Choline transporter-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Plasma-membrane choline transporter, putative

Species:

Leishmania major

UniProt:

Q4QFU7_LEIMA

TriTrypDb:

LmjF.14.0380 , LMJLV39_140009100 , LMJSD75_140009000

Length:

607

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005886	plasma membrane	3	14
GO:0016020	membrane	2	14
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	14

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Expansion

Sequence features

Q4QFU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFU7

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0009987	cellular process	1	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0055085	transmembrane transport	2	3

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	14
GO:0022857	transmembrane transporter activity	2	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	443	447	PF00656	0.467
CLV_NRD_NRD_1	595	597	PF00675	0.419
CLV_PCSK_KEX2_1	595	597	PF00082	0.419
CLV_PCSK_SKI1_1	320	324	PF00082	0.313
CLV_PCSK_SKI1_1	81	85	PF00082	0.412
DEG_MDM2_SWIB_1	369	377	PF02201	0.409
DEG_SPOP_SBC_1	231	235	PF00917	0.373
DEG_SPOP_SBC_1	303	307	PF00917	0.440
DEG_SPOP_SBC_1	413	417	PF00917	0.378
DEG_SPOP_SBC_1	441	445	PF00917	0.451

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA24	Leptomonas seymouri	56%	100%
A0A0S4KHP0	Bodo saltans	33%	100%
A0A3Q8I9V7	Leishmania donovani	93%	100%
A0A3S7XAV8	Leishmania donovani	36%	100%
A4H7J7	Leishmania braziliensis	77%	100%
A4HP90	Leishmania braziliensis	37%	100%
A4HVY0	Leishmania infantum	93%	100%
A4IDJ5	Leishmania infantum	36%	100%
D0A391	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9APN1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%

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