Translocon-associated protein subunit gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFW0_LEIMA

TriTrypDb:

LmjF.14.0250 , LMJLV39_140007600 , LMJSD75_140007600

Length:

172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QFW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW0

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006612	protein targeting to membrane	5	12
GO:0006613	cotranslational protein targeting to membrane	6	12
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0045047	protein targeting to ER	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0051668	localization within membrane	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0070972	protein localization to endoplasmic reticulum	6	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	12
GO:0072657	protein localization to membrane	4	12
GO:0090150	establishment of protein localization to membrane	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.406
CLV_NRD_NRD_1	166	168	PF00675	0.378
CLV_PCSK_FUR_1	164	168	PF00082	0.381
CLV_PCSK_KEX2_1	102	104	PF00082	0.426
CLV_PCSK_KEX2_1	166	168	PF00082	0.379
DOC_MAPK_gen_1	97	106	PF00069	0.563
DOC_MAPK_MEF2A_6	52	61	PF00069	0.336
DOC_MAPK_MEF2A_6	99	108	PF00069	0.550
DOC_USP7_MATH_1	138	142	PF00917	0.282
DOC_USP7_MATH_1	24	28	PF00917	0.561
DOC_USP7_MATH_1	91	95	PF00917	0.673
DOC_WW_Pin1_4	142	147	PF00397	0.274
LIG_14-3-3_CanoR_1	134	138	PF00244	0.345
LIG_14-3-3_CanoR_1	139	143	PF00244	0.234
LIG_Actin_WH2_2	56	74	PF00022	0.417
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BRCT_BRCA1_1	112	116	PF00533	0.404
LIG_BRCT_BRCA1_1	118	122	PF00533	0.401
LIG_BRCT_BRCA1_1	26	30	PF00533	0.580
LIG_deltaCOP1_diTrp_1	82	90	PF00928	0.628
LIG_eIF4E_1	23	29	PF01652	0.516
LIG_FHA_1	147	153	PF00498	0.274
LIG_FHA_1	66	72	PF00498	0.385
LIG_LIR_Gen_1	27	37	PF02991	0.326
LIG_LIR_Nem_3	119	124	PF02991	0.315
LIG_LIR_Nem_3	27	33	PF02991	0.427
LIG_LIR_Nem_3	36	40	PF02991	0.315
LIG_LIR_Nem_3	50	54	PF02991	0.319
LIG_LIR_Nem_3	64	69	PF02991	0.376
LIG_MLH1_MIPbox_1	112	116	PF16413	0.380
LIG_MLH1_MIPbox_1	118	122	PF16413	0.353
LIG_PTB_Apo_2	115	122	PF02174	0.274
LIG_SH2_PTP2	60	63	PF00017	0.286
LIG_SH2_STAP1	112	116	PF00017	0.305
LIG_SH2_STAP1	75	79	PF00017	0.279
LIG_SH2_STAT3	23	26	PF00017	0.589
LIG_SH2_STAT5	131	134	PF00017	0.347
LIG_SH2_STAT5	142	145	PF00017	0.289
LIG_SH2_STAT5	41	44	PF00017	0.361
LIG_SH2_STAT5	60	63	PF00017	0.319
LIG_TRFH_1	142	146	PF08558	0.289
LIG_TYR_ITIM	58	63	PF00017	0.368
LIG_UBA3_1	152	159	PF00899	0.274
LIG_WRC_WIRS_1	34	39	PF05994	0.323
MOD_GlcNHglycan	16	19	PF01048	0.456
MOD_GSK3_1	138	145	PF00069	0.234
MOD_GSK3_1	61	68	PF00069	0.356
MOD_NEK2_1	110	115	PF00069	0.316
MOD_NEK2_1	116	121	PF00069	0.311
MOD_NEK2_1	122	127	PF00069	0.310
MOD_NEK2_1	33	38	PF00069	0.324
MOD_PKA_2	133	139	PF00069	0.339
MOD_Plk_1	24	30	PF00069	0.539
MOD_Plk_4	110	116	PF00069	0.312
MOD_Plk_4	138	144	PF00069	0.235
MOD_Plk_4	24	30	PF00069	0.459
MOD_Plk_4	65	71	PF00069	0.328
MOD_ProDKin_1	142	148	PF00069	0.274
MOD_SUMO_rev_2	92	98	PF00179	0.566
TRG_ENDOCYTIC_2	112	115	PF00928	0.274
TRG_ENDOCYTIC_2	60	63	PF00928	0.285
TRG_ENDOCYTIC_2	75	78	PF00928	0.289
TRG_ER_diArg_1	101	103	PF00400	0.626
TRG_ER_diArg_1	164	167	PF00400	0.553
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK17	Leptomonas seymouri	86%	100%
A0A0S4IZQ6	Bodo saltans	58%	94%
A0A1X0NNS2	Trypanosomatidae	67%	89%
A0A3Q8I9P8	Leishmania donovani	97%	100%
A0A3S5IS67	Trypanosoma rangeli	63%	93%
A4H7I5	Leishmania braziliensis	92%	100%
A4HVW7	Leishmania infantum	97%	100%
C9ZT57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	89%
E9APL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BD78	Trypanosoma cruzi	64%	93%