PX domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PX domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QFW3_LEIMA

TriTrypDb:

LmjF.14.0220 , LMJLV39_140007200 , LMJSD75_140007200

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005543	phospholipid binding	3	12
GO:0008289	lipid binding	2	12
GO:0035091	phosphatidylinositol binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.738
CLV_C14_Caspase3-7	200	204	PF00656	0.689
CLV_C14_Caspase3-7	311	315	PF00656	0.574
CLV_C14_Caspase3-7	94	98	PF00656	0.429
CLV_NRD_NRD_1	253	255	PF00675	0.541
CLV_NRD_NRD_1	325	327	PF00675	0.503
CLV_NRD_NRD_1	42	44	PF00675	0.557
CLV_NRD_NRD_1	56	58	PF00675	0.327
CLV_NRD_NRD_1	81	83	PF00675	0.448
CLV_PCSK_KEX2_1	164	166	PF00082	0.526
CLV_PCSK_KEX2_1	253	255	PF00082	0.541
CLV_PCSK_KEX2_1	400	402	PF00082	0.524
CLV_PCSK_KEX2_1	42	44	PF00082	0.522
CLV_PCSK_KEX2_1	56	58	PF00082	0.327
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.572
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.524
CLV_PCSK_PC7_1	160	166	PF00082	0.605
CLV_PCSK_SKI1_1	146	150	PF00082	0.437
CLV_PCSK_SKI1_1	153	157	PF00082	0.448
CLV_PCSK_SKI1_1	167	171	PF00082	0.676
CLV_PCSK_SKI1_1	3	7	PF00082	0.503
CLV_PCSK_SKI1_1	384	388	PF00082	0.463
CLV_PCSK_SKI1_1	65	69	PF00082	0.327
CLV_Separin_Metazoa	429	433	PF03568	0.488
DEG_APCC_DBOX_1	145	153	PF00400	0.522
DEG_COP1_1	19	27	PF00400	0.525
DEG_MDM2_SWIB_1	226	233	PF02201	0.594
DEG_SPOP_SBC_1	179	183	PF00917	0.672
DEG_SPOP_SBC_1	219	223	PF00917	0.751
DOC_CYCLIN_RxL_1	381	389	PF00134	0.499
DOC_CYCLIN_yClb5_NLxxxL_5	103	110	PF00134	0.448
DOC_MAPK_gen_1	326	333	PF00069	0.551
DOC_MAPK_gen_1	56	64	PF00069	0.327
DOC_MAPK_MEF2A_6	326	335	PF00069	0.526
DOC_PP1_RVXF_1	332	338	PF00149	0.400
DOC_PP4_FxxP_1	130	133	PF00568	0.391
DOC_PP4_FxxP_1	22	25	PF00568	0.599
DOC_USP7_MATH_1	178	182	PF00917	0.649
DOC_USP7_MATH_1	220	224	PF00917	0.699
DOC_USP7_MATH_1	444	448	PF00917	0.658
DOC_USP7_MATH_1	81	85	PF00917	0.437
DOC_USP7_UBL2_3	176	180	PF12436	0.665
DOC_WW_Pin1_4	293	298	PF00397	0.535
DOC_WW_Pin1_4	445	450	PF00397	0.675
DOC_WW_Pin1_4	75	80	PF00397	0.470
LIG_14-3-3_CanoR_1	153	158	PF00244	0.564
LIG_14-3-3_CanoR_1	165	170	PF00244	0.588
LIG_14-3-3_CanoR_1	291	297	PF00244	0.563
LIG_14-3-3_CanoR_1	3	8	PF00244	0.502
LIG_14-3-3_CanoR_1	56	64	PF00244	0.327
LIG_14-3-3_CanoR_1	82	87	PF00244	0.448
LIG_Actin_WH2_2	138	155	PF00022	0.532
LIG_Actin_WH2_2	244	261	PF00022	0.559
LIG_Actin_WH2_2	265	283	PF00022	0.569
