Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleus and spindle associated protein 3, putative

Species:

Leishmania major

UniProt:

Q4QFV7_LEIMA

TriTrypDb:

LmjF.14.0280 , LMJLV39_140007900 , LMJSD75_140007900

Length:

964

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005819	spindle	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QFV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFV7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	673	677	PF00656	0.491
CLV_C14_Caspase3-7	87	91	PF00656	0.497
CLV_C14_Caspase3-7	925	929	PF00656	0.702
CLV_C14_Caspase3-7	930	934	PF00656	0.641
CLV_NRD_NRD_1	165	167	PF00675	0.503
CLV_NRD_NRD_1	222	224	PF00675	0.456
CLV_NRD_NRD_1	438	440	PF00675	0.467
CLV_NRD_NRD_1	459	461	PF00675	0.521
CLV_NRD_NRD_1	467	469	PF00675	0.441
CLV_NRD_NRD_1	540	542	PF00675	0.652
CLV_NRD_NRD_1	562	564	PF00675	0.494
CLV_NRD_NRD_1	599	601	PF00675	0.430
CLV_NRD_NRD_1	614	616	PF00675	0.294
CLV_NRD_NRD_1	634	636	PF00675	0.284
CLV_NRD_NRD_1	662	664	PF00675	0.445
CLV_NRD_NRD_1	772	774	PF00675	0.438
CLV_NRD_NRD_1	918	920	PF00675	0.806
CLV_PCSK_FUR_1	220	224	PF00082	0.418
CLV_PCSK_FUR_1	465	469	PF00082	0.503
CLV_PCSK_FUR_1	919	923	PF00082	0.672
CLV_PCSK_KEX2_1	165	167	PF00082	0.538
CLV_PCSK_KEX2_1	191	193	PF00082	0.469
CLV_PCSK_KEX2_1	222	224	PF00082	0.455
CLV_PCSK_KEX2_1	288	290	PF00082	0.461
CLV_PCSK_KEX2_1	438	440	PF00082	0.467
CLV_PCSK_KEX2_1	458	460	PF00082	0.343
CLV_PCSK_KEX2_1	467	469	PF00082	0.425
CLV_PCSK_KEX2_1	540	542	PF00082	0.652
CLV_PCSK_KEX2_1	562	564	PF00082	0.494
CLV_PCSK_KEX2_1	614	616	PF00082	0.570
CLV_PCSK_KEX2_1	634	636	PF00082	0.284
CLV_PCSK_KEX2_1	662	664	PF00082	0.551
CLV_PCSK_KEX2_1	772	774	PF00082	0.444
CLV_PCSK_KEX2_1	921	923	PF00082	0.633
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.491
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.461
CLV_PCSK_PC1ET2_1	921	923	PF00082	0.633
CLV_PCSK_PC7_1	630	636	PF00082	0.571
CLV_PCSK_PC7_1	658	664	PF00082	0.533
CLV_PCSK_SKI1_1	276	280	PF00082	0.509
CLV_PCSK_SKI1_1	397	401	PF00082	0.427
CLV_PCSK_SKI1_1	412	416	PF00082	0.480
CLV_PCSK_SKI1_1	431	435	PF00082	0.488
CLV_PCSK_SKI1_1	562	566	PF00082	0.369
CLV_PCSK_SKI1_1	594	598	PF00082	0.456
CLV_PCSK_SKI1_1	710	714	PF00082	0.431
CLV_PCSK_SKI1_1	823	827	PF00082	0.524
CLV_Separin_Metazoa	233	237	PF03568	0.482
DEG_APCC_DBOX_1	214	222	PF00400	0.388
DEG_APCC_DBOX_1	466	474	PF00400	0.475
DEG_APCC_DBOX_1	641	649	PF00400	0.482
