LeishMANIAdb
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Rap-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Rap-GAP domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QFS3_LEIMA
TriTrypDb:
LmjF.14.0620 * , LMJLV39_140012100 * , LMJSD75_140011700 *
Length:
668

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QFS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QFS3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 198 202 PF00656 0.732
CLV_C14_Caspase3-7 247 251 PF00656 0.737
CLV_C14_Caspase3-7 507 511 PF00656 0.648
CLV_NRD_NRD_1 120 122 PF00675 0.490
CLV_NRD_NRD_1 174 176 PF00675 0.447
CLV_NRD_NRD_1 390 392 PF00675 0.665
CLV_NRD_NRD_1 397 399 PF00675 0.530
CLV_NRD_NRD_1 446 448 PF00675 0.698
CLV_NRD_NRD_1 456 458 PF00675 0.601
CLV_NRD_NRD_1 517 519 PF00675 0.680
CLV_NRD_NRD_1 544 546 PF00675 0.740
CLV_NRD_NRD_1 561 563 PF00675 0.519
CLV_NRD_NRD_1 655 657 PF00675 0.686
CLV_NRD_NRD_1 662 664 PF00675 0.585
CLV_PCSK_FUR_1 515 519 PF00082 0.680
CLV_PCSK_FUR_1 559 563 PF00082 0.793
CLV_PCSK_KEX2_1 105 107 PF00082 0.523
CLV_PCSK_KEX2_1 120 122 PF00082 0.475
CLV_PCSK_KEX2_1 174 176 PF00082 0.447
CLV_PCSK_KEX2_1 390 392 PF00082 0.665
CLV_PCSK_KEX2_1 402 404 PF00082 0.440
CLV_PCSK_KEX2_1 446 448 PF00082 0.698
CLV_PCSK_KEX2_1 456 458 PF00082 0.601
CLV_PCSK_KEX2_1 517 519 PF00082 0.680
CLV_PCSK_KEX2_1 533 535 PF00082 0.433
CLV_PCSK_KEX2_1 544 546 PF00082 0.558
CLV_PCSK_KEX2_1 561 563 PF00082 0.519
CLV_PCSK_KEX2_1 625 627 PF00082 0.584
CLV_PCSK_KEX2_1 655 657 PF00082 0.686
CLV_PCSK_KEX2_1 662 664 PF00082 0.585
CLV_PCSK_PC1ET2_1 105 107 PF00082 0.523
CLV_PCSK_PC1ET2_1 402 404 PF00082 0.639
CLV_PCSK_PC1ET2_1 533 535 PF00082 0.698
CLV_PCSK_PC1ET2_1 625 627 PF00082 0.584
CLV_PCSK_PC7_1 398 404 PF00082 0.640
CLV_PCSK_PC7_1 442 448 PF00082 0.690
CLV_PCSK_SKI1_1 358 362 PF00082 0.740
CLV_PCSK_SKI1_1 390 394 PF00082 0.655
CLV_PCSK_SKI1_1 399 403 PF00082 0.494
CLV_PCSK_SKI1_1 47 51 PF00082 0.449
CLV_PCSK_SKI1_1 545 549 PF00082 0.714
CLV_PCSK_SKI1_1 625 629 PF00082 0.677
CLV_PCSK_SKI1_1 655 659 PF00082 0.684
CLV_PCSK_SKI1_1 662 666 PF00082 0.594
DEG_APCC_DBOX_1 173 181 PF00400 0.494
DEG_Nend_Nbox_1 1 3 PF02207 0.458
DEG_SCF_FBW7_1 157 163 PF00400 0.520
