NAD(P)-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFV6_LEIMA

TriTrypDb:

LmjF.14.0290 , LMJLV39_140008000 , LMJSD75_140008000

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFV6

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	2
GO:0006744	ubiquinone biosynthetic process	6	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0042180	cellular ketone metabolic process	3	2
GO:0042181	ketone biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901004	ubiquinone-6 metabolic process	6	2
GO:1901006	ubiquinone-6 biosynthetic process	7	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901661	quinone metabolic process	4	2
GO:1901663	quinone biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0044877	protein-containing complex binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.445
CLV_NRD_NRD_1	126	128	PF00675	0.637
CLV_PCSK_KEX2_1	126	128	PF00082	0.642
CLV_PCSK_KEX2_1	142	144	PF00082	0.413
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.413
CLV_PCSK_SKI1_1	126	130	PF00082	0.600
CLV_PCSK_SKI1_1	132	136	PF00082	0.344
CLV_PCSK_SKI1_1	147	151	PF00082	0.330
CLV_PCSK_SKI1_1	169	173	PF00082	0.547
CLV_PCSK_SKI1_1	198	202	PF00082	0.537
CLV_PCSK_SKI1_1	3	7	PF00082	0.667
DEG_SPOP_SBC_1	16	20	PF00917	0.783
DOC_CYCLIN_yClb1_LxF_4	43	49	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	209	212	PF00134	0.443
DOC_MAPK_MEF2A_6	207	215	PF00069	0.507
DOC_PP2B_LxvP_1	185	188	PF13499	0.575
DOC_PP2B_LxvP_1	208	211	PF13499	0.450
DOC_USP7_MATH_1	16	20	PF00917	0.758
DOC_USP7_UBL2_3	132	136	PF12436	0.554
DOC_WW_Pin1_4	12	17	PF00397	0.750
LIG_14-3-3_CanoR_1	3	12	PF00244	0.758
LIG_Actin_WH2_2	146	163	PF00022	0.396
LIG_BIR_II_1	1	5	PF00653	0.634
LIG_FHA_1	166	172	PF00498	0.447
LIG_FHA_1	182	188	PF00498	0.405
LIG_FHA_1	68	74	PF00498	0.423
LIG_FHA_2	52	58	PF00498	0.545
LIG_LIR_Gen_1	47	53	PF02991	0.438
LIG_LIR_Gen_1	57	67	PF02991	0.412
LIG_LIR_Nem_3	119	124	PF02991	0.504
LIG_LIR_Nem_3	47	51	PF02991	0.456
LIG_LIR_Nem_3	57	63	PF02991	0.407
LIG_MAD2	112	120	PF02301	0.407
LIG_NRP_CendR_1	277	280	PF00754	0.524
LIG_SH2_SRC	83	86	PF00017	0.501
LIG_SH2_STAP1	124	128	PF00017	0.597
LIG_SH2_STAT5	115	118	PF00017	0.429
LIG_SH2_STAT5	138	141	PF00017	0.362
LIG_SH3_3	156	162	PF00018	0.345
LIG_SH3_3	98	104	PF00018	0.496
LIG_UBA3_1	199	207	PF00899	0.542
MOD_CK1_1	11	17	PF00069	0.727
MOD_CK1_1	18	24	PF00069	0.729
MOD_CK1_1	183	189	PF00069	0.505
MOD_CK1_1	267	273	PF00069	0.587
MOD_CK2_1	252	258	PF00069	0.614
MOD_Cter_Amidation	140	143	PF01082	0.371
MOD_GlcNHglycan	116	119	PF01048	0.353
MOD_GlcNHglycan	174	177	PF01048	0.557
MOD_GlcNHglycan	20	23	PF01048	0.714
MOD_GlcNHglycan	28	31	PF01048	0.646
MOD_GSK3_1	1	8	PF00069	0.725
MOD_GSK3_1	11	18	PF00069	0.708
MOD_GSK3_1	260	267	PF00069	0.607
MOD_GSK3_1	47	54	PF00069	0.447
MOD_N-GLC_1	260	265	PF02516	0.643
MOD_NEK2_1	1	6	PF00069	0.770
MOD_NEK2_1	106	111	PF00069	0.485
MOD_NEK2_1	172	177	PF00069	0.624
MOD_NEK2_1	33	38	PF00069	0.552
MOD_PIKK_1	5	11	PF00454	0.709
MOD_PKA_2	160	166	PF00069	0.468
MOD_PKA_2	26	32	PF00069	0.679
MOD_Plk_1	271	277	PF00069	0.637
MOD_Plk_1	67	73	PF00069	0.411
MOD_Plk_2-3	47	53	PF00069	0.440
MOD_Plk_4	160	166	PF00069	0.425
MOD_ProDKin_1	12	18	PF00069	0.750
TRG_ER_diArg_1	126	128	PF00400	0.657
TRG_ER_diArg_1	243	246	PF00400	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I087	Leptomonas seymouri	75%	80%
A0A1X0NQ86	Trypanosomatidae	38%	91%
A0A3Q8I8Q3	Leishmania donovani	92%	100%
A0A422NX27	Trypanosoma rangeli	49%	100%
A4H7I8	Leishmania braziliensis	82%	83%
A4HVX1	Leishmania infantum	93%	100%
C9ZT51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	96%
E9APM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q9FVR6	Arabidopsis thaliana	30%	95%