Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

histone acetyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QFX1_LEIMA

TriTrypDb:

LmjF.14.0140 , LMJLV39_140006400 , LMJSD75_140006400

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFX1

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	11
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	11
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0045892	negative regulation of DNA-templated transcription	7	2
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045944	positive regulation of transcription by RNA polymerase II	8	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	11
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1902679	negative regulation of RNA biosynthetic process	7	2
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	11
GO:1903507	negative regulation of nucleic acid-templated transcription	8	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	11

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	2
GO:0003824	catalytic activity	1	11
GO:0004402	histone acetyltransferase activity	4	11
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008080	N-acetyltransferase activity	6	11
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0034212	peptide N-acetyltransferase activity	7	11
GO:0042393	histone binding	3	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0140110	transcription regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.564
CLV_NRD_NRD_1	290	292	PF00675	0.352
CLV_NRD_NRD_1	387	389	PF00675	0.263
CLV_NRD_NRD_1	89	91	PF00675	0.756
CLV_PCSK_FUR_1	136	140	PF00082	0.685
CLV_PCSK_KEX2_1	138	140	PF00082	0.686
CLV_PCSK_KEX2_1	290	292	PF00082	0.352
CLV_PCSK_KEX2_1	387	389	PF00082	0.263
CLV_PCSK_KEX2_1	473	475	PF00082	0.435
CLV_PCSK_KEX2_1	89	91	PF00082	0.756
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.479
CLV_PCSK_PC7_1	286	292	PF00082	0.352
CLV_PCSK_PC7_1	469	475	PF00082	0.425
CLV_PCSK_SKI1_1	259	263	PF00082	0.463
CLV_PCSK_SKI1_1	314	318	PF00082	0.263
CLV_PCSK_SKI1_1	473	477	PF00082	0.555
CLV_PCSK_SKI1_1	479	483	PF00082	0.551
DEG_SPOP_SBC_1	195	199	PF00917	0.720
DOC_CKS1_1	392	397	PF01111	0.552
DOC_CKS1_1	80	85	PF01111	0.667
DOC_MAPK_gen_1	290	297	PF00069	0.552
DOC_MAPK_MEF2A_6	290	297	PF00069	0.477
DOC_PP2B_LxvP_1	364	367	PF13499	0.463
DOC_SPAK_OSR1_1	376	380	PF12202	0.463
DOC_USP7_MATH_1	228	232	PF00917	0.685
DOC_USP7_MATH_1	245	249	PF00917	0.412
DOC_USP7_UBL2_3	473	477	PF12436	0.539
DOC_WW_Pin1_4	163	168	PF00397	0.394
DOC_WW_Pin1_4	197	202	PF00397	0.624
DOC_WW_Pin1_4	324	329	PF00397	0.463
DOC_WW_Pin1_4	351	356	PF00397	0.463
DOC_WW_Pin1_4	391	396	PF00397	0.463
DOC_WW_Pin1_4	79	84	PF00397	0.793
LIG_14-3-3_CanoR_1	247	252	PF00244	0.474