DEG_APCC_DBOX_1	764	772	PF00400	0.389
DEG_COP1_1	205	214	PF00400	0.532
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_ODPH_VHL_1	507	519	PF01847	0.467
DEG_SCF_FBW7_1	846	853	PF00400	0.647
DEG_SPOP_SBC_1	860	864	PF00917	0.695
DOC_ANK_TNKS_1	923	930	PF00023	0.659
DOC_CYCLIN_RxL_1	165	176	PF00134	0.497
DOC_CYCLIN_RxL_1	428	437	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	354	360	PF00134	0.538
DOC_MAPK_DCC_7	642	650	PF00069	0.530
DOC_MAPK_gen_1	165	173	PF00069	0.462
DOC_MAPK_gen_1	597	606	PF00069	0.384
DOC_MAPK_gen_1	736	745	PF00069	0.410
DOC_MAPK_gen_1	772	778	PF00069	0.407
DOC_MAPK_gen_1	798	806	PF00069	0.413
DOC_MAPK_MEF2A_6	223	232	PF00069	0.443
DOC_MAPK_MEF2A_6	600	608	PF00069	0.376
DOC_MAPK_MEF2A_6	736	745	PF00069	0.385
DOC_MAPK_NFAT4_5	601	609	PF00069	0.371
DOC_MAPK_RevD_3	602	615	PF00069	0.462
DOC_PP1_RVXF_1	50	57	PF00149	0.327
DOC_PP2B_LxvP_1	18	21	PF13499	0.374
DOC_PP2B_LxvP_1	208	211	PF13499	0.390
DOC_PP2B_LxvP_1	354	357	PF13499	0.547
DOC_PP2B_LxvP_1	358	361	PF13499	0.549
DOC_PP4_FxxP_1	199	202	PF00568	0.577
DOC_PP4_FxxP_1	415	418	PF00568	0.519
DOC_USP7_MATH_1	475	479	PF00917	0.498
DOC_USP7_MATH_1	860	864	PF00917	0.748
DOC_USP7_UBL2_3	187	191	PF12436	0.461
DOC_USP7_UBL2_3	597	601	PF12436	0.420
DOC_WW_Pin1_4	311	316	PF00397	0.585
DOC_WW_Pin1_4	421	426	PF00397	0.509
DOC_WW_Pin1_4	831	836	PF00397	0.571
DOC_WW_Pin1_4	846	851	PF00397	0.672
LIG_14-3-3_CanoR_1	115	121	PF00244	0.417
LIG_14-3-3_CanoR_1	220	230	PF00244	0.496
LIG_14-3-3_CanoR_1	402	407	PF00244	0.548
LIG_14-3-3_CanoR_1	662	670	PF00244	0.453
LIG_14-3-3_CanoR_1	710	719	PF00244	0.348
LIG_14-3-3_CanoR_1	733	743	PF00244	0.392
LIG_14-3-3_CanoR_1	773	779	PF00244	0.489
LIG_14-3-3_CanoR_1	97	101	PF00244	0.495
LIG_APCC_ABBA_1	743	748	PF00400	0.343
LIG_BIR_III_4	890	894	PF00653	0.566
LIG_BRCT_BRCA1_1	436	440	PF00533	0.600
LIG_BRCT_BRCA1_1	477	481	PF00533	0.372
LIG_BRCT_BRCA1_1	736	740	PF00533	0.426
LIG_BRCT_BRCA1_1	821	825	PF00533	0.535
LIG_BRCT_BRCA1_1	92	96	PF00533	0.514
LIG_DLG_GKlike_1	402	409	PF00625	0.575
LIG_FHA_1	150	156	PF00498	0.545
LIG_FHA_1	366	372	PF00498	0.446
LIG_FHA_1	525	531	PF00498	0.576
LIG_FHA_1	547	553	PF00498	0.603
LIG_FHA_1	711	717	PF00498	0.355
LIG_FHA_1	724	730	PF00498	0.398
LIG_FHA_1	778	784	PF00498	0.454
LIG_FHA_1	80	86	PF00498	0.458
LIG_FHA_1	906	912	PF00498	0.658
LIG_FHA_2	183	189	PF00498	0.525
LIG_FHA_2	261	267	PF00498	0.460
LIG_FHA_2	946	952	PF00498	0.786
