DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4201), putative

Species:

Leishmania major

UniProt:

Q4QFW4_LEIMA

TriTrypDb:

LmjF.14.0210 , LMJLV39_140007100 , LMJSD75_140007100

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005815	microtubule organizing center	2	2
GO:0005930	axoneme	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	11
GO:0005856	cytoskeleton	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9

Expansion

Sequence features

Q4QFW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0044782	cilium organization	5	2
GO:0060271	cilium assembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.599
CLV_C14_Caspase3-7	275	279	PF00656	0.749
CLV_C14_Caspase3-7	420	424	PF00656	0.525
CLV_NRD_NRD_1	108	110	PF00675	0.426
CLV_NRD_NRD_1	132	134	PF00675	0.518
CLV_NRD_NRD_1	24	26	PF00675	0.394
CLV_NRD_NRD_1	254	256	PF00675	0.560
CLV_NRD_NRD_1	32	34	PF00675	0.483
CLV_NRD_NRD_1	370	372	PF00675	0.270
CLV_NRD_NRD_1	399	401	PF00675	0.245
CLV_NRD_NRD_1	64	66	PF00675	0.510
CLV_NRD_NRD_1	9	11	PF00675	0.575
CLV_NRD_NRD_1	95	97	PF00675	0.507
CLV_PCSK_FUR_1	252	256	PF00082	0.574
CLV_PCSK_KEX2_1	108	110	PF00082	0.423
CLV_PCSK_KEX2_1	131	133	PF00082	0.612
CLV_PCSK_KEX2_1	24	26	PF00082	0.384
CLV_PCSK_KEX2_1	254	256	PF00082	0.582
CLV_PCSK_KEX2_1	32	34	PF00082	0.488
CLV_PCSK_KEX2_1	368	370	PF00082	0.247
CLV_PCSK_KEX2_1	399	401	PF00082	0.268
CLV_PCSK_KEX2_1	64	66	PF00082	0.510
CLV_PCSK_KEX2_1	8	10	PF00082	0.586
CLV_PCSK_KEX2_1	94	96	PF00082	0.542
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.462
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.247
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.303
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.617
CLV_PCSK_SKI1_1	103	107	PF00082	0.460
CLV_PCSK_SKI1_1	109	113	PF00082	0.451
CLV_PCSK_SKI1_1	255	259	PF00082	0.595
CLV_PCSK_SKI1_1	391	395	PF00082	0.249
CLV_PCSK_SKI1_1	419	423	PF00082	0.260
CLV_PCSK_SKI1_1	74	78	PF00082	0.500
DEG_APCC_DBOX_1	332	340	PF00400	0.533
DEG_APCC_DBOX_1	407	415	PF00400	0.521
DEG_Nend_Nbox_1	1	3	PF02207	0.576
DEG_SCF_FBW7_2	142	148	PF00400	0.617
DEG_SPOP_SBC_1	262	266	PF00917	0.629
DOC_CKS1_1	142	147	PF01111	0.624
DOC_CKS1_1	88	93	PF01111	0.568
DOC_CYCLIN_RxL_1	107	114	PF00134	0.542
DOC_MAPK_gen_1	319	328	PF00069	0.447
DOC_MAPK_gen_1	380	387	PF00069	0.533
DOC_USP7_MATH_1	166	170	PF00917	0.526
DOC_USP7_MATH_1	262	266	PF00917	0.708
DOC_USP7_MATH_1	75	79	PF00917	0.697
DOC_USP7_UBL2_3	317	321	PF12436	0.458
DOC_WW_Pin1_4	141	146	PF00397	0.552
DOC_WW_Pin1_4	87	92	PF00397	0.596
LIG_14-3-3_CanoR_1	14	22	PF00244	0.551
LIG_14-3-3_CanoR_1	168	176	PF00244	0.458
LIG_14-3-3_CanoR_1	32	36	PF00244	0.553
LIG_14-3-3_CanoR_1	74	84	PF00244	0.500
LIG_BIR_III_2	38	42	PF00653	0.652
LIG_BIR_III_4	56	60	PF00653	0.488
LIG_BRCT_BRCA1_1	206	210	PF00533	0.587
LIG_BRCT_BRCA1_1	54	58	PF00533	0.577
LIG_BRCT_BRCA1_1	77	81	PF00533	0.655
LIG_CaM_IQ_9	19	35	PF13499	0.454
LIG_CaM_IQ_9	241	257	PF13499	0.548
LIG_Clathr_ClatBox_1	291	295	PF01394	0.447
LIG_FHA_1	217	223	PF00498	0.415
LIG_FHA_1	321	327	PF00498	0.438
LIG_FHA_1	407	413	PF00498	0.526
LIG_FHA_1	420	426	PF00498	0.524
LIG_FHA_2	141	147	PF00498	0.606
LIG_FHA_2	273	279	PF00498	0.742
LIG_FHA_2	351	357	PF00498	0.455
LIG_FHA_2	88	94	PF00498	0.548
LIG_LIR_Gen_1	223	231	PF02991	0.533
LIG_LIR_Gen_1	293	299	PF02991	0.447
LIG_LIR_Gen_1	78	88	PF02991	0.646
LIG_LIR_Nem_3	100	105	PF02991	0.430
LIG_LIR_Nem_3	148	154	PF02991	0.546
