Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFW8_LEIMA

TriTrypDb:

LmjF.14.0170 , LMJLV39_140006700 , LMJSD75_140006700

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.466
CLV_C14_Caspase3-7	530	534	PF00656	0.645
CLV_NRD_NRD_1	290	292	PF00675	0.702
CLV_NRD_NRD_1	634	636	PF00675	0.700
CLV_NRD_NRD_1	663	665	PF00675	0.850
CLV_NRD_NRD_1	75	77	PF00675	0.620
CLV_PCSK_KEX2_1	290	292	PF00082	0.669
CLV_PCSK_KEX2_1	634	636	PF00082	0.665
CLV_PCSK_KEX2_1	663	665	PF00082	0.849
CLV_PCSK_KEX2_1	75	77	PF00082	0.620
CLV_PCSK_SKI1_1	157	161	PF00082	0.684
CLV_PCSK_SKI1_1	319	323	PF00082	0.548
CLV_PCSK_SKI1_1	42	46	PF00082	0.735
DEG_APCC_DBOX_1	413	421	PF00400	0.622
DEG_SCF_FBW7_1	144	151	PF00400	0.633
DEG_SCF_FBW7_1	262	268	PF00400	0.823
DEG_SIAH_1	594	602	PF03145	0.749
DEG_SPOP_SBC_1	221	225	PF00917	0.758
DEG_SPOP_SBC_1	558	562	PF00917	0.727
DOC_CKS1_1	145	150	PF01111	0.629
DOC_CKS1_1	182	187	PF01111	0.675
DOC_CKS1_1	192	197	PF01111	0.708
DOC_CKS1_1	262	267	PF01111	0.734
DOC_CKS1_1	327	332	PF01111	0.538
DOC_CKS1_1	36	41	PF01111	0.690
DOC_MAPK_gen_1	425	434	PF00069	0.522
DOC_MAPK_MEF2A_6	414	421	PF00069	0.620
DOC_MAPK_MEF2A_6	63	71	PF00069	0.696
DOC_MAPK_NFAT4_5	414	422	PF00069	0.616
DOC_PP1_RVXF_1	40	47	PF00149	0.699
DOC_PP1_RVXF_1	522	528	PF00149	0.630
DOC_PP2B_LxvP_1	115	118	PF13499	0.745
DOC_PP2B_LxvP_1	267	270	PF13499	0.774
DOC_PP4_FxxP_1	33	36	PF00568	0.718
DOC_USP7_MATH_1	12	16	PF00917	0.765
DOC_USP7_MATH_1	222	226	PF00917	0.852
DOC_USP7_MATH_1	26	30	PF00917	0.588
DOC_USP7_MATH_1	446	450	PF00917	0.482
DOC_USP7_MATH_1	558	562	PF00917	0.626
DOC_USP7_MATH_1	67	71	PF00917	0.692
DOC_USP7_MATH_1	679	683	PF00917	0.850
DOC_USP7_MATH_1	91	95	PF00917	0.688
DOC_WW_Pin1_4	144	149	PF00397	0.633
DOC_WW_Pin1_4	181	186	PF00397	0.672
DOC_WW_Pin1_4	191	196	PF00397	0.705
DOC_WW_Pin1_4	261	266	PF00397	0.815
DOC_WW_Pin1_4	300	305	PF00397	0.713
DOC_WW_Pin1_4	326	331	PF00397	0.636
DOC_WW_Pin1_4	35	40	PF00397	0.737
DOC_WW_Pin1_4	63	68	PF00397	0.540
DOC_WW_Pin1_4	675	680	PF00397	0.644
LIG_14-3-3_CanoR_1	247	252	PF00244	0.794
LIG_14-3-3_CanoR_1	425	430	PF00244	0.592
LIG_14-3-3_CanoR_1	556	564	PF00244	0.718
LIG_14-3-3_CanoR_1	625	630	PF00244	0.625
LIG_14-3-3_CanoR_1	634	640	PF00244	0.655
LIG_14-3-3_CanoR_1	646	651	PF00244	0.581
LIG_14-3-3_CanoR_1	83	88	PF00244	0.648
LIG_BRCT_BRCA1_1	560	564	PF00533	0.599
LIG_CSL_BTD_1	142	145	PF09270	0.678
LIG_DLG_GKlike_1	425	432	PF00625	0.531
LIG_FHA_1	112	118	PF00498	0.680
LIG_FHA_1	145	151	PF00498	0.633
LIG_FHA_1	171	177	PF00498	0.668
LIG_FHA_1	262	268	PF00498	0.782
