782	785	PF00928	0.595
TRG_ENDOCYTIC_2	87	90	PF00928	0.429
TRG_ER_diArg_1	177	179	PF00400	0.552
TRG_ER_diArg_1	232	234	PF00400	0.501
TRG_ER_diArg_1	272	275	PF00400	0.579
TRG_ER_diArg_1	505	508	PF00400	0.459
TRG_ER_diArg_1	818	820	PF00400	0.525
TRG_ER_diArg_1	976	978	PF00400	0.494
TRG_NES_CRM1_1	363	377	PF08389	0.537
TRG_NES_CRM1_1	852	866	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	283	287	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	818	822	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	836	840	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	901	905	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW77	Leptomonas seymouri	52%	97%
A0A0S4ITT6	Bodo saltans	26%	100%
A0A1X0NQF9	Trypanosomatidae	30%	100%
A0A3Q8I9T9	Leishmania donovani	94%	100%
A4H7H1	Leishmania braziliensis	77%	100%
A4HVV2	Leishmania infantum	94%	100%
C9ZT75	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9APK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BM93	Trypanosoma cruzi	29%	100%