CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-terminal conserved domain of Nudc./CS domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QFT9_LEIMA

TriTrypDb:

LmjF.14.0450 , LMJLV39_140010000 , LMJSD75_140009800

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	3
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QFT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFT9

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051082	unfolded protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.659
CLV_C14_Caspase3-7	274	278	PF00656	0.482
CLV_NRD_NRD_1	113	115	PF00675	0.413
CLV_NRD_NRD_1	310	312	PF00675	0.585
CLV_NRD_NRD_1	32	34	PF00675	0.228
CLV_NRD_NRD_1	45	47	PF00675	0.415
CLV_NRD_NRD_1	63	65	PF00675	0.432
CLV_PCSK_KEX2_1	45	47	PF00082	0.562
CLV_PCSK_SKI1_1	169	173	PF00082	0.333
CLV_PCSK_SKI1_1	252	256	PF00082	0.479
CLV_PCSK_SKI1_1	64	68	PF00082	0.535
DEG_APCC_DBOX_1	181	189	PF00400	0.519
DEG_SPOP_SBC_1	198	202	PF00917	0.425
DEG_SPOP_SBC_1	84	88	PF00917	0.493
DOC_MAPK_DCC_7	182	190	PF00069	0.439
DOC_MAPK_gen_1	191	199	PF00069	0.429
DOC_MAPK_MEF2A_6	182	190	PF00069	0.453
DOC_MAPK_MEF2A_6	191	199	PF00069	0.413
DOC_MAPK_MEF2A_6	5	13	PF00069	0.428
DOC_PIKK_1	269	276	PF02985	0.484
DOC_PP4_FxxP_1	38	41	PF00568	0.428
DOC_USP7_MATH_1	268	272	PF00917	0.477
DOC_USP7_MATH_1	44	48	PF00917	0.493
DOC_USP7_MATH_1	84	88	PF00917	0.567
DOC_USP7_UBL2_3	294	298	PF12436	0.611
LIG_14-3-3_CanoR_1	281	285	PF00244	0.467
LIG_14-3-3_CanoR_1	33	41	PF00244	0.428
LIG_14-3-3_CanoR_1	45	49	PF00244	0.410
LIG_14-3-3_CanoR_1	85	93	PF00244	0.694
LIG_BIR_II_1	1	5	PF00653	0.442
LIG_deltaCOP1_diTrp_1	249	255	PF00928	0.471
LIG_DLG_GKlike_1	5	13	PF00625	0.495
LIG_FHA_1	235	241	PF00498	0.448
LIG_FHA_2	229	235	PF00498	0.428
LIG_FHA_2	298	304	PF00498	0.441
LIG_FHA_2	37	43	PF00498	0.478
LIG_LIR_Apic_2	35	41	PF02991	0.428
LIG_LIR_Gen_1	218	225	PF02991	0.453
LIG_LIR_Gen_1	3	14	PF02991	0.275
LIG_LIR_Nem_3	218	223	PF02991	0.461
LIG_LIR_Nem_3	249	254	PF02991	0.337
LIG_LIR_Nem_3	25	31	PF02991	0.432
LIG_PCNA_PIPBox_1	49	58	PF02747	0.427
LIG_PCNA_yPIPBox_3	305	314	PF02747	0.534
LIG_PCNA_yPIPBox_3	45	56	PF02747	0.542
LIG_Pex14_1	251	255	PF04695	0.463
LIG_SH2_CRK	220	224	PF00017	0.476
LIG_SH2_STAP1	167	171	PF00017	0.307
LIG_SH2_STAT5	170	173	PF00017	0.522
LIG_SH2_STAT5	55	58	PF00017	0.561
LIG_SH3_3	178	184	PF00018	0.428
LIG_SUMO_SIM_anti_2	86	98	PF11976	0.543
LIG_SUMO_SIM_par_1	236	241	PF11976	0.479
LIG_TRAF2_1	107	110	PF00917	0.358
LIG_TRAF2_1	175	178	PF00917	0.439
LIG_TRAF2_1	95	98	PF00917	0.477
LIG_WRC_WIRS_1	24	29	PF05994	0.428
MOD_CK1_1	202	208	PF00069	0.427
MOD_CK1_1	83	89	PF00069	0.567
MOD_CK2_1	172	178	PF00069	0.428
MOD_CK2_1	297	303	PF00069	0.451
MOD_CK2_1	85	91	PF00069	0.528
MOD_CK2_1	92	98	PF00069	0.487
MOD_GlcNHglycan	82	85	PF01048	0.637
MOD_GSK3_1	193	200	PF00069	0.544
MOD_GSK3_1	234	241	PF00069	0.473
MOD_GSK3_1	32	39	PF00069	0.472
MOD_GSK3_1	80	87	PF00069	0.633
MOD_NEK2_1	172	177	PF00069	0.439
MOD_NEK2_1	320	325	PF00069	0.442
MOD_NEK2_2	250	255	PF00069	0.466
MOD_PIKK_1	170	176	PF00454	0.428
MOD_PIKK_1	320	326	PF00454	0.484
MOD_PIKK_1	36	42	PF00454	0.450
MOD_PK_1	193	199	PF00069	0.439
MOD_PKA_2	280	286	PF00069	0.448
MOD_PKA_2	32	38	PF00069	0.466
MOD_PKA_2	44	50	PF00069	0.465
MOD_PKA_2	84	90	PF00069	0.713
MOD_Plk_4	193	199	PF00069	0.494
MOD_Plk_4	23	29	PF00069	0.388
MOD_Plk_4	234	240	PF00069	0.458
MOD_Plk_4	250	256	PF00069	0.350
MOD_Plk_4	5	11	PF00069	0.438
MOD_SUMO_for_1	130	133	PF00179	0.438
MOD_SUMO_rev_2	124	130	PF00179	0.550
TRG_ENDOCYTIC_2	220	223	PF00928	0.476
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P482	Leptomonas seymouri	78%	99%
A0A0S4KFL2	Bodo saltans	56%	100%
A0A1X0NNN1	Trypanosomatidae	63%	100%
A0A3R7KDG6	Trypanosoma rangeli	63%	100%
A0A3S5H6R4	Leishmania donovani	96%	100%
A4H7K5	Leishmania braziliensis	86%	100%
A4HVY8	Leishmania infantum	96%	100%
C9ZT35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9APP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O35685	Mus musculus	44%	99%
Q17QG2	Bos taurus	44%	99%
Q5RB75	Pongo abelii	30%	91%
Q5ZIN1	Gallus gallus	44%	96%
Q63525	Rattus norvegicus	43%	99%
Q8IVD9	Homo sapiens	30%	91%
Q8R1N4	Mus musculus	30%	90%
Q9VVA6	Drosophila melanogaster	37%	99%
Q9Y266	Homo sapiens	44%	99%
V5BHT5	Trypanosoma cruzi	63%	79%