mRNA_triPase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mRNA capping enzyme, beta chain, putative

Species:

Leishmania major

UniProt:

Q4QFU1_LEIMA

TriTrypDb:

LmjF.14.0430 , LMJLV39_140009700 , LMJSD75_140009500

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 3
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFU1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006397	mRNA processing	7	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016071	mRNA metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004651	polynucleotide 5'-phosphatase activity	6	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.375
CLV_PCSK_KEX2_1	160	162	PF00082	0.506
CLV_PCSK_KEX2_1	356	358	PF00082	0.394
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.438
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.394
CLV_PCSK_SKI1_1	122	126	PF00082	0.330
CLV_PCSK_SKI1_1	228	232	PF00082	0.466
CLV_PCSK_SKI1_1	58	62	PF00082	0.370
DEG_APCC_DBOX_1	121	129	PF00400	0.322
DEG_APCC_DBOX_1	57	65	PF00400	0.367
DEG_Nend_UBRbox_4	1	3	PF02207	0.480
DOC_CKS1_1	24	29	PF01111	0.443
DOC_CKS1_1	316	321	PF01111	0.504
DOC_CYCLIN_yCln2_LP_2	316	322	PF00134	0.460
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.568
DOC_MAPK_gen_1	253	262	PF00069	0.304
DOC_MAPK_gen_1	90	98	PF00069	0.564
DOC_MAPK_MEF2A_6	149	156	PF00069	0.605
DOC_MAPK_MEF2A_6	233	241	PF00069	0.375
DOC_MAPK_MEF2A_6	75	82	PF00069	0.438
DOC_MAPK_MEF2A_6	90	98	PF00069	0.564
DOC_PP1_RVXF_1	275	282	PF00149	0.490
DOC_PP2B_LxvP_1	94	97	PF13499	0.580
DOC_USP7_MATH_1	249	253	PF00917	0.375
DOC_USP7_MATH_1	256	260	PF00917	0.212
DOC_USP7_MATH_1	286	290	PF00917	0.531
DOC_USP7_MATH_1	295	299	PF00917	0.500
DOC_USP7_MATH_1	362	366	PF00917	0.405
DOC_USP7_MATH_1	379	383	PF00917	0.541
DOC_WW_Pin1_4	23	28	PF00397	0.461
DOC_WW_Pin1_4	297	302	PF00397	0.649
DOC_WW_Pin1_4	315	320	PF00397	0.327
DOC_WW_Pin1_4	32	37	PF00397	0.463
DOC_WW_Pin1_4	67	72	PF00397	0.431
DOC_WW_Pin1_4	99	104	PF00397	0.524
LIG_14-3-3_CanoR_1	255	261	PF00244	0.329
LIG_14-3-3_CanoR_1	264	269	PF00244	0.197
LIG_14-3-3_CanoR_1	330	340	PF00244	0.518
LIG_CtBP_PxDLS_1	238	242	PF00389	0.375
LIG_EVH1_2	27	31	PF00568	0.499
LIG_FHA_1	197	203	PF00498	0.560
LIG_FHA_1	269	275	PF00498	0.318
LIG_FHA_1	316	322	PF00498	0.485
LIG_FHA_1	337	343	PF00498	0.437
LIG_FHA_1	368	374	PF00498	0.590
LIG_FHA_2	137	143	PF00498	0.511
LIG_FHA_2	336	342	PF00498	0.422
LIG_FHA_2	395	401	PF00498	0.586
LIG_FHA_2	72	78	PF00498	0.477
LIG_GBD_Chelix_1	56	64	PF00786	0.363
LIG_LIR_Apic_2	278	284	PF02991	0.466
LIG_LIR_Gen_1	289	297	PF02991	0.579
