HYPK_UBA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFT3_LEIMA

TriTrypDb:

LmjF.14.0520 , LMJLV39_140011000 , LMJSD75_140010600

Length:

109

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFT3

Function

Biological processes
Term	Name	Level	Count
GO:0010941	regulation of cell death	4	2
GO:0031647	regulation of protein stability	3	2
GO:0042981	regulation of apoptotic process	6	2
GO:0043066	negative regulation of apoptotic process	7	2
GO:0043067	regulation of programmed cell death	5	2
GO:0043069	negative regulation of programmed cell death	6	2
GO:0048519	negative regulation of biological process	3	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0050821	protein stabilization	4	2
GO:0060548	negative regulation of cell death	5	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.563
CLV_PCSK_SKI1_1	12	16	PF00082	0.600
CLV_PCSK_SKI1_1	84	88	PF00082	0.578
DOC_CKS1_1	77	82	PF01111	0.340
DOC_MAPK_gen_1	55	64	PF00069	0.658
DOC_MAPK_RevD_3	76	90	PF00069	0.328
DOC_USP7_UBL2_3	9	13	PF12436	0.555
DOC_WW_Pin1_4	76	81	PF00397	0.539
LIG_BIR_III_4	100	104	PF00653	0.484
LIG_FHA_1	21	27	PF00498	0.636
LIG_FHA_1	93	99	PF00498	0.526
LIG_PCNA_yPIPBox_3	84	98	PF02747	0.441
LIG_SH3_3	99	105	PF00018	0.501
LIG_TRAF2_1	33	36	PF00917	0.563
MOD_GlcNHglycan	16	19	PF01048	0.673
MOD_GSK3_1	21	28	PF00069	0.597
MOD_PIKK_1	43	49	PF00454	0.502
MOD_PKA_1	12	18	PF00069	0.548
MOD_Plk_1	92	98	PF00069	0.500
MOD_ProDKin_1	76	82	PF00069	0.539
MOD_SUMO_rev_2	6	11	PF00179	0.587
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I281	Leptomonas seymouri	59%	100%
A0A0S4KIP0	Bodo saltans	41%	95%
A0A1X0NQ53	Trypanosomatidae	39%	96%
A0A3R7M108	Trypanosoma rangeli	39%	97%
A0A3S7WSY1	Leishmania donovani	97%	100%
A4H7L0	Leishmania braziliensis	93%	100%
A4HVZ4	Leishmania infantum	97%	100%
C9ZT24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
E9APP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%