C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iguana/Dzip1-like DAZ-interacting protein N-terminal, putative

Species:

Leishmania major

UniProt:

Q4QFU2_LEIMA

TriTrypDb:

LmjF.14.0420 , LMJLV39_140009600 , LMJSD75_140009400

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005814	centriole	5	6
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	6
GO:0042995	cell projection	2	4

Expansion

Sequence features

Q4QFU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFU2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.643
CLV_NRD_NRD_1	179	181	PF00675	0.702
CLV_NRD_NRD_1	354	356	PF00675	0.707
CLV_NRD_NRD_1	813	815	PF00675	0.748
CLV_PCSK_KEX2_1	126	128	PF00082	0.643
CLV_PCSK_KEX2_1	181	183	PF00082	0.551
CLV_PCSK_KEX2_1	354	356	PF00082	0.707
CLV_PCSK_KEX2_1	431	433	PF00082	0.528
CLV_PCSK_KEX2_1	813	815	PF00082	0.748
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.551
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.528
CLV_PCSK_SKI1_1	120	124	PF00082	0.399
CLV_PCSK_SKI1_1	127	131	PF00082	0.521
CLV_PCSK_SKI1_1	27	31	PF00082	0.389
DEG_APCC_DBOX_1	250	258	PF00400	0.711
DEG_APCC_DBOX_1	353	361	PF00400	0.692
DEG_COP1_1	551	559	PF00400	0.742
DEG_ODPH_VHL_1	450	463	PF01847	0.621
DEG_ODPH_VHL_1	666	677	PF01847	0.811
DEG_SCF_FBW7_1	397	403	PF00400	0.594
DEG_SCF_FBW7_1	581	588	PF00400	0.730
DEG_SPOP_SBC_1	281	285	PF00917	0.841
DEG_SPOP_SBC_1	308	312	PF00917	0.599
DEG_SPOP_SBC_1	605	609	PF00917	0.852
DEG_SPOP_SBC_1	630	634	PF00917	0.613
DEG_SPOP_SBC_1	647	651	PF00917	0.813
DEG_SPOP_SBC_1	658	662	PF00917	0.662
DEG_SPOP_SBC_1	794	798	PF00917	0.725
DOC_CDC14_PxL_1	514	522	PF14671	0.605
DOC_CDC14_PxL_1	742	750	PF14671	0.819
DOC_CKS1_1	397	402	PF01111	0.724
DOC_CKS1_1	453	458	PF01111	0.845
DOC_CKS1_1	56	61	PF01111	0.635
DOC_CKS1_1	779	784	PF01111	0.754
DOC_CYCLIN_RxL_1	123	133	PF00134	0.642
DOC_CYCLIN_yCln2_LP_2	450	456	PF00134	0.817
DOC_CYCLIN_yCln2_LP_2	490	493	PF00134	0.640
DOC_CYCLIN_yCln2_LP_2	559	565	PF00134	0.782
DOC_CYCLIN_yCln2_LP_2	748	754	PF00134	0.826
DOC_MAPK_gen_1	248	256	PF00069	0.710
DOC_MAPK_gen_1	354	360	PF00069	0.692
DOC_MAPK_MEF2A_6	14	23	PF00069	0.635
DOC_MAPK_MEF2A_6	251	258	PF00069	0.710
DOC_MAPK_NFAT4_5	251	259	PF00069	0.710
DOC_PP1_RVXF_1	12	18	PF00149	0.635
DOC_PP2B_LxvP_1	450	453	PF13499	0.854
