Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFT5_LEIMA

TriTrypDb:

LmjF.14.0500 , LMJLV39_140010800 , LMJSD75_140010400

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFT5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.467
CLV_C14_Caspase3-7	349	353	PF00656	0.517
CLV_NRD_NRD_1	130	132	PF00675	0.654
CLV_NRD_NRD_1	390	392	PF00675	0.451
CLV_NRD_NRD_1	451	453	PF00675	0.592
CLV_NRD_NRD_1	73	75	PF00675	0.568
CLV_PCSK_KEX2_1	129	131	PF00082	0.681
CLV_PCSK_KEX2_1	451	453	PF00082	0.592
CLV_PCSK_KEX2_1	73	75	PF00082	0.571
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.516
CLV_PCSK_SKI1_1	13	17	PF00082	0.541
CLV_PCSK_SKI1_1	131	135	PF00082	0.530
CLV_PCSK_SKI1_1	316	320	PF00082	0.510
CLV_PCSK_SKI1_1	441	445	PF00082	0.541
CLV_PCSK_SKI1_1	480	484	PF00082	0.455
CLV_Separin_Metazoa	38	42	PF03568	0.610
DEG_APCC_DBOX_1	139	147	PF00400	0.573
DEG_ODPH_VHL_1	150	163	PF01847	0.434
DEG_SCF_FBW7_1	468	474	PF00400	0.525
DEG_SPOP_SBC_1	14	18	PF00917	0.539
DEG_SPOP_SBC_1	408	412	PF00917	0.523
DOC_CKS1_1	468	473	PF01111	0.531
DOC_CYCLIN_RxL_1	388	398	PF00134	0.567
DOC_MAPK_MEF2A_6	354	362	PF00069	0.567
DOC_PP4_FxxP_1	362	365	PF00568	0.600
DOC_USP7_MATH_1	177	181	PF00917	0.582
DOC_USP7_MATH_1	230	234	PF00917	0.668
DOC_USP7_MATH_1	274	278	PF00917	0.736
DOC_USP7_MATH_1	409	413	PF00917	0.605
DOC_USP7_MATH_1	419	423	PF00917	0.568
DOC_USP7_MATH_1	471	475	PF00917	0.510
DOC_USP7_MATH_1	537	541	PF00917	0.511
DOC_USP7_MATH_1	543	547	PF00917	0.523
DOC_USP7_UBL2_3	388	392	PF12436	0.449
DOC_WW_Pin1_4	105	110	PF00397	0.661
DOC_WW_Pin1_4	184	189	PF00397	0.643
DOC_WW_Pin1_4	251	256	PF00397	0.521
DOC_WW_Pin1_4	286	291	PF00397	0.481
DOC_WW_Pin1_4	42	47	PF00397	0.692
DOC_WW_Pin1_4	424	429	PF00397	0.538
DOC_WW_Pin1_4	445	450	PF00397	0.805
DOC_WW_Pin1_4	467	472	PF00397	0.526
LIG_14-3-3_CanoR_1	155	165	PF00244	0.553
LIG_14-3-3_CanoR_1	179	188	PF00244	0.585
LIG_14-3-3_CanoR_1	19	26	PF00244	0.536
LIG_14-3-3_CanoR_1	354	358	PF00244	0.546
LIG_14-3-3_CanoR_1	380	384	PF00244	0.379
LIG_14-3-3_CanoR_1	441	449	PF00244	0.546
LIG_14-3-3_CanoR_1	73	79	PF00244	0.591
LIG_Actin_WH2_2	139	157	PF00022	0.433
LIG_Actin_WH2_2	326	343	PF00022	0.507
LIG_Actin_WH2_2	364	382	PF00022	0.411
LIG_BIR_III_2	265	269	PF00653	0.669
LIG_BIR_III_4	225	229	PF00653	0.618
LIG_CaM_IQ_9	165	181	PF13499	0.464
LIG_Dynein_DLC8_1	39	45	PF01221	0.678
LIG_EVH1_2	255	259	PF00568	0.523
LIG_FHA_1	145	151	PF00498	0.515
LIG_FHA_1	282	288	PF00498	0.593
LIG_FHA_1	527	533	PF00498	0.374
LIG_FHA_2	115	121	PF00498	0.647
LIG_FHA_2	244	250	PF00498	0.553
LIG_FHA_2	370	376	PF00498	0.475
LIG_FHA_2	93	99	PF00498	0.662
LIG_GBD_Chelix_1	510	518	PF00786	0.534
LIG_LIR_Apic_2	361	365	PF02991	0.606
LIG_LIR_Nem_3	505	510	PF02991	0.639
LIG_NRBOX	346	352	PF00104	0.556
LIG_PDZ_Class_1	543	548	PF00595	0.541
LIG_SH2_CRK	507	511	PF00017	0.530
LIG_SH2_STAT3	312	315	PF00017	0.467
LIG_SH2_STAT5	503	506	PF00017	0.537
LIG_SH2_STAT5	531	534	PF00017	0.450
LIG_SH3_3	185	191	PF00018	0.614
LIG_SH3_3	224	230	PF00018	0.658
LIG_SH3_3	265	271	PF00018	0.668
LIG_SH3_3	36	42	PF00018	0.596
LIG_SH3_3	465	471	PF00018	0.553
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.431
LIG_TRAF2_1	334	337	PF00917	0.460
LIG_TRAF2_1	372	375	PF00917	0.483
LIG_TRAF2_1	499	502	PF00917	0.445
LIG_TRAF2_1	77	80	PF00917	0.730
MOD_CDK_SPxK_1	445	451	PF00069	0.603