LIG_LIR_Nem_3	194	200	PF02991	0.402
LIG_LIR_Nem_3	223	228	PF02991	0.572
LIG_LIR_Nem_3	293	297	PF02991	0.447
LIG_LIR_Nem_3	55	61	PF02991	0.577
LIG_LIR_Nem_3	78	84	PF02991	0.653
LIG_PCNA_PIPBox_1	120	129	PF02747	0.475
LIG_Pex14_2	290	294	PF04695	0.533
LIG_SH2_CRK	102	106	PF00017	0.440
LIG_SH2_CRK	119	123	PF00017	0.387
LIG_SH2_NCK_1	2	6	PF00017	0.626
LIG_SH2_PTP2	225	228	PF00017	0.497
LIG_SH2_SRC	183	186	PF00017	0.559
LIG_SH2_SRC	2	5	PF00017	0.659
LIG_SH2_STAT3	127	130	PF00017	0.574
LIG_SH2_STAT5	200	203	PF00017	0.402
LIG_SH2_STAT5	225	228	PF00017	0.542
LIG_SH2_STAT5	243	246	PF00017	0.354
LIG_SH3_3	85	91	PF00018	0.587
LIG_SUMO_SIM_par_1	49	56	PF11976	0.521
LIG_TRAF2_1	191	194	PF00917	0.491
LIG_TRAF2_1	353	356	PF00917	0.474
LIG_TRAF2_1	90	93	PF00917	0.567
LIG_TYR_ITIM	117	122	PF00017	0.564
LIG_TYR_ITIM	241	246	PF00017	0.467
LIG_UBA3_1	250	258	PF00899	0.599
MOD_CDK_SPxxK_3	87	94	PF00069	0.569
MOD_CK1_1	266	272	PF00069	0.722
MOD_CK2_1	300	306	PF00069	0.552
MOD_CK2_1	349	355	PF00069	0.457
MOD_CK2_1	87	93	PF00069	0.557
MOD_Cter_Amidation	62	65	PF01082	0.497
MOD_GlcNHglycan	233	236	PF01048	0.532
MOD_GlcNHglycan	265	268	PF01048	0.704
MOD_GSK3_1	262	269	PF00069	0.692
MOD_GSK3_1	427	434	PF00069	0.581
MOD_LATS_1	374	380	PF00433	0.533
MOD_N-GLC_1	300	305	PF02516	0.352
MOD_NEK2_1	204	209	PF00069	0.471
MOD_NEK2_1	210	215	PF00069	0.455
MOD_NEK2_1	263	268	PF00069	0.685
MOD_NEK2_1	364	369	PF00069	0.457
MOD_NEK2_1	42	47	PF00069	0.696
MOD_NEK2_1	421	426	PF00069	0.476
MOD_NEK2_1	84	89	PF00069	0.707
MOD_PIKK_1	189	195	PF00454	0.473
MOD_PKA_2	167	173	PF00069	0.502
MOD_PKA_2	31	37	PF00069	0.578
MOD_PKA_2	42	48	PF00069	0.598
MOD_Plk_1	299	305	PF00069	0.552
MOD_Plk_1	427	433	PF00069	0.597
MOD_Plk_1	437	443	PF00069	0.567
MOD_Plk_2-3	300	306	PF00069	0.536
MOD_Plk_2-3	309	315	PF00069	0.512
MOD_Plk_2-3	31	37	PF00069	0.602
MOD_Plk_4	17	23	PF00069	0.554
MOD_Plk_4	428	434	PF00069	0.576
MOD_ProDKin_1	141	147	PF00069	0.543
MOD_ProDKin_1	87	93	PF00069	0.587
MOD_SUMO_for_1	297	300	PF00179	0.447
MOD_SUMO_for_1	425	428	PF00179	0.497
TRG_DiLeu_BaEn_1	101	106	PF01217	0.421
TRG_DiLeu_BaEn_4	313	319	PF01217	0.533
TRG_DiLeu_BaLyEn_6	246	251	PF01217	0.567
TRG_ENDOCYTIC_2	102	105	PF00928	0.423
TRG_ENDOCYTIC_2	119	122	PF00928	0.440
TRG_ENDOCYTIC_2	151	154	PF00928	0.538
TRG_ENDOCYTIC_2	183	186	PF00928	0.559
TRG_ENDOCYTIC_2	2	5	PF00928	0.646
TRG_ENDOCYTIC_2	225	228	PF00928	0.575
TRG_ENDOCYTIC_2	243	246	PF00928	0.365
TRG_ER_diArg_1	131	133	PF00400	0.637
TRG_ER_diArg_1	162	165	PF00400	0.511
TRG_ER_diArg_1	180	183	PF00400	0.532
TRG_ER_diArg_1	24	26	PF00400	0.526
TRG_ER_diArg_1	240	243	PF00400	0.511
TRG_ER_diArg_1	251	254	PF00400	0.550
TRG_ER_diArg_1	369	371	PF00400	0.465
TRG_ER_diArg_1	407	410	PF00400	0.533
TRG_ER_diArg_1	7	10	PF00400	0.633
TRG_NLS_Bipartite_1	94	112	PF00514	0.567
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	74	79	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC16	Leptomonas seymouri	76%	100%
A0A0S4IZV5	Bodo saltans	37%	100%
A0A1X0NPB4	Trypanosomatidae	39%	100%
A0A3S5H6Q9	Leishmania donovani	93%	100%
A0A422NXD4	Trypanosoma rangeli	38%	100%
A4H7I1	Leishmania braziliensis	81%	100%
A4HVW3	Leishmania infantum	94%	100%
C9ZT63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9APL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q2M329	Homo sapiens	30%	80%
Q95LS7	Macaca fascicularis	29%	79%
Q9CR92	Mus musculus	29%	76%
V5BHR7	Trypanosoma cruzi	38%	100%