Putative carboxypeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carboxypeptidase, putative

Species:

Leishmania major

UniProt:

Q4QFW7_LEIMA

TriTrypDb:

LmjF.14.0180 , LMJLV39_140006800 , LMJSD75_140006800

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QFW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.364
CLV_NRD_NRD_1	336	338	PF00675	0.449
CLV_NRD_NRD_1	497	499	PF00675	0.381
CLV_NRD_NRD_1	500	502	PF00675	0.511
CLV_PCSK_KEX2_1	101	103	PF00082	0.449
CLV_PCSK_KEX2_1	497	499	PF00082	0.354
CLV_PCSK_SKI1_1	18	22	PF00082	0.338
CLV_PCSK_SKI1_1	185	189	PF00082	0.475
CLV_PCSK_SKI1_1	259	263	PF00082	0.403
CLV_PCSK_SKI1_1	280	284	PF00082	0.461
CLV_PCSK_SKI1_1	35	39	PF00082	0.406
CLV_PCSK_SKI1_1	59	63	PF00082	0.432
CLV_PCSK_SKI1_1	65	69	PF00082	0.404
CLV_Separin_Metazoa	84	88	PF03568	0.274
CLV_Separin_Metazoa	98	102	PF03568	0.256
DEG_APCC_DBOX_1	399	407	PF00400	0.299
DEG_APCC_DBOX_1	78	86	PF00400	0.327
DEG_Nend_UBRbox_3	1	3	PF02207	0.561
DOC_CKS1_1	201	206	PF01111	0.299
DOC_CKS1_1	316	321	PF01111	0.390
DOC_CYCLIN_RxL_1	256	264	PF00134	0.380
DOC_CYCLIN_yClb5_NLxxxL_5	12	21	PF00134	0.271
DOC_MAPK_gen_1	388	395	PF00069	0.359
DOC_PP4_MxPP_1	31	34	PF00568	0.307
DOC_USP7_MATH_1	145	149	PF00917	0.358
DOC_WW_Pin1_4	148	153	PF00397	0.386
DOC_WW_Pin1_4	200	205	PF00397	0.299
DOC_WW_Pin1_4	250	255	PF00397	0.302
DOC_WW_Pin1_4	315	320	PF00397	0.368
LIG_14-3-3_CanoR_1	105	110	PF00244	0.450
LIG_14-3-3_CanoR_1	215	224	PF00244	0.288
LIG_14-3-3_CanoR_1	247	251	PF00244	0.501
LIG_14-3-3_CanoR_1	52	58	PF00244	0.423
LIG_Actin_WH2_2	129	146	PF00022	0.327
LIG_BRCT_BRCA1_1	309	313	PF00533	0.320
LIG_Clathr_ClatBox_1	133	137	PF01394	0.299
LIG_CSL_BTD_1	125	128	PF09270	0.386
LIG_deltaCOP1_diTrp_1	220	226	PF00928	0.416
LIG_deltaCOP1_diTrp_1	408	416	PF00928	0.359
LIG_FHA_1	256	262	PF00498	0.487
LIG_FHA_1	296	302	PF00498	0.414
LIG_FHA_1	316	322	PF00498	0.372
LIG_FHA_1	444	450	PF00498	0.297
LIG_FHA_1	472	478	PF00498	0.349
LIG_FHA_2	127	133	PF00498	0.415
LIG_FHA_2	262	268	PF00498	0.412
LIG_FHA_2	348	354	PF00498	0.278
LIG_GBD_Chelix_1	60	68	PF00786	0.406
LIG_HP1_1	58	62	PF01393	0.263
LIG_LIR_Apic_2	249	254	PF02991	0.293
LIG_LIR_Apic_2	315	319	PF02991	0.359
LIG_LIR_Gen_1	151	159	PF02991	0.490
LIG_LIR_Gen_1	170	181	PF02991	0.264
LIG_LIR_Nem_3	151	156	PF02991	0.501
LIG_LIR_Nem_3	170	176	PF02991	0.228
LIG_LIR_Nem_3	310	316	PF02991	0.343
LIG_LIR_Nem_3	391	395	PF02991	0.334
LIG_NRBOX	467	473	PF00104	0.399
LIG_PCNA_yPIPBox_3	383	393	PF02747	0.354
LIG_Pex14_1	411	415	PF04695	0.443
LIG_SH2_CRK	153	157	PF00017	0.319
LIG_SH2_NCK_1	231	235	PF00017	0.299
LIG_SH2_SRC	173	176	PF00017	0.385
LIG_SH2_SRC	231	234	PF00017	0.299
LIG_SH2_STAP1	153	157	PF00017	0.344
LIG_SH2_STAP1	257	261	PF00017	0.523
LIG_SH2_STAP1	357	361	PF00017	0.395
LIG_SH2_STAT5	257	260	PF00017	0.487
LIG_SH2_STAT5	316	319	PF00017	0.409
LIG_SH2_STAT5	347	350	PF00017	0.390
LIG_SH2_STAT5	422	425	PF00017	0.368
LIG_SH2_STAT5	499	502	PF00017	0.364
LIG_SH3_3	376	382	PF00018	0.278
LIG_SH3_3	482	488	PF00018	0.325
