Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFU6_LEIMA

TriTrypDb:

LmjF.14.0390 , LMJLV39_140009200 , LMJSD75_140009100

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.494
CLV_C14_Caspase3-7	289	293	PF00656	0.585
CLV_C14_Caspase3-7	96	100	PF00656	0.512
CLV_NRD_NRD_1	20	22	PF00675	0.490
CLV_NRD_NRD_1	206	208	PF00675	0.446
CLV_NRD_NRD_1	285	287	PF00675	0.772
CLV_PCSK_KEX2_1	20	22	PF00082	0.464
CLV_PCSK_SKI1_1	116	120	PF00082	0.513
CLV_PCSK_SKI1_1	166	170	PF00082	0.566
CLV_PCSK_SKI1_1	20	24	PF00082	0.466
DEG_APCC_DBOX_1	19	27	PF00400	0.511
DOC_MAPK_gen_1	48	57	PF00069	0.432
DOC_MAPK_HePTP_8	55	67	PF00069	0.287
DOC_MAPK_MEF2A_6	48	57	PF00069	0.412
DOC_MAPK_MEF2A_6	58	67	PF00069	0.447
DOC_MAPK_NFAT4_5	50	58	PF00069	0.343
DOC_PP1_RVXF_1	258	264	PF00149	0.539
DOC_PP1_RVXF_1	46	52	PF00149	0.564
DOC_USP7_MATH_1	162	166	PF00917	0.419
LIG_14-3-3_CanoR_1	260	270	PF00244	0.577
LIG_14-3-3_CanoR_1	90	98	PF00244	0.475
LIG_BRCT_BRCA1_1	164	168	PF00533	0.403
LIG_FHA_1	133	139	PF00498	0.483
LIG_FHA_1	147	153	PF00498	0.273
LIG_FHA_1	197	203	PF00498	0.559
LIG_FHA_1	237	243	PF00498	0.449
LIG_FHA_2	280	286	PF00498	0.621
LIG_LIR_Apic_2	147	153	PF02991	0.424
LIG_LIR_Gen_1	199	205	PF02991	0.467
LIG_LIR_Gen_1	27	36	PF02991	0.484
LIG_LIR_Gen_1	44	53	PF02991	0.508
LIG_LIR_LC3C_4	133	138	PF02991	0.489
LIG_LIR_Nem_3	199	203	PF02991	0.405
LIG_LIR_Nem_3	27	32	PF02991	0.485
LIG_LIR_Nem_3	44	49	PF02991	0.453
LIG_PCNA_yPIPBox_3	191	201	PF02747	0.364
LIG_SH2_CRK	69	73	PF00017	0.495
LIG_SH2_STAP1	77	81	PF00017	0.400
LIG_SH2_STAT5	200	203	PF00017	0.489
LIG_SH2_STAT5	226	229	PF00017	0.462
LIG_SH2_STAT5	66	69	PF00017	0.408
LIG_SH2_STAT5	80	83	PF00017	0.382
LIG_SH3_1	69	75	PF00018	0.508
LIG_SH3_3	69	75	PF00018	0.488
LIG_SUMO_SIM_anti_2	215	222	PF11976	0.471
LIG_SUMO_SIM_par_1	32	37	PF11976	0.299
MOD_CK1_1	144	150	PF00069	0.523
MOD_CK1_1	253	259	PF00069	0.354
MOD_CK2_1	242	248	PF00069	0.431
MOD_CK2_1	279	285	PF00069	0.751
MOD_CK2_1	81	87	PF00069	0.520
MOD_Cter_Amidation	18	21	PF01082	0.508
MOD_GlcNHglycan	16	20	PF01048	0.574
MOD_GlcNHglycan	220	224	PF01048	0.537
MOD_GlcNHglycan	252	255	PF01048	0.570
MOD_GlcNHglycan	265	268	PF01048	0.540
MOD_GSK3_1	144	151	PF00069	0.467
MOD_GSK3_1	37	44	PF00069	0.425
MOD_GSK3_1	75	82	PF00069	0.478
MOD_GSK3_1	8	15	PF00069	0.579
MOD_GSK3_1	86	93	PF00069	0.501
MOD_N-GLC_1	261	266	PF02516	0.455
MOD_N-GLC_1	27	32	PF02516	0.424
MOD_N-GLC_1	41	46	PF02516	0.484
MOD_N-GLC_2	108	110	PF02516	0.448
MOD_N-GLC_2	159	161	PF02516	0.481
MOD_NEK2_1	218	223	PF00069	0.549
MOD_NEK2_1	263	268	PF00069	0.633
MOD_NEK2_1	272	277	PF00069	0.691
MOD_NEK2_1	53	58	PF00069	0.432
MOD_NEK2_1	81	86	PF00069	0.488
MOD_PIKK_1	27	33	PF00454	0.604
MOD_PKA_1	286	292	PF00069	0.772
MOD_Plk_1	132	138	PF00069	0.405
MOD_Plk_1	144	150	PF00069	0.375
MOD_Plk_1	242	248	PF00069	0.502
MOD_Plk_1	27	33	PF00069	0.468
MOD_Plk_1	34	40	PF00069	0.475
MOD_Plk_1	41	47	PF00069	0.488
MOD_Plk_2-3	292	298	PF00069	0.767
MOD_Plk_4	132	138	PF00069	0.449
MOD_Plk_4	196	202	PF00069	0.520
MOD_Plk_4	253	259	PF00069	0.529
MOD_Plk_4	75	81	PF00069	0.418
MOD_SUMO_for_1	230	233	PF00179	0.496
MOD_SUMO_rev_2	111	118	PF00179	0.524
MOD_SUMO_rev_2	121	126	PF00179	0.498
MOD_SUMO_rev_2	281	289	PF00179	0.707
TRG_DiLeu_BaEn_1	121	126	PF01217	0.469
TRG_ENDOCYTIC_2	200	203	PF00928	0.508
TRG_ENDOCYTIC_2	226	229	PF00928	0.599
TRG_ER_diArg_1	20	22	PF00400	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0V1	Leptomonas seymouri	54%	99%
A0A0S4KDQ4	Bodo saltans	45%	100%
A0A1X0NQ77	Trypanosomatidae	46%	96%
A0A381MFS8	Leishmania infantum	81%	97%
A0A3Q8I9T1	Leishmania donovani	79%	97%
A0A3R7N2S2	Trypanosoma rangeli	45%	94%
A0A3S7WSX7	Leishmania donovani	81%	97%
A4H7J8	Leishmania braziliensis	51%	96%
C9ZT43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	91%
E9AGK8	Leishmania infantum	78%	97%
E9APN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%
E9APN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	97%
E9APN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	97%
Q4QFU5	Leishmania major	91%	100%
V5BD72	Trypanosoma cruzi	45%	94%