Ion transport protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ion transport protein-like protein

Species:

Leishmania major

UniProt:

Q4QFT1_LEIMA

TriTrypDb:

LmjF.14.0540 , LMJLV39_140011200 , LMJSD75_140010800

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QFT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFT1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0005216	monoatomic ion channel activity	4	11
GO:0005227	calcium activated cation channel activity	6	11
GO:0005261	monoatomic cation channel activity	5	11
GO:0005267	potassium channel activity	6	11
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0015079	potassium ion transmembrane transporter activity	6	11
GO:0015267	channel activity	4	11
GO:0015269	calcium-activated potassium channel activity	7	11
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	11
GO:0016286	small conductance calcium-activated potassium channel activity	8	11
GO:0022803	passive transmembrane transporter activity	3	11
GO:0022836	gated channel activity	5	11
GO:0022839	monoatomic ion gated channel activity	6	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022890	inorganic cation transmembrane transporter activity	4	11
GO:0046873	metal ion transmembrane transporter activity	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.353
CLV_NRD_NRD_1	14	16	PF00675	0.463
CLV_NRD_NRD_1	322	324	PF00675	0.452
CLV_NRD_NRD_1	353	355	PF00675	0.345
CLV_NRD_NRD_1	421	423	PF00675	0.453
CLV_PCSK_KEX2_1	14	16	PF00082	0.469
CLV_PCSK_KEX2_1	2	4	PF00082	0.502
CLV_PCSK_KEX2_1	353	355	PF00082	0.344
CLV_PCSK_KEX2_1	421	423	PF00082	0.453
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.533
CLV_PCSK_PC7_1	10	16	PF00082	0.435
CLV_PCSK_SKI1_1	117	121	PF00082	0.279
CLV_PCSK_SKI1_1	14	18	PF00082	0.395
CLV_PCSK_SKI1_1	147	151	PF00082	0.545
CLV_PCSK_SKI1_1	3	7	PF00082	0.457
CLV_PCSK_SKI1_1	40	44	PF00082	0.425
CLV_PCSK_SKI1_1	412	416	PF00082	0.515
DEG_Nend_UBRbox_1	1	4	PF02207	0.643
DEG_SPOP_SBC_1	189	193	PF00917	0.559
DEG_SPOP_SBC_1	445	449	PF00917	0.748
DOC_CKS1_1	137	142	PF01111	0.336
DOC_MAPK_gen_1	204	213	PF00069	0.499
DOC_MAPK_gen_1	306	315	PF00069	0.625
DOC_MAPK_gen_1	333	341	PF00069	0.589
DOC_MAPK_gen_1	398	407	PF00069	0.635
DOC_MAPK_gen_1	421	429	PF00069	0.647
DOC_MAPK_HePTP_8	201	213	PF00069	0.554
DOC_MAPK_MEF2A_6	160	168	PF00069	0.355
DOC_MAPK_MEF2A_6	204	213	PF00069	0.554
DOC_MAPK_MEF2A_6	21	28	PF00069	0.566
DOC_MAPK_MEF2A_6	400	409	PF00069	0.638
DOC_PP1_RVXF_1	256	263	PF00149	0.279
DOC_PP4_FxxP_1	120	123	PF00568	0.334
DOC_USP7_MATH_1	362	366	PF00917	0.597
DOC_USP7_MATH_1	431	435	PF00917	0.688
DOC_USP7_MATH_1	445	449	PF00917	0.652
DOC_USP7_UBL2_3	17	21	PF12436	0.631
DOC_WW_Pin1_4	119	124	PF00397	0.311
DOC_WW_Pin1_4	136	141	PF00397	0.315
DOC_WW_Pin1_4	248	253	PF00397	0.270
LIG_14-3-3_CanoR_1	117	123	PF00244	0.467
LIG_14-3-3_CanoR_1	160	165	PF00244	0.433
LIG_14-3-3_CanoR_1	180	189	PF00244	0.549
