Putative stearic acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stearic acid desaturase, putative

Species:

Leishmania major

UniProt:

Q4QFT4_LEIMA

TriTrypDb:

LmjF.14.0510 , LMJLV39_140010900 , LMJSD75_140010500

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	3
GO:0016020	membrane	2	16
GO:0031090	organelle membrane	3	3
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4QFT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFT4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006629	lipid metabolic process	3	16
GO:0006631	fatty acid metabolic process	4	16
GO:0006633	fatty acid biosynthetic process	5	16
GO:0006636	unsaturated fatty acid biosynthetic process	6	16
GO:0008152	metabolic process	1	16
GO:0008610	lipid biosynthetic process	4	16
GO:0009058	biosynthetic process	2	16
GO:0009987	cellular process	1	16
GO:0016053	organic acid biosynthetic process	4	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0032787	monocarboxylic acid metabolic process	6	16
GO:0033559	unsaturated fatty acid metabolic process	5	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044255	cellular lipid metabolic process	3	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046394	carboxylic acid biosynthetic process	5	16
GO:0071704	organic substance metabolic process	2	16
GO:0072330	monocarboxylic acid biosynthetic process	6	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004768	stearoyl-CoA 9-desaturase activity	6	16
GO:0005488	binding	1	7
GO:0005506	iron ion binding	6	3
GO:0016215	acyl-CoA desaturase activity	5	16
GO:0016491	oxidoreductase activity	2	16
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	16
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	16
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.429
CLV_NRD_NRD_1	141	143	PF00675	0.208
CLV_NRD_NRD_1	178	180	PF00675	0.229
CLV_NRD_NRD_1	323	325	PF00675	0.404
CLV_NRD_NRD_1	356	358	PF00675	0.331
CLV_NRD_NRD_1	461	463	PF00675	0.414
CLV_PCSK_KEX2_1	141	143	PF00082	0.286
CLV_PCSK_KEX2_1	461	463	PF00082	0.416
CLV_PCSK_SKI1_1	216	220	PF00082	0.305
CLV_PCSK_SKI1_1	357	361	PF00082	0.312
CLV_PCSK_SKI1_1	396	400	PF00082	0.249
CLV_PCSK_SKI1_1	405	409	PF00082	0.260
DEG_MDM2_SWIB_1	210	217	PF02201	0.277
DEG_MDM2_SWIB_1	35	42	PF02201	0.477
DEG_Nend_Nbox_1	1	3	PF02207	0.668
DOC_CDC14_PxL_1	44	52	PF14671	0.471
DOC_CYCLIN_RxL_1	354	363	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	369	375	PF00134	0.483
DOC_CYCLIN_yCln2_LP_2	58	64	PF00134	0.538
DOC_MAPK_gen_1	461	467	PF00069	0.576
DOC_MAPK_MEF2A_6	170	177	PF00069	0.429
DOC_PP1_RVXF_1	382	389	PF00149	0.566
DOC_PP2B_LxvP_1	336	339	PF13499	0.575
DOC_PP2B_LxvP_1	58	61	PF13499	0.526
DOC_USP7_MATH_1	164	168	PF00917	0.477
DOC_USP7_MATH_1	248	252	PF00917	0.498
DOC_USP7_MATH_1	438	442	PF00917	0.610
DOC_WW_Pin1_4	244	249	PF00397	0.500
LIG_14-3-3_CanoR_1	304	310	PF00244	0.585
LIG_14-3-3_CanoR_1	59	65	PF00244	0.255
LIG_14-3-3_CanoR_1	88	95	PF00244	0.463
LIG_BRCT_BRCA1_1	250	254	PF00533	0.408
LIG_Clathr_ClatBox_1	359	363	PF01394	0.465
LIG_deltaCOP1_diTrp_1	204	211	PF00928	0.258
LIG_FHA_1	187	193	PF00498	0.265
LIG_FHA_1	75	81	PF00498	0.356
LIG_FHA_1	8	14	PF00498	0.664
LIG_FHA_2	131	137	PF00498	0.444
LIG_FHA_2	199	205	PF00498	0.265
LIG_FHA_2	245	251	PF00498	0.450
LIG_FHA_2	306	312	PF00498	0.527
LIG_LIR_Gen_1	157	166	PF02991	0.464
LIG_LIR_Gen_1	251	259	PF02991	0.434
LIG_LIR_Gen_1	286	296	PF02991	0.561
LIG_LIR_Gen_1	343	353	PF02991	0.527
LIG_LIR_Gen_1	387	393	PF02991	0.413
LIG_LIR_Gen_1	63	72	PF02991	0.208
LIG_LIR_Gen_1	83	94	PF02991	0.292
LIG_LIR_LC3C_4	171	175	PF02991	0.429
LIG_LIR_Nem_3	147	152	PF02991	0.511
LIG_LIR_Nem_3	157	161	PF02991	0.448
LIG_LIR_Nem_3	251	257	PF02991	0.479
LIG_LIR_Nem_3	261	266	PF02991	0.455
LIG_LIR_Nem_3	286	291	PF02991	0.486
LIG_LIR_Nem_3	294	298	PF02991	0.462
LIG_LIR_Nem_3	343	349	PF02991	0.515
LIG_LIR_Nem_3	63	67	PF02991	0.216
LIG_LIR_Nem_3	83	89	PF02991	0.313
LIG_NRBOX	49	55	PF00104	0.265
LIG_PDZ_Class_2	462	467	PF00595	0.577
LIG_Pex14_1	103	107	PF04695	0.458
LIG_Pex14_1	205	209	PF04695	0.244
LIG_Pex14_1	214	218	PF04695	0.286
LIG_Pex14_1	39	43	PF04695	0.265
LIG_Pex14_1	69	73	PF04695	0.265
LIG_Pex14_2	210	214	PF04695	0.416
LIG_Pex14_2	291	295	PF04695	0.472
LIG_Pex14_2	35	39	PF04695	0.485
LIG_SH2_CRK	158	162	PF00017	0.468
LIG_SH2_CRK	86	90	PF00017	0.458
LIG_SH2_GRB2like	263	266	PF00017	0.444
LIG_SH2_SRC	43	46	PF00017	0.474
LIG_SH2_STAT3	266	269	PF00017	0.408
LIG_SH2_STAT5	130	133	PF00017	0.449
LIG_SH2_STAT5	181	184	PF00017	0.527
LIG_SH2_STAT5	289	292	PF00017	0.464
LIG_SH2_STAT5	365	368	PF00017	0.462
LIG_SH2_STAT5	402	405	PF00017	0.433
LIG_SH2_STAT5	425	428	PF00017	0.512
LIG_SH2_STAT5	43	46	PF00017	0.384
LIG_SH2_STAT5	57	60	PF00017	0.213
LIG_SH3_1	371	377	PF00018	0.535
LIG_SH3_3	371	377	PF00018	0.574
LIG_SH3_3	454	460	PF00018	0.546
LIG_Sin3_3	72	79	PF02671	0.176
LIG_SUMO_SIM_par_1	365	370	PF11976	0.523
LIG_TRAF2_1	443	446	PF00917	0.575
LIG_WRC_WIRS_1	292	297	PF05994	0.478
MOD_CK1_1	12	18	PF00069	0.615
MOD_CK1_1	440	446	PF00069	0.623
MOD_CK2_1	12	18	PF00069	0.644
MOD_CK2_1	198	204	PF00069	0.265
MOD_CK2_1	440	446	PF00069	0.604
MOD_CMANNOS	211	214	PF00535	0.315
MOD_Cter_Amidation	322	325	PF01082	0.277
MOD_Cter_Amidation	355	358	PF01082	0.339
MOD_GlcNHglycan	440	443	PF01048	0.468
MOD_GlcNHglycan	445	450	PF01048	0.448
MOD_GSK3_1	226	233	PF00069	0.301
MOD_GSK3_1	244	251	PF00069	0.339
MOD_GSK3_1	9	16	PF00069	0.662
MOD_N-GLC_1	244	249	PF02516	0.235
MOD_NEK2_1	113	118	PF00069	0.450
MOD_NEK2_1	144	149	PF00069	0.457
MOD_NEK2_1	169	174	PF00069	0.440
MOD_NEK2_1	226	231	PF00069	0.319
MOD_NEK2_1	236	241	PF00069	0.466
MOD_NEK2_1	291	296	PF00069	0.475
MOD_NEK2_1	62	67	PF00069	0.282
MOD_NEK2_1	9	14	PF00069	0.646
MOD_PKA_1	384	390	PF00069	0.398
MOD_Plk_4	169	175	PF00069	0.556
MOD_Plk_4	248	254	PF00069	0.449
MOD_Plk_4	291	297	PF00069	0.602
MOD_Plk_4	9	15	PF00069	0.632
MOD_ProDKin_1	244	250	PF00069	0.500
MOD_SUMO_for_1	21	24	PF00179	0.591
MOD_SUMO_rev_2	12	21	PF00179	0.566
MOD_SUMO_rev_2	163	172	PF00179	0.408
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.455
TRG_ENDOCYTIC_2	158	161	PF00928	0.486
TRG_ENDOCYTIC_2	289	292	PF00928	0.493
TRG_ENDOCYTIC_2	37	40	PF00928	0.591
TRG_ENDOCYTIC_2	57	60	PF00928	0.279
TRG_ENDOCYTIC_2	86	89	PF00928	0.449
TRG_ER_diArg_1	460	462	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI5	Leptomonas seymouri	46%	100%
A0A0S4KNP4	Bodo saltans	42%	100%
A0A1X0NW01	Trypanosomatidae	45%	100%
A0A3Q8I9W7	Leishmania donovani	96%	100%
A0A3Q8IBJ0	Leishmania donovani	46%	100%
A0A3R7MEL0	Trypanosoma rangeli	47%	100%
A4H6I1	Leishmania braziliensis	83%	100%
A4HDT6	Leishmania braziliensis	47%	100%
A4HVZ3	Leishmania infantum	96%	100%
A4I134	Leishmania infantum	46%	100%
C9ZW73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9APP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AX71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
G5ED44	Caenorhabditis elegans	29%	100%
O00767	Homo sapiens	30%	100%
O44390	Trichoplusia ni	31%	100%
O94523	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	97%
P0DOW2	Anemone leveillei	27%	100%
P21147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	92%
Q12618	Ajellomyces capsulatus	37%	98%
Q4QAA5	Leishmania major	45%	100%
Q64420	Mesocricetus auratus	31%	100%
Q6US81	Spodoptera littoralis	32%	100%
Q99PL7	Mus musculus	29%	100%
Q9BH41	Acheta domesticus	27%	100%
Q9FV68	Limnanthes douglasii	27%	100%