Translocon-associated protein subunit gamma

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFW0_LEIMA

TriTrypDb:

LmjF.14.0250 , LMJLV39_140007600 , LMJSD75_140007600

Length:

172

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

Q4QFW0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFW0

Function

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Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006612	protein targeting to membrane	5	12
GO:0006613	cotranslational protein targeting to membrane	6	12
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.406
CLV_NRD_NRD_1	166	168	PF00675	0.378
CLV_PCSK_FUR_1	164	168	PF00082	0.381
CLV_PCSK_KEX2_1	102	104	PF00082	0.426
CLV_PCSK_KEX2_1	166	168	PF00082	0.379
DOC_MAPK_gen_1	97	106	PF00069	0.563
DOC_MAPK_MEF2A_6	52	61	PF00069	0.336
DOC_MAPK_MEF2A_6	99	108	PF00069	0.550
DOC_USP7_MATH_1	138	142	PF00917	0.282
DOC_USP7_MATH_1	24	28	PF00917	0.561

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK17	Leptomonas seymouri	86%	100%
A0A0S4IZQ6	Bodo saltans	58%	94%
A0A1X0NNS2	Trypanosomatidae	67%	89%
A0A3Q8I9P8	Leishmania donovani	97%	100%
A0A3S5IS67	Trypanosoma rangeli	63%	93%
A4H7I5	Leishmania braziliensis	92%	100%
A4HVW7	Leishmania infantum	97%	100%
C9ZT57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	89%
E9APL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BD78	Trypanosoma cruzi	64%	93%

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