DEG_SCF_FBW7_1 627 632 PF00400 0.646
DEG_SPOP_SBC_1 236 240 PF00917 0.615
DEG_SPOP_SBC_1 328 332 PF00917 0.787
DEG_SPOP_SBC_1 351 355 PF00917 0.594
DOC_CKS1_1 157 162 PF01111 0.575
DOC_CYCLIN_RxL_1 384 397 PF00134 0.661
DOC_CYCLIN_yCln2_LP_2 19 25 PF00134 0.457
DOC_CYCLIN_yCln2_LP_2 547 553 PF00134 0.628
DOC_MAPK_FxFP_2 147 150 PF00069 0.475
DOC_MAPK_gen_1 174 183 PF00069 0.420
DOC_MAPK_gen_1 423 431 PF00069 0.675
DOC_MAPK_gen_1 544 551 PF00069 0.668
DOC_MAPK_MEF2A_6 20 27 PF00069 0.458
DOC_MAPK_MEF2A_6 423 431 PF00069 0.675
DOC_MAPK_MEF2A_6 544 553 PF00069 0.666
DOC_PP1_RVXF_1 45 52 PF00149 0.452
DOC_PP2B_LxvP_1 34 37 PF13499 0.458
DOC_PP2B_LxvP_1 499 502 PF13499 0.738
DOC_PP2B_LxvP_1 547 550 PF13499 0.633
DOC_PP2B_PxIxI_1 92 98 PF00149 0.494
DOC_PP4_FxxP_1 147 150 PF00568 0.474
DOC_PP4_FxxP_1 27 30 PF00568 0.448
DOC_USP7_MATH_1 153 157 PF00917 0.553
DOC_USP7_MATH_1 236 240 PF00917 0.689
DOC_USP7_MATH_1 265 269 PF00917 0.819
DOC_USP7_MATH_1 285 289 PF00917 0.503
DOC_USP7_MATH_1 328 332 PF00917 0.713
DOC_USP7_MATH_1 455 459 PF00917 0.708
DOC_USP7_MATH_1 464 468 PF00917 0.668
DOC_USP7_MATH_1 657 661 PF00917 0.607
DOC_WW_Pin1_4 156 161 PF00397 0.577
DOC_WW_Pin1_4 18 23 PF00397 0.458
DOC_WW_Pin1_4 223 228 PF00397 0.827
DOC_WW_Pin1_4 261 266 PF00397 0.807
DOC_WW_Pin1_4 332 337 PF00397 0.688
DOC_WW_Pin1_4 35 40 PF00397 0.427
DOC_WW_Pin1_4 377 382 PF00397 0.672
DOC_WW_Pin1_4 486 491 PF00397 0.711
DOC_WW_Pin1_4 571 576 PF00397 0.739
DOC_WW_Pin1_4 606 611 PF00397 0.814
DOC_WW_Pin1_4 625 630 PF00397 0.442
DOC_WW_Pin1_4 65 70 PF00397 0.592
DOC_WW_Pin1_4 73 78 PF00397 0.546
DOC_WW_Pin1_4 86 91 PF00397 0.577
LIG_14-3-3_CanoR_1 120 126 PF00244 0.481
LIG_14-3-3_CanoR_1 13 19 PF00244 0.441
LIG_14-3-3_CanoR_1 152 158 PF00244 0.500
LIG_14-3-3_CanoR_1 175 181 PF00244 0.418
LIG_14-3-3_CanoR_1 291 297 PF00244 0.780
LIG_14-3-3_CanoR_1 327 336 PF00244 0.760
LIG_14-3-3_CanoR_1 337 344 PF00244 0.756
LIG_14-3-3_CanoR_1 390 395 PF00244 0.575
LIG_14-3-3_CanoR_1 446 455 PF00244 0.618
LIG_14-3-3_CanoR_1 471 479 PF00244 0.797
LIG_14-3-3_CanoR_1 60 69 PF00244 0.488
LIG_14-3-3_CanoR_1 655 664 PF00244 0.526
LIG_BRCT_BRCA1_1 334 338 PF00533 0.692
LIG_BRCT_BRCA1_1 370 374 PF00533 0.694
LIG_EVH1_1 36 40 PF00568 0.441
