Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QFS4_LEIMA

TriTrypDb:

LmjF.14.0610 , LMJLV39_140012000 , LMJSD75_140011600

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0020023	kinetoplast	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QFS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.552
CLV_C14_Caspase3-7	400	404	PF00656	0.736
CLV_NRD_NRD_1	232	234	PF00675	0.507
CLV_NRD_NRD_1	240	242	PF00675	0.471
CLV_NRD_NRD_1	357	359	PF00675	0.574
CLV_NRD_NRD_1	415	417	PF00675	0.726
CLV_NRD_NRD_1	419	421	PF00675	0.770
CLV_NRD_NRD_1	43	45	PF00675	0.603
CLV_NRD_NRD_1	433	435	PF00675	0.522
CLV_NRD_NRD_1	440	442	PF00675	0.717
CLV_PCSK_FUR_1	416	420	PF00082	0.607
CLV_PCSK_KEX2_1	232	234	PF00082	0.507
CLV_PCSK_KEX2_1	240	242	PF00082	0.471
CLV_PCSK_KEX2_1	357	359	PF00082	0.574
CLV_PCSK_KEX2_1	415	417	PF00082	0.727
CLV_PCSK_KEX2_1	418	420	PF00082	0.748
CLV_PCSK_KEX2_1	43	45	PF00082	0.603
CLV_PCSK_KEX2_1	433	435	PF00082	0.526
CLV_PCSK_KEX2_1	440	442	PF00082	0.793
CLV_PCSK_PC1ET2_1	433	435	PF00082	0.696
CLV_PCSK_PC7_1	415	421	PF00082	0.589
CLV_PCSK_SKI1_1	250	254	PF00082	0.497
CLV_PCSK_SKI1_1	340	344	PF00082	0.537
CLV_PCSK_SKI1_1	358	362	PF00082	0.569
CLV_PCSK_SKI1_1	365	369	PF00082	0.581
DEG_Nend_UBRbox_1	1	4	PF02207	0.584
DEG_SCF_FBW7_2	316	323	PF00400	0.587
DOC_CDC14_PxL_1	341	349	PF14671	0.641
DOC_CYCLIN_RxL_1	331	339	PF00134	0.503
DOC_MAPK_gen_1	232	238	PF00069	0.574
DOC_MAPK_HePTP_8	337	349	PF00069	0.643
DOC_MAPK_MEF2A_6	340	349	PF00069	0.525
DOC_PP1_RVXF_1	263	269	PF00149	0.406
DOC_PP1_RVXF_1	274	280	PF00149	0.519
DOC_PP2B_LxvP_1	234	237	PF13499	0.433
DOC_PP2B_LxvP_1	342	345	PF13499	0.635
DOC_USP7_MATH_1	18	22	PF00917	0.558
DOC_USP7_MATH_1	71	75	PF00917	0.771
DOC_USP7_MATH_2	284	290	PF00917	0.645
DOC_WW_Pin1_4	129	134	PF00397	0.676
DOC_WW_Pin1_4	225	230	PF00397	0.502
DOC_WW_Pin1_4	245	250	PF00397	0.434
DOC_WW_Pin1_4	316	321	PF00397	0.591
DOC_WW_Pin1_4	433	438	PF00397	0.738
LIG_14-3-3_CanoR_1	12	22	PF00244	0.644
LIG_14-3-3_CanoR_1	127	133	PF00244	0.657
LIG_14-3-3_CanoR_1	265	269	PF00244	0.522
LIG_14-3-3_CanoR_1	422	431	PF00244	0.590
LIG_APCC_ABBAyCdc20_2	166	172	PF00400	0.467
LIG_BIR_III_4	394	398	PF00653	0.645
LIG_BRCT_BRCA1_1	226	230	PF00533	0.606
LIG_CaM_IQ_9	52	68	PF13499	0.554
LIG_eIF4E_1	246	252	PF01652	0.544
LIG_EVH1_1	149	153	PF00568	0.539
LIG_FHA_1	240	246	PF00498	0.475
LIG_FHA_1	333	339	PF00498	0.529
LIG_FHA_1	437	443	PF00498	0.695
LIG_FHA_1	53	59	PF00498	0.664
LIG_FHA_2	280	286	PF00498	0.619
LIG_FHA_2	317	323	PF00498	0.586
LIG_FHA_2	359	365	PF00498	0.567
LIG_FHA_2	87	93	PF00498	0.715
LIG_GBD_Chelix_1	258	266	PF00786	0.426
LIG_LIR_Gen_1	155	165	PF02991	0.474
LIG_LIR_Gen_1	95	104	PF02991	0.740
LIG_LIR_Nem_3	317	321	PF02991	0.693
LIG_RPA_C_Fungi	251	263	PF08784	0.507
LIG_SH2_CRK	246	250	PF00017	0.440
LIG_SH2_NCK_1	318	322	PF00017	0.586
LIG_SH2_STAT3	53	56	PF00017	0.662
LIG_SH2_STAT5	261	264	PF00017	0.431
LIG_SH2_STAT5	278	281	PF00017	0.550
LIG_SH2_STAT5	318	321	PF00017	0.588
LIG_SH2_STAT5	341	344	PF00017	0.511
LIG_SH2_STAT5	464	467	PF00017	0.608
LIG_SH2_STAT5	53	56	PF00017	0.623