LIG_LIR_Apic_2	196	202	PF02991	0.567
LIG_LIR_Apic_2	257	261	PF02991	0.437
LIG_LIR_Apic_2	413	418	PF02991	0.497
LIG_LIR_Gen_1	181	190	PF02991	0.373
LIG_LIR_Gen_1	277	285	PF02991	0.504
LIG_LIR_Gen_1	374	384	PF02991	0.394
LIG_LIR_Gen_1	405	414	PF02991	0.507
LIG_LIR_Gen_1	442	450	PF02991	0.451
LIG_LIR_Gen_1	478	489	PF02991	0.390
LIG_LIR_Gen_1	496	504	PF02991	0.416
LIG_LIR_Gen_1	777	787	PF02991	0.389
LIG_LIR_Gen_1	841	850	PF02991	0.552
LIG_LIR_LC3C_4	205	210	PF02991	0.480
LIG_LIR_Nem_3	181	186	PF02991	0.382
LIG_LIR_Nem_3	277	282	PF02991	0.504
LIG_LIR_Nem_3	374	380	PF02991	0.413
LIG_LIR_Nem_3	405	409	PF02991	0.546
LIG_LIR_Nem_3	442	446	PF02991	0.433
LIG_LIR_Nem_3	478	484	PF02991	0.358
LIG_LIR_Nem_3	496	500	PF02991	0.372
LIG_LIR_Nem_3	569	575	PF02991	0.521
LIG_LIR_Nem_3	718	722	PF02991	0.461
LIG_LIR_Nem_3	737	743	PF02991	0.233
LIG_LIR_Nem_3	777	782	PF02991	0.375
LIG_LIR_Nem_3	786	791	PF02991	0.545
LIG_LIR_Nem_3	841	846	PF02991	0.542
LIG_MLH1_MIPbox_1	477	481	PF16413	0.372
LIG_MLH1_MIPbox_1	821	825	PF16413	0.541
LIG_PCNA_PIPBox_1	427	436	PF02747	0.615
LIG_REV1ctd_RIR_1	822	830	PF16727	0.579
LIG_RPA_C_Fungi	454	466	PF08784	0.589
LIG_SH2_CRK	138	142	PF00017	0.471
LIG_SH2_CRK	183	187	PF00017	0.451
LIG_SH2_CRK	406	410	PF00017	0.500
LIG_SH2_CRK	497	501	PF00017	0.416
LIG_SH2_CRK	637	641	PF00017	0.524
LIG_SH2_CRK	788	792	PF00017	0.540
LIG_SH2_CRK	843	847	PF00017	0.686
LIG_SH2_NCK_1	158	162	PF00017	0.420
LIG_SH2_NCK_1	497	501	PF00017	0.416
LIG_SH2_NCK_1	843	847	PF00017	0.659
LIG_SH2_PTP2	258	261	PF00017	0.480
LIG_SH2_STAP1	138	142	PF00017	0.496
LIG_SH2_STAP1	350	354	PF00017	0.448
LIG_SH2_STAP1	377	381	PF00017	0.399
LIG_SH2_STAP1	788	792	PF00017	0.435
LIG_SH2_STAT5	110	113	PF00017	0.352
LIG_SH2_STAT5	170	173	PF00017	0.410
LIG_SH2_STAT5	258	261	PF00017	0.504
LIG_SH2_STAT5	342	345	PF00017	0.413
LIG_SH2_STAT5	767	770	PF00017	0.481
LIG_SH2_STAT5	781	784	PF00017	0.277
LIG_SH3_3	174	180	PF00018	0.499
LIG_SH3_3	250	256	PF00018	0.617
LIG_SH3_3	388	394	PF00018	0.451
LIG_SH3_3	523	529	PF00018	0.558
LIG_SUMO_SIM_anti_2	205	212	PF11976	0.485
LIG_SUMO_SIM_anti_2	362	368	PF11976	0.302
LIG_SUMO_SIM_anti_2	448	454	PF11976	0.524
LIG_SUMO_SIM_anti_2	801	808	PF11976	0.519
LIG_SUMO_SIM_par_1	205	212	PF11976	0.535
LIG_SUMO_SIM_par_1	801	808	PF11976	0.519
LIG_SxIP_EBH_1	238	247	PF03271	0.469
LIG_TRAF2_1	122	125	PF00917	0.653
LIG_TRAF2_1	376	379	PF00917	0.466
LIG_TRAF2_1	913	916	PF00917	0.778
