Chromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFW9_LEIMA

TriTrypDb:

LmjF.14.0160 , LMJLV39_140006600 , LMJSD75_140006600

Length:

351

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.463
CLV_NRD_NRD_1	156	158	PF00675	0.664
CLV_NRD_NRD_1	93	95	PF00675	0.636
CLV_PCSK_FUR_1	93	97	PF00082	0.591
CLV_PCSK_KEX2_1	12	14	PF00082	0.463
CLV_PCSK_KEX2_1	181	183	PF00082	0.548
CLV_PCSK_KEX2_1	38	40	PF00082	0.596
CLV_PCSK_KEX2_1	74	76	PF00082	0.560
CLV_PCSK_KEX2_1	78	80	PF00082	0.567
CLV_PCSK_KEX2_1	93	95	PF00082	0.510
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.543
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.475
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.586
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.590
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.546
CLV_PCSK_SKI1_1	161	165	PF00082	0.538
CLV_PCSK_SKI1_1	332	336	PF00082	0.487
CLV_PCSK_SKI1_1	75	79	PF00082	0.707
DEG_SPOP_SBC_1	87	91	PF00917	0.527
DOC_CDC14_PxL_1	171	179	PF14671	0.630
DOC_CDC14_PxL_1	234	242	PF14671	0.461
DOC_MAPK_MEF2A_6	218	225	PF00069	0.417
DOC_MAPK_MEF2A_6	322	330	PF00069	0.404
DOC_MAPK_MEF2A_6	332	340	PF00069	0.312
DOC_MAPK_NFAT4_5	218	226	PF00069	0.416
DOC_PP1_RVXF_1	330	336	PF00149	0.498
DOC_PP2B_LxvP_1	119	122	PF13499	0.673
DOC_PP4_FxxP_1	248	251	PF00568	0.628
DOC_USP7_MATH_1	163	167	PF00917	0.618
DOC_USP7_UBL2_3	74	78	PF12436	0.536
DOC_WW_Pin1_4	199	204	PF00397	0.490
DOC_WW_Pin1_4	271	276	PF00397	0.580
DOC_WW_Pin1_4	299	304	PF00397	0.597
DOC_WW_Pin1_4	308	313	PF00397	0.586
DOC_WW_Pin1_4	98	103	PF00397	0.790
LIG_14-3-3_CanoR_1	161	166	PF00244	0.531
LIG_14-3-3_CanoR_1	227	234	PF00244	0.517
LIG_14-3-3_CanoR_1	267	271	PF00244	0.556
LIG_14-3-3_CanoR_1	322	327	PF00244	0.419
LIG_14-3-3_CanoR_1	96	101	PF00244	0.662
LIG_APCC_ABBA_1	285	290	PF00400	0.546
LIG_BIR_III_2	82	86	PF00653	0.640
LIG_BRCT_BRCA1_1	273	277	PF00533	0.559
LIG_deltaCOP1_diTrp_1	66	73	PF00928	0.552
LIG_FHA_1	160	166	PF00498	0.656
LIG_FHA_1	311	317	PF00498	0.642
LIG_FHA_1	343	349	PF00498	0.457
LIG_FHA_2	3	9	PF00498	0.473
LIG_FHA_2	303	309	PF00498	0.498
LIG_FHA_2	59	65	PF00498	0.534
LIG_FHA_2	87	93	PF00498	0.767
LIG_LIR_Nem_3	180	186	PF02991	0.406
LIG_LIR_Nem_3	2	6	PF02991	0.353
LIG_LIR_Nem_3	329	334	PF02991	0.422
LIG_NRBOX	113	119	PF00104	0.615
LIG_Pex14_2	204	208	PF04695	0.561
LIG_Pex14_2	331	335	PF04695	0.495
LIG_SH2_PTP2	296	299	PF00017	0.440
LIG_SH2_SRC	296	299	PF00017	0.416
LIG_SH2_STAP1	23	27	PF00017	0.386
LIG_SH2_STAT5	296	299	PF00017	0.383
LIG_SH2_STAT5	342	345	PF00017	0.436
