J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QFX4_LEIMA

TriTrypDb:

LmjF.14.0110 , LMJLV39_140006100 , LMJSD75_140006100

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QFX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	87	91	PF00656	0.523
CLV_NRD_NRD_1	223	225	PF00675	0.321
CLV_NRD_NRD_1	227	229	PF00675	0.319
CLV_NRD_NRD_1	238	240	PF00675	0.280
CLV_NRD_NRD_1	303	305	PF00675	0.476
CLV_NRD_NRD_1	33	35	PF00675	0.413
CLV_NRD_NRD_1	398	400	PF00675	0.366
CLV_NRD_NRD_1	433	435	PF00675	0.476
CLV_PCSK_FUR_1	303	307	PF00082	0.465
CLV_PCSK_KEX2_1	223	225	PF00082	0.321
CLV_PCSK_KEX2_1	227	229	PF00082	0.319
CLV_PCSK_KEX2_1	303	305	PF00082	0.423
CLV_PCSK_KEX2_1	33	35	PF00082	0.413
CLV_PCSK_KEX2_1	398	400	PF00082	0.373
CLV_PCSK_KEX2_1	432	434	PF00082	0.485
CLV_PCSK_KEX2_1	488	490	PF00082	0.374
CLV_PCSK_PC1ET2_1	305	307	PF00082	0.403
CLV_PCSK_PC1ET2_1	488	490	PF00082	0.385
CLV_PCSK_PC7_1	223	229	PF00082	0.412
CLV_PCSK_PC7_1	394	400	PF00082	0.364
CLV_PCSK_SKI1_1	177	181	PF00082	0.416
CLV_PCSK_SKI1_1	228	232	PF00082	0.311
CLV_PCSK_SKI1_1	263	267	PF00082	0.288
CLV_PCSK_SKI1_1	404	408	PF00082	0.440
CLV_PCSK_SKI1_1	461	465	PF00082	0.299
DEG_APCC_DBOX_1	168	176	PF00400	0.607
DEG_APCC_DBOX_1	227	235	PF00400	0.592
DEG_APCC_DBOX_1	433	441	PF00400	0.634
DEG_Nend_Nbox_1	1	3	PF02207	0.714
DEG_SCF_TRCP1_1	511	516	PF00400	0.688
DOC_MAPK_FxFP_2	151	154	PF00069	0.517
DOC_MAPK_gen_1	223	231	PF00069	0.554
DOC_MAPK_gen_1	303	309	PF00069	0.584
DOC_MAPK_gen_1	465	473	PF00069	0.522
DOC_MAPK_gen_1	73	81	PF00069	0.534
DOC_MAPK_JIP1_4	263	269	PF00069	0.476
DOC_MAPK_MEF2A_6	293	301	PF00069	0.540
DOC_PP1_RVXF_1	9	15	PF00149	0.563
DOC_PP4_FxxP_1	108	111	PF00568	0.520
DOC_PP4_FxxP_1	151	154	PF00568	0.517
DOC_USP7_UBL2_3	461	465	PF12436	0.550
DOC_USP7_UBL2_3	69	73	PF12436	0.460
DOC_WW_Pin1_4	27	32	PF00397	0.716
DOC_WW_Pin1_4	278	283	PF00397	0.576
DOC_WW_Pin1_4	379	384	PF00397	0.578
LIG_14-3-3_CanoR_1	132	138	PF00244	0.635
LIG_14-3-3_CanoR_1	19	28	PF00244	0.670
LIG_14-3-3_CanoR_1	33	39	PF00244	0.627
LIG_14-3-3_CanoR_1	432	440	PF00244	0.679
LIG_Actin_WH2_2	157	175	PF00022	0.453
LIG_BRCT_BRCA1_1	339	343	PF00533	0.431
LIG_BRCT_BRCA1_1	35	39	PF00533	0.720
LIG_FHA_1	289	295	PF00498	0.516
LIG_FHA_1	4	10	PF00498	0.755
LIG_FHA_2	380	386	PF00498	0.620
LIG_FHA_2	423	429	PF00498	0.681
LIG_FHA_2	457	463	PF00498	0.456
LIG_LIR_Apic_2	106	111	PF02991	0.476
LIG_LIR_Apic_2	165	171	PF02991	0.569
LIG_LIR_Gen_1	190	198	PF02991	0.533
LIG_LIR_Nem_3	190	195	PF02991	0.531
LIG_LIR_Nem_3	496	501	PF02991	0.484
LIG_Pex14_2	108	112	PF04695	0.520
LIG_Pex14_2	151	155	PF04695	0.527
LIG_Pex14_2	241	245	PF04695	0.560
LIG_Pex14_2	266	270	PF04695	0.546
LIG_Pex14_2	35	39	PF04695	0.720
LIG_SH2_CRK	498	502	PF00017	0.461
LIG_SH2_SRC	7	10	PF00017	0.616
LIG_SH2_STAT5	140	143	PF00017	0.624
LIG_SH3_3	291	297	PF00018	0.513
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.528
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.461
LIG_SxIP_EBH_1	204	214	PF03271	0.511
LIG_TRAF2_1	382	385	PF00917	0.611
LIG_UBA3_1	448	454	PF00899	0.495
LIG_WRC_WIRS_1	18	23	PF05994	0.732
MOD_CDC14_SPxK_1	30	33	PF00782	0.645
MOD_CDK_SPxK_1	27	33	PF00069	0.740
MOD_CDK_SPxxK_3	27	34	PF00069	0.646
MOD_CK1_1	213	219	PF00069	0.499
MOD_CK1_1	248	254	PF00069	0.533
MOD_CK1_1	27	33	PF00069	0.694