LIG_TRAF2_1	938	941	PF00917	0.663
LIG_TRAF2_1	948	951	PF00917	0.509
LIG_TRFH_1	406	410	PF08558	0.456
LIG_TYR_ITIM	136	141	PF00017	0.606
LIG_UBA3_1	366	375	PF00899	0.330
LIG_WRC_WIRS_1	716	721	PF05994	0.494
MOD_CK1_1	119	125	PF00069	0.539
MOD_CK1_1	226	232	PF00069	0.462
MOD_CK1_1	316	322	PF00069	0.593
MOD_CK1_1	543	549	PF00069	0.664
MOD_CK1_1	641	647	PF00069	0.555
MOD_CK1_1	723	729	PF00069	0.495
MOD_CK1_1	79	85	PF00069	0.440
MOD_CK1_1	896	902	PF00069	0.659
MOD_CK1_1	905	911	PF00069	0.708
MOD_CK2_1	119	125	PF00069	0.619
MOD_CK2_1	127	133	PF00069	0.658
MOD_CK2_1	260	266	PF00069	0.414
MOD_CK2_1	66	72	PF00069	0.553
MOD_CK2_1	842	848	PF00069	0.607
MOD_CK2_1	882	888	PF00069	0.798
MOD_CK2_1	895	901	PF00069	0.574
MOD_CK2_1	910	916	PF00069	0.730
MOD_CK2_1	945	951	PF00069	0.713
MOD_GlcNHglycan	130	133	PF01048	0.567
MOD_GlcNHglycan	18	21	PF01048	0.287
MOD_GlcNHglycan	3	6	PF01048	0.601
MOD_GlcNHglycan	317	321	PF01048	0.587
MOD_GlcNHglycan	344	347	PF01048	0.527
MOD_GlcNHglycan	546	549	PF01048	0.692
MOD_GlcNHglycan	60	63	PF01048	0.489
MOD_GlcNHglycan	736	739	PF01048	0.418
MOD_GlcNHglycan	884	887	PF01048	0.725
MOD_GlcNHglycan	904	907	PF01048	0.697
MOD_GSK3_1	115	122	PF00069	0.465
MOD_GSK3_1	294	301	PF00069	0.569
MOD_GSK3_1	316	323	PF00069	0.560
MOD_GSK3_1	338	345	PF00069	0.574
MOD_GSK3_1	421	428	PF00069	0.560
MOD_GSK3_1	484	491	PF00069	0.524
MOD_GSK3_1	540	547	PF00069	0.700
MOD_GSK3_1	58	65	PF00069	0.493
MOD_GSK3_1	751	758	PF00069	0.484
MOD_GSK3_1	838	845	PF00069	0.657
MOD_GSK3_1	846	853	PF00069	0.645
MOD_GSK3_1	860	867	PF00069	0.711
MOD_LATS_1	539	545	PF00433	0.684
MOD_N-GLC_1	249	254	PF02516	0.609
MOD_N-GLC_1	622	627	PF02516	0.565
MOD_N-GLC_1	723	728	PF02516	0.523
MOD_N-GLC_2	513	515	PF02516	0.508
MOD_N-GLC_2	568	570	PF02516	0.458
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	173	178	PF00069	0.366
MOD_NEK2_1	221	226	PF00069	0.491
MOD_NEK2_1	274	279	PF00069	0.519
MOD_NEK2_1	327	332	PF00069	0.608
MOD_NEK2_1	349	354	PF00069	0.472
MOD_NEK2_1	433	438	PF00069	0.573
MOD_NEK2_1	488	493	PF00069	0.577
MOD_NEK2_1	66	71	PF00069	0.592
MOD_NEK2_1	720	725	PF00069	0.517
MOD_NEK2_1	746	751	PF00069	0.358
MOD_NEK2_1	771	776	PF00069	0.514
MOD_NEK2_1	838	843	PF00069	0.634
MOD_NEK2_1	96	101	PF00069	0.383
MOD_NEK2_2	116	121	PF00069	0.535
MOD_NEK2_2	281	286	PF00069	0.399
MOD_NEK2_2	383	388	PF00069	0.396
MOD_NEK2_2	410	415	PF00069	0.460
MOD_NEK2_2	475	480	PF00069	0.493
MOD_PIKK_1	850	856	PF00454	0.614
MOD_PKA_1	540	546	PF00069	0.672
MOD_PKA_2	214	220	PF00069	0.423
MOD_PKA_2	221	227	PF00069	0.426
MOD_PKA_2	434	440	PF00069	0.554
MOD_PKA_2	540	546	PF00069	0.657
MOD_PKA_2	641	647	PF00069	0.468
MOD_PKA_2	771	777	PF00069	0.529
MOD_PKA_2	96	102	PF00069	0.503
MOD_PKB_1	458	466	PF00069	0.574
MOD_PKB_1	943	951	PF00069	0.637
MOD_Plk_1	249	255	PF00069	0.618
MOD_Plk_1	316	322	PF00069	0.579
MOD_Plk_1	62	68	PF00069	0.603
MOD_Plk_4	103	109	PF00069	0.509
MOD_Plk_4	142	148	PF00069	0.495
MOD_Plk_4	173	179	PF00069	0.498
MOD_Plk_4	214	220	PF00069	0.527
MOD_Plk_4	240	246	PF00069	0.503
MOD_Plk_4	254	260	PF00069	0.569
MOD_Plk_4	338	344	PF00069	0.458
MOD_Plk_4	410	416	PF00069	0.507
MOD_Plk_4	475	481	PF00069	0.368
MOD_Plk_4	715	721	PF00069	0.492
MOD_Plk_4	774	780	PF00069	0.386
MOD_Plk_4	799	805	PF00069	0.384
MOD_ProDKin_1	311	317	PF00069	0.586
MOD_ProDKin_1	421	427	PF00069	0.507
MOD_ProDKin_1	831	837	PF00069	0.573
MOD_ProDKin_1	846	852	PF00069	0.670
MOD_SUMO_for_1	261	264	PF00179	0.493
TRG_DiLeu_BaEn_1	442	447	PF01217	0.474
TRG_DiLeu_BaEn_4	502	508	PF01217	0.429
TRG_ENDOCYTIC_2	138	141	PF00928	0.475
TRG_ENDOCYTIC_2	170	173	PF00928	0.368
TRG_ENDOCYTIC_2	183	186	PF00928	0.352
TRG_ENDOCYTIC_2	377	380	PF00928	0.392
TRG_ENDOCYTIC_2	406	409	PF00928	0.469
TRG_ENDOCYTIC_2	497	500	PF00928	0.411
TRG_ENDOCYTIC_2	637	640	PF00928	0.523
TRG_ENDOCYTIC_2	788	791	PF00928	0.542
TRG_ENDOCYTIC_2	843	846	PF00928	0.708
TRG_ER_diArg_1	165	167	PF00400	0.466
TRG_ER_diArg_1	219	222	PF00400	0.410
TRG_ER_diArg_1	438	440	PF00400	0.467
TRG_ER_diArg_1	457	460	PF00400	0.396
TRG_ER_diArg_1	465	468	PF00400	0.437
TRG_ER_diArg_1	562	564	PF00400	0.497
TRG_ER_diArg_1	614	616	PF00400	0.588
TRG_ER_diArg_1	661	663	PF00400	0.542
TRG_ER_diArg_1	771	773	PF00400	0.435
TRG_ER_diArg_1	821	824	PF00400	0.425
TRG_NLS_MonoCore_2	918	923	PF00514	0.689
TRG_NLS_MonoExtC_3	918	923	PF00514	0.754
TRG_NLS_MonoExtN_4	918	925	PF00514	0.752
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	638	643	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK9	Leptomonas seymouri	79%	100%
A0A0S4IYU3	Bodo saltans	26%	83%
A0A1X0NQD8	Trypanosomatidae	46%	91%
A0A3S7WST9	Leishmania donovani	96%	100%
A0A422NXF4	Trypanosoma rangeli	47%	95%
A4H7I7	Leishmania braziliensis	89%	100%
A4HVX0	Leishmania infantum	96%	100%
C9ZT54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	93%
E9APM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BHS0	Trypanosoma cruzi	47%	96%