LIG_Actin_WH2_2	417	434	PF00022	0.504
LIG_BIR_III_4	300	304	PF00653	0.573
LIG_BRCT_BRCA1_1	222	226	PF00533	0.699
LIG_BRCT_BRCA1_1	95	99	PF00533	0.448
LIG_CaM_IQ_9	418	434	PF13499	0.504
LIG_deltaCOP1_diTrp_1	124	130	PF00928	0.448
LIG_eIF4E_1	70	76	PF01652	0.470
LIG_FHA_1	137	143	PF00498	0.526
LIG_FHA_1	377	383	PF00498	0.420
LIG_FHA_1	9	15	PF00498	0.516
LIG_FHA_2	21	27	PF00498	0.543
LIG_FHA_2	315	321	PF00498	0.546
LIG_FHA_2	369	375	PF00498	0.575
LIG_LIR_Apic_2	123	128	PF02991	0.447
LIG_LIR_Apic_2	19	25	PF02991	0.523
LIG_LIR_Apic_2	69	73	PF02991	0.470
LIG_LIR_Gen_1	227	237	PF02991	0.551
LIG_LIR_Gen_1	325	335	PF02991	0.423
LIG_LIR_Gen_1	436	446	PF02991	0.686
LIG_LIR_Gen_1	55	64	PF02991	0.327
LIG_LIR_Nem_3	168	172	PF02991	0.660
LIG_LIR_Nem_3	227	233	PF02991	0.563
LIG_LIR_Nem_3	264	268	PF02991	0.550
LIG_LIR_Nem_3	285	289	PF02991	0.534
LIG_LIR_Nem_3	392	397	PF02991	0.568
LIG_LIR_Nem_3	436	442	PF02991	0.612
LIG_LIR_Nem_3	55	61	PF02991	0.314
LIG_LIR_Nem_3	6	10	PF02991	0.433
LIG_LIR_Nem_3	69	75	PF02991	0.311
LIG_NRBOX	63	69	PF00104	0.412
LIG_Pex14_1	125	129	PF04695	0.448
LIG_Pex14_2	121	125	PF04695	0.440
LIG_Pex14_2	226	230	PF04695	0.608
LIG_REV1ctd_RIR_1	190	200	PF16727	0.642
LIG_REV1ctd_RIR_1	394	405	PF16727	0.471
LIG_SH2_CRK	356	360	PF00017	0.477
LIG_SH2_CRK	70	74	PF00017	0.375
LIG_SH2_GRB2like	328	331	PF00017	0.529
LIG_SH2_NCK_1	439	443	PF00017	0.420
LIG_SH2_SRC	232	235	PF00017	0.541
LIG_SH2_STAP1	228	232	PF00017	0.560
LIG_SH2_STAP1	289	293	PF00017	0.464
LIG_SH2_STAP1	378	382	PF00017	0.396
LIG_SH2_STAP1	398	402	PF00017	0.217
LIG_SH2_STAP1	58	62	PF00017	0.327
LIG_SH2_STAT5	172	175	PF00017	0.683
LIG_SH2_STAT5	232	235	PF00017	0.541
LIG_SH2_STAT5	268	271	PF00017	0.479
LIG_SH2_STAT5	323	326	PF00017	0.522
LIG_SH2_STAT5	328	331	PF00017	0.441
LIG_SH2_STAT5	378	381	PF00017	0.402
LIG_SH2_STAT5	439	442	PF00017	0.460
LIG_SH2_STAT5	7	10	PF00017	0.541
LIG_SH2_STAT5	92	95	PF00017	0.448
LIG_SH3_3	214	220	PF00018	0.761
LIG_SH3_3	22	28	PF00018	0.465
LIG_SH3_3	407	413	PF00018	0.586
LIG_SUMO_SIM_anti_2	347	353	PF11976	0.513
LIG_SUMO_SIM_par_1	59	66	PF11976	0.470
LIG_TRAF2_1	371	374	PF00917	0.596
LIG_TRFH_1	129	133	PF08558	0.468
LIG_TYR_ITIM	5	10	PF00017	0.529
LIG_UBA3_1	76	83	PF00899	0.412
MOD_CDK_SPxxK_3	75	82	PF00069	0.470
MOD_CK1_1	222	228	PF00069	0.637
MOD_CK1_1	236	242	PF00069	0.519
MOD_CK1_1	261	267	PF00069	0.576
MOD_CK1_1	448	454	PF00069	0.547
MOD_CK1_1	84	90	PF00069	0.437
MOD_CK2_1	165	171	PF00069	0.670
MOD_CK2_1	314	320	PF00069	0.587
