BBIP1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

BBIP1

Gene product:

Bardet-Biedl syndrome 18 protein

Species:

Leishmania major

UniProt:

Q4QFW5_LEIMA

TriTrypDb:

LmjF.14.0200 , LMJLV39_140007000 , LMJSD75_140007000

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0030665	clathrin-coated vesicle membrane	6	2
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0032991	protein-containing complex	1	6
GO:0034464	BBSome	2	6
GO:0060170	ciliary membrane	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW5

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	6
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	6
GO:0022607	cellular component assembly	4	6
GO:0030030	cell projection organization	4	6
GO:0030031	cell projection assembly	5	6
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0044782	cilium organization	5	6
GO:0051179	localization	1	2
GO:0051641	cellular localization	2	2
GO:0051668	localization within membrane	3	2
GO:0060271	cilium assembly	6	6
GO:0061512	protein localization to cilium	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070925	organelle assembly	5	6
GO:0071840	cellular component organization or biogenesis	2	6
GO:0072657	protein localization to membrane	4	2
GO:0097499	protein localization to non-motile cilium	7	2
GO:0097500	receptor localization to non-motile cilium	6	2
GO:0120031	plasma membrane bounded cell projection assembly	6	6
GO:0120036	plasma membrane bounded cell projection organization	5	6
GO:1903441	protein localization to ciliary membrane	5	2
GO:1990778	protein localization to cell periphery	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.602
CLV_C14_Caspase3-7	65	69	PF00656	0.452
CLV_PCSK_KEX2_1	66	68	PF00082	0.488
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.369
CLV_PCSK_SKI1_1	61	65	PF00082	0.375
DEG_Nend_UBRbox_2	1	3	PF02207	0.810
DEG_SCF_FBW7_1	145	152	PF00400	0.591
DEG_SPOP_SBC_1	177	181	PF00917	0.773
DOC_MAPK_JIP1_4	38	44	PF00069	0.530
DOC_USP7_MATH_1	129	133	PF00917	0.834
DOC_USP7_MATH_1	158	162	PF00917	0.763
DOC_USP7_MATH_1	182	186	PF00917	0.630
DOC_USP7_MATH_1	43	47	PF00917	0.530
DOC_USP7_UBL2_3	54	58	PF12436	0.413
DOC_WW_Pin1_4	111	116	PF00397	0.708
DOC_WW_Pin1_4	119	124	PF00397	0.570
DOC_WW_Pin1_4	145	150	PF00397	0.593
DOC_WW_Pin1_4	165	170	PF00397	0.543
DOC_WW_Pin1_4	178	183	PF00397	0.737
DOC_WW_Pin1_4	2	7	PF00397	0.296
DOC_WW_Pin1_4	79	84	PF00397	0.642
DOC_WW_Pin1_4	95	100	PF00397	0.644
LIG_14-3-3_CanoR_1	137	147	PF00244	0.823
LIG_FHA_1	13	19	PF00498	0.452
LIG_FHA_2	150	156	PF00498	0.785
LIG_FHA_2	79	85	PF00498	0.686
LIG_LIR_Nem_3	144	150	PF02991	0.592
LIG_MYND_1	39	43	PF01753	0.530
LIG_SH3_3	102	108	PF00018	0.664
LIG_TRAF2_1	140	143	PF00917	0.700
LIG_UBA3_1	25	30	PF00899	0.296
MOD_CDK_SPK_2	165	170	PF00069	0.593
MOD_CDK_SPxK_1	111	117	PF00069	0.714
MOD_CK1_1	132	138	PF00069	0.796
MOD_CK1_1	141	147	PF00069	0.649
MOD_CK1_1	172	178	PF00069	0.771
MOD_CK1_1	180	186	PF00069	0.662
MOD_CK2_1	149	155	PF00069	0.780
MOD_CK2_1	160	166	PF00069	0.650
MOD_CK2_1	83	89	PF00069	0.625
MOD_GlcNHglycan	124	127	PF01048	0.786
MOD_GlcNHglycan	132	135	PF01048	0.744
MOD_GlcNHglycan	162	165	PF01048	0.727
MOD_GlcNHglycan	184	187	PF01048	0.704
MOD_GSK3_1	129	136	PF00069	0.791
MOD_GSK3_1	141	148	PF00069	0.633
MOD_GSK3_1	149	156	PF00069	0.551
MOD_GSK3_1	165	172	PF00069	0.727
MOD_GSK3_1	176	183	PF00069	0.624
MOD_GSK3_1	79	86	PF00069	0.762
MOD_GSK3_1	95	102	PF00069	0.627
MOD_NEK2_1	78	83	PF00069	0.761
MOD_PIKK_1	138	144	PF00454	0.818
MOD_Plk_1	12	18	PF00069	0.452
MOD_Plk_1	158	164	PF00069	0.599
MOD_ProDKin_1	111	117	PF00069	0.711
MOD_ProDKin_1	119	125	PF00069	0.572
MOD_ProDKin_1	145	151	PF00069	0.594
MOD_ProDKin_1	165	171	PF00069	0.542
MOD_ProDKin_1	178	184	PF00069	0.736
MOD_ProDKin_1	2	8	PF00069	0.296
MOD_ProDKin_1	79	85	PF00069	0.645
MOD_ProDKin_1	95	101	PF00069	0.645
MOD_SUMO_rev_2	27	32	PF00179	0.491
MOD_SUMO_rev_2	50	60	PF00179	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II74	Leishmania donovani	78%	100%
A4H7I0	Leishmania braziliensis	71%	99%
A4HVW2	Leishmania infantum	78%	100%
E9APL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%