LIG_SUMO_SIM_par_1	132	137	PF11976	0.299
LIG_TRAF2_1	129	132	PF00917	0.311
LIG_TRAF2_1	3	6	PF00917	0.316
MOD_CDK_SPxxK_3	200	207	PF00069	0.299
MOD_CDK_SPxxK_3	315	322	PF00069	0.278
MOD_CK1_1	148	154	PF00069	0.404
MOD_CK2_1	126	132	PF00069	0.388
MOD_CK2_1	194	200	PF00069	0.368
MOD_CK2_1	261	267	PF00069	0.495
MOD_GlcNHglycan	147	150	PF01048	0.327
MOD_GlcNHglycan	291	294	PF01048	0.464
MOD_GlcNHglycan	309	312	PF01048	0.286
MOD_GSK3_1	144	151	PF00069	0.299
MOD_GSK3_1	196	203	PF00069	0.299
MOD_GSK3_1	246	253	PF00069	0.493
MOD_GSK3_1	261	268	PF00069	0.512
MOD_GSK3_1	343	350	PF00069	0.452
MOD_N-GLC_1	255	260	PF02516	0.463
MOD_NEK2_1	261	266	PF00069	0.376
MOD_PIKK_1	295	301	PF00454	0.412
MOD_PIKK_1	443	449	PF00454	0.256
MOD_PIKK_1	90	96	PF00454	0.538
MOD_PKA_2	104	110	PF00069	0.450
MOD_PKA_2	246	252	PF00069	0.349
MOD_PKB_1	142	150	PF00069	0.424
MOD_Plk_1	194	200	PF00069	0.293
MOD_Plk_4	175	181	PF00069	0.364
MOD_Plk_4	246	252	PF00069	0.394
MOD_Plk_4	27	33	PF00069	0.361
MOD_Plk_4	297	303	PF00069	0.330
MOD_Plk_4	343	349	PF00069	0.424
MOD_ProDKin_1	148	154	PF00069	0.386
MOD_ProDKin_1	200	206	PF00069	0.299
MOD_ProDKin_1	250	256	PF00069	0.302
MOD_ProDKin_1	315	321	PF00069	0.368
MOD_SUMO_for_1	271	274	PF00179	0.286
MOD_SUMO_for_1	70	73	PF00179	0.367
MOD_SUMO_rev_2	170	178	PF00179	0.403
MOD_SUMO_rev_2	5	10	PF00179	0.272
TRG_DiLeu_BaEn_1	297	302	PF01217	0.299
TRG_DiLeu_BaEn_1	473	478	PF01217	0.334
TRG_DiLeu_BaEn_4	5	11	PF01217	0.263
TRG_DiLeu_BaLyEn_6	316	321	PF01217	0.380
TRG_ENDOCYTIC_2	153	156	PF00928	0.371
TRG_ENDOCYTIC_2	173	176	PF00928	0.202
TRG_ENDOCYTIC_2	184	187	PF00928	0.282
TRG_ENDOCYTIC_2	392	395	PF00928	0.354
TRG_ENDOCYTIC_2	4	7	PF00928	0.390
TRG_ER_diArg_1	100	102	PF00400	0.448
TRG_ER_diArg_1	497	499	PF00400	0.353
TRG_NES_CRM1_1	13	27	PF08389	0.247
TRG_NES_CRM1_1	315	328	PF08389	0.299
TRG_NLS_MonoExtN_4	101	106	PF00514	0.263
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	280	285	PF00026	0.319
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	498	503	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	46%	100%
A0A1X0NY67	Trypanosomatidae	52%	100%
A0A1X0P441	Trypanosomatidae	55%	100%
A0A1X0P598	Trypanosomatidae	56%	100%
A0A3Q8IBW2	Leishmania donovani	96%	100%
A0A3Q8IJY8	Leishmania donovani	87%	100%
A0A3Q8IU74	Leishmania donovani	52%	100%
A0A3S7WSA3	Leishmania donovani	53%	100%
A0A422P042	Trypanosoma rangeli	52%	100%
A0A422P4R1	Trypanosoma rangeli	52%	100%
A4H716	Leishmania braziliensis	55%	100%
A4HLW4	Leishmania braziliensis	52%	100%
A4HVE5	Leishmania infantum	53%	100%
A4HVW0	Leishmania infantum	96%	100%
A4I993	Leishmania infantum	52%	100%
A4IC85	Leishmania infantum	86%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
P42663	Thermus aquaticus	32%	99%
P50848	Bacillus subtilis (strain 168)	31%	100%
Q4Q0D4	Leishmania major	96%	100%
Q4Q3T3	Leishmania major	51%	100%
Q4QGE5	Leishmania major	53%	100%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	32%	99%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	31%	100%
V5DQA0	Trypanosoma cruzi	54%	100%