LIG_EVH1_2 39 43 PF00568 0.443
LIG_FHA_1 140 146 PF00498 0.421
LIG_FHA_1 161 167 PF00498 0.529
LIG_FHA_1 219 225 PF00498 0.749
LIG_FHA_1 352 358 PF00498 0.708
LIG_FHA_1 474 480 PF00498 0.823
LIG_FHA_1 487 493 PF00498 0.582
LIG_FHA_1 546 552 PF00498 0.672
LIG_FHA_1 656 662 PF00498 0.689
LIG_FHA_2 245 251 PF00498 0.737
LIG_FHA_2 293 299 PF00498 0.819
LIG_FHA_2 505 511 PF00498 0.627
LIG_FHA_2 523 529 PF00498 0.387
LIG_FHA_2 74 80 PF00498 0.498
LIG_LIR_Apic_2 124 128 PF02991 0.470
LIG_LIR_Apic_2 146 150 PF02991 0.472
LIG_LIR_Apic_2 24 30 PF02991 0.453
LIG_LIR_Gen_1 335 346 PF02991 0.677
LIG_LIR_Gen_1 630 640 PF02991 0.632
LIG_LIR_Nem_3 335 341 PF02991 0.686
LIG_LIR_Nem_3 41 45 PF02991 0.451
LIG_LIR_Nem_3 615 621 PF02991 0.834
LIG_LIR_Nem_3 630 636 PF02991 0.450
LIG_MYND_1 497 501 PF01753 0.745
LIG_PCNA_PIPBox_1 119 128 PF02747 0.478
LIG_PCNA_yPIPBox_3 112 126 PF02747 0.502
LIG_PCNA_yPIPBox_3 382 391 PF02747 0.445
LIG_PTB_Apo_2 231 238 PF02174 0.613
LIG_REV1ctd_RIR_1 40 51 PF16727 0.448
LIG_SH2_SRC 495 498 PF00017 0.752
LIG_SH2_STAT5 125 128 PF00017 0.570
LIG_SH2_STAT5 18 21 PF00017 0.460
LIG_SH2_STAT5 185 188 PF00017 0.520
LIG_SH2_STAT5 495 498 PF00017 0.752
LIG_SH3_3 147 153 PF00018 0.616
LIG_SH3_3 158 164 PF00018 0.596
LIG_SH3_3 26 32 PF00018 0.451
LIG_SH3_3 274 280 PF00018 0.658
LIG_SH3_3 338 344 PF00018 0.758
LIG_SH3_3 34 40 PF00018 0.440
LIG_SH3_3 375 381 PF00018 0.573
LIG_SH3_3 499 505 PF00018 0.734
LIG_SH3_3 546 552 PF00018 0.746
LIG_SH3_3 607 613 PF00018 0.630
LIG_SH3_3 87 93 PF00018 0.584
LIG_SUMO_SIM_par_1 21 26 PF11976 0.456
LIG_SUMO_SIM_par_1 32 38 PF11976 0.443
LIG_SxIP_EBH_1 583 596 PF03271 0.564
LIG_WW_2 29 32 PF00397 0.453
LIG_WW_3 609 613 PF00397 0.630
MOD_CDC14_SPxK_1 574 577 PF00782 0.737
MOD_CDK_SPK_2 332 337 PF00069 0.771
MOD_CDK_SPK_2 73 78 PF00069 0.495
MOD_CDK_SPK_2 86 91 PF00069 0.480
MOD_CDK_SPxK_1 571 577 PF00069 0.747
MOD_CDK_SPxK_1 606 612 PF00069 0.628
MOD_CDK_SPxxK_3 377 384 PF00069 0.653
MOD_CK1_1 156 162 PF00069 0.596
MOD_CK1_1 165 171 PF00069 0.541
MOD_CK1_1 179 185 PF00069 0.410
MOD_CK1_1 21 27 PF00069 0.456
MOD_CK1_1 248 254 PF00069 0.767
MOD_CK1_1 268 274 PF00069 0.499
MOD_CK1_1 286 292 PF00069 0.614
MOD_CK1_1 329 335 PF00069 0.831
MOD_CK1_1 349 355 PF00069 0.625
