Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioredoxin-like, putative

Species:

Leishmania major

UniProt:

Q4QFW6_LEIMA

TriTrypDb:

LmjF.14.0190 , LMJLV39_140006900 , LMJSD75_140006900

Length:

199

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.798
CLV_PCSK_KEX2_1	100	102	PF00082	0.351
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.351
CLV_PCSK_SKI1_1	70	74	PF00082	0.392
DEG_APCC_DBOX_1	160	168	PF00400	0.557
DOC_CYCLIN_RxL_1	97	107	PF00134	0.582
DOC_PP1_RVXF_1	140	146	PF00149	0.463
DOC_USP7_MATH_1	122	126	PF00917	0.592
DOC_USP7_UBL2_3	115	119	PF12436	0.536
DOC_USP7_UBL2_3	87	91	PF12436	0.536
LIG_FHA_1	150	156	PF00498	0.486
LIG_FHA_2	6	12	PF00498	0.458
LIG_FHA_2	76	82	PF00498	0.617
LIG_LIR_Gen_1	118	129	PF02991	0.571
LIG_LIR_Gen_1	58	68	PF02991	0.592
LIG_LIR_Nem_3	118	124	PF02991	0.571
LIG_LIR_Nem_3	38	44	PF02991	0.513
LIG_LIR_Nem_3	58	63	PF02991	0.553
LIG_PDZ_Class_1	194	199	PF00595	0.633
LIG_Pex14_1	145	149	PF04695	0.415
LIG_Pex14_2	45	49	PF04695	0.536
LIG_PTB_Apo_2	44	51	PF02174	0.536
LIG_PTB_Apo_2	54	61	PF02174	0.536
LIG_PTB_Phospho_1	44	50	PF10480	0.536
LIG_SH2_NCK_1	121	125	PF00017	0.549
LIG_SH2_SRC	111	114	PF00017	0.592
LIG_SH2_SRC	121	124	PF00017	0.536
LIG_SH2_STAP1	9	13	PF00017	0.527
LIG_SH2_STAT5	41	44	PF00017	0.538
LIG_SH2_STAT5	88	91	PF00017	0.584
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.592
LIG_TRAF2_1	169	172	PF00917	0.560
LIG_WRC_WIRS_1	46	51	PF05994	0.536
MOD_CK1_1	125	131	PF00069	0.554
MOD_CK2_1	117	123	PF00069	0.617
MOD_GlcNHglycan	23	26	PF01048	0.603
MOD_GSK3_1	151	158	PF00069	0.475
MOD_GSK3_1	7	14	PF00069	0.552
MOD_N-GLC_1	125	130	PF02516	0.349
MOD_N-GLC_1	155	160	PF02516	0.520
MOD_NEK2_1	149	154	PF00069	0.440
MOD_NEK2_1	45	50	PF00069	0.543
MOD_NEK2_2	194	199	PF00069	0.712
MOD_Plk_1	11	17	PF00069	0.546
MOD_Plk_1	125	131	PF00069	0.549
MOD_Plk_1	58	64	PF00069	0.558
MOD_Plk_2-3	18	24	PF00069	0.555
MOD_Plk_2-3	5	11	PF00069	0.468
MOD_Plk_4	125	131	PF00069	0.549
MOD_Plk_4	45	51	PF00069	0.536
MOD_SUMO_for_1	180	183	PF00179	0.676
MOD_SUMO_for_1	28	31	PF00179	0.597
MOD_SUMO_for_1	83	86	PF00179	0.592
MOD_SUMO_rev_2	107	117	PF00179	0.548
MOD_SUMO_rev_2	3	8	PF00179	0.497
MOD_SUMO_rev_2	31	40	PF00179	0.472
TRG_ENDOCYTIC_2	121	124	PF00928	0.544
TRG_ER_diArg_1	101	104	PF00400	0.551
TRG_NLS_MonoExtC_3	98	103	PF00514	0.551
TRG_NLS_MonoExtN_4	99	104	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXV8	Leptomonas seymouri	80%	100%
A0A0S4J513	Bodo saltans	56%	100%
A0A1X0NP28	Trypanosomatidae	67%	100%
A0A3R7MRI8	Trypanosoma rangeli	66%	100%
A0A3S5H6Q8	Leishmania donovani	96%	100%
A4H7H9	Leishmania braziliensis	84%	100%
A4HVW1	Leishmania infantum	96%	100%
C9ZT65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	99%
E9APL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%