MOD_CDK_SPxxK_3	42	49	PF00069	0.567
MOD_CDK_SPxxK_3	445	452	PF00069	0.588
MOD_CK1_1	180	186	PF00069	0.598
MOD_CK1_1	187	193	PF00069	0.582
MOD_CK1_1	233	239	PF00069	0.654
MOD_CK1_1	311	317	PF00069	0.661
MOD_CK1_1	426	432	PF00069	0.674
MOD_CK1_1	460	466	PF00069	0.562
MOD_CK1_1	47	53	PF00069	0.692
MOD_CK2_1	243	249	PF00069	0.650
MOD_CK2_1	369	375	PF00069	0.491
MOD_CK2_1	471	477	PF00069	0.521
MOD_CK2_1	74	80	PF00069	0.565
MOD_CK2_1	92	98	PF00069	0.540
MOD_Cter_Amidation	71	74	PF01082	0.592
MOD_GlcNHglycan	180	183	PF01048	0.545
MOD_GlcNHglycan	221	225	PF01048	0.617
MOD_GlcNHglycan	402	405	PF01048	0.546
MOD_GlcNHglycan	411	414	PF01048	0.603
MOD_GlcNHglycan	421	424	PF01048	0.525
MOD_GlcNHglycan	436	440	PF01048	0.537
MOD_GlcNHglycan	46	49	PF01048	0.636
MOD_GlcNHglycan	464	468	PF01048	0.565
MOD_GlcNHglycan	539	542	PF01048	0.509
MOD_GlcNHglycan	89	92	PF01048	0.616
MOD_GSK3_1	112	119	PF00069	0.656
MOD_GSK3_1	14	21	PF00069	0.635
MOD_GSK3_1	177	184	PF00069	0.607
MOD_GSK3_1	22	29	PF00069	0.711
MOD_GSK3_1	239	246	PF00069	0.741
MOD_GSK3_1	336	343	PF00069	0.511
MOD_GSK3_1	40	47	PF00069	0.658
MOD_GSK3_1	409	416	PF00069	0.611
MOD_GSK3_1	419	426	PF00069	0.536
MOD_GSK3_1	435	442	PF00069	0.663
MOD_GSK3_1	463	470	PF00069	0.563
MOD_GSK3_1	99	106	PF00069	0.584
MOD_N-GLC_1	121	126	PF02516	0.563
MOD_N-GLC_1	419	424	PF02516	0.604
MOD_NEK2_1	15	20	PF00069	0.577
MOD_NEK2_1	250	255	PF00069	0.574
MOD_NEK2_1	379	384	PF00069	0.451
MOD_NEK2_1	418	423	PF00069	0.781
MOD_PIKK_1	230	236	PF00454	0.712
MOD_PIKK_1	281	287	PF00454	0.577
MOD_PIKK_1	311	317	PF00454	0.523
MOD_PIKK_1	40	46	PF00454	0.677
MOD_PK_1	260	266	PF00069	0.547
MOD_PKA_1	73	79	PF00069	0.611
MOD_PKA_2	112	118	PF00069	0.632
MOD_PKA_2	178	184	PF00069	0.570
MOD_PKA_2	18	24	PF00069	0.535
MOD_PKA_2	274	280	PF00069	0.594
MOD_PKA_2	321	327	PF00069	0.446
MOD_PKA_2	353	359	PF00069	0.543
MOD_PKA_2	379	385	PF00069	0.375
MOD_PKA_2	40	46	PF00069	0.677
MOD_PKA_2	450	456	PF00069	0.653
MOD_PKA_2	73	79	PF00069	0.611
MOD_Plk_1	336	342	PF00069	0.524
MOD_Plk_1	413	419	PF00069	0.662
MOD_Plk_1	463	469	PF00069	0.500
MOD_Plk_2-3	305	311	PF00069	0.468
MOD_Plk_4	413	419	PF00069	0.595
MOD_ProDKin_1	105	111	PF00069	0.658
MOD_ProDKin_1	184	190	PF00069	0.639
MOD_ProDKin_1	251	257	PF00069	0.520
MOD_ProDKin_1	286	292	PF00069	0.477
MOD_ProDKin_1	42	48	PF00069	0.692
MOD_ProDKin_1	424	430	PF00069	0.540
MOD_ProDKin_1	445	451	PF00069	0.806
MOD_ProDKin_1	467	473	PF00069	0.520
MOD_SUMO_for_1	133	136	PF00179	0.569
TRG_DiLeu_BaEn_1	128	133	PF01217	0.517
TRG_DiLeu_BaEn_1	296	301	PF01217	0.527
TRG_DiLeu_BaEn_4	374	380	PF01217	0.462
TRG_DiLeu_LyEn_5	296	301	PF01217	0.527
TRG_ENDOCYTIC_2	507	510	PF00928	0.616
TRG_ER_diArg_1	130	132	PF00400	0.632
TRG_ER_diArg_1	152	155	PF00400	0.444
TRG_ER_diArg_1	259	262	PF00400	0.615
TRG_NES_CRM1_1	291	304	PF08389	0.461
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	299	304	PF00026	0.628
TRG_Pf-PMV_PEXEL_1	488	492	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	512	517	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	523	527	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9D0	Leptomonas seymouri	36%	81%
A0A3S7WSW7	Leishmania donovani	86%	100%
A4H6I2	Leishmania braziliensis	62%	82%
A4HVZ2	Leishmania infantum	86%	100%
E9APP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	83%