LIG_APCC_ABBA_1	258	263	PF00400	0.457
LIG_BIR_II_1	1	5	PF00653	0.599
LIG_BRCT_BRCA1_1	140	144	PF00533	0.512
LIG_BRCT_BRCA1_1	312	316	PF00533	0.463
LIG_BRCT_BRCA1_1	482	486	PF00533	0.498
LIG_Clathr_ClatBox_1	292	296	PF01394	0.477
LIG_deltaCOP1_diTrp_1	161	165	PF00928	0.408
LIG_FHA_1	100	106	PF00498	0.674
LIG_FHA_1	145	151	PF00498	0.553
LIG_FHA_1	202	208	PF00498	0.730
LIG_FHA_1	219	225	PF00498	0.497
LIG_FHA_1	325	331	PF00498	0.463
LIG_FHA_1	337	343	PF00498	0.463
LIG_FHA_1	414	420	PF00498	0.552
LIG_FHA_1	436	442	PF00498	0.547
LIG_FHA_1	470	476	PF00498	0.477
LIG_FHA_1	486	492	PF00498	0.512
LIG_FHA_2	302	308	PF00498	0.536
LIG_FHA_2	459	465	PF00498	0.550
LIG_GBD_Chelix_1	293	301	PF00786	0.352
LIG_LIR_Apic_2	161	167	PF02991	0.399
LIG_LIR_Apic_2	283	288	PF02991	0.463
LIG_LIR_Gen_1	485	495	PF02991	0.491
LIG_LIR_Nem_3	162	168	PF02991	0.379
LIG_LIR_Nem_3	327	332	PF02991	0.463
LIG_LIR_Nem_3	37	43	PF02991	0.478
LIG_LIR_Nem_3	404	410	PF02991	0.463
LIG_LIR_Nem_3	482	487	PF02991	0.495
LIG_LIR_Nem_3	499	504	PF02991	0.635
LIG_MLH1_MIPbox_1	140	144	PF16413	0.512
LIG_Pex14_1	493	497	PF04695	0.509
LIG_Pex14_2	497	501	PF04695	0.591
LIG_PTAP_UEV_1	515	520	PF05743	0.487
LIG_PTB_Apo_2	17	24	PF02174	0.552
LIG_REV1ctd_RIR_1	141	150	PF16727	0.461
LIG_SH2_CRK	16	20	PF00017	0.463
LIG_SH2_STAP1	151	155	PF00017	0.491
LIG_SH2_STAP1	471	475	PF00017	0.449
LIG_SH2_STAP1	487	491	PF00017	0.384
LIG_SH2_STAT3	433	436	PF00017	0.463
LIG_SH2_STAT3	46	49	PF00017	0.463
LIG_SH2_STAT5	164	167	PF00017	0.385
LIG_SH2_STAT5	256	259	PF00017	0.458
LIG_SH2_STAT5	332	335	PF00017	0.463
LIG_SH2_STAT5	347	350	PF00017	0.463
LIG_SH2_STAT5	407	410	PF00017	0.463
LIG_SH2_STAT5	43	46	PF00017	0.469
LIG_SH2_STAT5	433	436	PF00017	0.463
LIG_SH2_STAT5	471	474	PF00017	0.544
LIG_SH2_STAT5	484	487	PF00017	0.309
LIG_SH2_STAT5	81	84	PF00017	0.669
LIG_SH3_1	502	508	PF00018	0.647
LIG_SH3_3	107	113	PF00018	0.570
LIG_SH3_3	389	395	PF00018	0.471
LIG_SH3_3	502	508	PF00018	0.570
LIG_SH3_3	513	519	PF00018	0.574
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.463
LIG_SUMO_SIM_anti_2	361	367	PF11976	0.463
LIG_SUMO_SIM_par_1	27	34	PF11976	0.552
LIG_SUMO_SIM_par_1	291	296	PF11976	0.464
LIG_SUMO_SIM_par_1	377	382	PF11976	0.463
LIG_TRAF2_1	422	425	PF00917	0.463
LIG_TRFH_1	256	260	PF08558	0.332
LIG_UBA3_1	311	320	PF00899	0.463
MOD_CDK_SPxK_1	391	397	PF00069	0.463
MOD_CK1_1	197	203	PF00069	0.724
MOD_CK1_1	205	211	PF00069	0.751
MOD_CK1_1	336	342	PF00069	0.547
MOD_CK1_1	74	80	PF00069	0.738
MOD_CK1_1	92	98	PF00069	0.774
MOD_CK2_1	301	307	PF00069	0.536
MOD_CK2_1	383	389	PF00069	0.463
MOD_CK2_1	458	464	PF00069	0.567
MOD_GlcNHglycan	115	119	PF01048	0.675
MOD_GlcNHglycan	140	143	PF01048	0.654
MOD_GlcNHglycan	204	207	PF01048	0.706
MOD_GlcNHglycan	230	233	PF01048	0.597
MOD_GlcNHglycan	234	237	PF01048	0.532
MOD_GlcNHglycan	3	6	PF01048	0.648
MOD_GlcNHglycan	515	519	PF01048	0.553
MOD_GlcNHglycan	83	86	PF01048	0.752
MOD_GSK3_1	138	145	PF00069	0.586
MOD_GSK3_1	159	166	PF00069	0.385
MOD_GSK3_1	180	187	PF00069	0.689
MOD_GSK3_1	197	204	PF00069	0.517
MOD_GSK3_1	218	225	PF00069	0.746
MOD_GSK3_1	228	235	PF00069	0.708
MOD_GSK3_1	243	250	PF00069	0.467
MOD_GSK3_1	297	304	PF00069	0.552
MOD_GSK3_1	379	386	PF00069	0.463
MOD_GSK3_1	469	476	PF00069	0.600
MOD_GSK3_1	485	492	PF00069	0.438
MOD_GSK3_1	514	521	PF00069	0.602
MOD_GSK3_1	67	74	PF00069	0.647
MOD_GSK3_1	81	88	PF00069	0.740
MOD_GSK3_1	99	106	PF00069	0.717
MOD_N-GLC_1	19	24	PF02516	0.352
MOD_N-GLC_1	222	227	PF02516	0.786
MOD_N-GLC_1	358	363	PF02516	0.263
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	144	149	PF00069	0.579
MOD_NEK2_1	19	24	PF00069	0.372
MOD_NEK2_1	194	199	PF00069	0.767
MOD_NEK2_1	406	411	PF00069	0.501
MOD_PIKK_1	180	186	PF00454	0.651
MOD_PKA_1	138	144	PF00069	0.534
MOD_PKA_1	473	479	PF00069	0.451
MOD_PKA_1	89	95	PF00069	0.750
MOD_PKA_2	138	144	PF00069	0.660
MOD_PKA_2	232	238	PF00069	0.712
MOD_PKA_2	473	479	PF00069	0.451
MOD_PKA_2	89	95	PF00069	0.750
MOD_PKB_1	136	144	PF00069	0.539
MOD_Plk_1	222	228	PF00069	0.594
MOD_Plk_1	358	364	PF00069	0.463
MOD_Plk_1	379	385	PF00069	0.463
MOD_Plk_1	479	485	PF00069	0.493
MOD_Plk_4	159	165	PF00069	0.399
MOD_Plk_4	406	412	PF00069	0.520
MOD_Plk_4	482	488	PF00069	0.497
MOD_Plk_4	506	512	PF00069	0.643
MOD_ProDKin_1	163	169	PF00069	0.403
MOD_ProDKin_1	197	203	PF00069	0.624
MOD_ProDKin_1	324	330	PF00069	0.463
MOD_ProDKin_1	351	357	PF00069	0.463
MOD_ProDKin_1	391	397	PF00069	0.463
MOD_ProDKin_1	79	85	PF00069	0.790
MOD_SUMO_rev_2	313	322	PF00179	0.463
MOD_SUMO_rev_2	384	392	PF00179	0.477
TRG_DiLeu_BaEn_1	307	312	PF01217	0.463
TRG_ENDOCYTIC_2	16	19	PF00928	0.463
TRG_ENDOCYTIC_2	487	490	PF00928	0.375
TRG_ENDOCYTIC_2	498	501	PF00928	0.490
TRG_ER_diArg_1	136	139	PF00400	0.697
TRG_ER_diArg_1	289	291	PF00400	0.552
TRG_NES_CRM1_1	307	318	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.263
TRG_Pf-PMV_PEXEL_1	447	452	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B0	Leptomonas seymouri	81%	100%
A0A1X0NNT9	Trypanosomatidae	59%	100%
A0A3R7M6T2	Trypanosoma rangeli	57%	100%
A4H7H5	Leishmania braziliensis	88%	100%
A4HVV6	Leishmania infantum	97%	100%
C9ZT70	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D7RTH9	Leishmania donovani	97%	100%
E9APK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O94446	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q2UMQ5	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	100%
Q4WHG1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	100%
V5BHR3	Trypanosoma cruzi	58%	100%