LIG_LIR_Gen_1	6	16	PF02991	0.401
LIG_LIR_Nem_3	354	358	PF02991	0.434
LIG_LIR_Nem_3	6	11	PF02991	0.401
LIG_Pex14_1	355	359	PF04695	0.382
LIG_SH2_CRK	166	170	PF00017	0.567
LIG_SH2_CRK	193	197	PF00017	0.551
LIG_SH2_STAT5	290	293	PF00017	0.621
LIG_SH2_STAT5	367	370	PF00017	0.402
LIG_SH2_STAT5	416	419	PF00017	0.516
LIG_SH3_3	189	195	PF00018	0.560
LIG_SH3_3	97	103	PF00018	0.541
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.443
LIG_SUMO_SIM_par_1	234	243	PF11976	0.356
LIG_SUMO_SIM_par_1	337	343	PF11976	0.416
MOD_CK1_1	23	29	PF00069	0.441
MOD_CK1_1	232	238	PF00069	0.312
MOD_CK1_1	273	279	PF00069	0.560
MOD_CK1_1	392	398	PF00069	0.758
MOD_CK2_1	183	189	PF00069	0.630
MOD_CK2_1	286	292	PF00069	0.550
MOD_CK2_1	331	337	PF00069	0.632
MOD_CK2_1	71	77	PF00069	0.594
MOD_GlcNHglycan	205	208	PF01048	0.471
MOD_GlcNHglycan	364	367	PF01048	0.380
MOD_GlcNHglycan	370	373	PF01048	0.450
MOD_GSK3_1	16	23	PF00069	0.434
MOD_GSK3_1	196	203	PF00069	0.601
MOD_GSK3_1	264	271	PF00069	0.325
MOD_GSK3_1	311	318	PF00069	0.488
MOD_GSK3_1	331	338	PF00069	0.463
MOD_GSK3_1	362	369	PF00069	0.427
MOD_GSK3_1	374	381	PF00069	0.487
MOD_GSK3_1	67	74	PF00069	0.529
MOD_N-GLC_1	16	21	PF02516	0.497
MOD_NEK2_1	106	111	PF00069	0.511
MOD_NEK2_1	18	23	PF00069	0.460
MOD_NEK2_1	196	201	PF00069	0.539
MOD_NEK2_1	270	275	PF00069	0.351
MOD_NEK2_1	368	373	PF00069	0.454
MOD_NEK2_1	404	409	PF00069	0.574
MOD_NEK2_1	86	91	PF00069	0.454
MOD_PIKK_1	196	202	PF00454	0.481
MOD_PIKK_1	268	274	PF00454	0.375
MOD_PK_1	264	270	PF00069	0.329
MOD_PK_1	81	87	PF00069	0.446
MOD_PKA_2	256	262	PF00069	0.329
MOD_PKB_1	253	261	PF00069	0.329
MOD_Plk_1	16	22	PF00069	0.534
MOD_Plk_1	336	342	PF00069	0.428
MOD_Plk_4	270	276	PF00069	0.375
MOD_Plk_4	3	9	PF00069	0.463
MOD_Plk_4	305	311	PF00069	0.595
MOD_Plk_4	404	410	PF00069	0.597
MOD_Plk_4	81	87	PF00069	0.474
MOD_ProDKin_1	23	29	PF00069	0.462
MOD_ProDKin_1	297	303	PF00069	0.647
MOD_ProDKin_1	315	321	PF00069	0.334
MOD_ProDKin_1	32	38	PF00069	0.463
MOD_ProDKin_1	67	73	PF00069	0.434
MOD_ProDKin_1	99	105	PF00069	0.515
MOD_SUMO_rev_2	206	211	PF00179	0.307
TRG_DiLeu_BaEn_1	413	418	PF01217	0.386
TRG_DiLeu_BaLyEn_6	120	125	PF01217	0.461
TRG_ENDOCYTIC_2	166	169	PF00928	0.558
TRG_ENDOCYTIC_2	193	196	PF00928	0.559
TRG_ENDOCYTIC_2	290	293	PF00928	0.576
TRG_NES_CRM1_1	50	65	PF08389	0.372
TRG_Pf-PMV_PEXEL_1	349	354	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D6	Leptomonas seymouri	37%	100%
A0A3Q8ID33	Leishmania donovani	93%	100%
A4H7K3	Leishmania braziliensis	78%	100%
A4HVY6	Leishmania infantum	92%	100%
E9APN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	96%