MOD_CK1_1	275	281	PF00069	0.569
MOD_CK1_1	516	522	PF00069	0.757
MOD_CK2_1	164	170	PF00069	0.531
MOD_CK2_1	187	193	PF00069	0.526
MOD_CK2_1	216	222	PF00069	0.585
MOD_CK2_1	34	40	PF00069	0.747
MOD_CK2_1	379	385	PF00069	0.620
MOD_CK2_1	81	87	PF00069	0.580
MOD_GlcNHglycan	116	120	PF01048	0.315
MOD_GlcNHglycan	164	167	PF01048	0.295
MOD_GlcNHglycan	21	24	PF01048	0.567
MOD_GlcNHglycan	340	343	PF01048	0.444
MOD_GlcNHglycan	455	459	PF01048	0.285
MOD_GlcNHglycan	511	514	PF01048	0.410
MOD_GlcNHglycan	515	518	PF01048	0.445
MOD_GSK3_1	115	122	PF00069	0.500
MOD_GSK3_1	13	20	PF00069	0.690
MOD_GSK3_1	179	186	PF00069	0.527
MOD_GSK3_1	23	30	PF00069	0.685
MOD_GSK3_1	241	248	PF00069	0.558
MOD_GSK3_1	273	280	PF00069	0.537
MOD_GSK3_1	509	516	PF00069	0.632
MOD_N-GLC_1	133	138	PF02516	0.489
MOD_N-GLC_1	248	253	PF02516	0.349
MOD_N-GLC_2	91	93	PF02516	0.396
MOD_NEK2_1	114	119	PF00069	0.489
MOD_NEK2_1	133	138	PF00069	0.505
MOD_NEK2_1	179	184	PF00069	0.577
MOD_NEK2_1	187	192	PF00069	0.523
MOD_NEK2_1	210	215	PF00069	0.518
MOD_NEK2_1	241	246	PF00069	0.573
MOD_NEK2_1	257	262	PF00069	0.483
MOD_NEK2_1	270	275	PF00069	0.476
MOD_NEK2_1	456	461	PF00069	0.462
MOD_NEK2_2	119	124	PF00069	0.513
MOD_PIKK_1	133	139	PF00454	0.585
MOD_PIKK_1	516	522	PF00454	0.743
MOD_PK_1	13	19	PF00069	0.722
MOD_PKA_1	33	39	PF00069	0.606
MOD_PKA_1	432	438	PF00069	0.657
MOD_PKA_2	203	209	PF00069	0.529
MOD_PKA_2	33	39	PF00069	0.663
MOD_PKA_2	432	438	PF00069	0.646
MOD_PKB_1	11	19	PF00069	0.613
MOD_Plk_1	248	254	PF00069	0.560
MOD_Plk_2-3	101	107	PF00069	0.511
MOD_Plk_4	13	19	PF00069	0.604
MOD_Plk_4	183	189	PF00069	0.507
MOD_Plk_4	203	209	PF00069	0.483
MOD_Plk_4	216	222	PF00069	0.547
MOD_Plk_4	241	247	PF00069	0.569
MOD_Plk_4	248	254	PF00069	0.552
MOD_Plk_4	314	320	PF00069	0.344
MOD_Plk_4	34	40	PF00069	0.752
MOD_Plk_4	67	73	PF00069	0.608
MOD_ProDKin_1	27	33	PF00069	0.718
MOD_ProDKin_1	278	284	PF00069	0.574
MOD_ProDKin_1	379	385	PF00069	0.580
MOD_SUMO_for_1	411	414	PF00179	0.565
TRG_ENDOCYTIC_2	158	161	PF00928	0.518
TRG_ENDOCYTIC_2	445	448	PF00928	0.461
TRG_ENDOCYTIC_2	498	501	PF00928	0.461
TRG_ER_diArg_1	11	14	PF00400	0.641
TRG_ER_diArg_1	223	225	PF00400	0.519
TRG_ER_diArg_1	227	229	PF00400	0.518
TRG_ER_diArg_1	303	306	PF00400	0.667
TRG_ER_diArg_1	33	35	PF00400	0.757
TRG_ER_diArg_1	350	353	PF00400	0.574
TRG_ER_diArg_1	397	399	PF00400	0.550
TRG_ER_diArg_1	432	434	PF00400	0.681
TRG_NES_CRM1_1	363	375	PF08389	0.537
TRG_NES_CRM1_1	462	477	PF08389	0.539
TRG_NLS_MonoExtN_4	303	308	PF00514	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6B2	Leptomonas seymouri	23%	100%
A0A0N1IK13	Leptomonas seymouri	77%	99%
A0A0S4ITI3	Bodo saltans	42%	100%
A0A1X0NQB1	Trypanosomatidae	57%	100%
A0A1X0NVK2	Trypanosomatidae	24%	100%
A0A3S7WSV3	Leishmania donovani	97%	100%
A0A3S7WYG6	Leishmania donovani	26%	100%
A0A422N8L2	Trypanosoma rangeli	23%	100%
A4H7H2	Leishmania braziliensis	86%	100%
A4HDG4	Leishmania braziliensis	25%	100%
A4HVV3	Leishmania infantum	97%	100%
C9ZT74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
D0A774	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9APK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AWU9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4QAM5	Leishmania major	23%	100%
V5BD52	Trypanosoma cruzi	56%	100%
V5DSF1	Trypanosoma cruzi	22%	100%