DOC_PP2B_LxvP_1	454	457	PF13499	0.777
DOC_PP2B_LxvP_1	461	464	PF13499	0.661
DOC_PP2B_LxvP_1	490	493	PF13499	0.763
DOC_PP2B_LxvP_1	520	523	PF13499	0.644
DOC_PP2B_LxvP_1	559	562	PF13499	0.667
DOC_PP2B_LxvP_1	724	727	PF13499	0.770
DOC_PP2B_LxvP_1	748	751	PF13499	0.823
DOC_SPAK_OSR1_1	808	812	PF12202	0.710
DOC_USP7_MATH_1	188	192	PF00917	0.754
DOC_USP7_MATH_1	223	227	PF00917	0.623
DOC_USP7_MATH_1	261	265	PF00917	0.773
DOC_USP7_MATH_1	296	300	PF00917	0.802
DOC_USP7_MATH_1	301	305	PF00917	0.774
DOC_USP7_MATH_1	307	311	PF00917	0.743
DOC_USP7_MATH_1	348	352	PF00917	0.460
DOC_USP7_MATH_1	386	390	PF00917	0.768
DOC_USP7_MATH_1	494	498	PF00917	0.806
DOC_USP7_MATH_1	510	514	PF00917	0.560
DOC_USP7_MATH_1	525	529	PF00917	0.653
DOC_USP7_MATH_1	533	537	PF00917	0.641
DOC_USP7_MATH_1	552	556	PF00917	0.530
DOC_USP7_MATH_1	585	589	PF00917	0.828
DOC_USP7_MATH_1	630	634	PF00917	0.761
DOC_USP7_MATH_1	648	652	PF00917	0.811
DOC_USP7_MATH_1	656	660	PF00917	0.710
DOC_USP7_MATH_1	668	672	PF00917	0.510
DOC_USP7_MATH_1	770	774	PF00917	0.821
DOC_USP7_MATH_1	780	784	PF00917	0.647
DOC_USP7_MATH_1	788	792	PF00917	0.530
DOC_USP7_MATH_1	794	798	PF00917	0.607
DOC_USP7_UBL2_3	119	123	PF12436	0.635
DOC_WW_Pin1_4	186	191	PF00397	0.797
DOC_WW_Pin1_4	209	214	PF00397	0.616
DOC_WW_Pin1_4	265	270	PF00397	0.827
DOC_WW_Pin1_4	289	294	PF00397	0.767
DOC_WW_Pin1_4	297	302	PF00397	0.590
DOC_WW_Pin1_4	384	389	PF00397	0.804
DOC_WW_Pin1_4	393	398	PF00397	0.705
DOC_WW_Pin1_4	400	405	PF00397	0.567
DOC_WW_Pin1_4	452	457	PF00397	0.833
DOC_WW_Pin1_4	466	471	PF00397	0.605
DOC_WW_Pin1_4	527	532	PF00397	0.782
DOC_WW_Pin1_4	543	548	PF00397	0.619
DOC_WW_Pin1_4	55	60	PF00397	0.547
DOC_WW_Pin1_4	550	555	PF00397	0.782
DOC_WW_Pin1_4	565	570	PF00397	0.580
DOC_WW_Pin1_4	581	586	PF00397	0.611
DOC_WW_Pin1_4	591	596	PF00397	0.701
DOC_WW_Pin1_4	638	643	PF00397	0.762
DOC_WW_Pin1_4	669	674	PF00397	0.786
DOC_WW_Pin1_4	682	687	PF00397	0.585
DOC_WW_Pin1_4	711	716	PF00397	0.787
DOC_WW_Pin1_4	737	742	PF00397	0.807
DOC_WW_Pin1_4	778	783	PF00397	0.633
LIG_14-3-3_CanoR_1	110	118	PF00244	0.635
LIG_14-3-3_CanoR_1	126	130	PF00244	0.379
LIG_14-3-3_CanoR_1	182	192	PF00244	0.720
LIG_14-3-3_CanoR_1	263	269	PF00244	0.752
LIG_14-3-3_CanoR_1	27	37	PF00244	0.589
LIG_14-3-3_CanoR_1	527	531	PF00244	0.685
LIG_Actin_WH2_2	353	370	PF00022	0.682