LIG_14-3-3_CanoR_1	206	212	PF00244	0.466
LIG_14-3-3_CanoR_1	306	315	PF00244	0.574
LIG_Actin_WH2_2	41	58	PF00022	0.537
LIG_BRCT_BRCA1_1	121	125	PF00533	0.388
LIG_BRCT_BRCA1_1	190	194	PF00533	0.552
LIG_CaM_IQ_9	310	326	PF13499	0.595
LIG_CtBP_PxDLS_1	491	495	PF00389	0.653
LIG_deltaCOP1_diTrp_1	233	239	PF00928	0.265
LIG_EH1_1	126	134	PF00400	0.449
LIG_EH1_1	289	297	PF00400	0.647
LIG_EVH1_2	140	144	PF00568	0.398
LIG_FHA_1	108	114	PF00498	0.522
LIG_FHA_1	190	196	PF00498	0.546
LIG_FHA_1	203	209	PF00498	0.415
LIG_FHA_1	224	230	PF00498	0.342
LIG_FHA_1	336	342	PF00498	0.621
LIG_FHA_1	344	350	PF00498	0.463
LIG_FHA_1	82	88	PF00498	0.388
LIG_FHA_1	97	103	PF00498	0.498
LIG_FHA_2	292	298	PF00498	0.613
LIG_FHA_2	41	47	PF00498	0.526
LIG_GBD_Chelix_1	64	72	PF00786	0.355
LIG_LIR_Gen_1	122	133	PF02991	0.449
LIG_LIR_Gen_1	139	150	PF02991	0.417
LIG_LIR_Gen_1	177	185	PF02991	0.561
LIG_LIR_Gen_1	22	33	PF02991	0.601
LIG_LIR_Gen_1	238	247	PF02991	0.301
LIG_LIR_Gen_1	268	277	PF02991	0.338
LIG_LIR_Gen_1	278	285	PF02991	0.422
LIG_LIR_Gen_1	384	393	PF02991	0.673
LIG_LIR_Gen_1	403	414	PF02991	0.532
LIG_LIR_Nem_3	139	145	PF02991	0.433
LIG_LIR_Nem_3	177	181	PF02991	0.542
LIG_LIR_Nem_3	22	28	PF02991	0.590
LIG_LIR_Nem_3	233	239	PF02991	0.378
LIG_LIR_Nem_3	244	250	PF02991	0.265
LIG_LIR_Nem_3	278	283	PF02991	0.484
LIG_LIR_Nem_3	384	388	PF02991	0.678
LIG_LIR_Nem_3	403	409	PF02991	0.520
LIG_MLH1_MIPbox_1	121	125	PF16413	0.355
LIG_NRBOX	340	346	PF00104	0.581
LIG_Pex14_1	265	269	PF04695	0.330
LIG_PTB_Apo_2	108	115	PF02174	0.553
LIG_PTB_Apo_2	167	174	PF02174	0.384
LIG_PTB_Apo_2	24	31	PF02174	0.541
LIG_PTB_Apo_2	73	80	PF02174	0.374
LIG_PTB_Phospho_1	167	173	PF10480	0.399
LIG_PTB_Phospho_1	24	30	PF10480	0.536
LIG_SH2_CRK	162	166	PF00017	0.355
LIG_SH2_CRK	280	284	PF00017	0.586
LIG_SH2_GRB2like	167	170	PF00017	0.448
LIG_SH2_GRB2like	25	28	PF00017	0.532
LIG_SH2_PTP2	25	28	PF00017	0.608
LIG_SH2_SRC	25	28	PF00017	0.592
LIG_SH2_SRC	30	33	PF00017	0.622
LIG_SH2_STAP1	162	166	PF00017	0.355
LIG_SH2_STAP1	337	341	PF00017	0.617
LIG_SH2_STAT5	124	127	PF00017	0.377
LIG_SH2_STAT5	155	158	PF00017	0.295
LIG_SH2_STAT5	167	170	PF00017	0.466
LIG_SH2_STAT5	173	176	PF00017	0.561
LIG_SH2_STAT5	25	28	PF00017	0.597
LIG_SH2_STAT5	269	272	PF00017	0.385
LIG_SH2_STAT5	337	340	PF00017	0.656
LIG_SH2_STAT5	385	388	PF00017	0.593
LIG_SH2_STAT5	406	409	PF00017	0.612
LIG_SH3_1	324	330	PF00018	0.656
LIG_SH3_3	324	330	PF00018	0.657
LIG_SUMO_SIM_anti_2	425	431	PF11976	0.665
LIG_SUMO_SIM_anti_2	43	49	PF11976	0.543
LIG_SUMO_SIM_par_1	337	342	PF11976	0.606
LIG_SUMO_SIM_par_1	67	73	PF11976	0.404
LIG_TRAF2_1	29	32	PF00917	0.635
LIG_TYR_ITIM	245	250	PF00017	0.330
MOD_CK1_1	107	113	PF00069	0.487
MOD_CK1_1	183	189	PF00069	0.538
MOD_CK1_1	238	244	PF00069	0.387
MOD_CK1_1	253	259	PF00069	0.244
MOD_CK1_1	286	292	PF00069	0.526
MOD_CK1_1	417	423	PF00069	0.530
MOD_CK1_1	449	455	PF00069	0.586
MOD_CK1_1	70	76	PF00069	0.437
MOD_CK2_1	26	32	PF00069	0.540
MOD_CK2_1	291	297	PF00069	0.517
MOD_CK2_1	362	368	PF00069	0.569
MOD_CK2_1	40	46	PF00069	0.363
MOD_CK2_1	452	458	PF00069	0.683
MOD_Cter_Amidation	12	15	PF01082	0.557
MOD_GlcNHglycan	106	109	PF01048	0.487
MOD_GlcNHglycan	182	185	PF01048	0.483
MOD_GlcNHglycan	255	258	PF01048	0.388
MOD_GlcNHglycan	308	311	PF01048	0.406
MOD_GlcNHglycan	377	380	PF01048	0.522
MOD_GlcNHglycan	449	452	PF01048	0.614
MOD_GlcNHglycan	483	486	PF01048	0.612
MOD_GlcNHglycan	76	79	PF01048	0.503
MOD_GSK3_1	223	230	PF00069	0.475
MOD_GSK3_1	335	342	PF00069	0.463
MOD_GSK3_1	362	369	PF00069	0.536
MOD_GSK3_1	445	452	PF00069	0.679
MOD_GSK3_1	486	493	PF00069	0.589
MOD_GSK3_1	70	77	PF00069	0.469
MOD_N-GLC_1	227	232	PF02516	0.399
MOD_N-GLC_1	26	31	PF02516	0.424
MOD_N-GLC_1	366	371	PF02516	0.657
MOD_N-GLC_1	81	86	PF02516	0.388
MOD_NEK2_1	1	6	PF00069	0.630
MOD_NEK2_1	190	195	PF00069	0.386
MOD_NEK2_1	223	228	PF00069	0.405
MOD_NEK2_1	235	240	PF00069	0.349
MOD_NEK2_1	275	280	PF00069	0.379
MOD_NEK2_1	301	306	PF00069	0.512
MOD_NEK2_1	339	344	PF00069	0.423
MOD_NEK2_1	366	371	PF00069	0.553
MOD_NEK2_1	415	420	PF00069	0.612
MOD_NEK2_1	446	451	PF00069	0.684
MOD_NEK2_1	494	499	PF00069	0.672
MOD_NEK2_1	67	72	PF00069	0.308
MOD_NEK2_1	86	91	PF00069	0.404
MOD_PIKK_1	223	229	PF00454	0.393
MOD_PIKK_1	86	92	PF00454	0.419
MOD_PK_1	160	166	PF00069	0.433
MOD_PKA_2	352	358	PF00069	0.486
MOD_Plk_1	227	233	PF00069	0.383
MOD_Plk_1	26	32	PF00069	0.540
MOD_Plk_1	40	46	PF00069	0.511
MOD_Plk_1	81	87	PF00069	0.315
MOD_Plk_4	160	166	PF00069	0.388
MOD_Plk_4	190	196	PF00069	0.468
MOD_Plk_4	207	213	PF00069	0.363
MOD_Plk_4	265	271	PF00069	0.396
MOD_Plk_4	278	284	PF00069	0.442
MOD_Plk_4	291	297	PF00069	0.453
MOD_Plk_4	339	345	PF00069	0.457
MOD_Plk_4	423	429	PF00069	0.540
MOD_Plk_4	46	52	PF00069	0.468
MOD_Plk_4	67	73	PF00069	0.322
MOD_Plk_4	81	87	PF00069	0.282
MOD_ProDKin_1	119	125	PF00069	0.311
MOD_ProDKin_1	136	142	PF00069	0.391
MOD_ProDKin_1	248	254	PF00069	0.318
MOD_SUMO_rev_2	464	474	PF00179	0.564
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.511
TRG_ENDOCYTIC_2	155	158	PF00928	0.307
TRG_ENDOCYTIC_2	162	165	PF00928	0.308
TRG_ENDOCYTIC_2	247	250	PF00928	0.335
TRG_ENDOCYTIC_2	25	28	PF00928	0.480
TRG_ENDOCYTIC_2	269	272	PF00928	0.337
TRG_ENDOCYTIC_2	280	283	PF00928	0.395
TRG_ENDOCYTIC_2	385	388	PF00928	0.574
TRG_ENDOCYTIC_2	406	409	PF00928	0.521
TRG_ER_diArg_1	14	16	PF00400	0.637
TRG_ER_diArg_1	305	308	PF00400	0.510
TRG_ER_diArg_1	352	354	PF00400	0.409
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A8	Leptomonas seymouri	72%	90%
A0A0S4IWT9	Bodo saltans	30%	94%
A0A1X0NNP7	Trypanosomatidae	44%	93%
A0A3S7WSZ6	Leishmania donovani	95%	100%
A0A422NNK5	Trypanosoma rangeli	41%	97%
A4H7L2	Leishmania braziliensis	79%	90%
A4HVZ6	Leishmania infantum	95%	100%
E9APP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	90%
V5BNC5	Trypanosoma cruzi	42%	97%