LIG_FHA_1	337	343	PF00498	0.593
LIG_FHA_1	491	497	PF00498	0.612
LIG_FHA_1	56	62	PF00498	0.719
LIG_FHA_1	614	620	PF00498	0.588
LIG_FHA_1	64	70	PF00498	0.721
LIG_FHA_2	105	111	PF00498	0.627
LIG_FHA_2	160	166	PF00498	0.624
LIG_FHA_2	301	307	PF00498	0.758
LIG_FHA_2	329	335	PF00498	0.683
LIG_FHA_2	349	355	PF00498	0.690
LIG_FHA_2	528	534	PF00498	0.635
LIG_FXI_DFP_1	409	413	PF00024	0.670
LIG_Integrin_RGD_1	531	533	PF01839	0.606
LIG_LIR_Apic_2	191	195	PF02991	0.723
LIG_LIR_Apic_2	30	36	PF02991	0.725
LIG_LIR_Apic_2	652	657	PF02991	0.739
LIG_LIR_Gen_1	107	116	PF02991	0.711
LIG_LIR_Gen_1	415	424	PF02991	0.515
LIG_LIR_Gen_1	565	574	PF02991	0.593
LIG_LIR_Nem_3	107	111	PF02991	0.687
LIG_LIR_Nem_3	140	146	PF02991	0.616
LIG_LIR_Nem_3	165	171	PF02991	0.567
LIG_LIR_Nem_3	415	419	PF02991	0.469
LIG_LIR_Nem_3	552	557	PF02991	0.725
LIG_LIR_Nem_3	561	567	PF02991	0.535
LIG_MYND_1	265	269	PF01753	0.814
LIG_NRBOX	416	422	PF00104	0.512
LIG_PDZ_Class_3	680	685	PF00595	0.690
LIG_Pex14_2	412	416	PF04695	0.532
LIG_SH2_CRK	567	571	PF00017	0.670
LIG_SH2_STAP1	567	571	PF00017	0.670
LIG_SH2_STAT5	158	161	PF00017	0.625
LIG_SH2_STAT5	504	507	PF00017	0.553
LIG_SH2_STAT5	608	611	PF00017	0.710
LIG_SH3_2	207	212	PF14604	0.725
LIG_SH3_3	117	123	PF00018	0.742
LIG_SH3_3	142	148	PF00018	0.624
LIG_SH3_3	17	23	PF00018	0.712
LIG_SH3_3	179	185	PF00018	0.553
LIG_SH3_3	204	210	PF00018	0.736
LIG_SH3_3	259	265	PF00018	0.726
LIG_SH3_3	324	330	PF00018	0.654
LIG_SH3_3	33	39	PF00018	0.656
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.623
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.615
LIG_SUMO_SIM_par_1	65	73	PF11976	0.675
LIG_TRAF2_1	303	306	PF00917	0.540
MOD_CDK_SPxxK_3	35	42	PF00069	0.731
MOD_CK1_1	149	155	PF00069	0.686
MOD_CK1_1	199	205	PF00069	0.712
MOD_CK1_1	220	226	PF00069	0.836
MOD_CK1_1	268	274	PF00069	0.699
MOD_CK1_1	29	35	PF00069	0.730
MOD_CK1_1	394	400	PF00069	0.601
MOD_CK1_1	448	454	PF00069	0.564
MOD_CK1_1	506	512	PF00069	0.587
MOD_CK1_1	562	568	PF00069	0.679
MOD_CK1_1	70	76	PF00069	0.679
MOD_CK2_1	149	155	PF00069	0.630
MOD_CK2_1	159	165	PF00069	0.623
MOD_CK2_1	300	306	PF00069	0.655
MOD_CK2_1	340	346	PF00069	0.561
MOD_CK2_1	469	475	PF00069	0.521
MOD_CK2_1	494	500	PF00069	0.506
MOD_CK2_1	56	62	PF00069	0.677
MOD_Cter_Amidation	288	291	PF01082	0.668
MOD_GlcNHglycan	139	142	PF01048	0.626
MOD_GlcNHglycan	14	17	PF01048	0.772
MOD_GlcNHglycan	199	202	PF01048	0.783
MOD_GlcNHglycan	217	220	PF01048	0.662
MOD_GlcNHglycan	224	227	PF01048	0.728
MOD_GlcNHglycan	238	241	PF01048	0.691