MOD_CK1_1 368 374 PF00069 0.621
MOD_CK1_1 38 44 PF00069 0.427
MOD_CK1_1 458 464 PF00069 0.809
MOD_CK1_1 467 473 PF00069 0.684
MOD_CK1_1 480 486 PF00069 0.629
MOD_CK1_1 61 67 PF00069 0.558
MOD_CK2_1 447 453 PF00069 0.585
MOD_CK2_1 522 528 PF00069 0.458
MOD_CK2_1 662 668 PF00069 0.601
MOD_GlcNHglycan 193 196 PF01048 0.675
MOD_GlcNHglycan 285 288 PF01048 0.607
MOD_GlcNHglycan 308 314 PF01048 0.562
MOD_GlcNHglycan 331 334 PF01048 0.706
MOD_GlcNHglycan 348 351 PF01048 0.658
MOD_GlcNHglycan 354 357 PF01048 0.691
MOD_GlcNHglycan 449 452 PF01048 0.683
MOD_GlcNHglycan 458 461 PF01048 0.680
MOD_GlcNHglycan 467 470 PF01048 0.572
MOD_GlcNHglycan 593 596 PF01048 0.672
MOD_GlcNHglycan 60 63 PF01048 0.484
MOD_GlcNHglycan 82 85 PF01048 0.525
MOD_GSK3_1 139 146 PF00069 0.423
MOD_GSK3_1 14 21 PF00069 0.447
MOD_GSK3_1 151 158 PF00069 0.578
MOD_GSK3_1 187 194 PF00069 0.572
MOD_GSK3_1 203 210 PF00069 0.572
MOD_GSK3_1 244 251 PF00069 0.803
MOD_GSK3_1 261 268 PF00069 0.574
MOD_GSK3_1 283 290 PF00069 0.777
MOD_GSK3_1 292 299 PF00069 0.684
MOD_GSK3_1 327 334 PF00069 0.825
MOD_GSK3_1 346 353 PF00069 0.718
MOD_GSK3_1 364 371 PF00069 0.568
MOD_GSK3_1 455 462 PF00069 0.705
MOD_GSK3_1 467 474 PF00069 0.700
MOD_GSK3_1 475 482 PF00069 0.603
MOD_GSK3_1 500 507 PF00069 0.654
MOD_GSK3_1 60 67 PF00069 0.490
MOD_GSK3_1 625 632 PF00069 0.667
MOD_LATS_1 136 142 PF00433 0.413
MOD_LATS_1 445 451 PF00433 0.620
MOD_NEK2_1 14 19 PF00069 0.443
MOD_NEK2_1 191 196 PF00069 0.626
MOD_NEK2_1 203 208 PF00069 0.570
MOD_NEK2_1 237 242 PF00069 0.618
MOD_NEK2_1 370 375 PF00069 0.733
MOD_NEK2_1 481 486 PF00069 0.699
MOD_NEK2_1 555 560 PF00069 0.773
MOD_NEK2_2 657 662 PF00069 0.609
MOD_PIKK_1 218 224 PF00454 0.836
MOD_PIKK_1 238 244 PF00454 0.523
MOD_PIKK_1 336 342 PF00454 0.841
MOD_PIKK_1 5 11 PF00454 0.411
MOD_PIKK_1 500 506 PF00454 0.723
MOD_PK_1 176 182 PF00069 0.411
MOD_PKA_1 390 396 PF00069 0.573
MOD_PKA_1 456 462 PF00069 0.704
MOD_PKA_1 655 661 PF00069 0.685
MOD_PKA_1 662 668 PF00069 0.602
MOD_PKA_2 151 157 PF00069 0.497
MOD_PKA_2 170 176 PF00069 0.444
MOD_PKA_2 290 296 PF00069 0.779
MOD_PKA_2 326 332 PF00069 0.750
MOD_PKA_2 336 342 PF00069 0.800
MOD_PKA_2 390 396 PF00069 0.573
MOD_PKA_2 455 461 PF00069 0.712