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_BIR_III_1	1	5	PF00653	0.637
LIG_BIR_III_3	1	5	PF00653	0.637
LIG_BRCT_BRCA1_1	2	6	PF00533	0.617
LIG_Clathr_ClatBox_1	20	24	PF01394	0.635
LIG_Clathr_ClatBox_1	357	361	PF01394	0.683
LIG_CtBP_PxDLS_1	447	451	PF00389	0.793
LIG_FHA_1	113	119	PF00498	0.576
LIG_FHA_1	156	162	PF00498	0.652
LIG_FHA_1	401	407	PF00498	0.736
LIG_FHA_1	551	557	PF00498	0.818
LIG_FHA_1	584	590	PF00498	0.803
LIG_FHA_1	614	620	PF00498	0.849
LIG_FHA_1	652	658	PF00498	0.798
LIG_FHA_2	30	36	PF00498	0.591
LIG_FHA_2	310	316	PF00498	0.831
LIG_FHA_2	48	54	PF00498	0.635
LIG_FHA_2	718	724	PF00498	0.840
LIG_FHA_2	98	104	PF00498	0.546
LIG_GSK3_LRP6_1	294	300	PF00069	0.620
LIG_GSK3_LRP6_1	384	389	PF00069	0.751
LIG_LIR_Apic_2	158	163	PF02991	0.633
LIG_LIR_Apic_2	764	768	PF02991	0.815
LIG_LIR_Gen_1	3	13	PF02991	0.529
LIG_LIR_Nem_3	16	20	PF02991	0.482
LIG_LIR_Nem_3	3	9	PF02991	0.529
LIG_LIR_Nem_3	791	795	PF02991	0.769
LIG_MYND_1	448	452	PF01753	0.856
LIG_MYND_1	488	492	PF01753	0.768
LIG_PDZ_Class_2	812	817	PF00595	0.700
LIG_PTB_Apo_2	40	47	PF02174	0.635
LIG_SH2_PTP2	160	163	PF00017	0.621
LIG_SH2_STAP1	132	136	PF00017	0.642
LIG_SH2_STAP1	78	82	PF00017	0.635
LIG_SH2_STAT3	134	137	PF00017	0.580
LIG_SH2_STAT3	537	540	PF00017	0.870
LIG_SH2_STAT5	160	163	PF00017	0.621
LIG_SH2_STAT5	164	167	PF00017	0.571
LIG_SH2_STAT5	680	683	PF00017	0.807
LIG_SH2_STAT5	75	78	PF00017	0.635
LIG_SH3_1	326	332	PF00018	0.644
LIG_SH3_3	187	193	PF00018	0.766
LIG_SH3_3	268	274	PF00018	0.823
LIG_SH3_3	284	290	PF00018	0.566
LIG_SH3_3	292	298	PF00018	0.702
LIG_SH3_3	326	332	PF00018	0.663
LIG_SH3_3	380	386	PF00018	0.803
LIG_SH3_3	394	400	PF00018	0.601
LIG_SH3_3	414	420	PF00018	0.467
LIG_SH3_3	450	456	PF00018	0.851
LIG_SH3_3	467	473	PF00018	0.551
LIG_SH3_3	488	494	PF00018	0.640
LIG_SH3_3	544	550	PF00018	0.828
LIG_SH3_3	551	557	PF00018	0.752
LIG_SH3_3	559	565	PF00018	0.621
LIG_SH3_3	586	592	PF00018	0.768
LIG_SH3_3	667	673	PF00018	0.671
LIG_SH3_3	697	703	PF00018	0.793
LIG_SH3_3	712	718	PF00018	0.795
LIG_SH3_3	743	749	PF00018	0.692
LIG_SH3_3	764	770	PF00018	0.783
LIG_SH3_3	776	782	PF00018	0.660
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.709
LIG_SUMO_SIM_par_1	19	24	PF11976	0.635
LIG_SUMO_SIM_par_1	356	361	PF11976	0.560
LIG_TRAF2_1	100	103	PF00917	0.502
LIG_UBA3_1	82	89	PF00899	0.635
