LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter, putative
Species:
Leishmania major
UniProt:
Q4QFU7_LEIMA
TriTrypDb:
LmjF.14.0380 , LMJLV39_140009100 , LMJSD75_140009000 *
Length:
607

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 14
GO:0016020 membrane 2 14
GO:0110165 cellular anatomical entity 1 14
GO:0005737 cytoplasm 2 1
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

Q4QFU7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFU7

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0009987 cellular process 1 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 14
GO:0022857 transmembrane transporter activity 2 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 443 447 PF00656 0.467
CLV_NRD_NRD_1 595 597 PF00675 0.419
CLV_PCSK_KEX2_1 595 597 PF00082 0.419
CLV_PCSK_SKI1_1 320 324 PF00082 0.313
CLV_PCSK_SKI1_1 81 85 PF00082 0.412
DEG_MDM2_SWIB_1 369 377 PF02201 0.409
DEG_SPOP_SBC_1 231 235 PF00917 0.373
DEG_SPOP_SBC_1 303 307 PF00917 0.440
DEG_SPOP_SBC_1 413 417 PF00917 0.378
DEG_SPOP_SBC_1 441 445 PF00917 0.451
DOC_CYCLIN_RxL_1 248 258 PF00134 0.506
DOC_CYCLIN_RxL_1 317 326 PF00134 0.513
DOC_CYCLIN_yCln2_LP_2 197 203 PF00134 0.441
DOC_MAPK_gen_1 318 327 PF00069 0.473
DOC_PP1_RVXF_1 249 256 PF00149 0.506
DOC_PP2B_LxvP_1 197 200 PF13499 0.435
DOC_PP2B_PxIxI_1 363 369 PF00149 0.276
DOC_PP4_FxxP_1 552 555 PF00568 0.378
DOC_SPAK_OSR1_1 435 439 PF12202 0.467
DOC_USP7_MATH_1 168 172 PF00917 0.485
DOC_USP7_MATH_1 203 207 PF00917 0.449
DOC_USP7_MATH_1 259 263 PF00917 0.314
DOC_USP7_MATH_1 311 315 PF00917 0.543
DOC_USP7_MATH_1 330 334 PF00917 0.378
DOC_USP7_MATH_1 429 433 PF00917 0.339
DOC_USP7_MATH_1 555 559 PF00917 0.340
DOC_WW_Pin1_4 207 212 PF00397 0.525
DOC_WW_Pin1_4 287 292 PF00397 0.276
LIG_14-3-3_CanoR_1 17 27 PF00244 0.644
LIG_14-3-3_CanoR_1 301 309 PF00244 0.493
LIG_14-3-3_CanoR_1 318 323 PF00244 0.569
LIG_14-3-3_CanoR_1 412 421 PF00244 0.272
LIG_14-3-3_CanoR_1 442 451 PF00244 0.440
LIG_14-3-3_CanoR_1 48 56 PF00244 0.646
LIG_Actin_WH2_2 169 186 PF00022 0.354
LIG_BIR_II_1 1 5 PF00653 0.682
LIG_BRCT_BRCA1_1 332 336 PF00533 0.314
LIG_BRCT_BRCA1_1 500 504 PF00533 0.471
LIG_BRCT_BRCA1_1 548 552 PF00533 0.471
LIG_deltaCOP1_diTrp_1 103 107 PF00928 0.658
LIG_deltaCOP1_diTrp_1 114 121 PF00928 0.513
LIG_EH1_1 541 549 PF00400 0.376
LIG_eIF4E_1 240 246 PF01652 0.361
LIG_FHA_1 159 165 PF00498 0.493
LIG_FHA_1 231 237 PF00498 0.407
LIG_FHA_1 288 294 PF00498 0.451
LIG_FHA_1 304 310 PF00498 0.493
LIG_FHA_1 377 383 PF00498 0.376
LIG_FHA_1 38 44 PF00498 0.615
LIG_FHA_1 489 495 PF00498 0.489
LIG_FHA_1 507 513 PF00498 0.344
LIG_FHA_1 526 532 PF00498 0.262
LIG_FHA_1 560 566 PF00498 0.516
LIG_FHA_2 140 146 PF00498 0.334
LIG_FHA_2 21 27 PF00498 0.638
LIG_FHA_2 441 447 PF00498 0.500
LIG_FHA_2 62 68 PF00498 0.625
LIG_GBD_Chelix_1 125 133 PF00786 0.256
LIG_LIR_Apic_2 549 555 PF02991 0.485
LIG_LIR_Gen_1 114 124 PF02991 0.489
LIG_LIR_Gen_1 333 342 PF02991 0.395
LIG_LIR_Gen_1 432 441 PF02991 0.458
LIG_LIR_Gen_1 448 459 PF02991 0.420
LIG_LIR_Gen_1 490 500 PF02991 0.468
LIG_LIR_Gen_1 501 512 PF02991 0.451
LIG_LIR_Gen_1 561 572 PF02991 0.526
LIG_LIR_Gen_1 580 590 PF02991 0.427
LIG_LIR_Nem_3 114 119 PF02991 0.474
LIG_LIR_Nem_3 333 337 PF02991 0.388
LIG_LIR_Nem_3 360 366 PF02991 0.342
LIG_LIR_Nem_3 415 421 PF02991 0.352
LIG_LIR_Nem_3 432 436 PF02991 0.458
LIG_LIR_Nem_3 448 454 PF02991 0.420
LIG_LIR_Nem_3 490 495 PF02991 0.463
LIG_LIR_Nem_3 501 507 PF02991 0.448
LIG_LIR_Nem_3 550 556 PF02991 0.362
LIG_LIR_Nem_3 561 567 PF02991 0.466
LIG_LIR_Nem_3 577 581 PF02991 0.490
LIG_LYPXL_yS_3 363 366 PF13949 0.490
LIG_NRBOX 522 528 PF00104 0.276
LIG_PCNA_PIPBox_1 280 289 PF02747 0.198
LIG_PCNA_yPIPBox_3 251 264 PF02747 0.453
LIG_Pex14_1 116 120 PF04695 0.378
LIG_Pex14_2 369 373 PF04695 0.428
LIG_Pex14_2 500 504 PF04695 0.489
LIG_SH2_CRK 240 244 PF00017 0.331
LIG_SH2_CRK 472 476 PF00017 0.486
LIG_SH2_CRK 553 557 PF00017 0.319
LIG_SH2_CRK 582 586 PF00017 0.515
LIG_SH2_GRB2like 468 471 PF00017 0.489
LIG_SH2_NCK_1 553 557 PF00017 0.356
LIG_SH2_SRC 296 299 PF00017 0.257
LIG_SH2_SRC 484 487 PF00017 0.513
LIG_SH2_STAP1 39 43 PF00017 0.669
LIG_SH2_STAP1 582 586 PF00017 0.528
LIG_SH2_STAT3 249 252 PF00017 0.516
LIG_SH2_STAT3 468 471 PF00017 0.426
LIG_SH2_STAT5 28 31 PF00017 0.664
LIG_SH2_STAT5 296 299 PF00017 0.284
LIG_SH2_STAT5 39 42 PF00017 0.580
LIG_SH2_STAT5 394 397 PF00017 0.344
LIG_SH2_STAT5 468 471 PF00017 0.471
LIG_SH2_STAT5 484 487 PF00017 0.499
LIG_SH2_STAT5 564 567 PF00017 0.426
LIG_SH2_STAT5 592 595 PF00017 0.591
LIG_SH3_3 399 405 PF00018 0.289
LIG_SUMO_SIM_anti_2 145 150 PF11976 0.373
LIG_SUMO_SIM_anti_2 312 317 PF11976 0.471
LIG_SUMO_SIM_par_1 323 329 PF11976 0.296
LIG_SUMO_SIM_par_1 522 528 PF11976 0.361
LIG_TYR_ITIM 238 243 PF00017 0.368
LIG_TYR_ITIM 361 366 PF00017 0.276
LIG_TYR_ITIM 551 556 PF00017 0.356
LIG_WRC_WIRS_1 430 435 PF05994 0.314
LIG_WRC_WIRS_1 515 520 PF05994 0.256
MOD_CK1_1 2 8 PF00069 0.679
MOD_CK1_1 206 212 PF00069 0.531
MOD_CK1_1 262 268 PF00069 0.420
MOD_CK1_1 326 332 PF00069 0.319
MOD_CK1_1 417 423 PF00069 0.365
MOD_CK1_1 50 56 PF00069 0.676
MOD_CK1_1 558 564 PF00069 0.520
MOD_CK2_1 574 580 PF00069 0.545
MOD_CK2_1 97 103 PF00069 0.685
MOD_GlcNHglycan 257 260 PF01048 0.396
MOD_GlcNHglycan 264 267 PF01048 0.447
MOD_GlcNHglycan 328 331 PF01048 0.353
MOD_GlcNHglycan 357 360 PF01048 0.464
MOD_GlcNHglycan 500 503 PF01048 0.271
MOD_GlcNHglycan 519 522 PF01048 0.178
MOD_GlcNHglycan 52 55 PF01048 0.565
MOD_GSK3_1 203 210 PF00069 0.465
MOD_GSK3_1 227 234 PF00069 0.402
MOD_GSK3_1 255 262 PF00069 0.378
MOD_GSK3_1 326 333 PF00069 0.369
MOD_GSK3_1 413 420 PF00069 0.332
MOD_GSK3_1 437 444 PF00069 0.451
MOD_GSK3_1 46 53 PF00069 0.765
MOD_GSK3_1 525 532 PF00069 0.369
MOD_GSK3_1 542 549 PF00069 0.315
MOD_GSK3_1 554 561 PF00069 0.327
MOD_GSK3_1 597 604 PF00069 0.559
MOD_GSK3_1 88 95 PF00069 0.700
MOD_N-GLC_1 18 23 PF02516 0.542
MOD_NEK2_1 20 25 PF00069 0.759
MOD_NEK2_1 255 260 PF00069 0.464
MOD_NEK2_1 304 309 PF00069 0.517
MOD_NEK2_1 323 328 PF00069 0.445
MOD_NEK2_1 352 357 PF00069 0.252
MOD_NEK2_1 37 42 PF00069 0.523
MOD_NEK2_1 437 442 PF00069 0.562
MOD_NEK2_1 542 547 PF00069 0.398
MOD_NEK2_1 574 579 PF00069 0.533
MOD_NEK2_1 92 97 PF00069 0.653
MOD_NEK2_2 168 173 PF00069 0.381
MOD_NEK2_2 259 264 PF00069 0.198
MOD_NEK2_2 559 564 PF00069 0.509
MOD_PIKK_1 590 596 PF00454 0.557
MOD_PIKK_1 85 91 PF00454 0.708
MOD_PKA_2 411 417 PF00069 0.336
MOD_PKA_2 441 447 PF00069 0.467
MOD_PKA_2 47 53 PF00069 0.668
MOD_Plk_1 597 603 PF00069 0.556
MOD_Plk_4 232 238 PF00069 0.374
MOD_Plk_4 259 265 PF00069 0.378
MOD_Plk_4 304 310 PF00069 0.563
MOD_Plk_4 311 317 PF00069 0.508
MOD_Plk_4 344 350 PF00069 0.310
MOD_Plk_4 389 395 PF00069 0.335
MOD_Plk_4 39 45 PF00069 0.612
MOD_Plk_4 422 428 PF00069 0.344
MOD_Plk_4 429 435 PF00069 0.344
MOD_Plk_4 514 520 PF00069 0.351
MOD_Plk_4 542 548 PF00069 0.340
MOD_Plk_4 559 565 PF00069 0.486
MOD_Plk_4 597 603 PF00069 0.634
MOD_ProDKin_1 207 213 PF00069 0.519
MOD_ProDKin_1 287 293 PF00069 0.276
TRG_DiLeu_BaEn_1 490 495 PF01217 0.507
TRG_DiLeu_BaLyEn_6 288 293 PF01217 0.314
TRG_ENDOCYTIC_2 214 217 PF00928 0.462
TRG_ENDOCYTIC_2 240 243 PF00928 0.338
TRG_ENDOCYTIC_2 363 366 PF00928 0.417
TRG_ENDOCYTIC_2 472 475 PF00928 0.472
TRG_ENDOCYTIC_2 553 556 PF00928 0.356
TRG_ENDOCYTIC_2 564 567 PF00928 0.452
TRG_ENDOCYTIC_2 582 585 PF00928 0.503
TRG_ER_diArg_1 107 110 PF00400 0.645
TRG_NES_CRM1_1 360 375 PF08389 0.217
TRG_Pf-PMV_PEXEL_1 435 439 PF00026 0.347

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA24 Leptomonas seymouri 56% 100%
A0A0S4KHP0 Bodo saltans 33% 100%
A0A3Q8I9V7 Leishmania donovani 93% 100%
A0A3S7XAV8 Leishmania donovani 36% 100%
A4H7J7 Leishmania braziliensis 77% 100%
A4HP90 Leishmania braziliensis 37% 100%
A4HVY0 Leishmania infantum 93% 100%
A4IDJ5 Leishmania infantum 36% 100%
D0A391 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9APN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9ASZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
Q4Q1K0 Leishmania major 36% 100%
Q75EG5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 27% 100%
Q870V7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS