Membrane-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFT0_LEIMA

TriTrypDb:

LmjF.14.0550 , LMJLV39_140011300 , LMJSD75_140010900

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QFT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	312	316	PF00656	0.620
CLV_C14_Caspase3-7	388	392	PF00656	0.593
CLV_MEL_PAP_1	69	75	PF00089	0.579
CLV_NRD_NRD_1	248	250	PF00675	0.708
CLV_NRD_NRD_1	516	518	PF00675	0.557
CLV_PCSK_KEX2_1	248	250	PF00082	0.708
CLV_PCSK_KEX2_1	516	518	PF00082	0.557
CLV_PCSK_SKI1_1	12	16	PF00082	0.549
CLV_PCSK_SKI1_1	243	247	PF00082	0.586
CLV_PCSK_SKI1_1	328	332	PF00082	0.566
CLV_PCSK_SKI1_1	398	402	PF00082	0.374
CLV_PCSK_SKI1_1	464	468	PF00082	0.253
DEG_APCC_DBOX_1	11	19	PF00400	0.352
DEG_Nend_Nbox_1	1	3	PF02207	0.375
DOC_CYCLIN_RxL_1	394	405	PF00134	0.571
DOC_CYCLIN_RxL_1	496	510	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	400	406	PF00134	0.584
DOC_MAPK_gen_1	168	175	PF00069	0.578
DOC_MAPK_gen_1	500	509	PF00069	0.366
DOC_MAPK_gen_1	70	79	PF00069	0.397
DOC_MAPK_HePTP_8	203	215	PF00069	0.453
DOC_MAPK_HePTP_8	499	511	PF00069	0.330
DOC_MAPK_HePTP_8	67	79	PF00069	0.389
DOC_MAPK_MEF2A_6	206	215	PF00069	0.533
DOC_MAPK_MEF2A_6	502	511	PF00069	0.364
DOC_MAPK_MEF2A_6	70	79	PF00069	0.397
DOC_PP2B_LxvP_1	228	231	PF13499	0.449
DOC_PP2B_LxvP_1	52	55	PF13499	0.378
DOC_PP2B_PxIxI_1	496	502	PF00149	0.340
DOC_USP7_MATH_1	189	193	PF00917	0.589
DOC_WW_Pin1_4	112	117	PF00397	0.418
DOC_WW_Pin1_4	222	227	PF00397	0.511
DOC_WW_Pin1_4	399	404	PF00397	0.610
DOC_WW_Pin1_4	50	55	PF00397	0.377
DOC_WW_Pin1_4	532	537	PF00397	0.426
DOC_WW_Pin1_4	83	88	PF00397	0.427
LIG_14-3-3_CanoR_1	206	211	PF00244	0.417
LIG_14-3-3_CanoR_1	249	255	PF00244	0.363
LIG_14-3-3_CanoR_1	359	363	PF00244	0.724
LIG_14-3-3_CanoR_1	435	444	PF00244	0.570
LIG_14-3-3_CanoR_1	516	524	PF00244	0.355
LIG_14-3-3_CanoR_1	72	78	PF00244	0.398
LIG_Actin_WH2_2	3	21	PF00022	0.351
LIG_Actin_WH2_2	346	361	PF00022	0.589
LIG_APCC_ABBA_1	3	8	PF00400	0.351
LIG_BIR_III_4	412	416	PF00653	0.769
LIG_Clathr_ClatBox_1	506	510	PF01394	0.359
LIG_CtBP_PxDLS_1	406	410	PF00389	0.534
LIG_deltaCOP1_diTrp_1	416	419	PF00928	0.580
LIG_FAT_LD_1	474	482	PF03623	0.274
LIG_FHA_1	115	121	PF00498	0.380
LIG_FHA_1	423	429	PF00498	0.588
LIG_FHA_1	451	457	PF00498	0.553
LIG_FHA_1	465	471	PF00498	0.274
LIG_FHA_1	506	512	PF00498	0.361
LIG_FHA_1	74	80	PF00498	0.408
LIG_FHA_1	84	90	PF00498	0.413
LIG_FHA_2	425	431	PF00498	0.725
LIG_GBD_Chelix_1	288	296	PF00786	0.274