LIG_SH3_3	101	107	PF00018	0.734
LIG_SH3_3	147	153	PF00018	0.736
LIG_SH3_3	223	229	PF00018	0.473
LIG_SUMO_SIM_par_1	334	339	PF11976	0.529
LIG_TRAF2_1	133	136	PF00917	0.604
LIG_TRAF2_1	320	323	PF00917	0.576
LIG_TRAF2_1	380	383	PF00917	0.569
LIG_TYR_ITIM	316	321	PF00017	0.591
LIG_UBA3_1	347	353	PF00899	0.534
LIG_WRC_WIRS_1	22	27	PF05994	0.531
MOD_CDK_SPK_2	245	250	PF00069	0.434
MOD_CDK_SPxxK_3	225	232	PF00069	0.608
MOD_CDK_SPxxK_3	433	440	PF00069	0.690
MOD_CK1_1	137	143	PF00069	0.670
MOD_CK1_1	21	27	PF00069	0.616
MOD_CK1_1	436	442	PF00069	0.726
MOD_CK1_1	76	82	PF00069	0.723
MOD_CK2_1	129	135	PF00069	0.671
MOD_CK2_1	145	151	PF00069	0.590
MOD_CK2_1	279	285	PF00069	0.495
MOD_CK2_1	316	322	PF00069	0.590
MOD_CK2_1	358	364	PF00069	0.567
MOD_Cter_Amidation	238	241	PF01082	0.501
MOD_Cter_Amidation	431	434	PF01082	0.603
MOD_GlcNHglycan	114	117	PF01048	0.633
MOD_GlcNHglycan	16	19	PF01048	0.704
MOD_GlcNHglycan	196	199	PF01048	0.736
MOD_GlcNHglycan	220	223	PF01048	0.657
MOD_GlcNHglycan	288	291	PF01048	0.744
MOD_GlcNHglycan	32	35	PF01048	0.506
MOD_GlcNHglycan	399	402	PF01048	0.677
MOD_GlcNHglycan	407	410	PF01048	0.684
MOD_GlcNHglycan	49	52	PF01048	0.628
MOD_GlcNHglycan	6	9	PF01048	0.582
MOD_GlcNHglycan	75	78	PF01048	0.629
MOD_GSK3_1	14	21	PF00069	0.672
MOD_GSK3_1	212	219	PF00069	0.717
MOD_GSK3_1	23	30	PF00069	0.626
MOD_GSK3_1	405	412	PF00069	0.691
MOD_GSK3_1	71	78	PF00069	0.726
MOD_NEK2_1	194	199	PF00069	0.667
MOD_NEK2_1	251	256	PF00069	0.407
MOD_NEK2_1	279	284	PF00069	0.596
MOD_NEK2_1	4	9	PF00069	0.580
MOD_NEK2_1	58	63	PF00069	0.744
MOD_NEK2_2	18	23	PF00069	0.522
MOD_NEK2_2	451	456	PF00069	0.641
MOD_PIKK_1	443	449	PF00454	0.631
MOD_PIKK_1	52	58	PF00454	0.705
MOD_PIKK_1	59	65	PF00454	0.681
MOD_PKA_1	65	71	PF00069	0.676
MOD_PKA_2	137	143	PF00069	0.650
MOD_PKA_2	239	245	PF00069	0.585
MOD_PKA_2	264	270	PF00069	0.426
MOD_PKA_2	423	429	PF00069	0.654
MOD_PKA_2	451	457	PF00069	0.620
MOD_PKA_2	59	65	PF00069	0.575
MOD_PKB_1	422	430	PF00069	0.656
MOD_PKB_1	441	449	PF00069	0.480
MOD_Plk_1	109	115	PF00069	0.758
MOD_Plk_1	321	327	PF00069	0.554
MOD_Plk_2-3	375	381	PF00069	0.748
MOD_Plk_2-3	87	93	PF00069	0.726
MOD_ProDKin_1	129	135	PF00069	0.676
MOD_ProDKin_1	225	231	PF00069	0.490
MOD_ProDKin_1	245	251	PF00069	0.427
MOD_ProDKin_1	316	322	PF00069	0.590
MOD_ProDKin_1	433	439	PF00069	0.737
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.538
TRG_ENDOCYTIC_2	318	321	PF00928	0.588
TRG_ER_diArg_1	231	233	PF00400	0.577
TRG_ER_diArg_1	273	276	PF00400	0.466
TRG_ER_diArg_1	357	359	PF00400	0.573
TRG_ER_diArg_1	415	418	PF00400	0.692
TRG_ER_diArg_1	419	422	PF00400	0.638
TRG_ER_diArg_1	440	443	PF00400	0.801
TRG_NLS_Bipartite_1	415	437	PF00514	0.602
TRG_NLS_MonoExtC_3	432	437	PF00514	0.566
TRG_NLS_MonoExtN_4	431	437	PF00514	0.599
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	334	339	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAF5	Leptomonas seymouri	50%	100%
A0A3Q8I8S7	Leishmania donovani	87%	100%
A4H7L8	Leishmania braziliensis	72%	100%
A4HW03	Leishmania infantum	87%	100%
E9APQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	93%