MOD_PKA_2 464 470 PF00069 0.659
MOD_PKA_2 522 528 PF00069 0.458
MOD_PKA_2 586 592 PF00069 0.672
MOD_PKA_2 640 646 PF00069 0.602
MOD_PKA_2 655 661 PF00069 0.437
MOD_PKA_2 662 668 PF00069 0.602
MOD_PKB_1 11 19 PF00069 0.434
MOD_PKB_1 325 333 PF00069 0.714
MOD_Plk_1 309 315 PF00069 0.641
MOD_Plk_1 416 422 PF00069 0.705
MOD_Plk_1 545 551 PF00069 0.669
MOD_Plk_1 629 635 PF00069 0.651
MOD_Plk_2-3 522 528 PF00069 0.458
MOD_Plk_4 121 127 PF00069 0.575
MOD_Plk_4 14 20 PF00069 0.447
MOD_Plk_4 143 149 PF00069 0.455
MOD_Plk_4 162 168 PF00069 0.530
MOD_Plk_4 176 182 PF00069 0.397
MOD_Plk_4 187 193 PF00069 0.483
MOD_Plk_4 203 209 PF00069 0.706
MOD_Plk_4 38 44 PF00069 0.443
MOD_Plk_4 390 396 PF00069 0.573
MOD_Plk_4 431 437 PF00069 0.700
MOD_Plk_4 629 635 PF00069 0.586
MOD_Plk_4 640 646 PF00069 0.446
MOD_ProDKin_1 156 162 PF00069 0.582
MOD_ProDKin_1 18 24 PF00069 0.457
MOD_ProDKin_1 223 229 PF00069 0.829
MOD_ProDKin_1 261 267 PF00069 0.805
MOD_ProDKin_1 332 338 PF00069 0.688
MOD_ProDKin_1 35 41 PF00069 0.427
MOD_ProDKin_1 377 383 PF00069 0.663
MOD_ProDKin_1 486 492 PF00069 0.711
MOD_ProDKin_1 571 577 PF00069 0.741
MOD_ProDKin_1 606 612 PF00069 0.817
MOD_ProDKin_1 625 631 PF00069 0.438
MOD_ProDKin_1 65 71 PF00069 0.594
MOD_ProDKin_1 73 79 PF00069 0.546
MOD_ProDKin_1 86 92 PF00069 0.574
MOD_SUMO_for_1 104 107 PF00179 0.515
MOD_SUMO_rev_2 397 404 PF00179 0.642
MOD_SUMO_rev_2 528 535 PF00179 0.694
MOD_SUMO_rev_2 620 627 PF00179 0.727
TRG_DiLeu_BaEn_1 10 15 PF01217 0.417
TRG_DiLeu_BaEn_4 306 312 PF01217 0.675
TRG_DiLeu_BaEn_4 530 536 PF01217 0.697
TRG_DiLeu_BaLyEn_6 29 34 PF01217 0.458
TRG_DiLeu_LyEn_5 10 15 PF01217 0.417
TRG_ENDOCYTIC_2 408 411 PF00928 0.652
TRG_ER_diArg_1 120 122 PF00400 0.490
TRG_ER_diArg_1 324 327 PF00400 0.708
TRG_ER_diArg_1 389 391 PF00400 0.669
TRG_ER_diArg_1 455 457 PF00400 0.690
TRG_ER_diArg_1 515 518 PF00400 0.682
TRG_ER_diArg_1 543 545 PF00400 0.733
TRG_ER_diArg_1 559 562 PF00400 0.528
TRG_ER_diArg_1 654 656 PF00400 0.677
TRG_ER_diArg_1 661 663 PF00400 0.581

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S7WSY4 Leishmania donovani 86% 100%
A4H7L9 Leishmania braziliensis 63% 100%
A4HW04 Leishmania infantum 75% 100%
E9APQ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS