Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFU5_LEIMA

TriTrypDb:

LmjF.14.0400 , LMJLV39_140009200 , LMJSD75_140009100

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.494
CLV_C14_Caspase3-7	289	293	PF00656	0.579
CLV_NRD_NRD_1	20	22	PF00675	0.503
CLV_NRD_NRD_1	206	208	PF00675	0.479
CLV_NRD_NRD_1	285	287	PF00675	0.813
CLV_PCSK_KEX2_1	20	22	PF00082	0.478
CLV_PCSK_KEX2_1	301	303	PF00082	0.606
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.590
CLV_PCSK_SKI1_1	116	120	PF00082	0.510
CLV_PCSK_SKI1_1	166	170	PF00082	0.573
CLV_PCSK_SKI1_1	20	24	PF00082	0.478
DEG_APCC_DBOX_1	19	27	PF00400	0.511
DOC_CYCLIN_yClb1_LxF_4	267	273	PF00134	0.509
DOC_MAPK_gen_1	48	57	PF00069	0.444
DOC_PP1_RVXF_1	258	264	PF00149	0.543
DOC_PP1_RVXF_1	46	52	PF00149	0.561
DOC_USP7_MATH_1	162	166	PF00917	0.439
DOC_USP7_MATH_1	98	102	PF00917	0.571
LIG_14-3-3_CanoR_1	260	270	PF00244	0.569
LIG_14-3-3_CanoR_1	90	98	PF00244	0.476
LIG_BRCT_BRCA1_1	164	168	PF00533	0.419
LIG_FHA_1	133	139	PF00498	0.496
LIG_FHA_1	147	153	PF00498	0.278
LIG_FHA_1	197	203	PF00498	0.562
LIG_FHA_1	237	243	PF00498	0.462
LIG_LIR_Apic_2	147	153	PF02991	0.437
LIG_LIR_Apic_2	93	98	PF02991	0.380
LIG_LIR_Gen_1	199	205	PF02991	0.481
LIG_LIR_Gen_1	27	36	PF02991	0.500
LIG_LIR_Gen_1	271	279	PF02991	0.637
LIG_LIR_Gen_1	303	310	PF02991	0.554
LIG_LIR_Gen_1	44	53	PF02991	0.516
LIG_LIR_LC3C_4	133	138	PF02991	0.490
LIG_LIR_Nem_3	199	203	PF02991	0.420
LIG_LIR_Nem_3	27	32	PF02991	0.502
LIG_LIR_Nem_3	44	49	PF02991	0.465
LIG_PCNA_yPIPBox_3	191	201	PF02747	0.352
LIG_PCNA_yPIPBox_3	228	242	PF02747	0.410
LIG_SH2_CRK	69	73	PF00017	0.501
LIG_SH2_NCK_1	95	99	PF00017	0.400
LIG_SH2_SRC	95	98	PF00017	0.351
LIG_SH2_STAP1	77	81	PF00017	0.415
LIG_SH2_STAT5	200	203	PF00017	0.500
LIG_SH2_STAT5	66	69	PF00017	0.418
LIG_SH2_STAT5	80	83	PF00017	0.390
LIG_SH3_1	69	75	PF00018	0.513
LIG_SH3_3	69	75	PF00018	0.494
LIG_SUMO_SIM_anti_2	215	222	PF11976	0.491
MOD_CK1_1	144	150	PF00069	0.521
MOD_CK1_1	236	242	PF00069	0.630
MOD_CK1_1	253	259	PF00069	0.353
MOD_CK2_1	242	248	PF00069	0.587
MOD_CK2_1	81	87	PF00069	0.513
MOD_Cter_Amidation	18	21	PF01082	0.519
MOD_GlcNHglycan	16	20	PF01048	0.580
MOD_GlcNHglycan	220	224	PF01048	0.562
MOD_GlcNHglycan	234	238	PF01048	0.575
MOD_GlcNHglycan	252	255	PF01048	0.576
MOD_GlcNHglycan	265	268	PF01048	0.544
MOD_GlcNHglycan	276	279	PF01048	0.610
MOD_GlcNHglycan	280	283	PF01048	0.636
MOD_GlcNHglycan	59	62	PF01048	0.414
MOD_GSK3_1	144	151	PF00069	0.478
MOD_GSK3_1	274	281	PF00069	0.630
MOD_GSK3_1	37	44	PF00069	0.440
MOD_GSK3_1	53	60	PF00069	0.382
MOD_GSK3_1	75	82	PF00069	0.483
MOD_GSK3_1	8	15	PF00069	0.550
MOD_N-GLC_1	261	266	PF02516	0.450
MOD_N-GLC_1	27	32	PF02516	0.442
MOD_N-GLC_1	41	46	PF02516	0.497
MOD_N-GLC_2	108	110	PF02516	0.450
MOD_N-GLC_2	159	161	PF02516	0.482
MOD_NEK2_1	218	223	PF00069	0.571
MOD_NEK2_1	263	268	PF00069	0.629
MOD_NEK2_1	53	58	PF00069	0.443
MOD_NEK2_1	81	86	PF00069	0.492
MOD_PIKK_1	27	33	PF00454	0.610
MOD_PKA_1	286	292	PF00069	0.769
MOD_Plk_1	132	138	PF00069	0.420
MOD_Plk_1	144	150	PF00069	0.386
MOD_Plk_1	233	239	PF00069	0.665
MOD_Plk_1	242	248	PF00069	0.497
MOD_Plk_1	27	33	PF00069	0.486
MOD_Plk_1	34	40	PF00069	0.487
MOD_Plk_1	41	47	PF00069	0.501
MOD_Plk_2-3	292	298	PF00069	0.762
MOD_Plk_4	132	138	PF00069	0.461
MOD_Plk_4	196	202	PF00069	0.526
MOD_Plk_4	253	259	PF00069	0.538
MOD_Plk_4	75	81	PF00069	0.431
MOD_SUMO_rev_2	111	118	PF00179	0.511
MOD_SUMO_rev_2	121	126	PF00179	0.486
MOD_SUMO_rev_2	281	289	PF00179	0.692
TRG_DiLeu_BaEn_1	121	126	PF01217	0.593
TRG_ENDOCYTIC_2	200	203	PF00928	0.518
TRG_ENDOCYTIC_2	226	229	PF00928	0.609
TRG_ENDOCYTIC_2	305	308	PF00928	0.546
TRG_ER_diArg_1	20	22	PF00400	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0V1	Leptomonas seymouri	57%	100%
A0A0S4KDQ4	Bodo saltans	43%	100%
A0A1X0NQ77	Trypanosomatidae	44%	99%
A0A381MFS8	Leishmania infantum	76%	100%
A0A3Q8I9T1	Leishmania donovani	86%	100%
A0A3R7N2S2	Trypanosoma rangeli	44%	97%
A0A3S7WSX7	Leishmania donovani	75%	100%
A4H7J8	Leishmania braziliensis	50%	100%
C9ZT43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	94%
E9AGK8	Leishmania infantum	83%	100%
E9APN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9APN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9APN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QFU6	Leishmania major	91%	100%
V5BD72	Trypanosoma cruzi	43%	97%