VWFA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

von Willebrand factor type A domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QFV9_LEIMA

TriTrypDb:

LmjF.14.0260 , LMJLV39_140007700 , LMJSD75_140007700

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	549	553	PF00656	0.471
CLV_C14_Caspase3-7	670	674	PF00656	0.585
CLV_MEL_PAP_1	582	588	PF00089	0.447
CLV_NRD_NRD_1	706	708	PF00675	0.480
CLV_PCSK_FUR_1	704	708	PF00082	0.542
CLV_PCSK_KEX2_1	660	662	PF00082	0.561
CLV_PCSK_KEX2_1	706	708	PF00082	0.482
CLV_PCSK_PC1ET2_1	660	662	PF00082	0.403
CLV_PCSK_SKI1_1	15	19	PF00082	0.482
CLV_PCSK_SKI1_1	413	417	PF00082	0.350
CLV_PCSK_SKI1_1	546	550	PF00082	0.614
CLV_PCSK_SKI1_1	661	665	PF00082	0.435
CLV_Separin_Metazoa	267	271	PF03568	0.396
DEG_APCC_DBOX_1	179	187	PF00400	0.531
DEG_Nend_UBRbox_2	1	3	PF02207	0.620
DEG_SPOP_SBC_1	387	391	PF00917	0.302
DOC_CYCLIN_RxL_1	21	32	PF00134	0.423
DOC_MAPK_gen_1	454	463	PF00069	0.381
DOC_MAPK_MEF2A_6	248	256	PF00069	0.507
DOC_PP2B_LxvP_1	201	204	PF13499	0.433
DOC_PP4_FxxP_1	153	156	PF00568	0.466
DOC_USP7_MATH_1	118	122	PF00917	0.592
DOC_USP7_MATH_1	128	132	PF00917	0.465
DOC_USP7_MATH_1	263	267	PF00917	0.497
DOC_USP7_MATH_1	328	332	PF00917	0.393
DOC_USP7_MATH_1	335	339	PF00917	0.392
DOC_USP7_MATH_1	364	368	PF00917	0.349
DOC_USP7_MATH_1	374	378	PF00917	0.308
DOC_USP7_MATH_1	486	490	PF00917	0.548
DOC_USP7_MATH_1	494	498	PF00917	0.562
DOC_USP7_MATH_1	505	509	PF00917	0.370
DOC_USP7_MATH_1	530	534	PF00917	0.547
DOC_USP7_MATH_1	6	10	PF00917	0.581
DOC_USP7_MATH_1	65	69	PF00917	0.507
DOC_USP7_MATH_1	94	98	PF00917	0.593
DOC_WW_Pin1_4	124	129	PF00397	0.497
DOC_WW_Pin1_4	396	401	PF00397	0.456
DOC_WW_Pin1_4	540	545	PF00397	0.675
DOC_WW_Pin1_4	663	668	PF00397	0.377
LIG_14-3-3_CanoR_1	206	212	PF00244	0.503
LIG_14-3-3_CanoR_1	270	275	PF00244	0.536
LIG_14-3-3_CanoR_1	413	423	PF00244	0.427
LIG_14-3-3_CanoR_1	93	99	PF00244	0.662
LIG_Actin_WH2_2	190	208	PF00022	0.386
LIG_BIR_III_4	550	554	PF00653	0.488
LIG_BRCT_BRCA1_1	3	7	PF00533	0.662
LIG_FHA_1	117	123	PF00498	0.492
LIG_FHA_1	146	152	PF00498	0.452
LIG_FHA_1	287	293	PF00498	0.540
LIG_FHA_1	340	346	PF00498	0.349
LIG_FHA_1	414	420	PF00498	0.388
LIG_FHA_1	52	58	PF00498	0.529
LIG_FHA_1	561	567	PF00498	0.558
LIG_FHA_1	639	645	PF00498	0.538
LIG_FHA_2	239	245	PF00498	0.465
LIG_FHA_2	518	524	PF00498	0.449
LIG_FHA_2	547	553	PF00498	0.567
LIG_FHA_2	615	621	PF00498	0.519
LIG_FHA_2	644	650	PF00498	0.510
LIG_FHA_2	668	674	PF00498	0.574
LIG_LIR_Apic_2	150	156	PF02991	0.491
LIG_LIR_Apic_2	659	665	PF02991	0.374
LIG_LIR_Gen_1	249	258	PF02991	0.467
LIG_LIR_Gen_1	666	673	PF02991	0.424
LIG_LIR_Nem_3	21	26	PF02991	0.291
LIG_LIR_Nem_3	249	254	PF02991	0.588
LIG_LIR_Nem_3	4	10	PF02991	0.670
LIG_LIR_Nem_3	666	671	PF02991	0.543
LIG_NRBOX	566	572	PF00104	0.415
LIG_PCNA_yPIPBox_3	375	383	PF02747	0.205
LIG_SH2_CRK	138	142	PF00017	0.351
LIG_SH2_CRK	23	27	PF00017	0.493
LIG_SH2_CRK	251	255	PF00017	0.469
LIG_SH2_CRK	568	572	PF00017	0.468
LIG_SH2_CRK	662	666	PF00017	0.463
LIG_SH2_CRK	668	672	PF00017	0.490
LIG_SH2_GRB2like	50	53	PF00017	0.353
LIG_SH2_STAP1	29	33	PF00017	0.246
LIG_SH2_STAT3	70	73	PF00017	0.427
LIG_SH2_STAT5	232	235	PF00017	0.431
LIG_SH2_STAT5	423	426	PF00017	0.293
LIG_SH2_STAT5	50	53	PF00017	0.420
LIG_SH2_STAT5	593	596	PF00017	0.453
LIG_SH2_STAT5	639	642	PF00017	0.411
LIG_SH2_STAT5	668	671	PF00017	0.441
LIG_SH2_STAT5	89	92	PF00017	0.439
LIG_SH3_3	160	166	PF00018	0.389
LIG_SH3_3	255	261	PF00018	0.494
LIG_SH3_3	397	403	PF00018	0.406
LIG_SH3_3	685	691	PF00018	0.601
LIG_SUMO_SIM_anti_2	646	657	PF11976	0.399
LIG_SUMO_SIM_par_1	140	145	PF11976	0.420
LIG_SUMO_SIM_par_1	207	212	PF11976	0.411
LIG_SUMO_SIM_par_1	315	321	PF11976	0.349
LIG_SUMO_SIM_par_1	426	432	PF11976	0.308
LIG_SUMO_SIM_par_1	44	49	PF11976	0.454
LIG_SUMO_SIM_par_1	514	520	PF11976	0.484
LIG_SUMO_SIM_par_1	654	659	PF11976	0.472
LIG_SxIP_EBH_1	153	165	PF03271	0.445
LIG_SxIP_EBH_1	412	425	PF03271	0.350
LIG_TRAF2_1	11	14	PF00917	0.514
LIG_TRAF2_1	617	620	PF00917	0.725
LIG_TYR_ITIM	566	571	PF00017	0.476
LIG_TYR_ITSM	247	254	PF00017	0.440
LIG_UBA3_1	378	383	PF00899	0.400
MOD_CDC14_SPxK_1	543	546	PF00782	0.508
MOD_CDK_SPxK_1	540	546	PF00069	0.543
MOD_CK1_1	282	288	PF00069	0.628
MOD_CK1_1	331	337	PF00069	0.345
MOD_CK1_1	367	373	PF00069	0.465
MOD_CK1_1	489	495	PF00069	0.564
MOD_CK1_1	573	579	PF00069	0.431
MOD_CK1_1	666	672	PF00069	0.410
MOD_CK1_1	85	91	PF00069	0.565
MOD_CK1_1	9	15	PF00069	0.620
MOD_CK2_1	124	130	PF00069	0.399
MOD_CK2_1	614	620	PF00069	0.555
MOD_CK2_1	643	649	PF00069	0.456
MOD_GlcNHglycan	101	104	PF01048	0.665
MOD_GlcNHglycan	2	6	PF01048	0.663
MOD_GlcNHglycan	281	284	PF01048	0.684
MOD_GlcNHglycan	320	323	PF01048	0.386
MOD_GlcNHglycan	333	336	PF01048	0.347
MOD_GlcNHglycan	37	40	PF01048	0.502
MOD_GlcNHglycan	370	373	PF01048	0.490
MOD_GlcNHglycan	484	487	PF01048	0.437
MOD_GlcNHglycan	488	491	PF01048	0.529
MOD_GlcNHglycan	496	499	PF01048	0.323
MOD_GlcNHglycan	507	510	PF01048	0.333
MOD_GlcNHglycan	572	575	PF01048	0.542
MOD_GlcNHglycan	596	599	PF01048	0.599
MOD_GlcNHglycan	618	623	PF01048	0.697
MOD_GlcNHglycan	675	678	PF01048	0.641
MOD_GlcNHglycan	83	87	PF01048	0.578
MOD_GSK3_1	109	116	PF00069	0.580
MOD_GSK3_1	124	131	PF00069	0.460
MOD_GSK3_1	151	158	PF00069	0.467
MOD_GSK3_1	270	277	PF00069	0.546
MOD_GSK3_1	278	285	PF00069	0.668
MOD_GSK3_1	331	338	PF00069	0.395
MOD_GSK3_1	364	371	PF00069	0.417
MOD_GSK3_1	428	435	PF00069	0.371
MOD_GSK3_1	482	489	PF00069	0.509
MOD_GSK3_1	614	621	PF00069	0.738
MOD_GSK3_1	663	670	PF00069	0.434
MOD_GSK3_1	85	92	PF00069	0.565
MOD_N-GLC_1	339	344	PF02516	0.467
MOD_N-GLC_1	51	56	PF02516	0.353
MOD_NEK2_1	109	114	PF00069	0.666
MOD_NEK2_1	19	24	PF00069	0.527
MOD_NEK2_1	221	226	PF00069	0.694
MOD_NEK2_1	238	243	PF00069	0.403
MOD_NEK2_1	296	301	PF00069	0.402
MOD_NEK2_1	339	344	PF00069	0.440
MOD_NEK2_1	37	42	PF00069	0.528
MOD_NEK2_1	570	575	PF00069	0.516
MOD_NEK2_1	591	596	PF00069	0.499
MOD_NEK2_1	627	632	PF00069	0.438
MOD_PIKK_1	116	122	PF00454	0.448
MOD_PIKK_1	178	184	PF00454	0.533
MOD_PIKK_1	432	438	PF00454	0.410
MOD_PIKK_1	560	566	PF00454	0.402
MOD_PIKK_1	573	579	PF00454	0.448
MOD_PIKK_1	9	15	PF00454	0.507
MOD_PKA_2	35	41	PF00069	0.431
MOD_Plk_1	364	370	PF00069	0.354
MOD_Plk_4	128	134	PF00069	0.430
MOD_Plk_4	155	161	PF00069	0.529
MOD_Plk_4	24	30	PF00069	0.420
MOD_Plk_4	328	334	PF00069	0.400
MOD_Plk_4	341	347	PF00069	0.199
MOD_Plk_4	358	364	PF00069	0.401
MOD_Plk_4	374	380	PF00069	0.236
MOD_Plk_4	401	407	PF00069	0.423
MOD_ProDKin_1	124	130	PF00069	0.497
MOD_ProDKin_1	396	402	PF00069	0.456
MOD_ProDKin_1	540	546	PF00069	0.664
MOD_ProDKin_1	663	669	PF00069	0.380
MOD_SUMO_for_1	382	385	PF00179	0.350
MOD_SUMO_rev_2	676	684	PF00179	0.731
TRG_DiLeu_BaEn_1	14	19	PF01217	0.425
TRG_DiLeu_BaEn_1	53	58	PF01217	0.491
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.415
TRG_ENDOCYTIC_2	173	176	PF00928	0.532
TRG_ENDOCYTIC_2	23	26	PF00928	0.502
TRG_ENDOCYTIC_2	251	254	PF00928	0.574
TRG_ENDOCYTIC_2	568	571	PF00928	0.477
TRG_ENDOCYTIC_2	668	671	PF00928	0.467
TRG_ER_diArg_1	703	706	PF00400	0.509
TRG_ER_diArg_1	90	93	PF00400	0.377
TRG_NES_CRM1_1	200	212	PF08389	0.412
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B7	Leptomonas seymouri	44%	97%
A0A0S4IW67	Bodo saltans	24%	83%
A0A1X0NPD4	Trypanosomatidae	29%	86%
A0A3S5H6R0	Leishmania donovani	94%	100%
A0A422NXB2	Trypanosoma rangeli	29%	87%
A4H7I6	Leishmania braziliensis	77%	100%
A4HVW8	Leishmania infantum	95%	100%
C9ZT55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	86%
E9APL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AXR7	Trypanosoma cruzi	29%	86%