LIG_WRC_WIRS_1	789	794	PF05994	0.768
MOD_CK1_1	112	118	PF00069	0.635
MOD_CK1_1	174	180	PF00069	0.675
MOD_CK1_1	264	270	PF00069	0.680
MOD_CK1_1	297	303	PF00069	0.771
MOD_CK1_1	310	316	PF00069	0.784
MOD_CK1_1	396	402	PF00069	0.614
MOD_CK1_1	441	447	PF00069	0.845
MOD_CK1_1	47	53	PF00069	0.557
MOD_CK1_1	497	503	PF00069	0.825
MOD_CK1_1	513	519	PF00069	0.557
MOD_CK1_1	568	574	PF00069	0.795
MOD_CK1_1	608	614	PF00069	0.855
MOD_CK1_1	615	621	PF00069	0.726
MOD_CK1_1	635	641	PF00069	0.521
MOD_CK1_1	651	657	PF00069	0.805
MOD_CK1_1	659	665	PF00069	0.719
MOD_CK1_1	679	685	PF00069	0.478
MOD_CK1_1	761	767	PF00069	0.806
MOD_CK1_1	796	802	PF00069	0.818
MOD_CK2_1	309	315	PF00069	0.784
MOD_CK2_1	47	53	PF00069	0.635
MOD_CK2_1	717	723	PF00069	0.838
MOD_CK2_1	97	103	PF00069	0.546
MOD_DYRK1A_RPxSP_1	527	531	PF00069	0.664
MOD_GlcNHglycan	146	149	PF01048	0.640
MOD_GlcNHglycan	333	337	PF01048	0.636
MOD_GlcNHglycan	350	353	PF01048	0.463
MOD_GlcNHglycan	388	391	PF01048	0.789
MOD_GlcNHglycan	443	446	PF01048	0.789
MOD_GlcNHglycan	507	510	PF01048	0.694
MOD_GlcNHglycan	558	562	PF01048	0.667
MOD_GlcNHglycan	638	641	PF01048	0.846
MOD_GlcNHglycan	650	653	PF01048	0.774
MOD_GlcNHglycan	661	664	PF01048	0.619
MOD_GlcNHglycan	723	727	PF01048	0.611
MOD_GlcNHglycan	754	757	PF01048	0.649
MOD_GlcNHglycan	772	775	PF01048	0.594
MOD_GlcNHglycan	782	785	PF01048	0.752
MOD_GlcNHglycan	804	807	PF01048	0.647
MOD_GSK3_1	121	128	PF00069	0.717
MOD_GSK3_1	182	189	PF00069	0.766
MOD_GSK3_1	205	212	PF00069	0.618
MOD_GSK3_1	219	226	PF00069	0.799
MOD_GSK3_1	259	266	PF00069	0.758
MOD_GSK3_1	29	36	PF00069	0.615
MOD_GSK3_1	297	304	PF00069	0.674
MOD_GSK3_1	307	314	PF00069	0.730
MOD_GSK3_1	396	403	PF00069	0.710
MOD_GSK3_1	492	499	PF00069	0.690
MOD_GSK3_1	548	555	PF00069	0.787
MOD_GSK3_1	567	574	PF00069	0.585
MOD_GSK3_1	581	588	PF00069	0.622
MOD_GSK3_1	604	611	PF00069	0.854
MOD_GSK3_1	630	637	PF00069	0.801
MOD_GSK3_1	643	650	PF00069	0.787
MOD_GSK3_1	676	683	PF00069	0.745
MOD_GSK3_1	703	710	PF00069	0.789
MOD_GSK3_1	740	747	PF00069	0.649
MOD_GSK3_1	754	761	PF00069	0.686
MOD_GSK3_1	793	800	PF00069	0.818
MOD_N-GLC_1	183	188	PF02516	0.767
MOD_N-GLC_1	264	269	PF02516	0.593
MOD_N-GLC_1	340	345	PF02516	0.690
MOD_N-GLC_1	609	614	PF02516	0.856
MOD_NEK2_1	144	149	PF00069	0.685
MOD_NEK2_1	259	264	PF00069	0.596
MOD_NEK2_1	28	33	PF00069	0.635
