C2H2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iguana/Dzip1-like DAZ-interacting protein N-terminal, putative

Species:

Leishmania major

UniProt:

Q4QFU2_LEIMA

TriTrypDb:

LmjF.14.0420 , LMJLV39_140009600 , LMJSD75_140009400

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005814	centriole	5	6
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	6
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043232	intracellular non-membrane-bounded organelle	4	6

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Expansion

Sequence features

Q4QFU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFU2

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.643
CLV_NRD_NRD_1	179	181	PF00675	0.702
CLV_NRD_NRD_1	354	356	PF00675	0.707
CLV_NRD_NRD_1	813	815	PF00675	0.748
CLV_PCSK_KEX2_1	126	128	PF00082	0.643
CLV_PCSK_KEX2_1	181	183	PF00082	0.551
CLV_PCSK_KEX2_1	354	356	PF00082	0.707
CLV_PCSK_KEX2_1	431	433	PF00082	0.528
CLV_PCSK_KEX2_1	813	815	PF00082	0.748
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.551

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSW0	Leishmania donovani	90%	100%
A4H7K2	Leishmania braziliensis	64%	97%
A4HVY5	Leishmania infantum	89%	100%
E9APN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%

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