Aa_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane amino acid transporter protein, putative

Species:

Leishmania major

UniProt:

Q4QFV2_LEIMA

TriTrypDb:

LmjF.14.0330 , LMJLV39_140008400 , LMJLV39_140008500 , LMJSD75_140008400

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QFV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFV2

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	2
GO:0006865	amino acid transport	5	2
GO:0009987	cellular process	1	2
GO:0015849	organic acid transport	5	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0055085	transmembrane transport	2	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0022857	transmembrane transporter activity	2	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.415
CLV_NRD_NRD_1	129	131	PF00675	0.783
CLV_NRD_NRD_1	592	594	PF00675	0.407
CLV_PCSK_KEX2_1	129	131	PF00082	0.783
CLV_PCSK_KEX2_1	592	594	PF00082	0.408
CLV_PCSK_SKI1_1	316	320	PF00082	0.576
CLV_PCSK_SKI1_1	327	331	PF00082	0.518
CLV_PCSK_SKI1_1	524	528	PF00082	0.314
CLV_PCSK_SKI1_1	592	596	PF00082	0.416
DEG_COP1_1	264	273	PF00400	0.444
DEG_Kelch_Keap1_1	115	120	PF01344	0.454
DEG_Nend_UBRbox_1	1	4	PF02207	0.565
DEG_SCF_FBW7_1	24	31	PF00400	0.552
DEG_SPOP_SBC_1	262	266	PF00917	0.503
DEG_SPOP_SBC_1	33	37	PF00917	0.450
DEG_SPOP_SBC_1	412	416	PF00917	0.491
DOC_CDC14_PxL_1	295	303	PF14671	0.484
DOC_CKS1_1	110	115	PF01111	0.620
DOC_CKS1_1	25	30	PF01111	0.588
DOC_CKS1_1	335	340	PF01111	0.221
DOC_CYCLIN_RxL_1	313	323	PF00134	0.336
DOC_CYCLIN_RxL_1	518	532	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.301
DOC_MAPK_gen_1	481	488	PF00069	0.221
DOC_MAPK_gen_1	524	533	PF00069	0.510
DOC_MAPK_MEF2A_6	393	400	PF00069	0.540
DOC_MAPK_MEF2A_6	524	533	PF00069	0.490
DOC_MAPK_RevD_3	579	593	PF00069	0.450
DOC_PIKK_1	177	185	PF02985	0.502
DOC_PP2B_LxvP_1	26	29	PF13499	0.525
DOC_PP2B_LxvP_1	437	440	PF13499	0.391
DOC_PP4_FxxP_1	22	25	PF00568	0.554
DOC_USP7_MATH_1	101	105	PF00917	0.551
DOC_USP7_MATH_1	155	159	PF00917	0.554
DOC_USP7_MATH_1	214	218	PF00917	0.482
DOC_USP7_MATH_1	231	235	PF00917	0.571
DOC_USP7_MATH_1	305	309	PF00917	0.400
DOC_USP7_MATH_1	33	37	PF00917	0.554
DOC_USP7_MATH_1	357	361	PF00917	0.438
DOC_USP7_MATH_1	412	416	PF00917	0.388
DOC_USP7_MATH_1	460	464	PF00917	0.388
DOC_USP7_UBL2_3	371	375	PF12436	0.518
DOC_WW_Pin1_4	109	114	PF00397	0.572
DOC_WW_Pin1_4	15	20	PF00397	0.620
DOC_WW_Pin1_4	24	29	PF00397	0.573
DOC_WW_Pin1_4	334	339	PF00397	0.221
DOC_WW_Pin1_4	489	494	PF00397	0.362
DOC_WW_Pin1_4	56	61	PF00397	0.583
DOC_WW_Pin1_4	604	609	PF00397	0.560
LIG_14-3-3_CanoR_1	252	262	PF00244	0.409
LIG_14-3-3_CanoR_1	530	534	PF00244	0.386
LIG_14-3-3_CanoR_1	569	578	PF00244	0.349
LIG_14-3-3_CanoR_1	599	606	PF00244	0.666
LIG_Actin_WH2_2	554	571	PF00022	0.358
LIG_BIR_III_4	218	222	PF00653	0.395
LIG_BRCT_BRCA1_1	233	237	PF00533	0.550
LIG_BRCT_BRCA1_1	322	326	PF00533	0.405
LIG_BRCT_BRCA1_1	335	339	PF00533	0.360
LIG_BRCT_BRCA1_1	493	497	PF00533	0.397
LIG_Clathr_ClatBox_1	473	477	PF01394	0.438
LIG_EH1_1	401	409	PF00400	0.391
LIG_eIF4E_1	402	408	PF01652	0.255
LIG_eIF4E_1	87	93	PF01652	0.441
LIG_FHA_1	116	122	PF00498	0.503
LIG_FHA_1	281	287	PF00498	0.506
LIG_FHA_1	330	336	PF00498	0.341
LIG_FHA_1	463	469	PF00498	0.427
LIG_FHA_1	511	517	PF00498	0.438
LIG_FHA_1	553	559	PF00498	0.316
LIG_FHA_1	605	611	PF00498	0.566
LIG_FHA_1	88	94	PF00498	0.581
LIG_FHA_2	192	198	PF00498	0.499
LIG_FHA_2	94	100	PF00498	0.602
LIG_HP1_1	446	450	PF01393	0.438
LIG_LIR_Gen_1	354	363	PF02991	0.430
LIG_LIR_Gen_1	494	505	PF02991	0.326
LIG_LIR_LC3C_4	300	303	PF02991	0.415
LIG_LIR_Nem_3	323	329	PF02991	0.390
LIG_LIR_Nem_3	354	358	PF02991	0.430
LIG_LIR_Nem_3	494	500	PF02991	0.362
LIG_LIR_Nem_3	536	540	PF02991	0.399
LIG_LIR_Nem_3	546	551	PF02991	0.357
LIG_LIR_Nem_3	601	606	PF02991	0.690
LIG_LYPXL_yS_3	395	398	PF13949	0.525
LIG_MAD2	379	387	PF02301	0.560
LIG_MLH1_MIPbox_1	493	497	PF16413	0.397
LIG_MYND_1	24	28	PF01753	0.550
LIG_PDZ_Class_1	611	616	PF00595	0.580
LIG_Pex14_1	391	395	PF04695	0.530
LIG_Pex14_2	105	109	PF04695	0.540
LIG_Pex14_2	322	326	PF04695	0.405
LIG_PTB_Apo_2	396	403	PF02174	0.560
LIG_PTB_Phospho_1	396	402	PF10480	0.560
LIG_REV1ctd_RIR_1	327	335	PF16727	0.221
LIG_SH2_CRK	402	406	PF00017	0.373
LIG_SH2_STAP1	362	366	PF00017	0.392
LIG_SH2_STAT5	367	370	PF00017	0.531
LIG_SH2_STAT5	525	528	PF00017	0.508
LIG_SH2_STAT5	87	90	PF00017	0.564
LIG_SH3_3	22	28	PF00018	0.604
LIG_SH3_3	48	54	PF00018	0.585
LIG_SH3_3	516	522	PF00018	0.560
LIG_SH3_3	528	534	PF00018	0.560
LIG_Sin3_3	572	579	PF02671	0.491
LIG_SUMO_SIM_anti_2	441	446	PF11976	0.244
LIG_SUMO_SIM_anti_2	470	475	PF11976	0.419
LIG_SUMO_SIM_anti_2	580	585	PF11976	0.391
LIG_SUMO_SIM_par_1	349	354	PF11976	0.434
LIG_SUMO_SIM_par_1	457	463	PF11976	0.525
LIG_SUMO_SIM_par_1	512	517	PF11976	0.491
LIG_SUMO_SIM_par_1	559	565	PF11976	0.320
LIG_SUMO_SIM_par_1	582	588	PF11976	0.244
LIG_SUMO_SIM_par_1	61	66	PF11976	0.444
LIG_TRAF2_1	194	197	PF00917	0.498
LIG_TRFH_1	53	57	PF08558	0.559
LIG_TYR_ITSM	599	606	PF00017	0.671
LIG_UBA3_1	421	428	PF00899	0.397
LIG_WRC_WIRS_1	326	331	PF05994	0.371
LIG_WRC_WIRS_1	352	357	PF05994	0.380
MOD_CDK_SPK_2	15	20	PF00069	0.531
MOD_CDK_SPxxK_3	109	116	PF00069	0.611
MOD_CK1_1	115	121	PF00069	0.523
MOD_CK1_1	275	281	PF00069	0.498
MOD_CK1_1	512	518	PF00069	0.491
MOD_CK1_1	557	563	PF00069	0.336
MOD_CK2_1	114	120	PF00069	0.594
MOD_CK2_1	160	166	PF00069	0.580
MOD_CK2_1	191	197	PF00069	0.469
MOD_CK2_1	489	495	PF00069	0.303
MOD_CK2_1	582	588	PF00069	0.494
MOD_CMANNOS	391	394	PF00535	0.360
MOD_GlcNHglycan	140	143	PF01048	0.787
MOD_GlcNHglycan	177	182	PF01048	0.753
MOD_GlcNHglycan	274	277	PF01048	0.667
MOD_GlcNHglycan	307	310	PF01048	0.496
MOD_GlcNHglycan	430	433	PF01048	0.363
MOD_GlcNHglycan	545	548	PF01048	0.417
MOD_GlcNHglycan	564	567	PF01048	0.396
MOD_GlcNHglycan	572	575	PF01048	0.336
MOD_GlcNHglycan	6	9	PF01048	0.807
MOD_GlcNHglycan	82	85	PF01048	0.715
MOD_GSK3_1	108	115	PF00069	0.528
MOD_GSK3_1	20	27	PF00069	0.575
MOD_GSK3_1	272	279	PF00069	0.447
MOD_GSK3_1	28	35	PF00069	0.415
MOD_GSK3_1	305	312	PF00069	0.368
MOD_GSK3_1	325	332	PF00069	0.366
MOD_GSK3_1	357	364	PF00069	0.425
MOD_GSK3_1	408	415	PF00069	0.331
MOD_GSK3_1	487	494	PF00069	0.356
MOD_GSK3_1	505	512	PF00069	0.339
MOD_GSK3_1	529	536	PF00069	0.548
MOD_GSK3_1	69	76	PF00069	0.563
MOD_N-GLC_1	123	128	PF02516	0.785
MOD_N-GLC_1	155	160	PF02516	0.705
MOD_N-GLC_1	39	44	PF02516	0.734
MOD_N-GLC_1	552	557	PF02516	0.568
MOD_NEK2_1	254	259	PF00069	0.445
MOD_NEK2_1	280	285	PF00069	0.395
MOD_NEK2_1	322	327	PF00069	0.352
MOD_NEK2_1	329	334	PF00069	0.295
MOD_NEK2_1	34	39	PF00069	0.520
MOD_NEK2_1	413	418	PF00069	0.318
MOD_NEK2_1	427	432	PF00069	0.292
MOD_NEK2_1	449	454	PF00069	0.552
MOD_NEK2_1	462	467	PF00069	0.376
MOD_NEK2_1	500	505	PF00069	0.414
MOD_NEK2_1	529	534	PF00069	0.506
MOD_NEK2_1	543	548	PF00069	0.335
MOD_NEK2_1	559	564	PF00069	0.254
MOD_NEK2_1	577	582	PF00069	0.162
MOD_NEK2_1	595	600	PF00069	0.725
MOD_NEK2_1	611	616	PF00069	0.605
MOD_NEK2_1	63	68	PF00069	0.593
MOD_NEK2_1	88	93	PF00069	0.528
MOD_NEK2_2	101	106	PF00069	0.448
MOD_PIKK_1	452	458	PF00454	0.525
MOD_PKA_2	138	144	PF00069	0.582
MOD_PKA_2	191	197	PF00069	0.541
MOD_PKA_2	529	535	PF00069	0.525
MOD_PKA_2	598	604	PF00069	0.672
MOD_PKA_2	73	79	PF00069	0.550
MOD_Plk_1	476	482	PF00069	0.491
MOD_Plk_4	132	138	PF00069	0.584
MOD_Plk_4	241	247	PF00069	0.414
MOD_Plk_4	264	270	PF00069	0.533
MOD_Plk_4	351	357	PF00069	0.354
MOD_Plk_4	438	444	PF00069	0.391
MOD_Plk_4	467	473	PF00069	0.418
MOD_Plk_4	500	506	PF00069	0.494
MOD_Plk_4	554	560	PF00069	0.325
MOD_Plk_4	579	585	PF00069	0.450
MOD_Plk_4	88	94	PF00069	0.511
MOD_ProDKin_1	109	115	PF00069	0.573
MOD_ProDKin_1	15	21	PF00069	0.621
MOD_ProDKin_1	24	30	PF00069	0.573
MOD_ProDKin_1	334	340	PF00069	0.221
MOD_ProDKin_1	489	495	PF00069	0.362
MOD_ProDKin_1	56	62	PF00069	0.586
MOD_ProDKin_1	604	610	PF00069	0.560
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.416
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.505
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.456
TRG_DiLeu_BaLyEn_6	58	63	PF01217	0.526
TRG_DiLeu_BaLyEn_6	590	595	PF01217	0.578
TRG_ENDOCYTIC_2	206	209	PF00928	0.466
TRG_ENDOCYTIC_2	395	398	PF00928	0.499
TRG_ENDOCYTIC_2	402	405	PF00928	0.357
TRG_ENDOCYTIC_2	525	528	PF00928	0.501
TRG_ENDOCYTIC_2	603	606	PF00928	0.642
TRG_ER_diArg_1	592	594	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.786
TRG_PTS1	613	616	PF00515	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C5	Leptomonas seymouri	62%	84%
A0A0N1PBG3	Leptomonas seymouri	30%	73%
A0A0S4ISI1	Bodo saltans	43%	100%
A0A3S7WST2	Leishmania donovani	87%	87%
A4H7J2	Leishmania braziliensis	69%	86%
A4HVX5	Leishmania infantum	88%	87%
E9APM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	88%