Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QFS9_LEIMA

TriTrypDb:

LmjF.14.0560 , LMJLV39_140011400 , LMJSD75_140011000

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QFS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	399	403	PF00656	0.783
CLV_NRD_NRD_1	226	228	PF00675	0.706
CLV_NRD_NRD_1	331	333	PF00675	0.523
CLV_NRD_NRD_1	335	337	PF00675	0.550
CLV_NRD_NRD_1	406	408	PF00675	0.515
CLV_NRD_NRD_1	41	43	PF00675	0.763
CLV_PCSK_KEX2_1	226	228	PF00082	0.776
CLV_PCSK_KEX2_1	329	331	PF00082	0.509
CLV_PCSK_KEX2_1	335	337	PF00082	0.547
CLV_PCSK_KEX2_1	41	43	PF00082	0.763
CLV_PCSK_KEX2_1	429	431	PF00082	0.644
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.579
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.664
CLV_PCSK_PC7_1	331	337	PF00082	0.435
CLV_PCSK_SKI1_1	126	130	PF00082	0.727
CLV_PCSK_SKI1_1	167	171	PF00082	0.709
CLV_PCSK_SKI1_1	318	322	PF00082	0.371
DEG_Nend_Nbox_1	1	3	PF02207	0.674
DOC_CYCLIN_yCln2_LP_2	272	278	PF00134	0.419
DOC_MAPK_gen_1	223	231	PF00069	0.571
DOC_MAPK_MEF2A_6	51	58	PF00069	0.566
DOC_PP1_RVXF_1	165	172	PF00149	0.508
DOC_PP1_SILK_1	425	430	PF00149	0.861
DOC_PP2B_LxvP_1	108	111	PF13499	0.578
DOC_PP2B_LxvP_1	272	275	PF13499	0.545
DOC_PP2B_PxIxI_1	53	59	PF00149	0.536
DOC_PP4_FxxP_1	449	452	PF00568	0.777
DOC_USP7_MATH_1	202	206	PF00917	0.562
DOC_USP7_MATH_1	24	28	PF00917	0.481
DOC_USP7_MATH_1	364	368	PF00917	0.792
DOC_USP7_MATH_1	411	415	PF00917	0.740
DOC_USP7_MATH_1	423	427	PF00917	0.699
DOC_USP7_MATH_1	63	67	PF00917	0.569
DOC_USP7_UBL2_3	299	303	PF12436	0.723
DOC_USP7_UBL2_3	321	325	PF12436	0.731
DOC_WW_Pin1_4	238	243	PF00397	0.483
DOC_WW_Pin1_4	255	260	PF00397	0.480
DOC_WW_Pin1_4	30	35	PF00397	0.493
DOC_WW_Pin1_4	340	345	PF00397	0.709
DOC_WW_Pin1_4	350	355	PF00397	0.747
DOC_WW_Pin1_4	407	412	PF00397	0.848
DOC_WW_Pin1_4	442	447	PF00397	0.790
LIG_14-3-3_CanoR_1	150	156	PF00244	0.505
LIG_14-3-3_CanoR_1	335	344	PF00244	0.761
LIG_14-3-3_CanoR_1	407	411	PF00244	0.796
LIG_14-3-3_CanoR_1	456	460	PF00244	0.802
LIG_BIR_III_2	31	35	PF00653	0.492
LIG_BIR_III_4	217	221	PF00653	0.580
LIG_BRCT_BRCA1_1	121	125	PF00533	0.578
LIG_BRCT_BRCA1_1	65	69	PF00533	0.568
LIG_FHA_1	116	122	PF00498	0.523
LIG_FHA_1	15	21	PF00498	0.576
LIG_FHA_1	172	178	PF00498	0.513
LIG_FHA_1	211	217	PF00498	0.550
LIG_FHA_1	24	30	PF00498	0.669
LIG_FHA_1	388	394	PF00498	0.708
LIG_FHA_1	411	417	PF00498	0.683
LIG_FHA_2	231	237	PF00498	0.564
LIG_FHA_2	249	255	PF00498	0.363
LIG_FHA_2	416	422	PF00498	0.766
LIG_FHA_2	93	99	PF00498	0.531
LIG_GBD_Chelix_1	282	290	PF00786	0.474
LIG_HP1_1	275	279	PF01393	0.280
LIG_IRF3_LxIS_1	282	289	PF10401	0.436
LIG_LIR_Apic_2	448	452	PF02991	0.776
LIG_LIR_Gen_1	23	32	PF02991	0.584
LIG_LIR_Gen_1	258	267	PF02991	0.520
LIG_LIR_Nem_3	122	128	PF02991	0.579
LIG_LIR_Nem_3	225	231	PF02991	0.515
LIG_LIR_Nem_3	23	28	PF02991	0.578
LIG_LIR_Nem_3	258	264	PF02991	0.518
LIG_LIR_Nem_3	382	386	PF02991	0.676
LIG_NRBOX	14	20	PF00104	0.661
LIG_PDZ_Class_2	456	461	PF00595	0.833
LIG_Pex14_1	115	119	PF04695	0.580
LIG_Pex14_2	180	184	PF04695	0.502
LIG_Pex14_2	69	73	PF04695	0.557
LIG_SH2_GRB2like	181	184	PF00017	0.505
LIG_SH2_GRB2like	192	195	PF00017	0.479
LIG_SH2_NCK_1	363	367	PF00017	0.671
LIG_SH2_SRC	234	237	PF00017	0.564
LIG_SH2_STAP1	224	228	PF00017	0.500
LIG_SH2_STAT5	119	122	PF00017	0.523
LIG_SH2_STAT5	181	184	PF00017	0.487
LIG_SH2_STAT5	224	227	PF00017	0.542
LIG_SH2_STAT5	234	237	PF00017	0.474
LIG_SH2_STAT5	294	297	PF00017	0.543
LIG_SH2_STAT5	36	39	PF00017	0.487
LIG_SH3_3	1	7	PF00018	0.649
LIG_SH3_3	236	242	PF00018	0.510
LIG_SH3_3	348	354	PF00018	0.714
LIG_SH3_3	416	422	PF00018	0.794
LIG_SH3_4	299	306	PF00018	0.729
LIG_SH3_4	355	362	PF00018	0.654
LIG_SUMO_SIM_anti_2	289	294	PF11976	0.436
LIG_SUMO_SIM_par_1	212	217	PF11976	0.488
LIG_SUMO_SIM_par_1	52	59	PF11976	0.565
LIG_UBA3_1	291	299	PF00899	0.646
LIG_WRPW_2	198	201	PF00400	0.536
MOD_CDK_SPK_2	350	355	PF00069	0.719
MOD_CDK_SPxxK_3	238	245	PF00069	0.522
MOD_CK1_1	23	29	PF00069	0.519
MOD_CK1_1	338	344	PF00069	0.760
MOD_CK1_1	367	373	PF00069	0.801
MOD_CK1_1	403	409	PF00069	0.819
MOD_CK1_1	410	416	PF00069	0.766
MOD_CK1_1	433	439	PF00069	0.870
MOD_CK1_1	442	448	PF00069	0.751
MOD_CK2_1	230	236	PF00069	0.493
MOD_CK2_1	92	98	PF00069	0.566
MOD_DYRK1A_RPxSP_1	238	242	PF00069	0.511
MOD_GlcNHglycan	121	124	PF01048	0.776
MOD_GlcNHglycan	22	25	PF01048	0.610
MOD_GlcNHglycan	345	348	PF01048	0.582
MOD_GlcNHglycan	413	416	PF01048	0.513
MOD_GlcNHglycan	438	441	PF01048	0.666
MOD_GSK3_1	115	122	PF00069	0.524
MOD_GSK3_1	20	27	PF00069	0.522
MOD_GSK3_1	248	255	PF00069	0.556
MOD_GSK3_1	334	341	PF00069	0.750
MOD_GSK3_1	372	379	PF00069	0.805
MOD_GSK3_1	396	403	PF00069	0.833
MOD_GSK3_1	406	413	PF00069	0.754
MOD_LATS_1	394	400	PF00433	0.828
MOD_N-GLC_1	115	120	PF02516	0.724
MOD_N-GLC_1	182	187	PF02516	0.699
MOD_N-GLC_1	193	198	PF02516	0.691
MOD_N-GLC_1	210	215	PF02516	0.717
MOD_N-GLC_1	387	392	PF02516	0.533
MOD_N-GLC_1	63	68	PF02516	0.770
MOD_NEK2_1	14	19	PF00069	0.600
MOD_NEK2_1	20	25	PF00069	0.573
MOD_NEK2_1	252	257	PF00069	0.567
MOD_NEK2_1	286	291	PF00069	0.436
MOD_NEK2_1	84	89	PF00069	0.559
MOD_PIKK_1	367	373	PF00454	0.829
MOD_PKA_1	335	341	PF00069	0.747
MOD_PKA_2	222	228	PF00069	0.451
MOD_PKA_2	334	340	PF00069	0.729
MOD_PKA_2	379	385	PF00069	0.844
MOD_PKA_2	395	401	PF00069	0.688
MOD_PKA_2	406	412	PF00069	0.742
MOD_PKA_2	455	461	PF00069	0.759
MOD_Plk_1	115	121	PF00069	0.524
MOD_Plk_1	193	199	PF00069	0.479
MOD_Plk_1	210	216	PF00069	0.508
MOD_Plk_4	124	130	PF00069	0.554
MOD_Plk_4	14	20	PF00069	0.552
MOD_Plk_4	230	236	PF00069	0.502
MOD_Plk_4	24	30	PF00069	0.630
MOD_Plk_4	248	254	PF00069	0.388
MOD_Plk_4	379	385	PF00069	0.816
MOD_Plk_4	423	429	PF00069	0.840
MOD_Plk_4	65	71	PF00069	0.495
MOD_Plk_4	85	91	PF00069	0.327
MOD_ProDKin_1	238	244	PF00069	0.485
MOD_ProDKin_1	255	261	PF00069	0.482
MOD_ProDKin_1	30	36	PF00069	0.491
MOD_ProDKin_1	340	346	PF00069	0.709
MOD_ProDKin_1	350	356	PF00069	0.740
MOD_ProDKin_1	407	413	PF00069	0.850
MOD_ProDKin_1	442	448	PF00069	0.789
MOD_SUMO_for_1	302	305	PF00179	0.729
MOD_SUMO_for_1	310	313	PF00179	0.671
MOD_SUMO_for_1	320	323	PF00179	0.542
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.476
TRG_DiLeu_BaLyEn_6	449	454	PF01217	0.775
TRG_ENDOCYTIC_2	181	184	PF00928	0.505
TRG_ENDOCYTIC_2	228	231	PF00928	0.572
TRG_ER_diArg_1	226	228	PF00400	0.576
TRG_ER_diArg_1	330	332	PF00400	0.720
TRG_ER_diArg_1	386	389	PF00400	0.719
TRG_NLS_MonoCore_2	328	333	PF00514	0.780

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W9	Leptomonas seymouri	36%	100%
A0A3S7WSX8	Leishmania donovani	87%	94%
A4H7L3	Leishmania braziliensis	67%	94%
A4HVZ8	Leishmania infantum	87%	94%
E9APQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	94%