MOD_GlcNHglycan	251	254	PF01048	0.542
MOD_GlcNHglycan	270	273	PF01048	0.727
MOD_GlcNHglycan	396	399	PF01048	0.602
MOD_GlcNHglycan	561	564	PF01048	0.601
MOD_GlcNHglycan	576	579	PF01048	0.595
MOD_GlcNHglycan	58	61	PF01048	0.686
MOD_GSK3_1	106	113	PF00069	0.530
MOD_GSK3_1	12	19	PF00069	0.604
MOD_GSK3_1	144	151	PF00069	0.633
MOD_GSK3_1	217	224	PF00069	0.821
MOD_GSK3_1	230	237	PF00069	0.752
MOD_GSK3_1	261	268	PF00069	0.810
MOD_GSK3_1	336	343	PF00069	0.580
MOD_GSK3_1	490	497	PF00069	0.592
MOD_GSK3_1	503	510	PF00069	0.458
MOD_GSK3_1	558	565	PF00069	0.712
MOD_GSK3_1	63	70	PF00069	0.713
MOD_GSK3_1	645	652	PF00069	0.720
MOD_GSK3_1	675	682	PF00069	0.855
MOD_GSK3_1	79	86	PF00069	0.612
MOD_N-GLC_1	507	512	PF02516	0.541
MOD_NEK2_1	196	201	PF00069	0.785
MOD_NEK2_1	373	378	PF00069	0.647
MOD_NEK2_1	420	425	PF00069	0.509
MOD_NEK2_1	45	50	PF00069	0.668
MOD_NEK2_1	487	492	PF00069	0.564
MOD_NEK2_1	527	532	PF00069	0.676
MOD_NEK2_1	559	564	PF00069	0.659
MOD_NEK2_1	606	611	PF00069	0.812
MOD_NEK2_1	633	638	PF00069	0.751
MOD_NEK2_2	67	72	PF00069	0.646
MOD_NEK2_2	91	96	PF00069	0.691
MOD_PIKK_1	224	230	PF00454	0.853
MOD_PIKK_1	657	663	PF00454	0.813
MOD_PKA_2	229	235	PF00069	0.688
MOD_PKA_2	574	580	PF00069	0.678
MOD_PKA_2	633	639	PF00069	0.753
MOD_PKA_2	645	651	PF00069	0.579
MOD_Plk_4	111	117	PF00069	0.730
MOD_Plk_4	171	177	PF00069	0.668
MOD_Plk_4	340	346	PF00069	0.530
MOD_Plk_4	391	397	PF00069	0.651
MOD_Plk_4	487	493	PF00069	0.602
MOD_Plk_4	625	631	PF00069	0.729
MOD_Plk_4	67	73	PF00069	0.688
MOD_ProDKin_1	144	150	PF00069	0.629
MOD_ProDKin_1	181	187	PF00069	0.674
MOD_ProDKin_1	191	197	PF00069	0.706
MOD_ProDKin_1	261	267	PF00069	0.818
MOD_ProDKin_1	300	306	PF00069	0.714
MOD_ProDKin_1	326	332	PF00069	0.637
MOD_ProDKin_1	35	41	PF00069	0.735
MOD_ProDKin_1	63	69	PF00069	0.540
MOD_ProDKin_1	675	681	PF00069	0.643
MOD_SUMO_for_1	599	602	PF00179	0.588
TRG_DiLeu_BaEn_1	566	571	PF01217	0.581
TRG_DiLeu_BaEn_2	154	160	PF01217	0.623
TRG_DiLeu_BaLyEn_6	262	267	PF01217	0.591
TRG_ENDOCYTIC_2	54	57	PF00928	0.587
TRG_ENDOCYTIC_2	567	570	PF00928	0.560
TRG_ER_diArg_1	295	298	PF00400	0.695
TRG_ER_diArg_1	375	378	PF00400	0.592
TRG_ER_diArg_1	424	427	PF00400	0.502
TRG_ER_diArg_1	524	527	PF00400	0.528
TRG_ER_diArg_1	633	635	PF00400	0.655
TRG_ER_diArg_1	74	76	PF00400	0.631
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B4	Leptomonas seymouri	45%	100%
A0A3Q8I8P4	Leishmania donovani	95%	100%
A4H7H8	Leishmania braziliensis	77%	100%
A4HVV9	Leishmania infantum	95%	100%
E9APL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%