MOD_NEK2_1	367	372	PF00069	0.687
MOD_NEK2_1	406	411	PF00069	0.790
MOD_NEK2_1	526	531	PF00069	0.808
MOD_NEK2_1	613	618	PF00069	0.856
MOD_NEK2_1	636	641	PF00069	0.777
MOD_NEK2_1	735	740	PF00069	0.836
MOD_NEK2_1	795	800	PF00069	0.827
MOD_NEK2_2	788	793	PF00069	0.725
MOD_PIKK_1	121	127	PF00454	0.719
MOD_PIKK_1	205	211	PF00454	0.745
MOD_PIKK_1	494	500	PF00454	0.851
MOD_PIKK_1	708	714	PF00454	0.811
MOD_PIKK_1	76	82	PF00454	0.635
MOD_PK_1	758	764	PF00069	0.602
MOD_PKA_2	109	115	PF00069	0.635
MOD_PKA_2	125	131	PF00069	0.376
MOD_PKA_2	367	373	PF00069	0.583
MOD_PKA_2	47	53	PF00069	0.635
MOD_PKA_2	526	532	PF00069	0.726
MOD_PKA_2	735	741	PF00069	0.792
MOD_PKB_1	180	188	PF00069	0.752
MOD_Plk_1	332	338	PF00069	0.695
MOD_Plk_1	609	615	PF00069	0.857
MOD_Plk_4	155	161	PF00069	0.677
MOD_Plk_4	374	380	PF00069	0.734
MOD_Plk_4	486	492	PF00069	0.646
MOD_Plk_4	676	682	PF00069	0.808
MOD_Plk_4	696	702	PF00069	0.494
MOD_ProDKin_1	186	192	PF00069	0.801
MOD_ProDKin_1	209	215	PF00069	0.616
MOD_ProDKin_1	265	271	PF00069	0.828
MOD_ProDKin_1	289	295	PF00069	0.767
MOD_ProDKin_1	297	303	PF00069	0.589
MOD_ProDKin_1	384	390	PF00069	0.808
MOD_ProDKin_1	393	399	PF00069	0.704
MOD_ProDKin_1	400	406	PF00069	0.573
MOD_ProDKin_1	452	458	PF00069	0.833
MOD_ProDKin_1	466	472	PF00069	0.599
MOD_ProDKin_1	527	533	PF00069	0.780
MOD_ProDKin_1	543	549	PF00069	0.620
MOD_ProDKin_1	55	61	PF00069	0.547
MOD_ProDKin_1	550	556	PF00069	0.781
MOD_ProDKin_1	565	571	PF00069	0.581
MOD_ProDKin_1	581	587	PF00069	0.611
MOD_ProDKin_1	591	597	PF00069	0.699
MOD_ProDKin_1	638	644	PF00069	0.763
MOD_ProDKin_1	669	675	PF00069	0.786
MOD_ProDKin_1	682	688	PF00069	0.580
MOD_ProDKin_1	711	717	PF00069	0.783
MOD_ProDKin_1	737	743	PF00069	0.802
MOD_ProDKin_1	778	784	PF00069	0.632
TRG_DiLeu_BaEn_1	103	108	PF01217	0.635
TRG_DiLeu_BaEn_1	252	257	PF01217	0.708
TRG_ENDOCYTIC_2	602	605	PF00928	0.803
TRG_ER_diArg_1	179	182	PF00400	0.708
TRG_ER_diArg_1	232	235	PF00400	0.724
TRG_ER_diArg_1	353	355	PF00400	0.710
TRG_ER_diArg_1	813	815	PF00400	0.748
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.636

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSW0	Leishmania donovani	90%	100%
A4H7K2	Leishmania braziliensis	64%	97%
A4HVY5	Leishmania infantum	89%	100%
E9APN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%