Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFX3_LEIMA

TriTrypDb:

LmjF.14.0120 , LMJLV39_140006200 , LMJSD75_140006200

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0035869	ciliary transition zone	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	226	228	PF00675	0.553
CLV_NRD_NRD_1	276	278	PF00675	0.700
CLV_NRD_NRD_1	294	296	PF00675	0.467
CLV_NRD_NRD_1	300	302	PF00675	0.656
CLV_NRD_NRD_1	332	334	PF00675	0.707
CLV_PCSK_FUR_1	292	296	PF00082	0.548
CLV_PCSK_FUR_1	308	312	PF00082	0.726
CLV_PCSK_KEX2_1	226	228	PF00082	0.556
CLV_PCSK_KEX2_1	292	294	PF00082	0.619
CLV_PCSK_KEX2_1	300	302	PF00082	0.652
CLV_PCSK_KEX2_1	310	312	PF00082	0.583
CLV_PCSK_KEX2_1	332	334	PF00082	0.682
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.769
DEG_SIAH_1	60	68	PF03145	0.677
DOC_USP7_MATH_1	16	20	PF00917	0.707
DOC_USP7_MATH_1	76	80	PF00917	0.743
DOC_WW_Pin1_4	265	270	PF00397	0.790
DOC_WW_Pin1_4	293	298	PF00397	0.752
DOC_WW_Pin1_4	301	306	PF00397	0.818
DOC_WW_Pin1_4	46	51	PF00397	0.649
LIG_14-3-3_CanoR_1	254	260	PF00244	0.593
LIG_14-3-3_CanoR_1	277	285	PF00244	0.622
LIG_14-3-3_CanoR_1	342	350	PF00244	0.671
LIG_EH1_1	174	182	PF00400	0.545
LIG_eIF4E_1	175	181	PF01652	0.606
LIG_eIF4E_1	325	331	PF01652	0.696
LIG_EVH1_1	68	72	PF00568	0.708
LIG_FHA_1	105	111	PF00498	0.819
LIG_FHA_1	151	157	PF00498	0.671
LIG_FHA_1	177	183	PF00498	0.604
LIG_FHA_1	335	341	PF00498	0.449
LIG_FHA_2	219	225	PF00498	0.723
LIG_LIR_Gen_1	153	162	PF02991	0.538
LIG_LIR_Gen_1	245	256	PF02991	0.613
LIG_LIR_Gen_1	279	289	PF02991	0.491
LIG_LIR_Nem_3	134	139	PF02991	0.699
LIG_LIR_Nem_3	153	158	PF02991	0.360
LIG_LIR_Nem_3	245	251	PF02991	0.605
LIG_LIR_Nem_3	279	284	PF02991	0.493
LIG_LIR_Nem_3	345	350	PF02991	0.570
LIG_PROFILIN_1	83	89	PF00235	0.544
LIG_PTAP_UEV_1	52	57	PF05743	0.682
LIG_RPA_C_Fungi	222	234	PF08784	0.673
LIG_SH2_CRK	350	354	PF00017	0.676
LIG_SH2_STAP1	281	285	PF00017	0.641
LIG_SH2_STAT3	338	341	PF00017	0.596
LIG_SH2_STAT5	155	158	PF00017	0.580
LIG_SH2_STAT5	329	332	PF00017	0.568
LIG_SH3_2	261	266	PF14604	0.698
LIG_SH3_3	100	106	PF00018	0.749
LIG_SH3_3	107	113	PF00018	0.788
LIG_SH3_3	119	125	PF00018	0.744
LIG_SH3_3	21	27	PF00018	0.658
LIG_SH3_3	258	264	PF00018	0.700
LIG_SH3_3	28	34	PF00018	0.713
LIG_SH3_3	299	305	PF00018	0.595
LIG_SH3_3	316	322	PF00018	0.603
LIG_SH3_3	38	44	PF00018	0.695
LIG_SH3_3	4	10	PF00018	0.737
LIG_SH3_3	47	53	PF00018	0.667
LIG_SH3_3	55	61	PF00018	0.570
LIG_SH3_3	66	72	PF00018	0.492
LIG_SH3_3	80	86	PF00018	0.712
LIG_SH3_3	93	99	PF00018	0.753
LIG_SUMO_SIM_par_1	129	134	PF11976	0.695
LIG_TRAF2_1	157	160	PF00917	0.646
LIG_TYR_ITSM	151	158	PF00017	0.670
MOD_CDK_SPxxK_3	293	300	PF00069	0.762
MOD_CDK_SPxxK_3	301	308	PF00069	0.679
MOD_CK1_1	19	25	PF00069	0.591
MOD_CK1_1	3	9	PF00069	0.599
MOD_CK1_1	54	60	PF00069	0.559
MOD_CK2_1	218	224	PF00069	0.731
MOD_CK2_1	239	245	PF00069	0.613
MOD_CK2_1	276	282	PF00069	0.550
MOD_DYRK1A_RPxSP_1	301	305	PF00069	0.577
MOD_GlcNHglycan	140	143	PF01048	0.538
MOD_GlcNHglycan	19	22	PF01048	0.599
MOD_GlcNHglycan	278	281	PF01048	0.660
MOD_GlcNHglycan	325	328	PF01048	0.496
MOD_GlcNHglycan	53	56	PF01048	0.708
MOD_GlcNHglycan	78	81	PF01048	0.747
MOD_GlcNHglycan	89	92	PF01048	0.816
MOD_GSK3_1	205	212	PF00069	0.526
MOD_GSK3_1	272	279	PF00069	0.527
MOD_N-GLC_1	202	207	PF02516	0.599
MOD_NEK2_1	1	6	PF00069	0.607
MOD_NEK2_1	150	155	PF00069	0.649
MOD_NEK2_1	207	212	PF00069	0.675
MOD_NEK2_1	276	281	PF00069	0.681
MOD_PIKK_1	207	213	PF00454	0.671
MOD_PKA_2	218	224	PF00069	0.576
MOD_PKA_2	276	282	PF00069	0.642
MOD_Plk_1	202	208	PF00069	0.537
MOD_Plk_4	105	111	PF00069	0.657
MOD_Plk_4	176	182	PF00069	0.477
MOD_Plk_4	218	224	PF00069	0.653
MOD_Plk_4	61	67	PF00069	0.719
MOD_ProDKin_1	265	271	PF00069	0.789
MOD_ProDKin_1	293	299	PF00069	0.757
MOD_ProDKin_1	301	307	PF00069	0.820
MOD_ProDKin_1	46	52	PF00069	0.646
TRG_ENDOCYTIC_2	155	158	PF00928	0.545
TRG_ENDOCYTIC_2	281	284	PF00928	0.519
TRG_ENDOCYTIC_2	349	352	PF00928	0.644
TRG_ER_diArg_1	292	295	PF00400	0.670
TRG_ER_diArg_1	300	302	PF00400	0.762
TRG_ER_diArg_1	331	333	PF00400	0.665
TRG_Pf-PMV_PEXEL_1	154	159	PF00026	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NPB8	Trypanosomatidae	34%	74%
A0A3Q8I9R2	Leishmania donovani	88%	100%
A4H7H3	Leishmania braziliensis	76%	100%
A4HVV4	Leishmania infantum	88%	100%
C9ZT73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	71%
E9APK6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%