LIG_SH2_STAT5	4	7	PF00017	0.530
LIG_SH3_3	200	206	PF00018	0.564
LIG_SH3_3	330	336	PF00018	0.443
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.661
LIG_SUMO_SIM_par_1	133	139	PF11976	0.544
LIG_SUMO_SIM_par_1	250	255	PF11976	0.584
LIG_TRAF2_1	128	131	PF00917	0.712
LIG_TRAF2_1	280	283	PF00917	0.546
LIG_TRAF2_1	5	8	PF00917	0.395
LIG_TRAF2_1	61	64	PF00917	0.543
MOD_CK2_1	2	8	PF00069	0.574
MOD_CK2_1	58	64	PF00069	0.561
MOD_CK2_1	86	92	PF00069	0.603
MOD_DYRK1A_RPxSP_1	98	102	PF00069	0.724
MOD_GlcNHglycan	144	149	PF01048	0.560
MOD_GlcNHglycan	243	246	PF01048	0.528
MOD_GlcNHglycan	278	281	PF01048	0.637
MOD_GSK3_1	159	166	PF00069	0.667
MOD_GSK3_1	187	194	PF00069	0.480
MOD_GSK3_1	302	309	PF00069	0.477
MOD_GSK3_1	322	329	PF00069	0.397
MOD_GSK3_1	94	101	PF00069	0.725
MOD_LATS_1	230	236	PF00433	0.432
MOD_LATS_1	320	326	PF00433	0.450
MOD_N-GLC_1	150	155	PF02516	0.580
MOD_NEK2_1	150	155	PF00069	0.671
MOD_NEK2_1	241	246	PF00069	0.531
MOD_NEK2_1	266	271	PF00069	0.557
MOD_NEK2_1	276	281	PF00069	0.467
MOD_NEK2_1	344	349	PF00069	0.431
MOD_NEK2_1	86	91	PF00069	0.694
MOD_PK_1	232	238	PF00069	0.554
MOD_PK_1	96	102	PF00069	0.658
MOD_PKA_1	94	100	PF00069	0.640
MOD_PKA_2	226	232	PF00069	0.509
MOD_PKA_2	266	272	PF00069	0.587
MOD_PKB_1	94	102	PF00069	0.707
MOD_Plk_1	144	150	PF00069	0.559
MOD_Plk_1	32	38	PF00069	0.499
MOD_Plk_4	130	136	PF00069	0.526
MOD_Plk_4	187	193	PF00069	0.514
MOD_Plk_4	326	332	PF00069	0.364
MOD_Plk_4	344	350	PF00069	0.478
MOD_ProDKin_1	199	205	PF00069	0.492
MOD_ProDKin_1	271	277	PF00069	0.580
MOD_ProDKin_1	299	305	PF00069	0.603
MOD_ProDKin_1	308	314	PF00069	0.588
MOD_ProDKin_1	98	104	PF00069	0.787
MOD_SUMO_for_1	25	28	PF00179	0.390
TRG_DiLeu_BaEn_1	131	136	PF01217	0.553
TRG_DiLeu_BaEn_3	129	135	PF01217	0.585
TRG_DiLeu_BaEn_3	144	150	PF01217	0.398
TRG_ENDOCYTIC_2	3	6	PF00928	0.389
TRG_ER_diArg_1	12	14	PF00400	0.461
TRG_ER_diArg_1	93	96	PF00400	0.636
TRG_NLS_Bipartite_1	78	99	PF00514	0.645
TRG_NLS_MonoExtC_3	156	161	PF00514	0.664
TRG_NLS_MonoExtC_3	93	98	PF00514	0.641
TRG_NLS_MonoExtN_4	157	162	PF00514	0.562
TRG_NLS_MonoExtN_4	93	99	PF00514	0.659
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I624	Leptomonas seymouri	52%	90%
A0A1X0NPE6	Trypanosomatidae	29%	100%
A0A3Q8ID14	Leishmania donovani	91%	98%
A0A422NX90	Trypanosoma rangeli	31%	100%
A4H7H7	Leishmania braziliensis	80%	98%
A4HVV8	Leishmania infantum	91%	98%
C9ZT68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9APL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	98%
V5BM97	Trypanosoma cruzi	29%	100%