LIG_Integrin_isoDGR_2	145	147	PF01839	0.381
LIG_LIR_Gen_1	117	127	PF02991	0.217
LIG_LIR_Gen_1	129	139	PF02991	0.205
LIG_LIR_Gen_1	179	186	PF02991	0.596
LIG_LIR_Gen_1	209	218	PF02991	0.279
LIG_LIR_Gen_1	424	433	PF02991	0.547
LIG_LIR_Nem_3	117	122	PF02991	0.373
LIG_LIR_Nem_3	129	134	PF02991	0.205
LIG_LIR_Nem_3	179	183	PF02991	0.615
LIG_LIR_Nem_3	209	213	PF02991	0.279
LIG_LIR_Nem_3	253	259	PF02991	0.375
LIG_LIR_Nem_3	267	273	PF02991	0.360
LIG_LIR_Nem_3	274	279	PF02991	0.349
LIG_LIR_Nem_3	324	330	PF02991	0.783
LIG_LIR_Nem_3	416	422	PF02991	0.723
LIG_LIR_Nem_3	424	429	PF02991	0.682
LIG_LRP6_Inhibitor_1	451	457	PF00058	0.353
LIG_LYPXL_yS_3	276	279	PF13949	0.352
LIG_MYND_1	399	403	PF01753	0.584
LIG_MYND_1	55	59	PF01753	0.380
LIG_NRBOX	210	216	PF00104	0.488
LIG_NRBOX	41	47	PF00104	0.354
LIG_NRBOX	476	482	PF00104	0.387
LIG_Pex14_2	126	130	PF04695	0.224
LIG_Pex14_2	176	180	PF04695	0.624
LIG_Pex14_2	381	385	PF04695	0.778
LIG_SH2_CRK	463	467	PF00017	0.453
LIG_SH2_SRC	389	392	PF00017	0.589
LIG_SH2_STAP1	171	175	PF00017	0.575
LIG_SH2_STAT5	17	20	PF00017	0.358
LIG_SH2_STAT5	256	259	PF00017	0.450
LIG_SH2_STAT5	278	281	PF00017	0.346
LIG_SH2_STAT5	389	392	PF00017	0.693
LIG_SH2_STAT5	426	429	PF00017	0.667
LIG_SH3_3	108	114	PF00018	0.459
LIG_SH3_3	216	222	PF00018	0.274
LIG_SH3_3	400	406	PF00018	0.584
LIG_SH3_3	485	491	PF00018	0.274
LIG_SH3_3	52	58	PF00018	0.377
LIG_Sin3_3	210	217	PF02671	0.319
LIG_SUMO_SIM_anti_2	209	215	PF11976	0.224
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.449
LIG_SUMO_SIM_anti_2	508	513	PF11976	0.358
LIG_SUMO_SIM_par_1	505	510	PF11976	0.359
LIG_TYR_ITSM	272	279	PF00017	0.366
LIG_WRC_WIRS_1	127	132	PF05994	0.224
LIG_WW_2	55	58	PF00397	0.376
MOD_CDK_SPK_2	532	537	PF00069	0.426
MOD_CDK_SPxxK_3	532	539	PF00069	0.429
MOD_CK1_1	129	135	PF00069	0.242
MOD_CK1_1	224	230	PF00069	0.487
MOD_CK1_1	262	268	PF00069	0.393
MOD_CK1_1	298	304	PF00069	0.604
MOD_CK1_1	402	408	PF00069	0.602
MOD_CK1_1	436	442	PF00069	0.600
MOD_CK1_1	542	548	PF00069	0.532
MOD_CK2_1	424	430	PF00069	0.727
MOD_CK2_1	525	531	PF00069	0.418
MOD_Cter_Amidation	166	169	PF01082	0.380
MOD_GlcNHglycan	123	126	PF01048	0.224
MOD_GlcNHglycan	156	159	PF01048	0.410
MOD_GlcNHglycan	20	23	PF01048	0.555
MOD_GlcNHglycan	259	262	PF01048	0.601
MOD_GlcNHglycan	280	283	PF01048	0.274
MOD_GlcNHglycan	285	288	PF01048	0.256
MOD_GlcNHglycan	303	306	PF01048	0.361
MOD_GlcNHglycan	435	438	PF01048	0.389
MOD_GlcNHglycan	518	521	PF01048	0.584
MOD_GlcNHglycan	545	548	PF01048	0.717
MOD_GSK3_1	129	136	PF00069	0.224
MOD_GSK3_1	220	227	PF00069	0.596
MOD_GSK3_1	250	257	PF00069	0.367
MOD_GSK3_1	268	275	PF00069	0.340
MOD_GSK3_1	294	301	PF00069	0.466
MOD_GSK3_1	424	431	PF00069	0.558
MOD_GSK3_1	537	544	PF00069	0.574
MOD_GSK3_1	83	90	PF00069	0.423
MOD_N-GLC_1	254	259	PF02516	0.602
MOD_N-GLC_1	301	306	PF02516	0.370
MOD_N-GLC_1	383	388	PF02516	0.582
MOD_N-GLC_1	394	399	PF02516	0.443
MOD_N-GLC_1	433	438	PF02516	0.387
MOD_NEK2_1	120	125	PF00069	0.237
MOD_NEK2_1	126	131	PF00069	0.263
MOD_NEK2_1	133	138	PF00069	0.237
MOD_NEK2_1	18	23	PF00069	0.346
MOD_NEK2_1	295	300	PF00069	0.671
MOD_NEK2_1	358	363	PF00069	0.618
MOD_NEK2_1	385	390	PF00069	0.593
MOD_NEK2_1	422	427	PF00069	0.568
MOD_NEK2_1	428	433	PF00069	0.542
MOD_NEK2_1	6	11	PF00069	0.344
MOD_NEK2_1	89	94	PF00069	0.430
MOD_NEK2_2	254	259	PF00069	0.376
MOD_PIKK_1	352	358	PF00454	0.592
MOD_PIKK_1	455	461	PF00454	0.595
MOD_PIKK_1	510	516	PF00454	0.367
MOD_PK_1	40	46	PF00069	0.357
MOD_PKA_1	516	522	PF00069	0.352
MOD_PKA_2	18	24	PF00069	0.358
MOD_PKA_2	358	364	PF00069	0.618
MOD_PKA_2	516	522	PF00069	0.352
MOD_PKA_2	542	548	PF00069	0.547
MOD_PKB_1	537	545	PF00069	0.471
MOD_Plk_1	254	260	PF00069	0.380
MOD_Plk_1	301	307	PF00069	0.572
MOD_Plk_4	115	121	PF00069	0.391
MOD_Plk_4	126	132	PF00069	0.257
MOD_Plk_4	206	212	PF00069	0.534
MOD_Plk_4	224	230	PF00069	0.438
MOD_Plk_4	254	260	PF00069	0.389
MOD_Plk_4	326	332	PF00069	0.773
MOD_Plk_4	366	372	PF00069	0.568
MOD_Plk_4	40	46	PF00069	0.357
MOD_Plk_4	424	430	PF00069	0.727
MOD_ProDKin_1	112	118	PF00069	0.414
MOD_ProDKin_1	222	228	PF00069	0.512
MOD_ProDKin_1	399	405	PF00069	0.610
MOD_ProDKin_1	50	56	PF00069	0.378
MOD_ProDKin_1	532	538	PF00069	0.427
MOD_ProDKin_1	83	89	PF00069	0.428
MOD_SUMO_rev_2	312	318	PF00179	0.585
TRG_DiLeu_BaEn_1	475	480	PF01217	0.224
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.361
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.564
TRG_ENDOCYTIC_2	171	174	PF00928	0.607
TRG_ENDOCYTIC_2	276	279	PF00928	0.352
TRG_ENDOCYTIC_2	426	429	PF00928	0.703
TRG_ENDOCYTIC_2	463	466	PF00928	0.580
TRG_ER_diArg_1	181	184	PF00400	0.632
TRG_ER_diArg_1	247	249	PF00400	0.340
TRG_ER_diArg_1	499	502	PF00400	0.340
TRG_ER_diArg_1	515	517	PF00400	0.339
TRG_ER_diArg_1	536	539	PF00400	0.596
TRG_ER_diArg_1	69	72	PF00400	0.372
TRG_NES_CRM1_1	66	80	PF08389	0.388
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9APP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%