HIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HIT domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QFW1_LEIMA

TriTrypDb:

LmjF.14.0240 , LMJLV39_140007500 , LMJSD75_140007500

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW1

PDB structure(s): 3ksv_A

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044281	small molecule metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	132	134	PF00082	0.471
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.513
CLV_PCSK_SKI1_1	9	13	PF00082	0.510
DOC_CYCLIN_RxL_1	19	31	PF00134	0.452
DOC_PP1_RVXF_1	112	118	PF00149	0.536
DOC_PP1_RVXF_1	23	30	PF00149	0.443
DOC_PP2B_LxvP_1	41	44	PF13499	0.455
DOC_USP7_MATH_1	21	25	PF00917	0.558
DOC_USP7_MATH_1	67	71	PF00917	0.535
DOC_USP7_MATH_1	76	80	PF00917	0.535
DOC_USP7_MATH_2	44	50	PF00917	0.419
DOC_USP7_UBL2_3	106	110	PF12436	0.555
LIG_14-3-3_CanoR_1	133	141	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.440
LIG_FHA_1	117	123	PF00498	0.504
LIG_LIR_Nem_3	79	85	PF02991	0.457
LIG_SH2_CRK	82	86	PF00017	0.455
LIG_SH2_STAP1	134	138	PF00017	0.565
LIG_SH3_3	70	76	PF00018	0.525
LIG_TRAF2_1	92	95	PF00917	0.455
LIG_UBA3_1	40	45	PF00899	0.497
LIG_UBA3_1	6	12	PF00899	0.416
MOD_GSK3_1	104	111	PF00069	0.607
MOD_N-GLC_1	87	92	PF02516	0.325
MOD_NEK2_2	116	121	PF00069	0.516
MOD_PKA_1	132	138	PF00069	0.450
MOD_PKA_2	132	138	PF00069	0.450
TRG_ENDOCYTIC_2	82	85	PF00928	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q7	Leptomonas seymouri	73%	100%
A0A0S4JN40	Bodo saltans	34%	81%
A0A1X0NNT0	Trypanosomatidae	61%	100%
A0A3S5IS68	Trypanosoma rangeli	59%	100%
A0A3S7WSU6	Leishmania donovani	96%	100%
A4H7I4	Leishmania braziliensis	85%	100%
A4HVW6	Leishmania infantum	96%	100%
C4LYI2	Entamoeba histolytica	41%	100%
C9ZT59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9APL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
F4K1R2	Arabidopsis thaliana	40%	72%
O07513	Bacillus subtilis (strain 168)	44%	98%
O07817	Neisseria gonorrhoeae	36%	100%
O66536	Aquifex aeolicus (strain VF5)	40%	100%
O84390	Chlamydia trachomatis (strain D/UW-3/Cx)	32%	100%
O94586	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	54%	100%
P0ACE7	Escherichia coli (strain K12)	30%	100%
P0ACE8	Escherichia coli O157:H7	30%	100%
P0ACE9	Shigella flexneri	30%	100%
P26724	Azospirillum brasilense	40%	100%
P32083	Mesomycoplasma hyorhinis	36%	100%
P32084	Synechococcus elongatus (strain PCC 7942 / FACHB-805)	37%	100%
P42855	Brassica juncea	34%	100%
P42856	Zea mays	38%	100%
P44956	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	31%	100%
P47378	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	35%	100%
P49773	Homo sapiens	35%	100%
P49774	Mycobacterium leprae (strain TN)	31%	100%
P49776	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	78%
P53795	Caenorhabditis elegans	37%	100%
P62958	Bos taurus	34%	100%
P62959	Rattus norvegicus	33%	100%
P64382	Helicobacter pylori (strain ATCC 700392 / 26695)	37%	100%
P64383	Helicobacter pylori (strain J99 / ATCC 700824)	37%	100%
P70349	Mus musculus	33%	100%
P73481	Synechocystis sp. (strain PCC 6803 / Kazusa)	41%	100%
P75504	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	36%	99%
P80912	Oryctolagus cuniculus	35%	100%
P94252	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	45%	100%
P95937	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	29%	100%
P9WML0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	39%	99%
P9WML1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	39%	99%
Q04344	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	90%
Q23921	Dictyostelium discoideum	35%	100%
Q58276	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	43%	100%
Q59WG0	Candida albicans (strain SC5314 / ATCC MYA-2876)	44%	93%
Q5PNN8	Danio rerio	36%	89%
Q5RF69	Pongo abelii	34%	100%
Q89AG5	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	31%	100%
Q8GUN2	Arabidopsis thaliana	35%	97%
Q8SQ21	Bos taurus	31%	87%
Q9BX68	Homo sapiens	31%	87%
Q9D0S9	Mus musculus	27%	87%
Q9Z863	Chlamydia pneumoniae	31%	100%
Q9ZDL1	Rickettsia prowazekii (strain Madrid E)	31%	100%
V5BMC8	Trypanosoma cruzi	59%	100%