MOD_CK2_1	368	374	PF00069	0.634
MOD_CK2_1	84	90	PF00069	0.392
MOD_GlcNHglycan	198	202	PF01048	0.668
MOD_GlcNHglycan	235	238	PF01048	0.541
MOD_GlcNHglycan	260	263	PF01048	0.527
MOD_GlcNHglycan	360	363	PF01048	0.547
MOD_GlcNHglycan	50	53	PF01048	0.366
MOD_GlcNHglycan	93	96	PF01048	0.448
MOD_GSK3_1	180	187	PF00069	0.588
MOD_GSK3_1	218	225	PF00069	0.670
MOD_GSK3_1	228	235	PF00069	0.410
MOD_GSK3_1	289	296	PF00069	0.539
MOD_GSK3_1	364	371	PF00069	0.584
MOD_GSK3_1	376	383	PF00069	0.362
MOD_GSK3_1	44	51	PF00069	0.416
MOD_GSK3_1	444	451	PF00069	0.647
MOD_GSK3_1	71	78	PF00069	0.470
MOD_GSK3_1	84	91	PF00069	0.308
MOD_N-GLC_2	330	332	PF02516	0.515
MOD_NEK2_1	184	189	PF00069	0.551
MOD_NEK2_1	191	196	PF00069	0.471
MOD_NEK2_1	258	263	PF00069	0.506
MOD_NEK2_1	308	313	PF00069	0.560
MOD_NEK2_1	358	363	PF00069	0.528
MOD_NEK2_1	376	381	PF00069	0.484
MOD_NEK2_2	289	294	PF00069	0.527
MOD_PIKK_1	314	320	PF00454	0.545
MOD_PIKK_1	376	382	PF00454	0.492
MOD_PK_1	82	88	PF00069	0.448
MOD_PKA_1	56	62	PF00069	0.327
MOD_PKA_1	82	88	PF00069	0.448
MOD_PKA_2	133	139	PF00069	0.454
MOD_PKA_2	56	62	PF00069	0.327
MOD_PKA_2	81	87	PF00069	0.437
MOD_PKB_1	165	173	PF00069	0.672
MOD_Plk_1	18	24	PF00069	0.561
MOD_Plk_1	228	234	PF00069	0.547
MOD_Plk_1	289	295	PF00069	0.544
MOD_Plk_4	138	144	PF00069	0.534
MOD_Plk_4	180	186	PF00069	0.589
MOD_Plk_4	308	314	PF00069	0.561
MOD_Plk_4	71	77	PF00069	0.340
MOD_Plk_4	88	94	PF00069	0.270
MOD_ProDKin_1	293	299	PF00069	0.534
MOD_ProDKin_1	445	451	PF00069	0.680
MOD_ProDKin_1	75	81	PF00069	0.470
MOD_SUMO_rev_2	320	329	PF00179	0.548
TRG_DiLeu_BaEn_1	138	143	PF01217	0.533
TRG_ENDOCYTIC_2	328	331	PF00928	0.420
TRG_ENDOCYTIC_2	356	359	PF00928	0.493
TRG_ENDOCYTIC_2	394	397	PF00928	0.558
TRG_ENDOCYTIC_2	439	442	PF00928	0.415
TRG_ENDOCYTIC_2	58	61	PF00928	0.313
TRG_ENDOCYTIC_2	7	10	PF00928	0.509
TRG_ER_diArg_1	143	146	PF00400	0.483
TRG_ER_diArg_1	41	43	PF00400	0.564
TRG_ER_diArg_1	56	58	PF00400	0.327
TRG_Pf-PMV_PEXEL_1	384	389	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	403	408	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW83	Leptomonas seymouri	73%	78%
A0A0S4IZJ1	Bodo saltans	26%	81%
A0A1X0NNT5	Trypanosomatidae	30%	80%
A0A3R7LA20	Trypanosoma rangeli	30%	92%
A0A3S7WSS9	Leishmania donovani	98%	100%
A4H7I2	Leishmania braziliensis	91%	100%
A4HVW4	Leishmania infantum	98%	100%
C9ZT62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	86%
E9APL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BMA1	Trypanosoma cruzi	30%	91%